Chrysophanol-induced necrotic-like cell death through an impaired mitochondrial ATP synthesis in Hep3B human liver cancer cells

Archives of Pharmacal Research

Volumn 35, Issue 5, 2012, Pages 887-895

  Ni, Chien Hang ^a   Chen, Po Yuan ^b   Lu, Hsu Feng ^c   Yang, Jai Sing ^b   Huang, Hui Ying ^b   Wu, Shin Hwar ^b,d   Ip, Siu Wan ^b   Wu, Chin Tung ^d   Chiang, Su Yin ^e   Lin, Jaung Geng ^b   Wood, W Gibson ^f   Chung, Jing Gung ^b,g  

^a E DA HOSPITAL   (Taiwan)

^b CHINA MEDICAL UNIVERSITY   (Taiwan)

^c CHENG HSIN GENERAL HOSPITAL   (Taiwan)

^d NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

^e CHANGHUA CHRISTIAN HOSPITAL   (Taiwan)

^f UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^g ASIA UNIVERSITY   (Taiwan)

Author keywords

Chrysophanol; Human liver cancer cells (Hep3B); Mitochondrial membrane potential; Necrosis; Reactive oxygen species

Indexed keywords

ANTINEOPLASTIC AGENT; APOPTOTIC PROTEASE ACTIVATING FACTOR 1; CALCIUM ION; CASPASE 8; CASPASE 9; CATALASE; CHRYSOPHANIC ACID; CYTOCHROME C; PROTEIN BAX; PROTEIN BCL 2; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE;

ARTICLE; CANCER CELL; CANCER INHIBITION; CELL CYCLE PROGRESSION; CELL DEATH; CELL DENSITY; CELL STRAIN HEP3B; CELL STRUCTURE; CELL VIABILITY; COMET ASSAY; CONTROLLED STUDY; DNA DAMAGE; ENZYME SYNTHESIS; FLOW CYTOMETRY; HUMAN; HUMAN CELL; LIVER CANCER; MITOCHONDRIAL MEMBRANE POTENTIAL; S PHASE CELL CYCLE CHECKPOINT;

ADENOSINE TRIPHOSPHATE; ANTHRAQUINONES; CARCINOMA, HEPATOCELLULAR; CELL DEATH; CELL LINE, TUMOR; HUMANS; LIVER NEOPLASMS; MITOCHONDRIA, LIVER; NECROSIS;

EID: 84862835740     PISSN: 02536269     EISSN: 19763786     Source Type: Journal    
DOI: 10.1007/s12272-012-0514-z     Document Type: Article

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