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Volumn 18, Issue 6, 2012, Pages 661-670

Resuscitation and transfusion management in trauma patients: Emerging concepts

Author keywords

goal directed transfusions; ROTEM; thrombelastometry; transfusion management; traumatic coagulopathy

Indexed keywords

ANTICOAGULANT AGENT; FRESH FROZEN PLASMA; PROTHROMBIN COMPLEX; RECOMBINANT BLOOD CLOTTING FACTOR 7A; TRANEXAMIC ACID;

EID: 84870237779     PISSN: 10705295     EISSN: 15317072     Source Type: Journal    
DOI: 10.1097/MCC.0b013e328357b209     Document Type: Review
Times cited : (60)

References (113)
  • 2
    • 34250672791 scopus 로고    scopus 로고
    • Epidemiology of urban trauma deaths: A comprehensive reassessment 10 years later
    • DOI 10.1007/s00268-007-9087-2
    • Cothren CC, Moore EE, Hedegaard HB, Meng K. Epidemiology of urban trauma deaths: a comprehensive reassessment 10 years later. World J Surg 2007; 31:1507-1511. (Pubitemid 46945377)
    • (2007) World Journal of Surgery , vol.31 , Issue.7 , pp. 1507-1511
    • Cothren, C.C.1    Moore, E.E.2    Hedegaard, H.B.3    Meng, K.4
  • 3
    • 0038070597 scopus 로고    scopus 로고
    • Effect of a voluntary trauma system on preventable death and inappropriate care in a rural state
    • discussion 9-70
    • Esposito TJ, Sanddal TL, Reynolds SA, Sanddal ND. Effect of a voluntary trauma system on preventable death and inappropriate care in a rural state. J Trauma 2003; 54:663-669; discussion 9-70.
    • (2003) J Trauma , vol.54 , pp. 663-669
    • Esposito, T.J.1    Sanddal, T.L.2    Reynolds, S.A.3    Sanddal, N.D.4
  • 4
    • 77950408835 scopus 로고    scopus 로고
    • Causes of death in US special operations forces in the global war on terrorism: 2001-2004
    • Holcomb J, Caruso J, McMullin N, et al. Causes of death in US Special Operations Forces in the global war on terrorism: 2001-2004. US Army Med Dep J 2007; 24-37.
    • (2007) US Army Med Dep J , pp. 24-37
    • Holcomb, J.1    Caruso, J.2    McMullin, N.3
  • 6
    • 35848943443 scopus 로고    scopus 로고
    • Acute coagulopathy of trauma: Mechanism, identification and effect
    • DOI 10.1097/MCC.0b013e3282f1e78f, PII 0007519820071200000010
    • Brohi K, Cohen MJ, Davenport RA. Acute coagulopathy of trauma: mechanism, identification and effect. Curr Opin Crit Care 2007; 13:680-685. (Pubitemid 350059533)
    • (2007) Current Opinion in Critical Care , vol.13 , Issue.6 , pp. 680-685
    • Brohi, K.1    Cohen, M.J.2    Davenport, R.A.3
  • 9
    • 33846989776 scopus 로고    scopus 로고
    • Damage control resuscitation: Directly addressing the early coagulopathy of trauma
    • Holcomb JB, Jenkins D, Rhee P, et al. Damage control resuscitation: directly addressing the early coagulopathy of trauma. J Trauma 2007; 62:307-310.
    • (2007) J Trauma , vol.62 , pp. 307-310
    • Holcomb, J.B.1    Jenkins, D.2    Rhee, P.3
  • 10
    • 79958837159 scopus 로고    scopus 로고
    • Trauma-induced coagulopathy - A review of the systematic reviews: Is there sufficient evidence to guide clinical transfusion practice?
    • Curry N, Stanworth S, Hopewell S, et al. Trauma-induced coagulopathy - a review of the systematic reviews: is there sufficient evidence to guide clinical transfusion practice? Transfus Med Rev 2011; 25:217-231.
    • (2011) Transfus Med Rev , vol.25 , pp. 217-231
    • Curry, N.1    Stanworth, S.2    Hopewell, S.3
  • 11
    • 68049091024 scopus 로고    scopus 로고
    • Transfusion in trauma: Why and how should we change our current practice?
    • Theusinger OM, Spahn DR, Ganter MT. Transfusion in trauma: why and how should we change our current practice? Curr Opin Anaesthesiol 2009; 22:305-312.
    • (2009) Curr Opin Anaesthesiol , vol.22 , pp. 305-312
    • Theusinger, O.M.1    Spahn, D.R.2    Ganter, M.T.3
  • 12
    • 67650607443 scopus 로고    scopus 로고
    • Preconditions of hemostasisin trauma: A review. The influence of acidosis, hypocalcemia, anemia, and hypothermia on functional hemostasis in trauma
    • Lier H, Krep H, Schroeder S, Stuber F. Preconditions of hemostasisin trauma: a review. The influence of acidosis, hypocalcemia, anemia, and hypothermia on functional hemostasis in trauma. J Trauma 2008; 65:951-960.
    • (2008) J Trauma , vol.65 , pp. 951-960
    • Lier, H.1    Krep, H.2    Schroeder, S.3    Stuber, F.4
  • 13
    • 84855578327 scopus 로고    scopus 로고
    • Acute coagulopathy and early deaths post major trauma
    • Mitra B, Cameron PA, Mori A, Fitzgerald M. Acute coagulopathy and early deaths post major trauma. Injury 2012; 43:22-25.
    • (2012) Injury , vol.43 , pp. 22-25
    • Mitra, B.1    Cameron, P.A.2    Mori, A.3    Fitzgerald, M.4
  • 15
    • 30344436377 scopus 로고    scopus 로고
    • Is hypothermia simply a marker of shock and injury severity or an independent risk factor for mortality in trauma patients? Analysis of a large national trauma registry
    • DOI 10.1097/01.ta.0000188647.03665.fd
    • Shafi S, Elliott AC, Gentilello L. Is hypothermia simply a marker of shock and injury severity or an independent risk factor for mortality in trauma patients? Analysis of a large national trauma registry. J Trauma 2005; 59:1081-1085. (Pubitemid 43060961)
    • (2005) Journal of Trauma - Injury, Infection and Critical Care , vol.59 , Issue.5 , pp. 1081-1085
    • Shafi, S.1    Elliott, A.C.2    Gentilello, L.3
  • 16
    • 0033169065 scopus 로고    scopus 로고
    • Marked temperature dependence of the platelet calcium signal induced by human von Willebrand factor
    • Kermode JC, Zheng Q, Milner EP. Marked temperature dependence of the platelet calcium signal induced by human von Willebrand factor. Blood 1999; 94:199-207. (Pubitemid 29300150)
    • (1999) Blood , vol.94 , Issue.1 , pp. 199-207
    • Kermode, J.C.1    Zheng, Q.2    Milner, E.P.3
  • 17
    • 0348163468 scopus 로고    scopus 로고
    • The Effect of Temperature and pH on the Activity of Factor VIIa: Implications for the Efficacy of High-Dose Factor VIIa in Hypothermic and Acidotic Patients
    • DOI 10.1097/01.TA.0000066184.20808.A5
    • Meng ZH, Wolberg AS, Monroe DM 3rd, Hoffman M. The effect of temperature and pH on the activity of factor VIIa: implications for the efficacy of highdose factor VIIa in hypothermic and acidotic patients. J Trauma 2003; 55:886-891. (Pubitemid 38004660)
    • (2003) Journal of Trauma - Injury, Infection and Critical Care , vol.55 , Issue.5 , pp. 886-891
    • Meng, Z.H.1    Wolberg, A.S.2    Monroe III, D.M.3    Hoffman, M.4
  • 18
    • 80055079344 scopus 로고    scopus 로고
    • Hyperfibrinolysis diagnosed by rotational thromboelastometry (ROTEM) is associated with higher mortality in patients with severe trauma
    • Theusinger OM, Wanner GA, Emmert MY, et al. Hyperfibrinolysis diagnosed by rotational thromboelastometry (ROTEM) is associated with higher mortality in patients with severe trauma. Anesth Analg 2011; 113:1003-1012.
