Hyperhomocysteinemia stimulates hepatic glucose output and PEPCK expression

Acta Biochimica et Biophysica Sinica

Volumn 41, Issue 12, 2009, Pages 1027-1032

  Yu, Xue ^a   Huang, Youguang ^b   Hu, Qiang ^b   Ma, Lanqing ^b  

^a BEIJING HOSPITAL   (China)

^b KUNMING MEDICAL UNIVERSITY   (China)

Author keywords

Homocysteine; Insulin resistance; Phosphoenolpyruvate carboxykinase (PEPCK); Protein kinase A

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; GLUCOSE; HOMOCYSTEINE; ISOQUINOLINE DERIVATIVE; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; PHOSPHOENOLPYRUVATE CARBOXYKINASE (ATP); PROTEIN KINASE INHIBITOR; SULFONAMIDE;

ANIMAL; ARTICLE; BAGG ALBINO MOUSE; BIOSYNTHESIS; DRUG ANTAGONISM; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; HYPERHOMOCYSTEINEMIA; INSULIN RESISTANCE; LIVER CELL; METABOLISM; MOUSE; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CYCLIC AMP-DEPENDENT PROTEIN KINASES; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GLUCOSE; HEPATOCYTES; HOMOCYSTEINE; HYPERHOMOCYSTEINEMIA; INSULIN RESISTANCE; ISOQUINOLINES; MICE; MICE, INBRED BALB C; PHOSPHOENOLPYRUVATE CARBOXYKINASE (ATP); PROTEIN KINASE INHIBITORS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SULFONAMIDES;

MUS;

EID: 71949112727     PISSN: 16729145     EISSN: 17457270     Source Type: Journal    
DOI: 10.1093/abbs/gmp097     Document Type: Article

References (24)

