In vivo expression of HGF/NK1 and GLP-1 from dsAAV vectors enhances pancreatic β-cell proliferation and improves pathology in the db/db mouse model of diabetes

Diabetes

Volumn 59, Issue 12, 2010, Pages 3108-3116

  Gaddy, Daniel F ^a   Riedel, Michael J ^b   Pejawar Gaddy, Sharmila ^a   Kieffer, Timothy J ^b   Robbins, Paul D ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCAGON LIKE PEPTIDE 1; PARVOVIRUS VECTOR; RECOMBINANT SCATTER FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DRUG ACTIVITY; DRUG DELIVERY SYSTEM; FEMALE; GENE THERAPY; GENE TRANSFER; HYPERGLYCEMIA; IN VITRO STUDY; IN VIVO STUDY; INSULIN RELEASE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; CELL DIVISION; DEPENDOVIRUS; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 2; DNA PRIMERS; FEMALE; GENES, REPORTER; GENETIC VECTORS; GLUCAGON-LIKE PEPTIDE 1; GREEN FLUORESCENT PROTEINS; HEPATOCYTE GROWTH FACTOR; INSULIN-SECRETING CELLS; MALE; MICE; MICE, INBRED C57BL; PEPTIDE FRAGMENTS; PLASMIDS; POLYMERASE CHAIN REACTION; RECOMBINANT PROTEINS;

EID: 78249243314     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db09-1886     Document Type: Article

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