    • (2011) Anesth Analg , vol.113 , pp. 1003-1012
    • Theusinger, O.M.1    Wanner, G.A.2    Emmert, M.Y.3
  • 19
    • 42449113389 scopus 로고    scopus 로고
    • The in vitro effects of fibrinogen concentrate, factor XIII and fresh frozen plasma on impaired clot formation after 60% dilution
    • DOI 10.1213/01.ane.0b013e3181684339, PII 0000053920080500000007
    • Haas T, Fries D, Velik-Salchner C, et al. The in vitro effects of fibrinogen concentrate, factor XIII and fresh frozen plasma on impaired clot formation after 60% dilution. Anesth Analg 2008; 106:1360-1365; table of contents. (Pubitemid 351571061)
    • (2008) Anesthesia and Analgesia , vol.106 , Issue.5 , pp. 1360-1365
    • Haas, T.1    Fries, D.2    Velik-Salchner, C.3    Reif, C.4    Klingler, A.5    Innerhofer, P.6
  • 20
    • 67649439010 scopus 로고    scopus 로고
    • Finding the optimal concentration range for fibrinogen replacement after severe haemodilution: An in vitro model
    • Bolliger D, Szlam F, Molinaro RJ, et al. Finding the optimal concentration range for fibrinogen replacement after severe haemodilution: an in vitro model. Br J Anaesth 2009; 102:793-799.
    • (2009) Br J Anaesth , vol.102 , pp. 793-799
    • Bolliger, D.1    Szlam, F.2    Molinaro, R.J.3
  • 22
    • 79958796259 scopus 로고    scopus 로고
    • Pathophysiology of early trauma-induced coagulopathy: Emerging evidence for hemodilution and coagulation factor depletion
    • Shaz BH, Winkler AM, James AB, et al. Pathophysiology of early trauma-induced coagulopathy: emerging evidence for hemodilution and coagulation factor depletion. J Trauma 2011; 70:1401-1407.
    • (2011) J Trauma , vol.70 , pp. 1401-1407
    • Shaz, B.H.1    Winkler, A.M.2    James, A.B.3
  • 25
    • 78751580640 scopus 로고    scopus 로고
    • Disseminated intravascular coagulation at an early phase of trauma is associated with consumption coagulopathy and excessive fibrinolysis both by plasmin and neutrophil elastase
    • Hayakawa M, Sawamura A, Gando S, et al. Disseminated intravascular coagulation at an early phase of trauma is associated with consumption coagulopathy and excessive fibrinolysis both by plasmin and neutrophil elastase. Surgery 2011; 149:221-230.
    • (2011) Surgery , vol.149 , pp. 221-230
    • Hayakawa, M.1    Sawamura, A.2    Gando, S.3
  • 26
    • 84855610540 scopus 로고    scopus 로고
    • Early coagulopathy in trauma patients: An on-scene and hospital admission study
    • Floccard B, Rugeri L, Faure A, et al. Early coagulopathy in trauma patients: an on-scene and hospital admission study. Injury 2012; 43:26-32.
    • (2012) Injury , vol.43 , pp. 26-32
    • Floccard, B.1    Rugeri, L.2    Faure, A.3
  • 27
    • 0035116929 scopus 로고    scopus 로고
    • Tissue factor pathway inhibitor response does not correlate with tissue factor-induced disseminated intravascular coagulation and multiple organ dysfunction syndrome in trauma patients
    • Gando S, Nanzaki S, Morimoto Y, et al. Tissue factor pathway inhibitor response does not correlate with tissue factor-induced disseminated intra-vascular coagulation and multiple organ dysfunction syndrome in trauma patients. Crit Care Med 2001; 29:262-266. (Pubitemid 32171768)
    • (2001) Critical Care Medicine , vol.29 , Issue.2 , pp. 262-266
    • Gando, S.1    Nanzaki, S.2    Morimoto, Y.3    Ishitani, T.4    Kemmotsu, O.5
  • 28
    • 77956201218 scopus 로고    scopus 로고
    • Primary fibrinolysis is integral in the pathogenesis of the acute coagulopathy of trauma
    • discussion 43-44
    • Kashuk JL, Moore EE, Sawyer M, et al. Primary fibrinolysis is integral in the pathogenesis of the acute coagulopathy of trauma. Ann Surg 2010; 252:434-442; discussion 43-44.
    • (2010) Ann Surg , vol.252 , pp. 434-442
    • Kashuk, J.L.1    Moore, E.E.2    Sawyer, M.3
  • 29
    • 70350459505 scopus 로고    scopus 로고
    • Hyperfibrinolysis after major trauma: Differential diagnosis of lysis patterns and prognostic value of thrombelastometry
    • Schochl H, Frietsch T, Pavelka M, Jambor C. Hyperfibrinolysis after major trauma: differential diagnosis of lysis patterns and prognostic value of thrombelastometry. J Trauma 2009; 67:125-131.
    • (2009) J Trauma , vol.67 , pp. 125-131
    • Schochl, H.1    Frietsch, T.2    Pavelka, M.3    Jambor, C.4
  • 30
    • 77950681467 scopus 로고    scopus 로고
    • Goal-directed coagulation management of major trauma patients using thromboelastometry (ROTEM)-guided administration of fibrinogen concentrate and prothrombin complex concentrate
    • Schochl H, Nienaber U, Hofer G, et al. Goal-directed coagulation management of major trauma patients using thromboelastometry (ROTEM)-guided administration of fibrinogen concentrate and prothrombin complex concentrate. Crit Care 2010; 14:R55.
