Trauma and Aggressive Homeostasis Management

Anesthesiology Clinics

Volumn 31, Issue 1, 2013, Pages 21-39

  Neligan, Patrick J ^a   Baranov, Dimitry ^b  

^a UNIVERSITY HOSPITAL GALWAY   (Ireland)

^b HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Brain injury; Cooling; Glycemic control; Homeostasis; Hyperglycemia; Hypothermia; Inflammation; Lactic acidosis

Indexed keywords

ANTIFIBRINOLYTIC AGENT; LACTIC ACID;

ABDOMINAL COMPARTMENT SYNDROME; BLOOD CLOTTING DISORDER; GLYCEMIC CONTROL; HEART ARREST; HEART SURGERY; HEMORRHAGIC SHOCK; HOMEOSTASIS; HUMAN; HYPERGLYCEMIA; HYPOGLYCEMIA; HYPOTHERMIA; INDUCED HYPOTHERMIA; INJURY; LACTIC ACIDOSIS; RESUSCITATION; REVIEW; RISK ASSESSMENT; STRESS; TRAUMATIC BRAIN INJURY;

ACIDOSIS, LACTIC; BRAIN INJURIES; HOMEOSTASIS; HUMANS; HYPERGLYCEMIA; HYPOTHERMIA, INDUCED; INSULIN; LACTIC ACID; OXYGEN; SHOCK, HEMORRHAGIC; WOUNDS AND INJURIES;

EID: 84872768417     PISSN: 19322275     EISSN: 22103538     Source Type: Journal    
DOI: 10.1016/j.anclin.2012.10.007     Document Type: Review

References (142)

1. Gladden L.B. Lactate metabolism: a new paradigm for the third millennium. J Physiol 2004, 558:5-30.
2. Lang C.H., Obih J.C., Bagby G.J., et al. Increased glucose uptake by intestinal mucosa and muscularis in hypermetabolic sepsis. Am J Physiol 1991, 261:G287-G294.
3. Langouche L., Van den B.G. Glucose metabolism and insulin therapy. Crit Care Clin 2006, 22:119-129. vii.
4. Gropper M.A. Evidence-based management of critically ill patients: analysis and implementation. Anesth Analg 2004, 99:566-572.
5. Capes S.E., Hunt D., Malmberg K., et al. Stress hyperglycaemia and increased risk of death after myocardial infarction in patients with and without diabetes: a systematic overview. Lancet 2000, 355:773-778.
6. Umpierrez G.E., Isaacs S.D., Bazargan N., et al. Hyperglycemia: an independent marker of in-hospital mortality in patients with undiagnosed diabetes. J Clin Endocrinol Metab 2002, 87:978-982.
7. Montori V.M., Bistrian B.R., McMahon M.M. Hyperglycemia in acutely ill patients. JAMA 2002, 288:2167-2169.
8. Guha M., Bai W., Nadler J.L., et al. Molecular mechanisms of tumor necrosis factor alpha gene expression in monocytic cells via hyperglycemia-induced oxidant stress-dependent and-independent pathways. J Biol Chem 2000, 275:17728-17739.
9. Sampson M.J., Davies I.R., Brown J.C., et al. Monocyte and neutrophil adhesion molecule expression during acute hyperglycemia and after antioxidant treatment in type 2 diabetes and control patients. Arterioscler Thromb Vasc Biol 2002, 22:1187-1193.
10. Lin L.H., Hopf H.W. Paradigm of the injury-repair continuum during critical illness. Crit Care Med 2003, 31:S493-S495.
11. Wahab N.N., Cowden E.A., Pearce N.J., et al. Is blood glucose an independent predictor of mortality in acute myocardial infarction in the thrombolytic era?. J Am Coll Cardiol 2002, 40:1748-1754.
12. Iwakura K., Ito H., Ikushima M., et al. Association between hyperglycemia and the no-reflow phenomenon in patients with acute myocardial infarction. J Am Coll Cardiol 2003, 41:1-7.
13. O'Neill P.A., Davies I., Fullerton K.J., et al. Stress hormone and blood glucose response following acute stroke in the elderly. Stroke 1991, 22:842-847.
