Pancreatic islet response to hyperglycemia is dependent on peroxisome proliferator-activated receptor alpha (PPARα)

FEBS Letters

Volumn 579, Issue 11, 2005, Pages 2284-2288

  Bihan, Hélène ^a,e   Rouault, Christine ^a   Reach, Gérard ^a,e   Poitout, Vincent ^b   Staels, Bart ^c,d   Guerre Millo, Michèle ^c  

^a HÔTEL DIEU   (France)

^b PACIFIC NORTHWEST RESEARCH INSTITUTE   (United States)

^c INSERM   (France)

^d UNIV LILLE   (France)

^e AVICENNE HOSPITAL   (France)

Author keywords

Fatty acid; High fat diet; Insulin secretion

Indexed keywords

GLUCOSE; INSULIN; MESSENGER RNA; PALMITIC ACID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; DISEASE COURSE; HOMEOSTASIS; HYPERGLYCEMIA; INSULIN RELEASE; MALE; MOUSE; NONHUMAN; PANCREAS ISLET; PHENOTYPE; PRIORITY JOURNAL; WILD TYPE;

EID: 17644378054     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2005.03.020     Document Type: Article

References (30)

1. T. Aoyama, J.M. Peters, N. Iritani, T. Nakajima, K. Furihata, T. Hashimoto, and F.J. Gonzalez Altered constitutive expression of fatty acid-metabolizing enzymes in mice lacking the peroxisome proliferator-activated receptor alpha (PPARalpha) J. Biol. Chem. 273 1998 5678 5684
2. F. Djouadi, C.J. Weinheimer, J.E. Saffitz, C. Pitchford, J. Bastin, F.J. Gonzalez, and D.P. Kelly A gender-related defect in lipid metabolism and glucose homeostasis in peroxisome proliferator-activated receptor alpha-deficient mice J. Clin. Invest. 102 1998 1083 1091
3. Y.T. Zhou, M. Shimabukuro, M.Y. Wang, Y. Lee, M. Higa, J.L. Milburn, C.B. Newgard, and R.H. Unger Role of peroxisome proliferator-activated receptor alpha in disease of pancreatic beta cells Proc. Natl. Acad. Sci. USA 95 1998 8898 8903
4. R. Roduit, J. Morin, F. Masse, L. Segall, E. Roche, C.B. Newgard, F. Assimacopoulos-Jeannet, and M. Prentki Glucose downregulates the expression of the peroxisome proliferator-activated receptor-alpha gene in the pancreatic beta-cell J. Biol. Chem. 275 2000 35799 35806
5. R. Laybutt, W. Hasenkamp, A. Groff, S. Grey, J.C. Jonas, H. Kaneto, A. Sharma, S. Bonner-Weir, and G. Weir Beta-cell adaptation to hyperglycemia Diabetes 50 2001 S180 S181
6. H. Yoshikawa, Y. Tajiri, Y. Sako, T. Hashimoto, F. Umeda, and H. Nawata Effects of free fatty acids on beta-cell functions: a possible involvement of peroxisome proliferator-activated receptors alpha or pancreatic/duodenal homeobox Metabolism 50 2001 613 618
7. K. Tordjman, K.N. Standley, C. Bernal-Mizrachi, T.C. Leone, T. Coleman, D.P. Kelly, and C.F. Semenkovich PPARalpha suppresses insulin secretion and induces UCP2 in insulinoma cells J. Lipid Res. 43 2002 936 943
8. S. Gremlich, C. Nolan, R. Roduit, R. Burcelin, M.L. Peyot, V. Delghingaro-Augusto, B. Desvergne, L. Michalik, M. Prentki, and W. Wahli Pancreatic islet adaptation to fasting is dependent on peroxisome proliferator-activated receptor {alpha} transcriptional up-regulation of fatty acid oxidation Endocrinology 146 2005 375 382
9. M. Guerre-Millo, C. Rouault, P. Poulain, J. Andre, V. Poitout, J.M. Peters, F.J. Gonzalez, J.C. Fruchart, G. Reach, and B. Staels PPAR-alpha-null mice are protected from high-fat diet-induced insulin resistance Diabetes 50 2001 2809 2814
10. S.S. Lee, T. Pineau, J. Drago, E.J. Lee, J.W. Owens, D.L. Kroetz, P.M. Fernandez-Salguero, H. Westphal, and F.J. Gonzalez Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators Mol. Cell. Biol. 15 1995 3012 3022
11. T.E. Akiyama, C.J. Nicol, C. Fievet, B. Staels, J.M. Ward, J. Auwerx, S.S. Lee, F.J. Gonzalez, and J.M. Peters Peroxisome proliferator-activated receptor-alpha regulates lipid homeostasis, but is not associated with obesity: studies with congenic mouse lines J. Biol. Chem. 276 2001 39088 39093
12. R.S. Surwit, A.E. Petro, P. Parekh, and S. Collins Low plasma leptin in response to dietary fat in diabetes- and obesity-prone mice Diabetes 46 1997 1516 1520
13. V. Poitout, C. Rouault, M. Guerre-Millo, I. Briaud, and G. Reach Inhibition of insulin secretion by leptin in normal rodent islets of Langerhans Endocrinology 139 1998 822 826