    • (2010) Crit Care , vol.14
    • Schochl, H.1    Nienaber, U.2    Hofer, G.3
  • 31
    • 0030908865 scopus 로고    scopus 로고
    • Predicting life-threatening coagulopathy in the massively transfused trauma patient: Hypothermia and acidoses revisited
    • discussion 61-62
    • Cosgriff N, Moore EE, Sauaia A, et al. Predicting life-threatening coagulopathy in the massively transfused trauma patient: hypothermia and acidoses revisited. J Trauma 1997; 42:857-861; discussion 61-62.
    • (1997) J Trauma , vol.42 , pp. 857-861
    • Cosgriff, N.1    Moore, E.E.2    Sauaia, A.3
  • 32
    • 43349104717 scopus 로고    scopus 로고
    • Prediction of mortality and of the need for massive transfusion in casualties arriving at combat support hospitals in Iraq
    • discussion S5-S6
    • Cancio LC, Wade CE, West SA, Holcomb JB. Prediction of mortality and of the need for massive transfusion in casualties arriving at combat support hospitals in Iraq. J Trauma 2008; 64:S51-S55; discussion S5-S6.
    • (2008) J Trauma , vol.64
    • Cancio, L.C.1    Wade, C.E.2    West, S.A.3    Holcomb, J.B.4
  • 33
    • 78650851133 scopus 로고    scopus 로고
    • The role of rotation thromboelastometry in early prediction of massive transfusion
    • discussion 8-9
    • Leemann H, Lustenberger T, Talving P, et al. The role of rotation thromboelastometry in early prediction of massive transfusion. J Trauma 2010; 69:1403-1408; discussion 8-9.
    • (2010) J Trauma , vol.69 , pp. 1403-1408
    • Leemann, H.1    Lustenberger, T.2    Talving, P.3
  • 34
    • 80053195836 scopus 로고    scopus 로고
    • Prevention and treatment of coagulopathy in patients receiving massive transfusions
    • Levi M, Fries D, Gombotz H, et al. Prevention and treatment of coagulopathy in patients receiving massive transfusions. Vox Sang 2011; 101:154-174.
    • (2011) Vox Sang , vol.101 , pp. 154-174
    • Levi, M.1    Fries, D.2    Gombotz, H.3
  • 35
    • 78651309437 scopus 로고    scopus 로고
    • Revalidation and update of the TASH-score: A scoring system to predict the probability for massive transfusion as a surrogate for life-threatening haemorrhage after severe injury
    • Maegele M, Lefering R, Wafaisade A, et al. Revalidation and update of the TASH-Score: a scoring system to predict the probability for massive transfusion as a surrogate for life-threatening haemorrhage after severe injury. Vox Sang 2011; 100:231-238.
    • (2011) Vox Sang , vol.100 , pp. 231-238
    • Maegele, M.1    Lefering, R.2    Wafaisade, A.3
  • 36
    • 78650621732 scopus 로고    scopus 로고
    • Reappraising the concept of massive transfusion in trauma
    • Stanworth SJ, Morris TP, Gaarder C, et al. Reappraising the concept of massive transfusion in trauma. Crit Care 2010; 14:R239.
    • (2010) Crit Care , vol.14
    • Stanworth, S.J.1    Morris, T.P.2    Gaarder, C.3
  • 37
    • 33644880815 scopus 로고    scopus 로고
    • The emergency room transfusion score (ETS): Prediction of blood transfusion requirement in initial resuscitation after severe trauma
    • Ruchholtz S, Pehle B, Lewan U, et al. The emergency room transfusion score (ETS): prediction of blood transfusion requirement in initial resuscitation after severe trauma. Transfus Med 2006; 16:49-56.
    • (2006) Transfus Med , vol.16 , pp. 49-56
    • Ruchholtz, S.1    Pehle, B.2    Lewan, U.3
  • 38
    • 67650072457 scopus 로고    scopus 로고
    • Damage control resuscitation for patients with major trauma
    • Jansen JO, Thomas R, Loudon MA, Brooks A. Damage control resuscitation for patients with major trauma. BMJ 2009; 338:b1778.
    • (2009) BMJ , vol.338
    • Jansen, J.O.1    Thomas, R.2    Loudon, M.A.3    Brooks, A.4
  • 39
    • 77950525508 scopus 로고    scopus 로고
    • Management of bleeding following major trauma: An updated European guideline
    • Rossaint R, Bouillon B, Cerny V, et al. Management of bleeding following major trauma: an updated European guideline. Crit Care 2010; 14:R52.
    • (2010) Crit Care , vol.14
    • Rossaint, R.1    Bouillon, B.2    Cerny, V.3
  • 40
    • 78049515689 scopus 로고    scopus 로고
    • Blood transfusion and the anaesthetist: Management of massive haemorrhage
    • Thomas D, Wee M, Clyburn P, et al. Blood transfusion and the anaesthetist: management of massive haemorrhage. Anaesthesia 2010; 65:1153-1161.
    • (2010) Anaesthesia , vol.65 , pp. 1153-1161
    • Thomas, D.1    Wee, M.2    Clyburn, P.3
  • 41
    • 79952337188 scopus 로고    scopus 로고
    • The acute management of trauma hemorrhage: A systematic review of randomized controlled trials
    • Curry N, Hopewell S, Doree C, et al. The acute management of trauma hemorrhage: a systematic review of randomized controlled trials. Crit Care 2011; 15:R92.
    • (2011) Crit Care , vol.15
    • Curry, N.1    Hopewell, S.2    Doree, C.3
  • 42
    • 77956487533 scopus 로고    scopus 로고
    • Definition and drivers of acute traumatic coagulopathy: Clinical and experimental investigations
    • Frith D, Goslings JC, Gaarder C, et al. Definition and drivers of acute traumatic coagulopathy: clinical and experimental investigations. J Thromb Haemost 2010; 8:1919-1925.
    • (2010) J Thromb Haemost , vol.8 , pp. 1919-1925
    • Frith, D.1    Goslings, J.C.2    Gaarder, C.3
  • 43
    • 67650289742 scopus 로고    scopus 로고
    • Increased mortality associated with the early coagulopathy of trauma in combat casualties
    • discussion 63-65
    • Niles SE, McLaughlin DF, Perkins JG, et al. Increased mortality associated with the early coagulopathy of trauma in combat casualties. J Trauma 2008; 64:1459-1463; discussion 63-65.
    • (2008) J Trauma , vol.64 , pp. 1459-1463
    • Niles, S.E.1    McLaughlin, D.F.2    Perkins, J.G.3
  • 44
    • 58149117496 scopus 로고    scopus 로고
    • The prevalence of abnormal results of conventional coagulation tests on admission to a trauma center
    • Hess JR, Lindell AL, Stansbury LG, et al. The prevalence of abnormal results of conventional coagulation tests on admission to a trauma center. Transfusion 2009; 49:34-39.