14. Yendamuri S., Fulda G.J., Tinkoff G.H. Admission hyperglycemia as a prognostic indicator in trauma. J Trauma 2003, 55:33-38.
15. Laird A.M., Miller P.R., Kilgo P.D., et al. Relationship of early hyperglycemia to mortality in trauma patients. J Trauma 2004, 56:1058-1062.
16. Sung J., Bochicchio G.V., Joshi M., et al. Admission hyperglycemia is predictive of outcome in critically ill trauma patients. J Trauma 2005, 59:80-83.
17. Bochicchio G.V., Sung J., Joshi M., et al. Persistent hyperglycemia is predictive of outcome in critically ill trauma patients. J Trauma 2005, 58:921-924.
18. Bochicchio G.V., Salzano L., Joshi M., et al. Admission preoperative glucose is predictive of morbidity and mortality in trauma patients who require immediate operative intervention. Am Surg 2005, 71:171-174.
19. Vogelzang M., Nijboer J.M., van dH I., et al. Hyperglycemia has a stronger relation with outcome in trauma patients than in other critically ill patients. J Trauma 2006, 60:873-877.
20. Desai D., March R., Watters J.M. Hyperglycemia after trauma increases with age. J Trauma 1989, 29:719-723.
21. Gale S.C., Sicoutris C., Reilly P.M., et al. Poor glycemic control is associated with increased mortality in critically ill trauma patients. Am Surg 2007, 73:454-460.
22. Sung J., Bochicchio G.V., Joshi M., et al. Admission serum albumin is predictive of outcome in critically ill trauma patients. Am Surg 2004, 70:1099-1102.
23. Jeschke M.G., Klein D., Bolder U., et al. Insulin attenuates the systemic inflammatory response in endotoxemic rats. Endocrinology 2004, 145:4084-4093.
24. Takebayashi K., Aso Y., Inukai T. Initiation of insulin therapy reduces serum concentrations of high-sensitivity C-reactive protein in patients with type 2 diabetes. Metabolism 2004, 53:693-699.
25. Stentz F.B., Umpierrez G.E., Cuervo R., et al. Proinflammatory cytokines, markers of cardiovascular risks, oxidative stress, and lipid peroxidation in patients with hyperglycemic crises. Diabetes 2004, 53:2079-2086.
26. Jeschke M.G., Einspanier R., Klein D., et al. Insulin attenuates the systemic inflammatory response to thermal trauma. Mol Med 2002, 8:443-450.
27. Jonassen A.K., Sack M.N., Mjos O.D., et al. Myocardial protection by insulin at reperfusion requires early administration and is mediated via Akt and p70s6 kinase cell-survival signaling. Circ Res 2001, 89:1191-1198.
28. Chaudhuri A., Janicke D., Wilson M.F., et al. anti-inflammatory and profibrinolytic effect of insulin in acute ST-segment-elevation myocardial infarction. Circulation 2004, 109:849-854.
29. Lazar H.L., Chipkin S.R., Fitzgerald C.A., et al. Tight glycemic control in diabetic coronary artery bypass graft patients improves perioperative outcomes and decreases recurrent ischemic events. Circulation 2004, 109:1497-1502.
30. Van den B.G., Wouters P., Weekers F., et al. Intensive insulin therapy in the critically ill patients. N Engl J Med 2001, 345:1359-1367.
31. Finney S.J., Zekveld C., Elia A., et al. Glucose control and mortality in critically ill patients. JAMA 2003, 290:2041-2047.
32. Zerr K.J., Furnary A.P., Grunkemeier G.L., et al. Glucose control lowers the risk of wound infection in diabetics after open heart operations. Ann Thorac Surg 1997, 63:356-361.
33. Furnary A.P., Zerr K.J., Grunkemeier G.L., et al. Continuous intravenous insulin infusion reduces the incidence of deep sternal wound infection in diabetic patients after cardiac surgical procedures. Ann Thorac Surg 1999, 67:352-360.
34. Furnary A.P., Gao G., Grunkemeier G.L., et al. Continuous insulin infusion reduces mortality in patients with diabetes undergoing coronary artery bypass grafting. J Thorac Cardiovasc Surg 2003, 125:1007-1021.
