-
1
-
-
0032499024
-
Homocysteine and atherothrombosis
-
Welch GN, Loscalzo J, (1998) Homocysteine and atherothrombosis. N Engl J Med 338: 1042-1050.
-
(1998)
N Engl J Med
, vol.338
, pp. 1042-1050
-
-
Welch, G.N.1
Loscalzo, J.2
-
2
-
-
0034023742
-
Homocysteine and atherothrombosis- mechanisms for injury
-
Thambyrajah J, Townend JN, (2000) Homocysteine and atherothrombosis- mechanisms for injury. Eur Heart J 21: 967-974.
-
(2000)
Eur Heart J
, vol.21
, pp. 967-974
-
-
Thambyrajah, J.1
Townend, J.N.2
-
4
-
-
0345535616
-
Homocysteine-induced endoplasmic reticulum stress and growth arrest leads to specific changes in gene expression in human vascular endothelial cells
-
Outinen PA, Sood SK, Pfeifer SI, Pamidi S, Podor TJ, et al. (1999) Homocysteine-induced endoplasmic reticulum stress and growth arrest leads to specific changes in gene expression in human vascular endothelial cells. Blood 94: 959-967.
-
(1999)
Blood
, vol.94
, pp. 959-967
-
-
Outinen, P.A.1
Sood, S.K.2
Pfeifer, S.I.3
Pamidi, S.4
Podor, T.J.5
-
5
-
-
0034678050
-
Homocysteine accelerates endothelial cell senescence
-
Xu D, Neville R, Finkel T, (2000) Homocysteine accelerates endothelial cell senescence. FEBS Lett 470: 20-24.
-
(2000)
FEBS Lett
, vol.470
, pp. 20-24
-
-
Xu, D.1
Neville, R.2
Finkel, T.3
-
6
-
-
0035929641
-
Homocysteine induces programmed cell death in human vascular endothelial cells through activation of the unfolded protein response
-
Zhang C, Cai Y, Adachi MT, Oshiro S, Aso T, et al. (2001) Homocysteine induces programmed cell death in human vascular endothelial cells through activation of the unfolded protein response. J Biol Chem 276: 35867-35874.
-
(2001)
J Biol Chem
, vol.276
, pp. 35867-35874
-
-
Zhang, C.1
Cai, Y.2
Adachi, M.T.3
Oshiro, S.4
Aso, T.5
-
7
-
-
0034666267
-
Homocysteine elicits a DNA damage response in neurons that promotes apoptosis and hypersensitivity to excitotoxicity
-
Kruman II, Culmsee C, Chan SL, Kruman Y, Guo Z, et al. (2000) Homocysteine elicits a DNA damage response in neurons that promotes apoptosis and hypersensitivity to excitotoxicity. J Neurosci 20: 6920-6926.
-
(2000)
J Neurosci
, vol.20
, pp. 6920-6926
-
-
Kruman, I.I.1
Culmsee, C.2
Chan, S.L.3
Kruman, Y.4
Guo, Z.5
-
8
-
-
0033562966
-
Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls
-
Kaufman RJ, (1999) Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls. Genes Dev 13: 1211-1233.
-
(1999)
Genes Dev
, vol.13
, pp. 1211-1233
-
-
Kaufman, R.J.1
-
9
-
-
26444442450
-
Endoplasmic reticulum stress: cell life and death decisions
-
Xu C, Bailly-Maitre B, Reed JC, (2005) Endoplasmic reticulum stress: cell life and death decisions. J Clin Invest 115: 2656-2664.
-
(2005)
J Clin Invest
, vol.115
, pp. 2656-2664
-
-
Xu, C.1
Bailly-Maitre, B.2
Reed, J.C.3
-
10
-
-
0032054744
-
CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum
-
Zinszner H, Kuroda M, Wang X, Batchvarova N, Lightfoot RT, et al. (1998) CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum. Genes Dev 12: 982-995.
-
(1998)
Genes Dev
, vol.12
, pp. 982-995
-
-
Zinszner, H.1
Kuroda, M.2
Wang, X.3
Batchvarova, N.4
Lightfoot, R.T.5
-
11
-
-
0035144493
-
Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating bcl2 and perturbing the cellular redox state
-
Mccullough KD, Martindale JL, Klotz L-O, Aw T-Y, Holbrook NJ, (2001) Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating bcl2 and perturbing the cellular redox state. Mol Cell Biol 21: 1249-1259.