    • (2009) Transfusion , vol.49 , pp. 34-39
    • Hess, J.R.1    Lindell, A.L.2    Stansbury, L.G.3
  • 45
    • 79961030007 scopus 로고    scopus 로고
    • Diagnostic performance and therapeutic consequence of thromboelastometry activated by kaolin versus a panel of specific reagents
    • Larsen OH, Fenger-Eriksen C, Christiansen K, et al. Diagnostic performance and therapeutic consequence of thromboelastometry activated by kaolin versus a panel of specific reagents. Anesthesiology 2011; 115:294-302.
    • (2011) Anesthesiology , vol.115 , pp. 294-302
    • Larsen, O.H.1    Fenger-Eriksen, C.2    Christiansen, K.3
  • 46
    • 84893562967 scopus 로고    scopus 로고
    • Utility of interim ROTEM((R)) values of clot strength, A5 and A10, in predicting final assessment of coagulation status in severely injured battle patients
    • Woolley T, Midwinter M, Spencer P, et al. Utility of interim ROTEM((R)) values of clot strength, A5 and A10, in predicting final assessment of coagulation status in severely injured battle patients. Injury 2012.
    • (2012) Injury
    • Woolley, T.1    Midwinter, M.2    Spencer, P.3
  • 47
    • 77955464428 scopus 로고    scopus 로고
    • In vitro factor XIII supplementation increases clot firmness in rotation thromboelastometry (ROTEM)
    • Theusinger OM, Baulig W, Asmis LM, et al. In vitro factor XIII supplementation increases clot firmness in Rotation Thromboelastometry (ROTEM). Thromb Haemost 2010; 104:385-391.
    • (2010) Thromb Haemost , vol.104 , pp. 385-391
    • Theusinger, O.M.1    Baulig, W.2    Asmis, L.M.3
  • 48
    • 76449107138 scopus 로고    scopus 로고
    • Rotation thromboelastometry (ROTEM) stability and reproducibility over time
    • Theusinger OM, Nurnberg J, Asmis LM, et al. Rotation thromboelastometry (ROTEM) stability and reproducibility over time. Eur J Cardiothorac Surg 2010; 37:677-683.
    • (2010) Eur J Cardiothorac Surg , vol.37 , pp. 677-683
    • Theusinger, O.M.1    Nurnberg, J.2    Asmis, L.M.3
  • 49
    • 80051737043 scopus 로고    scopus 로고
    • Prevalence and impact of abnormal ROTEM(R) assays in severe blunt trauma: Results of the 'Diagnosis and treatment of trauma-induced coagulopathy (DIA-TRE-TIC) study'
    • Tauber H, Innerhofer P, Breitkopf R, et al. Prevalence and impact of abnormal ROTEM(R) assays in severe blunt trauma: results of the 'Diagnosis and Treatment of Trauma-Induced Coagulopathy (DIA-TRE-TIC) study'. Br J Anaesth 2011; 107:378-387.
    • (2011) Br J Anaesth , vol.107 , pp. 378-387
    • Tauber, H.1    Innerhofer, P.2    Breitkopf, R.3
  • 50
    • 79953280012 scopus 로고    scopus 로고
    • Thromboelastography (TEG) or thromboelastometry (ROTEM) to monitor haemotherapy versus usual care in patients with massive transfusion
    • Afshari A, Wikkelso A, Brok J, et al. Thromboelastography (TEG) or thromboelastometry (ROTEM) to monitor haemotherapy versus usual care in patients with massive transfusion. Cochrane Database Syst Rev 2011; CD007871.
    • (2011) Cochrane Database Syst Rev
    • Afshari, A.1    Wikkelso, A.2    Brok, J.3
  • 51
    • 73449134837 scopus 로고    scopus 로고
    • Use of rotation thromboelastometry (ROTEM) to achieve successful treatment of polytrauma with fibrinogen concentrate and prothrombin complex concentrate
    • Schochl H, Forster L, Woidke R, et al. Use of rotation thromboelastometry (ROTEM) to achieve successful treatment of polytrauma with fibrinogen concentrate and prothrombin complex concentrate. Anaesthesia 2010; 65:199-203.
    • (2010) Anaesthesia , vol.65 , pp. 199-203
    • Schochl, H.1    Forster, L.2    Woidke, R.3
  • 52
    • 0029248007 scopus 로고
    • Multiple resuscitation regimens in a near-fatal porcine aortic injury hemorrhage model
    • Stern SA, Dronen SC, Wang X. Multiple resuscitation regimens in a near-fatal porcine aortic injury hemorrhage model. Acad Emerg Med 1995; 2:89-97.
    • (1995) Acad Emerg Med , vol.2 , pp. 89-97
    • Stern, S.A.1    Dronen, S.C.2    Wang, X.3
  • 54
    • 84907414316 scopus 로고    scopus 로고
    • Timing and volume of fluid administration for patients with bleeding
    • Kwan I, Bunn F, Roberts I. Timing and volume of fluid administration for patients with bleeding. Cochrane Database Syst Rev 2003; CD002245.
    • (2003) Cochrane Database Syst Rev
    • Kwan, I.1    Bunn, F.2    Roberts, I.3
  • 55
    • 78650715323 scopus 로고    scopus 로고
    • Ideal permissive hypotension to resuscitate uncontrolled hemorrhagic shock and the tolerance time in rats
    • Li T, Zhu Y, Hu Y, et al. Ideal permissive hypotension to resuscitate uncontrolled hemorrhagic shock and the tolerance time in rats. Anesthesiology 2011; 114:111-119.
    • (2011) Anesthesiology , vol.114 , pp. 111-119
    • Li, T.1    Zhu, Y.2    Hu, Y.3
  • 56
    • 77953020808 scopus 로고    scopus 로고
    • Prolonged permissive hypotensive resuscitation is associated with poor outcome in primary blast injury with controlled hemorrhage
    • Garner J, Watts S, Parry C, et al. Prolonged permissive hypotensive resuscitation is associated with poor outcome in primary blast injury with controlled hemorrhage. Ann Surg 2010; 251:1131-1139.
    • (2010) Ann Surg , vol.251 , pp. 1131-1139
    • Garner, J.1    Watts, S.2    Parry, C.3
  • 57
    • 79952787275 scopus 로고    scopus 로고
    • Hypotensive resuscitation strategy reduces transfusion requirements and severe postoperative coagulopathy in trauma patients with hemorrhagic shock: Preliminary results of a randomized controlled trial
    • Morrison CA, Carrick MM, Norman MA, et al. Hypotensive resuscitation strategy reduces transfusion requirements and severe postoperative coagulopathy in trauma patients with hemorrhagic shock: preliminary results of a randomized controlled trial. J Trauma 2011; 70:652-663.
    • (2011) J Trauma , vol.70 , pp. 652-663
    • Morrison, C.A.1    Carrick, M.M.2    Norman, M.A.3
  • 59
    • 79953285696 scopus 로고    scopus 로고
    • Colloids versus crystalloids for fluid resuscitation in critically ill patients
    • Perel P, Roberts I. Colloids versus crystalloids for fluid resuscitation in critically ill patients. Cochrane Database Syst Rev 2011; CD000567.