35. Van den Berghe G., Wouters P.J., Bouillon R., et al. Outcome benefit of intensive insulin therapy in the critically ill: insulin dose versus glycemic control. Crit Care Med 2003, 31:359-366.
36. Langouche L., Vanhorebeek I., Vlasselaers D., et al. Intensive insulin therapy protects the endothelium of critically ill patients. J Clin Invest 2005, 115:2277-2286.
37. Vanhorebeek I., De Vos R., Mesotten D., et al. Protection of hepatocyte mitochondrial ultrastructure and function by strict blood glucose control with insulin in critically ill patients. Lancet 2005, 365:53-59.
38. Krinsley J.S. Effect of an intensive glucose management protocol on the mortality of critically ill adult patients. Mayo Clin Proc 2004, 79:992-1000.
39. Van den Berghe G. How does blood glucose control with insulin save lives in intensive care?. J Clin Invest 2004, 114:1187-1195.
40. Van den Berghe G., Wilmer A., Hermans G., et al. Intensive insulin therapy in the medical ICU. N Engl J Med 2006, 354:449-461.
41. Montori V.M., Devereaux P.J., Adhikari N.K.J., et al. Randomized trials stopped early for benefit: a systematic review. JAMA 2005, 294:2203-2209.
42. Brunkhorst F.M., Engel C., Bloos F., et al. Intensive insulin therapy and pentastarch resuscitation in severe sepsis (visep study). N Engl J Med 2008, 358:125-139.
43. Preiser J.C., Devos P., Ruiz-Santana S., et al. A prospective randomised multi-centre controlled trial on tight glucose control by intensive insulin therapy in adult intensive care units: the Glucontrol study. Intensive Care Med 2009, 35:1738-1748.
44. NICE-SUGAR Study Investigators, Finfer S., Chittock D.R., et al. Intensive versus conventional glucose control in critically ill patients. N Engl J Med 2009, 360:1283-1297.
45. Jeremitsky E., Omert L.A., Dunham C.M., et al. The impact of hyperglycemia on patients with severe brain injury. J Trauma 2005, 58:47-50.
46. Yang S.Y., Zhang S., Wang M.L. Clinical significance of admission hyperglycemia and factors related to it in patients with acute severe head injury. Surg Neurol 1995, 44:373-377.
47. Garg R., Chaudhuri A., Munschauer F., et al. Hyperglycemia, insulin, and acute ischemic stroke: a mechanistic justification for a trial of insulin infusion therapy. Stroke 2006, 37:267-273.
48. Wagner K.R., Kleinholz M., de Court-Myers G.M., et al. Hyperglycemic versus normoglycemic stroke: topography of brain metabolites, intracellular pH, and infarct size. J Cereb Blood Flow Metab 1992, 12:213-222.
49. 2 modulation on cortical intracellular acidosis, NADH redox state, and infarction in the ischemic penumbra ò editorial comment. Stroke 1999, 30:160-170.
50. Van den B.G., Wouters P., Weekers F., et al. Intensive insulin therapy in the surgical intensive care unit. N Engl J Med 2001, 345:1359-1367.
51. Malmberg K., Ryden L., Efendic S., et al. Randomized trial of insulin-glucose infusion followed by subcutaneous insulin treatment in diabetic patients with acute myocardial infarction (DIGAMI study): effects on mortality at 1 year. J Am Coll Cardiol 1995, 26:57-65.
52. Goodman J.C., Valadka A.B., Gopinath S.P., et al. Extracellular lactate and glucose alterations in the brain after head injury measured by microdialysis. Crit Care Med 1999, 27:1965-1973.
53. Vespa P., Boonyaputthikul R., McArthur D.L., et al. Intensive insulin therapy reduces microdialysis glucose values without altering glucose utilization or improving the lactate/pyruvate ratio after traumatic brain injury. Crit Care Med 2006, 34:850-856.
54. Strong A.J., Boutelle M.G., Vespa P.M., et al. Treatment of critical care patients with substantial acute ischemic or traumatic brain injury. Crit Care Med 2005, 33:2147-2149.