-
(2001)
Mol Cell Biol
, vol.21
, pp. 1249-1259
-
-
McCullough, K.D.1
Martindale, J.L.2
Klotz, L.-O.3
Aw, T.-Y.4
Holbrook, N.J.5
-
12
-
-
0033658966
-
Reduced mRNA abundance of the main enzymes involved in methionine metabolism in human liver cirrhosis and hepatocellular carcinoma
-
Avila MA, Berasain C, Torres L, Martin-Duce A, Corrales FJ, et al. (2000) Reduced mRNA abundance of the main enzymes involved in methionine metabolism in human liver cirrhosis and hepatocellular carcinoma. J Hepatol 33: 907-914.
-
(2000)
J Hepatol
, vol.33
, pp. 907-914
-
-
Avila, M.A.1
Berasain, C.2
Torres, L.3
Martin-Duce, A.4
Corrales, F.J.5
-
13
-
-
33645878608
-
Alcohol consumption and plasma homocysteine
-
Sakuta H, Suzuki T, (2005) Alcohol consumption and plasma homocysteine. Alcohol 37: 73-77.
-
(2005)
Alcohol
, vol.37
, pp. 73-77
-
-
Sakuta, H.1
Suzuki, T.2
-
14
-
-
0037162531
-
Folate deficiency disturbs hepatic methionine metabolism and promotes liver injury in the ethanol-fed micropig
-
Halsted CH, Villanueva JA, Devlin AM, Niemelä O, Parkkila S, (2002) Folate deficiency disturbs hepatic methionine metabolism and promotes liver injury in the ethanol-fed micropig. Proc Nalt Acad Sci USA 99: 10072-10077.
-
(2002)
Proc Nalt Acad Sci USA
, vol.99
, pp. 10072-10077
-
-
Halsted, C.H.1
Villanueva, J.A.2
Devlin, A.M.3
Niemelä, O.4
Parkkila, S.5
-
15
-
-
0029120110
-
Carbon tetrachloride-induced hepatic injury is associated with global DNA hypomethylation and homocysteinemia: effect of S-adenosylmethionine treatment
-
Varela-Moreiras G, Alonso-Aperte E, Rubio M, Gasso M, Deulofeu R, (1995) Carbon tetrachloride-induced hepatic injury is associated with global DNA hypomethylation and homocysteinemia: effect of S-adenosylmethionine treatment. Hepatology 22: 1310-1315.
-
(1995)
Hepatology
, vol.22
, pp. 1310-1315
-
-
Varela-Moreiras, G.1
Alonso-Aperte, E.2
Rubio, M.3
Gasso, M.4
Deulofeu, R.5
-
16
-
-
17844385292
-
Hyperhomocysteinemia and the MTHFR C677T polymorphism promote steatosis and fibrosis in chronic hepatitis C patients
-
Adinolfi LE, Ingrosso D, Cesaro G, Cimmino A, D'Anto M, et al. (2005) Hyperhomocysteinemia and the MTHFR C677T polymorphism promote steatosis and fibrosis in chronic hepatitis C patients. Hepatology 41: 995-1003.
-
(2005)
Hepatology
, vol.41
, pp. 995-1003
-
-
Adinolfi, L.E.1
Ingrosso, D.2
Cesaro, G.3
Cimmino, A.4
D'Anto, M.5
-
17
-
-
11144230938
-
Abnormal lipid metabolism in cystathionine β-synthase- deficient mice, an animal model for hyperhomocysteinemia
-
Namekata K, EnokidoY, Ishii I, Nagai Y, Harada T, et al. (2004) Abnormal lipid metabolism in cystathionine β-synthase- deficient mice, an animal model for hyperhomocysteinemia. J Biol Che65m 279: 52961-52969.
-
(2004)
J Biol Che65m
, vol.279
, pp. 52961-52969
-
-
Namekata, K.1
Enokido, Y.2
Ishii, I.3
Nagai, Y.4
Harada, T.5
-
18
-
-
0035014266
-
Homocysteine-induced endoplasmic reticulum stress causes dysregulation of the cholesterol and triglyceride biosynthetic pathways
-
Werstuck GH, Lentz SR, Dayal S, Hossain GS, Sood SK, et al. (2001) Homocysteine-induced endoplasmic reticulum stress causes dysregulation of the cholesterol and triglyceride biosynthetic pathways. J Clin Invest 107: 1263-1273.