    • (2011) Cochrane Database Syst Rev
    • Perel, P.1    Roberts, I.2
  • 60
    • 80054107339 scopus 로고    scopus 로고
    • Resuscitation with hydroxyethyl starch improves renal function and lactate clearance in penetrating trauma in a randomized controlled study: The FIRST trial (Fluids in resuscitation of severe trauma)
    • James MF, Michell WL, Joubert IA, et al. Resuscitation with hydroxyethyl starch improves renal function and lactate clearance in penetrating trauma in a randomized controlled study: the FIRST trial (Fluids in Resuscitation of Severe Trauma). Br J Anaesth 2011; 107: 693-702.
    • (2011) Br J Anaesth , vol.107 , pp. 693-702
    • James, M.F.1    Michell, W.L.2    Joubert, I.A.3
  • 61
    • 33847005075 scopus 로고    scopus 로고
    • Hypertonic saline resuscitation: Efficacy may require early treatment in severely injured patients
    • Hashiguchi N, Lum L, Romeril E, et al. Hypertonic saline resuscitation: efficacy may require early treatment in severely injured patients. J Trauma 2007; 62:299-306.
    • (2007) J Trauma , vol.62 , pp. 299-306
    • Hashiguchi, N.1    Lum, L.2    Romeril, E.3
  • 62
    • 79951637133 scopus 로고    scopus 로고
    • Out-of-hospital hypertonic resuscitation after traumatic hypovolemic shock: A randomized, placebo controlled trial
    • Bulger EM, May S, Kerby JD, et al. Out-of-hospital hypertonic resuscitation after traumatic hypovolemic shock: a randomized, placebo controlled trial. Ann Surg 2011; 253:431-441.
    • (2011) Ann Surg , vol.253 , pp. 431-441
    • Bulger, E.M.1    May, S.2    Kerby, J.D.3
  • 64
    • 67650289567 scopus 로고    scopus 로고
    • Optimizing outcomes in damage control resuscitation: Identifying blood product ratios associated with improved survival
    • Gunter OL Jr, Au BK, Isbell JM, et al. Optimizing outcomes in damage control resuscitation: identifying blood product ratios associated with improved survival. J Trauma 2008; 65:527-534.
    • (2008) J Trauma , vol.65 , pp. 527-534
    • Gunter Jr., O.L.1    Au, B.K.2    Isbell, J.M.3
  • 65
    • 80051747390 scopus 로고    scopus 로고
    • Increased platelet:RBC ratios are associated with improved survival after massive transfusion
    • Holcomb JB, Zarzabal LA, Michalek JE, et al. Increased platelet:RBC ratios are associated with improved survival after massive transfusion. J Trauma 2011; 71:S318-S328.
    • (2011) J Trauma , vol.71
    • Holcomb, J.B.1    Zarzabal, L.A.2    Michalek, J.E.3
  • 66
    • 52449086212 scopus 로고    scopus 로고
    • Increased plasma and platelet to red blood cell ratios improves outcome in 466 massively transfused civilian trauma patients
    • Holcomb JB, Wade CE, Michalek JE, et al. Increased plasma and platelet to red blood cell ratios improves outcome in 466 massively transfused civilian trauma patients. Ann Surg 2008; 248:447-458.
    • (2008) Ann Surg , vol.248 , pp. 447-458
    • Holcomb, J.B.1    Wade, C.E.2    Michalek, J.E.3
  • 67
    • 67649233456 scopus 로고    scopus 로고
    • Postinjury life threatening coagulopathy: Is 1:1 fresh frozen plasma:packed red blood cells the answer?
    • discussion 70-71
    • Kashuk JL, Moore EE, Johnson JL, et al. Postinjury life threatening coagulopathy: is 1:1 fresh frozen plasma:packed red blood cells the answer? J Trauma 2008; 65:261-270; discussion 70-71.
    • (2008) J Trauma , vol.65 , pp. 261-270
    • Kashuk, J.L.1    Moore, E.E.2    Johnson, J.L.3
  • 68
    • 46749111502 scopus 로고    scopus 로고
    • Red blood cell to plasma ratios transfused during massive transfusion are associated with mortality in severe multiply injury: A retrospective analysis from the Trauma Registry of the Deutsche Gesellschaft für Unfallchirurgie
    • DOI 10.1111/j.1423-0410.2008.01074.x
    • Maegele M, Lefering R, Paffrath T, et al. Red-blood-cell to plasma ratios transfused during massive transfusion are associated with mortality in severe multiple injury: a retrospective analysis from the Trauma Registry of the Deutsche Gesellschaft fur Unfallchirurgie. Vox Sang 2008; 95:112-119. (Pubitemid 351951900)
    • (2008) Vox Sanguinis , vol.95 , Issue.2 , pp. 112-119
    • Maegele, M.1    Lefering, R.2    Paffrath, T.3    Tjardes, T.4    Simanski, C.5    Bouillon, B.6
  • 69
    • 55449102909 scopus 로고    scopus 로고
    • Early aggressive use of fresh frozen plasma does not improve outcome in critically injured trauma patients
    • Scalea TM, Bochicchio KM, Lumpkins K, et al. Early aggressive use of fresh frozen plasma does not improve outcome in critically injured trauma patients. Ann Surg 2008; 248:578-584.
    • (2008) Ann Surg , vol.248 , pp. 578-584
    • Scalea, T.M.1    Bochicchio, K.M.2    Lumpkins, K.3
  • 70
    • 67651146608 scopus 로고    scopus 로고
    • The relationship of blood product ratio to mortality: Survival benefit or survival bias?
    • discussion 62-64
    • Snyder CW, Weinberg JA, McGwin G Jr, et al. The relationship of blood product ratio to mortality: survival benefit or survival bias? J Trauma 2009; 66:358-362; discussion 62-64.
    • (2009) J Trauma , vol.66 , pp. 358-362
    • Snyder, C.W.1    Weinberg, J.A.2    McGwin Jr., G.3
  • 71
    • 67650631680 scopus 로고    scopus 로고
    • An FFP:PRBC transfusion ratio ≥1:1.5 is associated with a lower risk of mortality after massive transfusion
    • Sperry JL, Ochoa JB, Gunn SR, et al. An FFP:PRBC transfusion ratio ≥1:1.5 is associated with a lower risk of mortality after massive transfusion. J Trauma 2008; 65:986-993.
    • (2008) J Trauma , vol.65 , pp. 986-993
    • Sperry, J.L.1    Ochoa, J.B.2    Gunn, S.R.3
  • 72
    • 64749102829 scopus 로고    scopus 로고
    • A high ratio of plasma and platelets to packed red blood cells in the first 6 h of massive transfusion improves outcomes in a large multicenter study
    • discussion 70
    • Zink KA, Sambasivan CN, Holcomb JB, et al. A high ratio of plasma and platelets to packed red blood cells in the first 6 h of massive transfusion improves outcomes in a large multicenter study. Am J Surg 2009; 197:565-570; discussion 70.