55. Oddo M., Schmidt J.M., Carrera E., et al. Impact of tight glycemic control on cerebral glucose metabolism after severe brain injury: a microdialysis study. Crit Care Med 2008, 36:3233-3238.
56. Vespa P., McArthur D.L., Stein N., et al. Tight glycemic control increases metabolic distress in traumatic brain injury: a randomized controlled within-subjects trial. Crit Care Med 2012, 40:1923-1929.
57. Magnoni S., Tedesco C., Carbonara M., et al. Relationship between systemic glucose and cerebral glucose is preserved in patients with severe traumatic brain injury, but glucose delivery to the brain may become limited when oxidative metabolism is impaired: implications for glycemic control. Crit Care Med 2012, 40:1785-1791.
58. Dabrowski G.P., Steinberg S.M., Ferrara J.J., et al. A critical assessment of endpoints of shock resuscitation. Surg Clin North Am 2000, 80:825-844.
59. Eddy V.A., Morris J.A., Cullinane D.C. Hypothermia, coagulopathy, and acidosis. Surg Clin North Am 2000, 80:845-854.
60. Runciman W.B., Skowronski G.A. Pathophysiology of haemorrhagic shock. Anaesth Intensive Care 1984, 12:193-205.
61. Schlichtig R., Grogono A.W., Severinghaus J.W. Current Status of acid-base quantitation in physiology and medicine. Anesthesiol Clin North Am 1998, 16:211-233.
62. Fencl V., Leith D.E. Stewart's quantitative acid-base chemistry: applications in biology and medicine. Respir Physiol 1993, 91:1-16.
63. Brill S.A., Stewart T.R., Brundage S.I., et al. Base deficit does not predict mortality when secondary to hyperchloremic acidosis. Shock 2002, 17:459-462.
64. Stewart P.A. Modern quantitative acid-base chemistry. Can J Physiol Pharmacol 1983, 61:1444-1461.
65. Fencl V., Jabor A., Kazda A., et al. Diagnosis of metabolic acid-base disturbances in critically ill patients. Am J Respir Crit Care Med 2000, 162:2246-2251.
66. Gunnerson K., Saul M., He S., et al. Lactate versus non-lactate metabolic acidosis: a retrospective outcome evaluation of critically ill patients. Crit Care 2006, 10:R22.
67. Kaplan L.J., Kellum J.A. Initial pH, base deficit, lactate, anion gap, strong ion difference, and strong ion gap predict outcome from major vascular injury. Crit Care Med 2004, 32:1120-1124.
68. Martin M.J., FitzSullivan E., Salim A., et al. Discordance between lactate and base deficit in the surgical intensive care unit: which one do you trust?. Am J Surg 2006, 191:625-630.
69. Pal J.D., Victorino G.P., Twomey P., et al. Admission serum lactate levels do not predict mortality in the acutely injured patient. J Trauma 2006, 60:583-587.
70. Aslar A.K., Kuzu M.A., Elhan A.H., et al. Admission lactate level and the APACHE II score are the most useful predictors of prognosis following torso trauma. Injury 2004, 35:746-752.
71. Husain F.A., Martin M.J., Mullenix P.S., et al. Serum lactate and base deficit as predictors of mortality and morbidity. Am J Surg 2003, 185:485-491.
72. James J.H., Luchette F.A., McCarter F.D., et al. Lactate is an unreliable indicator of tissue hypoxia in injury or sepsis. Lancet 1999, 354:505-508.
73. Mikkelsen M.E., Miltiades A.N., Gaieski D.F., et al. Serum lactate is associated with mortality in severe sepsis independent of organ failure and shock. Crit Care Med 2009, 37:1670-1677.
74. Lee S.W., Hong Y.S., Park D.W., et al. Lactic acidosis not hyperlactatemia as a predictor of in hospital mortality in septic emergency patients. Emerg Med J 2008, 25:659-665.
75. Vitek V., Cowley R.A. Blood lactate in the prognosis of various forms of shock. Ann Surg 1971, 173:308-313.
76. Abramson D., Scalea T.M., Hitchcock R., et al. Lactate clearance and survival following injury. J Trauma 1993, 35:584-588.