-
(2001)
J Clin Invest
, vol.107
, pp. 1263-1273
-
-
Werstuck, G.H.1
Lentz, S.R.2
Dayal, S.3
Hossain, G.S.4
Sood, S.K.5
-
19
-
-
19044385595
-
Cystathionine β-synthase deficiency promotes oxidative stress, fibrosis and steatosis in mice liver
-
Robert K, Nehme J, Bourdon E, Pivert G, Friguet B, et al. (2005) Cystathionine β-synthase deficiency promotes oxidative stress, fibrosis and steatosis in mice liver. Gastroenterology 128: 1405-1415.
-
(2005)
Gastroenterology
, vol.128
, pp. 1405-1415
-
-
Robert, K.1
Nehme, J.2
Bourdon, E.3
Pivert, G.4
Friguet, B.5
-
20
-
-
71949112727
-
Hyperhomocysteinemia stimulates hepatic glucose output and PEPCK expression
-
Yu X, Huang Y, Hu Q, Ma L, (2009) Hyperhomocysteinemia stimulates hepatic glucose output and PEPCK expression. Acta Biochim Biophys Sin 41: 1027-1032.
-
(2009)
Acta Biochim Biophys Sin
, vol.41
, pp. 1027-1032
-
-
Yu, X.1
Huang, Y.2
Hu, Q.3
Ma, L.4
-
21
-
-
79953665989
-
Inhibition of hepatic glycogen synthesis by hyperhomocysteinemia mediated by TRB3
-
Liu WJ, Ma LQ, Liu WH, Zhou W, Zhang KQ, et al. (2011) Inhibition of hepatic glycogen synthesis by hyperhomocysteinemia mediated by TRB3. Am J Pathol 178: 1489-1499.
-
(2011)
Am J Pathol
, vol.178
, pp. 1489-1499
-
-
Liu, W.J.1
Ma, L.Q.2
Liu, W.H.3
Zhou, W.4
Zhang, K.Q.5
-
22
-
-
78149346094
-
Hepatocyte proliferation during liver regeneration is impaired in mice with methionine diet-induced hyperhomocysteinemia
-
Liu WH, Zhao YS, Gao SY, Li SD, Cao J, et al. (2010) Hepatocyte proliferation during liver regeneration is impaired in mice with methionine diet-induced hyperhomocysteinemia. Am J Pathol 177: 2357-2365.
-
(2010)
Am J Pathol
, vol.177
, pp. 2357-2365
-
-
Liu, W.H.1
Zhao, Y.S.2
Gao, S.Y.3
Li, S.D.4
Cao, J.5
-
23
-
-
3042698674
-
Perturbations in homocysteine-linked redox homeostasis in a murine model for hyperhomocysteinemia
-
Vitvitsky V, Dayal S, Stabler S, Zhou Y, Wang H, et al. (2004) Perturbations in homocysteine-linked redox homeostasis in a murine model for hyperhomocysteinemia. Am J Physiol Regul Integr Comp Physiol 287: R39-46.
-
(2004)
Am J Physiol Regul Integr Comp Physiol
, vol.287
-
-
Vitvitsky, V.1
Dayal, S.2
Stabler, S.3
Zhou, Y.4
Wang, H.5
-
24
-
-
0028988585
-
Inhibitors of mammalian G1 cyclin-dependent kinases
-
Sherr CJ, Roberts JM, (1995) Inhibitors of mammalian G1 cyclin-dependent kinases. Genes Dev 9: 1149-1163.
-
(1995)
Genes Dev
, vol.9
, pp. 1149-1163
-
-
Sherr, C.J.1
Roberts, J.M.2
-
25
-
-
0033543728
-
A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy
-
Komarov PG, Komarova EA, Kondratov RV, Christov-Tselkov K, Coon JS, et al. (1999) A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy. Science 285: 1733-1737.
-
(1999)
Science
, vol.285
, pp. 1733-1737
-
-
Komarov, P.G.1
Komarova, E.A.2
Kondratov, R.V.3
Christov-Tselkov, K.4
Coon, J.S.5
-
26
-
-
0032127493
-
Identification of novel stress-induced genes downstream of chop
-
Wang X-Z, Kuroda M, Batchvarova JSN, Kimmel R, Chung P, et al. (1998) Identification of novel stress-induced genes downstream of chop. EMBO J 17: 3619-3630.