    • (2009) Am J Surg , vol.197 , pp. 565-570
    • Zink, K.A.1    Sambasivan, C.N.2    Holcomb, J.B.3
  • 73
    • 75749084434 scopus 로고    scopus 로고
    • Increased number of coagulation products in relationship to red blood cell products transfused improves mortality in trauma patients
    • Shaz BH, Dente CJ, Nicholas J, et al. Increased number of coagulation products in relationship to red blood cell products transfused improves mortality in trauma patients. Transfusion 2010; 50:493-500.
    • (2010) Transfusion , vol.50 , pp. 493-500
    • Shaz, B.H.1    Dente, C.J.2    Nicholas, J.3
  • 74
    • 77953088469 scopus 로고    scopus 로고
    • The effect of plasma transfusion on morbidity and mortality: A systematic review and meta-analysis
    • Murad MH, Stubbs JR, Gandhi MJ, et al. The effect of plasma transfusion on morbidity and mortality: a systematic review and meta-analysis. Transfusion 2010; 50:1370-1383.
    • (2010) Transfusion , vol.50 , pp. 1370-1383
    • Murad, M.H.1    Stubbs, J.R.2    Gandhi, M.J.3
  • 75
    • 77949344207 scopus 로고    scopus 로고
    • Should weincrease the ratio of plasma/platelets to red blood cells in massive transfusion: What is the evidence?
    • Phan HH, Wisner DH. Should weincrease the ratio of plasma/platelets to red blood cells in massive transfusion: what is the evidence? Vox Sang 2010; 98:395-402.
    • (2010) Vox Sang , vol.98 , pp. 395-402
    • Phan, H.H.1    Wisner, D.H.2
  • 76
    • 77952541592 scopus 로고    scopus 로고
    • Impact of plasma transfusion in trauma patients who do not require massive transfusion
    • Inaba K, Branco BC, Rhee P, et al. Impact of plasma transfusion in trauma patients who do not require massive transfusion. J Am Coll Surg 2010; 210:957-965.
    • (2010) J Am Coll Surg , vol.210 , pp. 957-965
    • Inaba, K.1    Branco, B.C.2    Rhee, P.3
  • 77
    • 84859078843 scopus 로고    scopus 로고
    • Prevalence of survivor bias in observational studies on fresh frozen plasma:erythrocyte ratios in trauma requiring massive transfusion
    • Ho AM, Dion PW, Yeung JH, et al. Prevalence of survivor bias in observational studies on fresh frozen plasma:erythrocyte ratios in trauma requiring massive transfusion. Anesthesiology 2012; 116:716-728.
    • (2012) Anesthesiology , vol.116 , pp. 716-728
    • Ho, A.M.1    Dion, P.W.2    Yeung, J.H.3
  • 78
    • 67649979539 scopus 로고    scopus 로고
    • Association between duration of storage of transfused red blood cells and morbidity and mortality in adult patients: Myth or reality?
    • Lelubre C, Piagnerelli M, Vincent JL. Association between duration of storage of transfused red blood cells and morbidity and mortality in adult patients: myth or reality? Transfusion 2009; 49:1384-1394.
    • (2009) Transfusion , vol.49 , pp. 1384-1394
    • Lelubre, C.1    Piagnerelli, M.2    Vincent, J.L.3
  • 79
    • 78751634887 scopus 로고    scopus 로고
    • Hemostatic effects of fresh frozen plasma may be maximal at red cell ratios of 1:2
    • discussion 5-6
    • Davenport R, Curry N, Manson J, et al. Hemostatic effects of fresh frozen plasma may be maximal at red cell ratios of 1:2. J Trauma 2011; 70:90-95; discussion 5-6.
    • (2011) J Trauma , vol.70 , pp. 90-95
    • Davenport, R.1    Curry, N.2    Manson, J.3
  • 80
    • 43349088932 scopus 로고    scopus 로고
    • The ratio of fibrinogen to red cells transfused affects survival in casualties receiving massive transfusions at an army combat support hospital
    • discussion S85
    • Stinger HK, Spinella PC, Perkins JG, et al. The ratio of fibrinogen to red cells transfused affects survival in casualties receiving massive transfusions at an army combat support hospital. J Trauma 2008; 64:S79-S85; discussion S85.
    • (2008) J Trauma , vol.64
    • Stinger, H.K.1    Spinella, P.C.2    Perkins, J.G.3
  • 81
    • 78751635896 scopus 로고    scopus 로고
    • Improved survival after hemostatic resuscitation: Does the emperor have no clothes?
    • Magnotti LJ, Zarzaur BL, Fischer PE, et al. Improved survival after hemostatic resuscitation: does the emperor have no clothes? J Trauma 2011; 70:97-102.
    • (2011) J Trauma , vol.70 , pp. 97-102
    • Magnotti, L.J.1    Zarzaur, B.L.2    Fischer, P.E.3
  • 82
    • 33746892274 scopus 로고    scopus 로고
    • Practice guidelines for perioperative blood transfusion and adjuvant therapies: An updated report by the American society of anesthesiologists task force on perioperative blood transfusion and adjuvant therapies
    • Practice guidelines for perioperative blood transfusion and adjuvant therapies: an updated report by the American Society of Anesthesiologists Task Force on Perioperative Blood Transfusion and Adjuvant Therapies. Anesthesiology 2006; 105:198-208.
    • (2006) Anesthesiology , vol.105 , pp. 198-208
  • 83
    • 77954849876 scopus 로고    scopus 로고
    • Towards early individual goal-directed coagulation management in trauma patients
    • Spahn DR, Ganter MT. Towards early individual goal-directed coagulation management in trauma patients. Br J Anaesth 2010; 105:103-105.
    • (2010) Br J Anaesth , vol.105 , pp. 103-105
    • Spahn, D.R.1    Ganter, M.T.2
  • 84
    • 33646759539 scopus 로고    scopus 로고
    • Physiologic transfusion triggers: Do we have to use (our) brain?
    • Spahn DR, Madjdpour C. Physiologic transfusion triggers: do we have to use (our) brain? Anesthesiology 2006; 104:905-906.
    • (2006) Anesthesiology , vol.104 , pp. 905-906
    • Spahn, D.R.1    Madjdpour, C.2
  • 85
    • 33646379367 scopus 로고    scopus 로고
    • Anemia and perioperative red blood cell transfusion: A matter of tolerance
    • DOI 10.1097/01.CCM.0000214317.26717.73, PII 0000324620060500100003
    • Madjdpour C, Spahn DR, Weiskopf RB. Anemia and perioperative red blood cell transfusion: a matter of tolerance. Crit Care Med 2006; 34:S102-S108. (Pubitemid 43670475)
    • (2006) Critical Care Medicine , vol.34 , Issue.5 SUPPL.