77. McNelis J., Marini C.P., Jurkiewicz A., et al. Prolonged lactate clearance is associated with increased mortality in the surgical intensive care unit. Am J Surg 2001, 182:481-485.
78. Nguyen H.B., Rivers E.P., Knoblich B.P., et al. Early lactate clearance is associated with improved outcome in severe sepsis and septic shock. Crit Care Med 2004, 32:1637-1642.
79. Balogh Z., McKinley B.A., Cocanour C.S., et al. Supranormal trauma resuscitation causes more cases of abdominal compartment syndrome. Arch Surg 2003, 138:637-642.
80. Luchette F.A., Jenkins W.A., Friend L.A., et al. Hypoxia is not the sole cause of lactate production during shock. J Trauma 2002, 52:415-419.
81. Constant J.S., Feng J.J., Zabel D.D., et al. Lactate elicits vascular endothelial growth factor from macrophages: a possible alternative to hypoxia. Wound Repair Regen 2000, 8:353-360.
82. James J.H., Wagner K.R., King J.K., et al. Stimulation of both aerobic glycolysis and Na(+)-K(+)-ATPase activity in skeletal muscle by epinephrine or amylin. Am J Physiol 1999, 277:E176-E186.
83. Clausen T. Na+-K+ pump regulation and skeletal muscle contractility. Physiol Rev 2003, 83:1269-1324.
84. Arnold R.C., Shapiro N.I., Jones A.E., et al. Multicenter study of early lactate clearance as a determinant of survival in patients with presumed sepsis. Shock 2009, 32:35-39.
85. Jones A.E., Shapiro N.I., Trzeciak S., et al. Lactate clearance vs central venous oxygen saturation as goals of early sepsis therapy: a randomized clinical trial. JAMA 2010, 303:739-746.
86. Jansen T.C., van Bommel J., Schoonderbeek F.J., et al. Early lactate-guided therapy in intensive care unit patients: a multicenter, open-label, randomized controlled trial. Am J Respir Crit Care Med 2010, 182:752-761.
87. Schurr A. Lactate, glucose and energy metabolism in the ischemic brain (Review). Int J Mol Med 2002, 10:131-136.
88. Payne R.S., Tseng M.T., Schurr A. The glucose paradox of cerebral ischemia: evidence for corticosterone involvement. Brain Res 2003, 971:9-17.
89. Lapostolle F., Sebbah J.L., Couvreur J., et al. Risk factors for onset of hypothermia in trauma victims: the HypoTraum study. Crit Care 2012, 16:R142.
90. Frink M., Flohe S., van G.M., et al. Facts and fiction: the impact of hypothermia on molecular mechanisms following major challenge. Mediators Inflamm 2012, 2012:762840.
91. Danzl D.F., Pozos R.S., Auerbach P.S., et al. Multicenter hypothermia survey. Ann Emerg Med 1987, 16:1042-1055.
92. Beilman G.J., Blondet J.J., Nelson T.R., et al. Early hypothermia in severely injured trauma patients is a significant risk factor for multiple organ dysfunction syndrome but not mortality. Ann Surg 2009, 249:845-850.
93. Waibel B.H., Schlitzkus L.L., Newell M.A., et al. Impact of hypothermia (below 36 degrees C) in the rural trauma patient. J Am Coll Surg 2009, 209:580-588.
94. ROSOMOFF HL Protective effects of hypothermia against pathological processes of the nervous system. Ann N Y Acad Sci 1959, 80:475-486.
95. Hypothermia after Cardiac Arrest Study Group Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest. N Engl J Med 2002, 346:549-556.
96. Bernard S.A., Gray T.W., Buist M.D., et al. Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia. N Engl J Med 2002, 346:557-563.
97. Holzer M., Bernard S.A., Hachimi-Idrissi S., et al. Hypothermia for neuroprotection after cardiac arrest: systematic review and individual patient data meta-analysis. Crit Care Med 2005, 33:414-418.
98. Marion D.W., Leonov Y., Ginsberg M., et al. Resuscitative hypothermia. Crit Care Med 1996, 24:S81-S89.
99. Nolan J.P., Morley P.T., Vanden Hoek T.L., et al. Therapeutic hypothermia after cardiac arrest: an advisory statement by the advanced life support task force of the International Liaison Committee on Resuscitation. Circulation 2003, 108:118-121.
