Relationship between systemic glucose and cerebral glucose is preserved in patients with severe traumatic brain injury, but glucose delivery to the brain may become limited when oxidative metabolism is impaired: Implications for glycemic control

Critical Care Medicine

Volumn 40, Issue 6, 2012, Pages 1785-1791

  Magnoni, Sandra ^a   Tedesco, Cecilia ^a   Carbonara, Marco ^a   Pluderi, Mauro ^b   Colombo, Angelo ^a   Stocchetti, Nino ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b MAGGIORE HOSPITAL   (Italy)

Author keywords

brain injury; brain ischemia; glucose; glucose transport; microdialysis; neurochemistry

Indexed keywords

GLUCOSE; LACTIC ACID; PYRUVIC ACID;

ADULT; AEROBIC METABOLISM; AGED; ARTICLE; BRAIN METABOLISM; BRAIN PERFUSION; CLINICAL ARTICLE; FEMALE; GLUCOSE BLOOD LEVEL; GLUCOSE BRAIN LEVEL; GLUCOSE TRANSPORT; GLYCEMIC CONTROL; HUMAN; HUMAN TISSUE; INTRACRANIAL PRESSURE; MALE; MEAN ARTERIAL PRESSURE; MICRODIALYSIS; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SUBCUTANEOUS FAT; TRAUMATIC BRAIN INJURY;

ADULT; AGED; AGED, 80 AND OVER; BLOOD GLUCOSE; BRAIN; BRAIN INJURIES; FEMALE; GLUCOSE; HUMANS; MALE; MICRODIALYSIS; MIDDLE AGED; PROSPECTIVE STUDIES; RETROSPECTIVE STUDIES; SEVERITY OF ILLNESS INDEX; YOUNG ADULT;

EID: 84861490565     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0b013e318246bd45     Document Type: Article

References (40)