    • Madjdpour, C.1    Spahn, D.R.2    Weiskopf, R.B.3
  • 88
    • 0036785686 scopus 로고    scopus 로고
    • The effects of perioperatively administered colloids and crystalloids on primary platelet-mediated hemostasis and clot formation
    • table of contents
    • Innerhofer P, Fries D, Margreiter J, et al. The effects of perioperatively administered colloids and crystalloids on primary platelet-mediated hemostasis and clot formation. Anesth Analg 2002; 95:858-865; table of contents.
    • (2002) Anesth Analg , vol.95 , pp. 858-865
    • Innerhofer, P.1    Fries, D.2    Margreiter, J.3
  • 90
    • 41349087159 scopus 로고    scopus 로고
    • Less impairment of hemostasis and reduced blood loss in pigs after resuscitation from hemorrhagic shock using the small-volume concept with hypertonic saline/hydroxyethyl starch as compared to administration of 4% gelatin or 6% hydroxyethyl starch solution
    • DOI 10.1213/ane.0b013e318165df18, PII 0000053920080400000008
    • Haas T, Fries D, Holz C, et al. Less impairment of hemostasis and reduced blood loss in pigs after resuscitation from hemorrhagic shock using the small-volume concept with hypertonic saline/hydroxyethyl starch as compared to administration of 4% gelatin or 6% hydroxyethyl starch solution. Anesth Analg 2008; 106:1078-1086; table of contents. (Pubitemid 351450529)
    • (2008) Anesthesia and Analgesia , vol.106 , Issue.4 , pp. 1078-1086
    • Haas, T.1    Fries, D.2    Holz, C.3    Innerhofer, P.4    Streif, W.5    Klingler, A.6    Hanke, A.7    Velik-Salchner, C.8
  • 91
    • 77954717667 scopus 로고    scopus 로고
    • Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): A randomised, placebo-controlled trial
    • Shakur H, Roberts I, Bautista R, et al. Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial. Lancet 2010; 376:23-32.
    • (2010) Lancet , vol.376 , pp. 23-32
    • Shakur, H.1    Roberts, I.2    Bautista, R.3
  • 92
    • 79953163189 scopus 로고    scopus 로고
    • The importance of early treatment with tranexamic acid in bleeding trauma patients: An exploratory analysis of the CRASH-2 randomised controlled trial
    • 101 e1-101 e2
    • Roberts I, Shakur H, Afolabi A, et al. The importance of early treatment with tranexamic acid in bleeding trauma patients: an exploratory analysis of the CRASH-2 randomised controlled trial. Lancet 2011; 377:1096-1101; 101 e1-101 e2.
    • (2011) Lancet , vol.377 , pp. 1096-1101
    • Roberts, I.1    Shakur, H.2    Afolabi, A.3
  • 93
    • 84857508828 scopus 로고    scopus 로고
    • Avoidable mortality from giving tranexamic acid to bleeding trauma patients: An estimation based on WHO mortality data, a systematic literature review and data from the CRASH-2 trial
    • Ker K, Kiriya J, Perel P, et al. Avoidable mortality from giving tranexamic acid to bleeding trauma patients: an estimation based on WHO mortality data, a systematic literature review and data from the CRASH-2 trial. BMC Emerg Med 2012; 12:3.
    • (2012) BMC Emerg Med , vol.12 , pp. 3
    • Ker, K.1    Kiriya, J.2    Perel, P.3
  • 94
    • 84859136754 scopus 로고    scopus 로고
    • CRASH-2 (Clinical randomisation of an antifibrinolytic in significant haemorrhage) intracranial bleeding study: The effect of tranexamic acid in traumatic brain injury - A nested randomised, placebo-controlled trial
    • 1-54
    • Perel P, Salman RA, Kawahara T, et al. CRASH-2 (Clinical Randomisation of an Antifibrinolytic in Significant Haemorrhage) intracranial bleeding study: the effect of tranexamic acid in traumatic brain injury - a nested randomised, placebo-controlled trial. Health Technol Assess 2012; 16:iii-xii, 1-54.
    • (2012) Health Technol Assess , vol.16
    • Perel, P.1    Salman, R.A.2    Kawahara, T.3
  • 95
    • 84861509156 scopus 로고    scopus 로고
    • Factor XIII and tranexamic acid but not recombinant factor VIIa attenuate tissue plasminogen activator-induced hyperfibrinolysis in human whole blood
    • Dirkmann D, Gorlinger K, Gisbertz C, et al. Factor XIII and tranexamic acid but not recombinant factor VIIa attenuate tissue plasminogen activator-induced hyperfibrinolysis in human whole blood. Anesth Analg 2012; 114:1182-1188.
    • (2012) Anesth Analg , vol.114 , pp. 1182-1188
    • Dirkmann, D.1    Gorlinger, K.2    Gisbertz, C.3
  • 96
    • 84861525830 scopus 로고    scopus 로고
    • The inhibiting effect of factor XIII on hyperfibrinolysis
    • Theusinger OM. The inhibiting effect of factor XIII on hyperfibrinolysis. Anesth Analg 2012; 114:1149-1150.
    • (2012) Anesth Analg , vol.114 , pp. 1149-1150
    • Theusinger, O.M.1
  • 97
    • 0030464395 scopus 로고    scopus 로고
    • Factor XIII deficiency: Pathogenic mechanisms and clinical significance
    • Egbring R, Kroniger A, Seitz R. Factor XIII deficiency: pathogenic mechanisms and clinical significance. Semin Thromb Hemostat 1996; 22:419-425. (Pubitemid 27050712)
    • (1996) Seminars in Thrombosis and Hemostasis , vol.22 , Issue.5 , pp. 419-425
    • Egbring, R.1    Kroniger, A.2    Seitz, R.3
  • 98
    • 3042662496 scopus 로고    scopus 로고
    • The impact of factor XIII on coagulation kinetics and clot strength determined by thrombelastogrhy
    • Nielsen VG, Gurley WQJr, Burch TM. The impact of factor XIII on coagulation kinetics and clot strength determined by thrombelastography. Anesth Analg 2004; 99:120-123. (Pubitemid 38808177)
    • (2004) Anesthesia and Analgesia , vol.99 , Issue.1 , pp. 120-123
    • Nielsen, V.G.1    Gurley Jr., W.Q.2    Burch, T.M.3
  • 99
    • 84855671155 scopus 로고    scopus 로고
    • Dosing of 3-factor prothrombin complex concentrate for international normalized ratio reversal
    • Baggs JH, Patanwala AE, Williams EM, Erstad BL. Dosing of 3-factor prothrombin complex concentrate for international normalized ratio reversal. Ann Pharmacother 2012; 46:51-56.
