Cytochrome P450 regulation by α-tocopherol in Pxr-Null and PXR-humanized mice

Drug Metabolism and Disposition

Volumn 41, Issue 2, 2013, Pages 406-413

  Johnson, Caroline H ^a   Bonzo, Jessica A ^a   Cheng, Jie ^a   Krausz, Kristopher W ^a   Kang, Dong Wook ^b   Luecke, Hans ^b   Idle, Jeffrey R ^c   Gonzalez, Frank J ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^c UNIVERSITY OF BERN   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TOCOPHEROL; CYTOCHROME P450; CYTOCHROME P450 2C; CYTOCHROME P450 2C29; CYTOCHROME P450 2C37; CYTOCHROME P450 2C55; CYTOCHROME P450 3A11; PREGNANE X RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CYP2C GENE; CYP2C29 GENE; CYP2C37 GENE; CYP2C55 GENE; CYP3A11 GENE; CYTOCHROME P450 GENE; GENE CONTROL; GENE EXPRESSION; IN VIVO STUDY; MALE; MASS SPECTROMETRY; METABOLITE; METABOLOMICS; MOUSE; MOUSE STRAIN; MULTIGENE FAMILY; NONHUMAN; NULL ALLELE; PRIORITY JOURNAL; PROTEIN FUNCTION; VITAMIN METABOLISM; WILD TYPE;

ALPHA-TOCOPHEROL; ANIMALS; BIOLOGICAL MARKERS; BIOTRANSFORMATION; CHROMATOGRAPHY, LIQUID; CYTOCHROME P-450 CYP3A; CYTOCHROME P-450 ENZYME SYSTEM; DRUG PARTIAL AGONISM; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENES, REPORTER; HEP G2 CELLS; HUMANS; ISOENZYMES; LIVER; MALE; MASS SPECTROMETRY; METABOLOMICS; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; RECEPTORS, STEROID; SPECIES SPECIFICITY; TIME FACTORS; TRANSFECTION;

MURINAE; MUS;

EID: 84872723628     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.112.048009     Document Type: Article

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