100. Merchant R.M., Soar J., Skrifvars M.B., et al. Therapeutic hypothermia utilization among physicians after resuscitation from cardiac arrest. Crit Care Med 2006, 34(7):1935-1940.
101. Tisherman S.A. Hypothermia and injury. Curr Opin Crit Care 2004, 10:512-519.
102. Meyer D.M., Horton J.W. Effect of moderate hypothermia in the treatment of canine hemorrhagic shock. Ann Surg 1988, 207:462-469.
103. Crippen D., Safar P., Porter L., et al. Improved survival of hemorrhagic shock with oxygen and hypothermia in rats. Resuscitation 1991, 21:271-281.
104. Leonov Y., Safar P., Sterz F., et al. Extending the golden hour of hemorrhagic shock tolerance with oxygen plus hypothermia in awake rats. An exploratory study. Resuscitation 2002, 52:193-202.
105. Prueckner S., Safar P., Kentner R., et al. Mild hypothermia increases survival from severe pressure-controlled hemorrhagic shock in rats. J Trauma 2001, 50:253-262.
106. Wu X., Kochanek P.M., Cochran K., et al. Mild hypothermia improves survival after prolonged, traumatic hemorrhagic shock in pigs. J Trauma 2005, 59:291-299.
107. Mizushima Y., Wang P., Cioffi W.G., et al. Should normothermia be restored and maintained during resuscitation after trauma and hemorrhage?. J Trauma 2000, 48:58-65.
108. Theusinger O.M., Madjdpour C., Spahn D.R. Resuscitation and transfusion management in trauma patients: emerging concepts. Curr Opin Crit Care 2012, [Epub ahead of print].
109. Schreiber M.A. Coagulopathy in the trauma patient. Curr Opin Crit Care 2005, 11:590-597.
110. Patt A., McCroskey B.L., Moore E.E. Hypothermia-induced coagulopathies in trauma. Surg Clin North Am 1988, 68:775-785.
111. Gubler K.D., Gentilello L.M., Hassantash S.A., et al. The impact of hypothermia on dilutional coagulopathy. J Trauma 1994, 36:847-851.
112. Rohrer M.J., Natale A.M. Effect of hypothermia on the coagulation cascade. Crit Care Med 1992, 20:1402-1405.
113. Watts D.D., Trask A., Soeken K., et al. Hypothermic coagulopathy in trauma: effect of varying levels of hypothermia on enzyme speed, platelet function, and fibrinolytic activity. J Trauma 1998, 44:846-854.
114. Wolberg A.S., Meng Z.H., Monroe D.M., et al. A systematic evaluation of the effect of temperature on coagulation enzyme activity and platelet function. J Trauma 2004, 56:1221-1228.
115. Misgav M., Martinowitz U. Harefuah 2011, 150:99-103. 207. [in Hebrew].
116. Lee K.R., Chung S.P., Park I.C., et al. Effect of induced and spontaneous hypothermia on survival time of uncontrolled hemorrhagic shock rat model. Yonsei Med J 2002, 43:511-517.
117. Resnick D.K., Marion D.W., Darby J.M. The effect of hypothermia on the incidence of delayed traumatic intracerebral hemorrhage. Neurosurgery 1994, 34:252-255.
118. Roberts I., Shakur H., Afolabi A., et al. The importance of early treatment with tranexamic acid in bleeding trauma patients: an exploratory analysis of the CRASH-2 randomised controlled trial. Lancet 2011, 377:1096-1101. 1101.
119. Roberts I., Shakur H., Ker K., et al. Antifibrinolytic drugs for acute traumatic injury. Cochrane Database Syst Rev 2011, (1). CD004896.
120. Sorensen B., Fries D. Emerging treatment strategies for trauma-induced coagulopathy. Br J Surg 2012, 1(Suppl 99):40-50.
121. Perel P., Prieto-Merino D., Shakur H., et al. Predicting early death in patients with traumatic bleeding: development and validation of prognostic model. BMJ 2012, 345:e5166.