14. I. Briaud, J.S. Harmon, C.L. Kelpe, V.B. Segu, and V. Poitout Lipotoxicity of the pancreatic beta-cell is associated with glucose-dependent esterification of fatty acids into neutral lipids Diabetes 50 2001 315 321
15. P. Chomczynski, and N. Sacchi Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction Anal. Biochem. 162 1987 156 159
16. G. Lazennec, L. Canaple, D. Saugy, and W. Wahli Activation of peroxisome proliferator-activated receptors (PPARs) by their ligands and protein kinase A activators Mol. Endocrinol. 14 2000 1962 1975
17. E.D. Rosen, R.N. Kulkarni, P. Sarraf, U. Ozcan, T. Okada, C.H. Hsu, D. Eisenman, M.A. Magnuson, F.J. Gonzalez, C.R. Kahn, and B.M. Spiegelman Targeted elimination of peroxisome proliferator-activated receptor gamma in beta cells leads to abnormalities in islet mass without compromising glucose homeostasis Mol. Cell. Biol. 23 2003 7222 7229
18. I. Briaud, C.L. Kelpe, L.M. Johnson, P.O. Tran, and V. Poitout Differential effects of hyperlipidemia on insulin secretion in islets of langerhans from hyperglycemic versus normoglycemic rats Diabetes 51 2002 662 668
19. M.J. Holness, N.D. Smith, G.K. Greenwood, and M.C. Sugden Acute (24 h) activation of peroxisome proliferator-activated receptor-alpha (PPARalpha) reverses high-fat feeding-induced insulin hypersecretion in vivo and in perifused pancreatic islets J. Endocrinol. 177 2003 197 205
20. H. Hosokawa, B.E. Corkey, and J.L. Leahy Beta-cell hypersensitivity to glucose following 24-h exposure of rat islets to fatty acids Diabetologia 40 1997 392 397
21. Y.Q. Liu, K. Tornheim, and J.L. Leahy Fatty acid-induced beta cell hypersensitivity to glucose. Increased phosphofructokinase activity and lowered glucose-6-phosphate content J. Clin. Invest. 101 1998 1870 1875
22. Y.Q. Liu, K. Tornheim, and J.L. Leahy Shared biochemical properties of glucotoxicity and lipotoxicity in islets decrease citrate synthase activity and increase phosphofructokinase activity Diabetes 47 1998 1889 1893
23. D.A. Nielsen, M. Welsh, M.J. Casadaban, and D.F. Steiner Control of insulin gene expression in pancreatic beta-cells and in an insulin-producing cell line, RIN-5F cells. I. Effects of glucose and cyclic AMP on the transcription of insulin mRNA J. Biol. Chem. 260 1985 13585 13589
24. C.L. Kelpe, P.C. Moore, S.D. Parazzoli, B. Wicksteed, C.J. Rhodes, and V. Poitout Palmitate inhibition of insulin gene expression is mediated at the transcriptional level via ceramide synthesis J. Biol. Chem. 278 2003 30015 30021
25. G. Chinetti, S. Lestavel, J.C. Fruchart, V. Clavey, and B. Staels Peroxisome proliferator-activated receptor alpha reduces cholesterol esterification in macrophages Circ. Res. 92 2003 212 217
26. J.S. Harmon, C.E. Gleason, Y. Tanaka, V. Poitout, and R.P. Robertson Antecedent hyperglycemia, not hyperlipidemia, is associated with increased islet triacylglycerol content and decreased insulin gene mRNA level in Zucker diabetic fatty rats Diabetes 50 2001 2481 2486
27. E.H. Koh, M.S. Kim, J.Y. Park, H.S. Kim, J.Y. Youn, H.S. Park, J.H. Youn, and K.U. Lee Peroxisome proliferator-activated receptor (PPAR)-alpha activation prevents diabetes in OLETF rats: comparison with PPAR-gamma activation Diabetes 52 2003 2331 2337
28. M. Guerre-Millo, P. Gervois, E. Raspe, L. Madsen, P. Poulain, B. Derudas, J.M. Herbert, D.A. Winegar, T.M. Willson, J.C. Fruchart, R.K. Berge, and B. Staels Peroxisome proliferator-activated receptor alpha activators improve insulin sensitivity and reduce adiposity J. Biol. Chem. 275 2000 16638 16642
29. J.M. Ye, P.J. Doyle, M.A. Iglesias, D.G. Watson, G.J. Cooney, and E.W. Kraegen Peroxisome proliferator-activated receptor (PPAR)-alpha activation lowers muscle lipids and improves insulin sensitivity in high fat-fed rats: comparison with PPAR-gamma activation Diabetes 50 2001 411 417
30. R.N. Bergman, M. Ader, K. Huecking, and G. Van Citters Accurate assessment of beta-cell function: the hyperbolic correction Diabetes 51 2002 S212 S220