    • (2012) Ann Pharmacother , vol.46 , pp. 51-56
    • Baggs, J.H.1    Patanwala, A.E.2    Williams, E.M.3    Erstad, B.L.4
  • 100
    • 84857822338 scopus 로고    scopus 로고
    • Rapid warfarin reversal: A 3-factor prothrombin complex concentrate and recombinant factor VIIa cocktail for intracerebral hemorrhage
    • Sarode R, Matevosyan K, Bhagat R, et al. Rapid warfarin reversal: a 3-factor prothrombin complex concentrate and recombinant factor VIIa cocktail for intracerebral hemorrhage. J Neurosurg 2012; 116:491-497.
    • (2012) J Neurosurg , vol.116 , pp. 491-497
    • Sarode, R.1    Matevosyan, K.2    Bhagat, R.3
  • 101
    • 80053185411 scopus 로고    scopus 로고
    • Prothrombin complex concentrate reduces blood loss and enhances thrombin generation in a pig model with blunt liver injury under severe hypothermia
    • Honickel M, Rieg A, Rossaint R, et al. Prothrombin complex concentrate reduces blood loss and enhances thrombin generation in a pig model with blunt liver injury under severe hypothermia. Thromb Haemost 2011; 106:724-733.
    • (2011) Thromb Haemost , vol.106 , pp. 724-733
    • Honickel, M.1    Rieg, A.2    Rossaint, R.3
  • 102
    • 79955800289 scopus 로고    scopus 로고
    • Potential use of prothrombin complex concentrate in trauma resuscitation
    • McSwain N Jr, Barbeau J. Potential use of prothrombin complex concentrate in trauma resuscitation. J Trauma 2011; 70:S53-S56.
    • (2011) J Trauma , vol.70
    • McSwain Jr., N.1    Barbeau, J.2
  • 103
    • 80054894351 scopus 로고    scopus 로고
    • Three- or four-factor prothrombin complex concentrate for emergency anticoagulation reversal: What are we really looking for?
    • author's reply 470-471
    • Marietta M, Pedrazzi P, Luppi M. Three- or four-factor prothrombin complex concentrate for emergency anticoagulation reversal: what are we really looking for? Blood Transfus 2011; 9:469; author's reply 470-471.
    • (2011) Blood Transfus , vol.9 , pp. 469
    • Marietta, M.1    Pedrazzi, P.2    Luppi, M.3
  • 104
    • 79960814790 scopus 로고    scopus 로고
    • Prothrombin complex concentrate versus standard therapies for INR reversal in trauma patients receiving warfarin
    • Chapman SA, Irwin ED, Beal AL, et al. Prothrombin complex concentrate versus standard therapies for INR reversal in trauma patients receiving warfarin. Ann Pharmacother 2011; 45:869-875.
    • (2011) Ann Pharmacother , vol.45 , pp. 869-875
    • Chapman, S.A.1    Irwin, E.D.2    Beal, A.L.3
  • 105
    • 79958050406 scopus 로고    scopus 로고
    • Use of prothrombin complex concentrate for vitamin K antagonist reversal before surgical treatment of intracranial hemorrhage
    • Wong Y. Use of prothrombin complex concentrate for vitamin K antagonist reversal before surgical treatment of intracranial hemorrhage. Clin Med Insights Case Rep 2011; 4:1-6.
    • (2011) Clin Med Insights Case Rep , vol.4 , pp. 1-6
    • Wong, Y.1
  • 107
    • 79953699396 scopus 로고    scopus 로고
    • Three or four factor prothrombin complex concentrate for emergency anticoagulation reversal?
    • Makris M, Van Veen JJ. Three or four factor prothrombin complex concentrate for emergency anticoagulation reversal? Blood Transfus 2011; 9:117-119.
    • (2011) Blood Transfus , vol.9 , pp. 117-119
    • Makris, M.1    Van Veen, J.J.2
  • 108
    • 79953680507 scopus 로고    scopus 로고
    • Emergency reversal of anticoagulation with a three-factor prothrombin complex concentrate in patients with intracranial haemorrhage
    • Imberti D, Barillari G, Biasioli C, et al. Emergency reversal of anticoagulation with a three-factor prothrombin complex concentrate in patients with intracranial haemorrhage. Blood Transfus 2011; 9:148-155.
    • (2011) Blood Transfus , vol.9 , pp. 148-155
    • Imberti, D.1    Barillari, G.2    Biasioli, C.3
  • 109
    • 79951667284 scopus 로고    scopus 로고
    • Fixed versus variable dose of prothrombin complex concentrate for counteracting vitamin K antagonist therapy
    • Khorsand N, Veeger NJ, Muller M, et al. Fixed versus variable dose of prothrombin complex concentrate for counteracting vitamin K antagonist therapy. Transfus Med 2011; 21:116-123.
    • (2011) Transfus Med , vol.21 , pp. 116-123
    • Khorsand, N.1    Veeger, N.J.2    Muller, M.3
  • 110
    • 78651092385 scopus 로고    scopus 로고
    • Efficacy of prothrombin complex concentrate to reverse the anticoagulant effect of the pentasaccharide fondaparinux in a rabbit model
    • Godier A, Durand M, Emmerich J, et al. Efficacy of prothrombin complex concentrate to reverse the anticoagulant effect of the pentasaccharide fondaparinux in a rabbit model. Thromb Haemost 2011; 105:161-168.
    • (2011) Thromb Haemost , vol.105 , pp. 161-168
    • Godier, A.1    Durand, M.2    Emmerich, J.3
  • 111
    • 79953306391 scopus 로고    scopus 로고
    • Clinical review: Prothrombin complex concentrates - Evaluation of safety and thrombogenicity
    • Sorensen B, Spahn DR, Innerhofer P, et al. Clinical review: prothrombin complex concentrates - evaluation of safety and thrombogenicity. Crit Care 2011; 15:201.
    • (2011) Crit Care , vol.15 , pp. 201
    • Sorensen, B.1    Spahn, D.R.2    Innerhofer, P.3
  • 112
    • 38349116191 scopus 로고    scopus 로고
    • Recombinant factor VIIa for the prevention and treatment of bleeding in patients without haemophilia
    • Stanworth SJ, Birchall J, Doree CJ, Hyde C. Recombinant factor VIIa for the prevention and treatment of bleeding in patients without haemophilia. Cochrane Database Syst Rev 2007; CD005011.
    • (2007) Cochrane Database Syst Rev
    • Stanworth, S.J.1    Birchall, J.2    Doree, C.J.3    Hyde, C.4
  • 113
    • 33846512437 scopus 로고    scopus 로고
    • Transfusion algorithms and how they apply to blood conservation: The high-risk cardiac surgical patient
    • DOI 10.1016/j.hoc.2006.11.009, PII S0889858806001936, Inflamation, Hemostasis, and Blood Conservation Strategies
    • Steiner ME, Despotis GJ. Transfusion algorithms and how they applyto blood conservation: the high-risk cardiac surgical patient. Hematol Oncol Clin North Am 2007; 21:177-184. (Pubitemid 46156985)
    • (2007) Hematology/Oncology Clinics of North America , vol.21 , Issue.1 , pp. 177-184
    • Steiner, M.E.1    Despotis, G.J.2


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