122. Torossian A., Ruehlmann S., Middeke M., et al. Mild preseptic hypothermia is detrimental in rats. Crit Care Med 2004, 32:1899-1903.
123. Hashiguchi N., Shiozaki T., Ogura H., et al. Mild hypothermia reduces expression of heat shock protein 60 in leukocytes from severely head-injured patients. J Trauma 2003, 55:1054-1060.
124. Gregory J.S., Flancbaum L., Townsend M.C., et al. Incidence and timing of hypothermia in trauma patients undergoing operations. J Trauma 1991, 31:795-798.
125. Little R.A., Stoner H.B. Body temperature after accidental injury. Br J Surg 1981, 68:221-224.
126. Bernabei A.F., Levison M.A., Bender J.S. The effects of hypothermia and injury severity on blood loss during trauma laparotomy. J Trauma 1992, 33:835-839.
127. Jurkovich G.J., Greiser W.B., Luterman A., et al. Hypothermia in trauma victims: an ominous predictor of survival. J Trauma 1987, 27:1019-1024.
128. Luna G.K., Maier R.V., Pavlin E.G., et al. Incidence and effect of hypothermia in seriously injured patients. J Trauma 1987, 27:1014-1018.
129. Martin R.S., Kilgo P.D., Miller P.R., et al. Injury-associated hypothermia: an analysis of the 2004 National Trauma Data Bank. Shock 2005, 24:114-118.
130. Shafi S., Elliott A.C., Gentilello L. Is hypothermia simply a marker of shock and injury severity or an independent risk factor for mortality in trauma patients? Analysis of a large national trauma registry. J Trauma 2005, 59:1081-1085.
131. Wang H.E., Callaway C.W., Peitzman A.B., et al. Admission hypothermia and outcome after major trauma. Crit Care Med 2005, 33:1296-1301.
132. Gentilello L.M., Jurkovich G.J., Stark M.S., et al. Is hypothermia in the victim of major trauma protective or harmful? A randomized, prospective study. Ann Surg 1997, 226:439-447.
133. Clifton G.L., Miller E.R., Choi S.C., et al. Lack of effect of induction of hypothermia after acute brain injury. N Engl J Med 2001, 344:556-563.
134. Shiozaki T., Hayakata T., Taneda M., et al. A multicenter prospective randomized controlled trial of the efficacy of mild hypothermia for severely head injured patients with low intracranial pressure. Mild Hypothermia Study Group in Japan. J Neurosurg 2001, 94:50-54.
135. Henderson W.R., Dhingra V.K., Chittock D.R., et al. Hypothermia in the management of traumatic brain injury. A systematic review and meta-analysis. Intensive Care Med 2003, 29:1637-1644.
136. McIntyre L.A., Fergusson D.A., Hebert P.C., et al. Prolonged therapeutic hypothermia after traumatic brain injury in adults: a systematic review. JAMA 2003, 289:2992-2999.
137. Sydenham E., Roberts I., Alderson P. Hypothermia for traumatic head injury. Cochrane Database Syst Rev 2009, (2). CD001048.
138. Fox J.L., Vu E.N., Doyle-Waters M., et al. Prophylactic hypothermia for traumatic brain injury: a quantitative systematic review. CJEM 2010, 12:355-364.
139. Polderman K.H., Tjong Tjin J.R., Peerdeman S.M., et al. Effects of therapeutic hypothermia on intracranial pressure and outcome in patients with severe head injury. Intensive Care Med 2002, 28:1563-1573.
140. Jiang J.Y., Xu W., Li W.P., et al. Effect of long-term mild hypothermia or short-term mild hypothermia on outcome of patients with severe traumatic brain injury. J Cereb Blood Flow Metab 2006, 26:771-776.
141. Zhi D., Zhang S., Lin X. Study on therapeutic mechanism and clinical effect of mild hypothermia in patients with severe head injury. Surg Neurol 2003, 59:381-385.
142. Clifton G.L., Valadka A., Zygun D., et al. Very early hypothermia induction in patients with severe brain injury (the National Acute Brain Injury Study: Hypothermia II): a randomised trial. Lancet Neurol 2011, 10:131-139.