1. Zou CG and Banerjee R. Homocysteine and redox signaling. Antioxid Redox Signal 2005, 7: 547-559.
2. Kruman II, Culmsee C, Chan SL, Kruman Y, Guo Z, Penix L and Mattson MP. Homocysteine elicits a DNA damage response in neurons that promotes apoptosis and hypersensitivity to excitotoxicity. J Neurosci 2000, 20: 6920-6926.
3. Zou CG, Zhao YS, Gao XY, Li SD, Cao XZ, Zhang M and Zhang KQ. Homocysteine promotes proliferation and activation of microglia. Neurobiol Aging 2008, doi:10.1016/j.neurobiolaging.11.007.
4. Robert K, Nehme J, Bourdon E, Pivert G, Friguet B, Delcayre C and Delabar JM, et al. Cystathionine b-synthase deficiency promotes oxidative stress, fibrosis and steatosis in mice liver. Gastroenterology 2005, 128: 1405-1415.
5. Zou CG, Gao XY, Zhao YS, Li SD, Cao XZ, Zhang Y and Zhang KQ. Homocysteine enhances cell proliferation in hepatic myofibroblastic stellate cells. J Mol Med 2009, 87: 75-84.
6. Emoto M, Kanda H, Shoji T, Kawagishi T, Komatsu M, Mori K and Tahara H, et al. Impact of insulin resistance and nephropathy on homocysteine in type 2 diabetes. Diabetes Care 2001, 24: 533-538.
7. Meigs JB, Jacques PF, Selhub J, Singer DE, Nathan DM, Rifai N and D'Agostino RB, et al. Fasting plasma homocysteine levels in the insulin resistance syndrome: T he Framingham offspring study. Diabetes Care 2001, 24: 1403-1410.
8. Sanchez-Margalet V, Valle M, Ruz FJ, Gascon F, Mateo J and Goberna R. Elevated plasma total homocysteine levels in hyperinsulinemic obese subjects. J Nutr Biochem 2002, 13: 75-79.
9. Fonseca VA, Fink LM and Kern PA. Insulin sensitivity and plasma homocysteine concentrations in non-diabetic obese and normal weight subjects. Atherosclerosis 2003, 167: 105-109.
10. Martos R, Valle M, Morales R, Canete R, Gavilan MI and Sanchez-Margalet V. Hyperhomocysteinemia correlates with insulin resistance and low-grade systemic inflammation in obese prepubertal children. Metabolism 2006, 55: 72-77.
11. Oron-Herman M, Rosenthal T and Sela BA. Hyperhomocysteinemia as a component of syndrome X. Metabolism 2003, 52: 1491-1495.
12. Setola E, Monti LD, Galluccio E, Palloshi A, Fragasso G, Paroni R and Magni F, et al. Insulin resistance and endothelial function are improved after folate and vitamin B12 therapy in patients with metabolic syndrome: relationship between homocysteine levels and hyperinsulinemia. Eur J Endocrinol 2004, 151: 483-489.
13. Golbahar J, Aminzadeh MA, Kassab SE and Omrani GR. Hyperhomocysteinemia induces insulin resistance in male Sprague-Dawley rats. Diabetes Res Clin Pract 2007, 76: 1-5.
14. Najib S and Sánchez-Margalet V. Homocysteine thiolactone inhibits insulin signaling. Protective effect of glutathione. J Mol Endocrinol 2001, 27: 85-91.
15. Najib S and Sánchez-Margalet V. Homocysteine thiolactone inhibits insulin-stimulated DNA and protein synthesis: Possible role of mitogenactivated protein kinase (MAPK), glycogen synthase kinase-3 (GSK-3) and p70 S6K phosphorylation. J Mol Endocrinol 2005, 34: 119-126.
16. Vitvitsky V, Dayal S, Stabler S, Zhou Y, Wang H, Lentz SR and Banerjee R. Perturbations in homocysteine-linked redox homeostasis in a murine model for hyperhomocysteinemia. Am J Physiol Regul Integr Comp Physiol 2004, 287: R39-R46.
17. Murata M, Okimura Y, Iida K, Matsumoto M, Sowa H, Kaji H and Kojima M, et al. Ghrelin modulates the downstream molecules of insulin signaling in hepatoma cells. J Biol Chem 2002, 277: 5667-5674.
18. Woo CW, Siow YL, Pierce GN, Choy PC, Minuk GY, Mymin D and Karmin O. Hyperhomocysteinemia induces hepatic cholesterol biosynthesis and lipid accumulation via activation of transcription factors. Am J Physiol Endocrinol Metab 2005, 288: E1002-E1010.
19. Li Y, Jiang C, Xu G, Wang N, Zhu Y, Tang C and Wang X. Homocysteine upregulates resistin production from adipocytes in vivo and in vitro. Diabetes 2008, 57: 817-827.
20. Sun Y, Liu S, Ferguson S, Wang L, Klepcyk P, Yun JS and Friedman JE. Phosphoenolpyruvate carboxykinase overexpression selectively attenuates insulin signaling and hepatic insulin sensitivity in transgenic mice. J Biol Chem 2002, 277: 23301-23307.
21. Franckhauser S, Munoz S, Elias I, Ferre T and Bosch F. Adipose overexpression of phosphoenolpyruvate carboxykinase leads to high susceptibility to diet-induced insulin resistance and obesity. Diabetes 2006, 55: 273-280.
22. Barthel A and Schmoll D. Novel concepts in insulin regulation of hepatic gluconeogenesis. Am J Physiol Endocrinol Metab 2003, 285: E685-E692.
23. Shao J, Qiao L, Janssen RC, Pagliassotti M and Friedman JE. Chronic hyperglycemia enhances PEPCK gene expression and hepatocellular glucose production via elevated liver activating protein/liver inhibitory protein ratio. Diabetes 2005, 54: 976-984.
24. Woo CWH, Siow YL and Karmin O. Homocysteine activates cAMP-response element binding protein in HepG2 through cAMP/ PKA signaling pathway. Arterioscler Thromb Vasc Biol 2006, 26: 1043-1050.