-
(1998)
EMBO J
, vol.17
, pp. 3619-3630
-
-
Wang, X.-Z.1
Kuroda, M.2
Batchvarova, J.S.N.3
Kimmel, R.4
Chung, P.5
-
27
-
-
8544283103
-
CHOP is involved in endoplasmic reticulum stress-induced apoptosis by enhancing dr5 expression in human carcinoma cells
-
Yamaguchi H, Wang H-G, (2004) CHOP is involved in endoplasmic reticulum stress-induced apoptosis by enhancing dr5 expression in human carcinoma cells. J Biol Chem 279: 45495-45502.
-
(2004)
J Biol Chem
, vol.279
, pp. 45495-45502
-
-
Yamaguchi, H.1
Wang, H.-G.2
-
28
-
-
17144417669
-
TRB3,a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death
-
Ohoka N, Yoshii S, Hattori T, Onozaki K, Hayashi H, (2005) TRB3,a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death. EMBO J 24: 1243-1255.
-
(2005)
EMBO J
, vol.24
, pp. 1243-1255
-
-
Ohoka, N.1
Yoshii, S.2
Hattori, T.3
Onozaki, K.4
Hayashi, H.5
-
29
-
-
24144472287
-
Role of chop in hepatic apoptosis in the murine model of intragastric ethanol feeding
-
Ji C, Mehrian-Shai R, Chan C, Hsu Y-H, Kaplowitz N, (2005) Role of chop in hepatic apoptosis in the murine model of intragastric ethanol feeding. Alcohol Clin Exp Res 29: 1496-1503.
-
(2005)
Alcohol Clin Exp Res
, vol.29
, pp. 1496-1503
-
-
Ji, C.1
Mehrian-Shai, R.2
Chan, C.3
Hsu, Y.-H.4
Kaplowitz, N.5
-
30
-
-
0038242819
-
TRB3: A tribbles homolog that inhibits Akt/PKB activation by lnsulin in liver
-
Du K, Herzig S, Kulkarni RN, Montminy M, (2003) TRB3: A tribbles homolog that inhibits Akt/PKB activation by lnsulin in liver. Science 300: 1574-1577.
-
(2003)
Science
, vol.300
, pp. 1574-1577
-
-
Du, K.1
Herzig, S.2
Kulkarni, R.N.3
Montminy, M.4
-
31
-
-
14044261099
-
Protects cells from ER stress-induced lipid accumulation and apoptosis by inhibiting glycogen synthase kinase-3
-
Kim AJ, Shi Y, Austin RC, Werstuck GH, (2004) Protects cells from ER stress-induced lipid accumulation and apoptosis by inhibiting glycogen synthase kinase-3. J Cell Sci 118: 89-99.
-
(2004)
J Cell Sci
, vol.118
, pp. 89-99
-
-
Kim, A.J.1
Shi, Y.2
Austin, R.C.3
Werstuck, G.H.4
-
32
-
-
0033587742
-
Lithium activates the serine/threonine kinase Akt-1 and suppresses glutamate-induced inhibition of Akt-1 activity in neurons
-
Chalecka-Franaszek E, Chuang D-M, (1999) Lithium activates the serine/threonine kinase Akt-1 and suppresses glutamate-induced inhibition of Akt-1 activity in neurons. Proc Nalt Acad Sci USA 96: 8745-8750.
-
(1999)
Proc Nalt Acad Sci USA
, vol.96
, pp. 8745-8750
-
-
Chalecka-Franaszek, E.1
Chuang, D.-M.2
-
33
-
-
0034716905
-
Tribbles coordinates mitosis and morphogenesis in drosophila by regulating string/CDC25 proteolysis
-
Mata J, Curado S, Ephrussi A, Rørth P, (2000) Tribbles coordinates mitosis and morphogenesis in drosophila by regulating string/CDC25 proteolysis. Cell 101: 511-522.
-
(2000)
Cell
, vol.101
, pp. 511-522
-
-
Mata, J.1
Curado, S.2
Ephrussi, A.3
Rørth, P.4
-
34
-
-
34447503956
-
TRB3 inhibits the transcriptional activation of stress-regulated genes by a negative feedback on the ATF4 pathway
-
Jousse C, Deval C, Maurin A-C, Parry L, Cherasse Y, et al. (2007) TRB3 inhibits the transcriptional activation of stress-regulated genes by a negative feedback on the ATF4 pathway. J Biol Chem 282: 15851-15861.
