Early hypothermia in severely injured trauma patients is a significant risk factor for multiple organ dysfunction syndrome but not mortality

Annals of Surgery

Volumn 249, Issue 5, 2009, Pages 845-850

  Beilman, Greg J ^a   Blondet, Juan J ^a   Nelson, Teresa R ^b   Nathens, Avery B ^c   Moore, Frederick A ^d   Rhee, Peter ^e   Puyana, Juan Carlos ^f   Moore, Ernest E ^g   Cohn, Stephen M ^h  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^b Technomics Research LLC   (United States)

^c ST MICHAEL'S HOSPITAL   (Canada)

^d UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^e UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^f UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^g UNIVERSITY OF COLORADO   (United States)

^h Mays Cancer Center at UT Health San Antonio   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ARTICLE; BLOOD TRANSFUSION; CLINICAL TRIAL; DIAGNOSTIC VALUE; FEMALE; HOSPITALIZATION; HUMAN; HYPOTENSION; HYPOTHERMIA; INJURY SEVERITY; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; MULTIPLE ORGAN FAILURE; NEAR INFRARED SPECTROSCOPY; OBSERVATIONAL STUDY; OXYGEN SATURATION; PERFUSION; PRIORITY JOURNAL; PROSPECTIVE STUDY; STATISTICAL ANALYSIS; TREATMENT OUTCOME;

ADULT; FEMALE; HUMANS; HYPOTHERMIA; MALE; MIDDLE AGED; MULTIPLE ORGAN FAILURE; PROSPECTIVE STUDIES; RISK FACTORS; TRAUMA CENTERS; UNITED STATES; WOUNDS AND INJURIES;

EID: 67649553316     PISSN: 00034932     EISSN: 15281140     Source Type: Journal    
DOI: 10.1097/SLA.0b013e3181a41f6f     Document Type: Article

References (33)

1. Gregory JS, Flancbaum L, Townsend MC, et al. Incidence and timing of hypothermia in trauma patients undergoing operations. J Trauma. 1991;31: 795-798.
2. Luna GK, Maier RV, Pavlin EG, et al. Incidence and effect of hypothermia in seriously injured patients. J Trauma. 1987;27:1014 -1018.
3. Jurkovich GJ, Greiser WB, Luterman A, et al. Hypothermia in trauma victims: an ominous predictor of survival. J Trauma. 1987;27:1019-1024.
4. Kashuk JL, Moore EE, Millikan JS, et al. Major abdominal vascular trauma - a unified approach. J Trauma. 1982;22:672- 678.
5. Kirkpatrick AW, Chun R, Brown R, et al. Hypothermia and the trauma patient. Can J Surg. 1999;42:333-344.
6. Ferrara A, MacArthur JD, Wright HK, et al. Hypothermia and acidosis worsen coagulation in the patient requiring massive transfusion. Am J Surg. 1990;160:515-518.
7. Burch JM, Ortiz VB, Richardson J, et al. Abbreviated laparotomy and planned reoperation for critically ill patients. Ann Surg. 1992;215:476-483.
8. Martin RS, Kilgo PD, Miller PR, et al. Injury-associated hypothermia: an analysis of the 2004 national trauma bank. Shock. 2005;24:114-118.
9. Steinemann S, Shackford SR, Davis JW. Implications of admission hypothermia in trauma patients. J Trauma. 1990;30:200-202.
10. Gentilello LM, Jurkovich GJ, Stark MS, et al. Is hypothermia in the victim of major trauma protective or harmful? Ann Surg. 1997;226:439-449.
11. Committee on Trauma, American College of Surgeons. Advanced Trauma Life Support Program for Doctors. [Instructor Manual]. Chicago, IL: American College of Surgeons; 1997.
12. Takasu A, Carrillo P, Stezoski SW, et al. Mild or moderate hypothermia but not increased oxygen breathing prolongs survival during lethal uncontrolled hemorrhagic shock in rats, with monitoring of visceral dysoxia. Crit Care Med. 1999;27:1557-1564.
13. Hildebrand F, Giannoudis PV, van Griensven M, et al. Pathophysiologic changes and effects of hypothermia on outcome in elective surgery and trauma patients. Am J Surg. 2004;187:363-371.
14. The Hypothermia After Cardiac Arrest Study Group. Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest. N Engl J Med 2002;346:549-556.
15. Bernard SA, Gray TW, Buist MD, et al. Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia. N Engl J Med. 2002;346:557-563.
16. Cohn SM, Nathens AB, Moore FA, et al. Tissue oxygen saturation predicts the development of organ dysfunction during traumatic shock resuscitation. J Trauma. 2007;62:44-55.
17. Wang HE, Callaway CW, Peitzman AB, et al. Admission hypothermia and outcome after major trauma. Crit Care Med. 2005;33:1296-1301.
18. Clifton GL, Miller ER, Choi SC, et al. Hypothermia on admission in patients with severe brain injury. J Neurotrauma. 2002;19:293-301.
19. Gubler KD, Gentilello LM, Hassantash SA, et al. The impact of hypothermia on dilutional coagulopathy. J Trauma. 1994;36:847-851.
20. Marshall JC, Cook DJ, Christou NV, et al. Multiple organ dysfunction score: a reliable descriptor of a complex clinical outcome. Crit Care Med. 1995;23: 1638-1652.
21. Moore FA, Sauaia A, Moore EE, et al. Postinjury multiple organ failure: a bimodal phenomenon. J Trauma. 1996;40:501-510.
22. Seekamp A, van Griensven M, Hildebrandt F, et al. Adenosine-triphosphate in trauma-related and elective hypothermia. J Trauma. 1999;47:673-693.
23. Hoesch RE, Geocadin RG. Therapeutic hypothermia for global and focal ischemic brain injury-a cool way to improve neurologic outcomes. Neurologist. 2007;13:331-342.
24. Gregory JS, Bergstein JM, Aprahamian C, et al. Comparison of three methods of rewarming from hypothermia: advantages of extracorporeal blood warming. J Trauma. 1991;31:1247-1251.
25. Husum H, Olsen T, Murad M, et al. Preventing port-injury hypothermia during prolonged prehospital evacuation. Prehosp Disast Med. 2002;17:23-26.
26. Beekley AC, Watts DM. Combat trauma experience with the United States Army 102nd Forward Surgical Team in Afghanistan. Am J Surg. 2004;187: 652-654.
27. Bernabei AF, Levison MA, Bender JS. The effects of hypothermia and injury severity on blood loss during trauma laparotomy. J Trauma. 1992;33:835-839.
28. Stoner HB. Responses to trauma: fifty years of ebb and flow. Circ Shock. 1993;39:316-319.
29. Edwards JD, Redmond AD, Nightingale P, et al. Oxygen consumption following trauma: a reappraisal in severely injured patients requiring mechanical ventilation. Br J Surg. 1988;75:690-692.
30. Stoner HB. Effect of injury on shivering thermogenesis in the rat. J Physiol. 1971;214:599-615.
31. Stoner HB. Effect of injury on the responses to thermal stimulation of the hypothalamus. J Appl Physiol. 1972;33:665-671.
32. Reed II RL, Gentilello LM. Temperature-associated injuries and syndromes. In: Moore EE, Feliciano DV, Mattox KL. Trauma. 5th ed. McGraw-Hill; 2004:1099-1109.
33. 2) measurements identify supply dependency over a gradient of physiologic variables [abstract]. J Surg Res. 2008;144:337.