1. Crone C: Facilitated transfer of glucose from blood into brain tissue. J Physiol (Lond) 1965; 181:103-113
2. Vannucci SJ, Maher F, Simpson IA: Glucose transporter proteins in brain: Delivery of glucose to neurons and glia. Glia 1997; 21:2-21
3. Bolinder J, Ungerstedt U, Arner P: Long-term continuous glucose monitoring with microdialysis in ambulatory insulin-dependent diabetic patients. Lancet 1993; 342:1080-1085
4. Hutchinson PJ, O'Connell MT, Maskell LB, et al: Monitoring by subcutaneous microdialysis in neurosurgical intensive care. Acta Neurochir Suppl 1999; 75:57-59
5. Hillered L, Persson L, Nilsson P, et al: Continuous monitoring of cerebral metabolism in traumatic brain injury: A focus on cerebral microdialysis. Curr Opin Crit Care 2006; 12:112-118
6. Vespa PM, McArthur D, O'Phelan K, et al: Persistently low extracellular glucose correlates with poor outcome 6 months after human traumatic brain injury despite a lack of increased lactate: A microdialysis study.J Cereb Blood Flow Metab 2003; 23: 865-877
7. Bergsneider M, Hovda DA, Shalmon E, et al: Cerebral hyperglycolysis following severe traumatic brain injury in humans: A positron emission tomography study.J Neurosurg 1997; 86:241-251
8. Kawamata T, Katayama Y, Hovda DA, et al: Administration of excitatory amino acid antagonists via microdialysis attenuates the increase in glucose utilization seen following concussive brain injury. J Cereb Blood Flow Metab 1992; 12:12-24.
9. Parkin M, Hopwood S, Jones DA, et al: Dynamic changes in brain glucose and lactate in pericontusional areas of the human cerebral cortex, monitored with rapid sampling on-line microdialysis: Relationship with depolarisation-like events. J Cereb Blood Flow Metab 2005; 25:402-413
10. Lund-Andersen H: Transport of glucose from blood to brain. Physiol Rev 1979; 59:305-352
11. Choi IY, Lee SP, Kim SG, et al: In vivo measurements of brain glucose transport using the reversible Michaelis-Menten model and simultaneous measurements of cerebral blood flow changes during hypoglycemia.J Cereb Blood Flow Metab 2001; 21:653-663
12. Gruetter R, Ugurbil K, Seaquist ER: Steady-state cerebral glucose concentrations and transport in the human brain. J Neurochem 1998; 70:397-408
13. Diaz-Parejo P, Ståhl N, Xu W, et al: Cerebral energy metabolism during transient hyperglycemia in patients with severe brain trauma. Intensive Care Med 2003; 29:544-550
14. Oddo M, Schmidt JM, Carrera E, et al: Impact of tight glycemic control on cerebral glucose metabolism after severe brain injury: A microdialysis study. Crit Care Med 2008; 36:3233-3238
15. Vespa P, Boonyaputthikul R, McArthur DL, et al: Intensive insulin therapy reduces microdialysis glucose values without altering glucose utilization or improving the lactate/pyruvate ratio after traumatic brain injury. Crit Care Med 2006; 34:850-856
16. Schlenk F, Nagel A, Graetz D, et al: Hyperglycemia and cerebral glucose in aneurysmal subarachnoid hemorrhage. Intensive Care Med 2008; 34: 1200-1207
17. Lonjon M, Risso JJ, Palmier B, et al: Effects of hypothermic deep-anaesthesia on energy metabolism at brain and peripheral levels: A multi-probe microdialysis study in free-moving rat. Neurosci Lett 2001; 304:21-24
18. Poca MA, Sahuquillo J, Vilalta A, et al: Percutaneous implantation of cerebral microdialysis catheters by twist-drill craniostomy in neurocritical patients: Description of the technique and results of a feasibility study in 97 patients. J Neurotrauma 2006; 23:1510-1517
19. Hutchinson PJ, al-Rawi PG, O'Connell MT, et al: On-line monitoring of substrate delivery and brain metabolism in head injury. Acta Neurochir Suppl 2000; 76:431-435
20. Reinstrup P, Stahl N, Mellergard P, et al: Intracerebral microdialysis in clinical practice: Baseline values for chemical markers during wakefulness, anesthesia, and neurosurgery. Neurosurgery 2000; 47:701-709; discussion 709-710
21. Ungerstedt U, Rostami E: Microdialysis in neurointensive care. Curr Pharm Des 2004; 10:2145-2152
22. Vespa PM, O'Phelan K, McArthur D, et al: Pericontusional brain tissue exhibits persistent elevation of lactate/pyruvate ratio independent of cerebral perfusion pressure. Crit Care Med 2007; 35:1153-1160
23. Finfer S, Chittock DR, Su SY, et al; NICE-SUGAR Study Investigators: Intensive versus conventional glucose control in critically ill patients. N Engl J Med 2009; 360:1283-1297
24. Lourido J, Ederoth P, Sundvall N, et al: Correlation between blood glucose concentration and glucose concentration in subcutaneous adipose tissue evaluated with microdialysis during intensive care. Scand J Clin Lab Invest 2002; 62:285-292
25. Nielsen JK, Djurhuus CB, Gravholt CH, et al: Continuous glucose monitoring in interstitial subcutaneous adipose tissue and skeletal muscle reflects excursions in cerebral cortex. Diabetes 2005; 54:1635-1639
26. Zetterling M, Hillered L, Enblad P, et al: Relation between brain interstitial and systemic glucose concentrations after subarachnoid hemorrhage. J Neurosurg 2011; 115:66-74
27. Gruetter R, Novotny EJ, Boulware SD, et al: Direct measurement of brain glucose concentrations in humans by 13C NMR spectroscopy. Proc Natl Acad Sci USA 1992; 89:1109-1112
28. Sehba FA, Bederson JB: Mechanisms of acute brain injury after subarachnoid hemorrhage. Neurol Res 2006; 28:381-398
29. Bouma GJ, Muizelaar JP, Choi SC, et al: Cerebral circulation and metabolism after severe traumatic brain injury: The elusive role of ischemia. J Neurosurg 1991; 75:685-693
30. Hlatky R, Valadka AB, Goodman JC, et al: Patterns of energy substrates during ischemia measured in the brain by microdialysis.J Neurotrauma 2004; 21:894-906
31. Hutchinson PJ, Gupta AK, Fryer TF, et al: Correlation between cerebral blood flow, substrate delivery, and metabolism in head injury: A combined microdialysis and triple oxygen positron emission tomography study. J Cereb Blood Flow Metab 2002; 22:735-745
32. Belli A, Sen J, Petzold A, et al: Metabolic failure precedes intracranial pressure rises in traumatic brain injury: A microdialysis study. Acta Neurochir (Wien) 2008; 150:461-469; discussion 470.
33. Timofeev I, Czosnyka M, Carpenter KL, et al: Interaction between brain chemistry and physiology after traumatic brain injury: Impact of autoregulation and microdialysis catheter location. J Neurotrauma 2011; 28:849-860
34. Coles JP, Fryer TD, Smielewski P, et al: Incidence and mechanisms of cerebral ischemia in early clinical head injury. J Cereb Blood Flow Metab 2004; 24:202-211
35. Vespa P, Bergsneider M, Hattori N, et al: Metabolic crisis without brain ischemia is common after traumatic brain injury: A combined microdialysis and positron emission tomography study. J Cereb Blood Flow Metab 2005; 25:763-774
36. Marcoux J, McArthur DA, Miller C, et al: Persistent metabolic crisis as measured by elevated cerebral microdialysis lactate-pyruvate ratio predicts chronic frontal lobe brain atrophy after traumatic brain injury. Crit Care Med 2008; 36:2871-2877
37. Timofeev I, Carpenter KL, Nortje J, et al:Cerebral extracellular chemistry and outcome following traumatic brain injury: A microdialysis study of 223 patients. Brain 2011; 134(Pt 2):484-494
38. Oddo M, Schmidt JM, Mayer SA, et al: Glucose control after severe brain injury. Curr Opin Clin Nutr Metab Care 2008; 11:134-139
39. Strong AJ: The management of plasma glucose in acute cerebral ischaemia and traumatic brain injury: More research needed. Intensive Care Med 2008; 34: 1169-1172
40. Marshall LF, Marshall SB, Klauber MR, et al: The diagnosis of head injury requires a classification based on computed axial tomography. J Neurotrauma 1992; 9(Suppl 1):S287-S292