-
(2007)
J Biol Chem
, vol.282
, pp. 15851-15861
-
-
Jousse, C.1
Deval, C.2
Maurin, A.-C.3
Parry, L.4
Cherasse, Y.5
-
35
-
-
34948831425
-
Dose dependent effects of alcohol on insulin signaling: partial explanation for biphasic alcohol impact on human health: Biphasic effects of alcohol on insulin signaling
-
He L, Marecki JC, Serrero G, Simmen FA, Ronis MJJ, et al. (2007) Dose dependent effects of alcohol on insulin signaling: partial explanation for biphasic alcohol impact on human health: Biphasic effects of alcohol on insulin signaling. Mol Endocrinol 21: 2541-2550.
-
(2007)
Mol Endocrinol
, vol.21
, pp. 2541-2550
-
-
He, L.1
Marecki, J.C.2
Serrero, G.3
Simmen, F.A.4
Ronis, M.J.J.5
-
36
-
-
0033551070
-
New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway
-
Cantley LC, Neel BG, (1999) New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway. Proc Nalt Acad Sci USA 96: 4240-4245.
-
(1999)
Proc Nalt Acad Sci USA
, vol.96
, pp. 4240-4245
-
-
Cantley, L.C.1
Neel, B.G.2
-
37
-
-
2542582293
-
Homocysteine enhances endothelial apoptosis via upregulation of Fas-mediated pathways
-
Suhara T, Fukuo K, Yasuda O, Tsubakimoto, Takemura Y, et al. (2004) Homocysteine enhances endothelial apoptosis via upregulation of Fas-mediated pathways. Hypertension 43: 1208-1213.
-
(2004)
Hypertension
, vol.43
, pp. 1208-1213
-
-
Suhara, T.1
Fukuo, K.2
Yasuda, O.3
Tsubakimoto, T.Y.4
-
38
-
-
0037077230
-
Akt enhances mdm2-mediated ubiquitination and degradation of p53
-
Ogawara Y, Kishishita S, Obata T, (2002) Akt enhances mdm2-mediated ubiquitination and degradation of p53. J Biol Chem 277: 21843-21850.
-
(2002)
J Biol Chem
, vol.277
, pp. 21843-21850
-
-
Ogawara, Y.1
Kishishita, S.2
Obata, T.3
-
39
-
-
0036371158
-
P21WAF1 control of epithelial cell cycle and cell fate
-
Weinberg WC. Denning MF, (2002) P21WAF1 control of epithelial cell cycle and cell fate. Crit Rev Oral Biol Med 13: 453-464.
-
(2002)
Crit Rev Oral Biol Med
, vol.13
, pp. 453-464
-
-
Weinberg, W.C.1
Denning, M.F.2
-
40
-
-
0038003956
-
Decisions on life and death: FOXO Forkhead transcription factors are in command when PKB/Akt is off duty
-
Burgering BMT, Medema RH, (2003) Decisions on life and death: FOXO Forkhead transcription factors are in command when PKB/Akt is off duty. J Leukoc Biol 73: 689-701.
-
(2003)
J Leukoc Biol
, vol.73
, pp. 689-701
-
-
Burgering, B.M.T.1
Medema, R.H.2
-
41
-
-
33645282568
-
Elevated Homocysteine Reduces Apolipoprotein A-I Expression in Hyperhomocysteinemic Mice and in Males With Coronary Artery Disease
-
Mikael LG, Genest J Jr, Rozen R, (2006) Elevated Homocysteine Reduces Apolipoprotein A-I Expression in Hyperhomocysteinemic Mice and in Males With Coronary Artery Disease. Circ Res 98: 564-571.
-
(2006)
Circ Res
, vol.98
, pp. 564-571
-
-
Mikael, L.G.1
Genest Jr., J.2
Rozen, R.3
-
42
-
-
17144403395
-
Homocysteine promotes p38-dependent chemotaxis in bovine aortic smooth muscle cells
-
Akasaka K, Akasaka N, Di Luozzo G, Sasajima T, Sumpio BE, (2005) Homocysteine promotes p38-dependent chemotaxis in bovine aortic smooth muscle cells. J Vasc Surg 41: 517-522.
-
(2005)
J Vasc Surg
, vol.41
, pp. 517-522
-
-
Akasaka, K.1
Akasaka, N.2
Di Luozzo, G.3
Sasajima, T.4
Sumpio, B.E.5
|