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Volumn 5, Issue 9, 2008, Pages 542-553

Fibrates and future PPARα agonists in the treatment of cardiovascular disease

Author keywords

[No Author keywords available]

Indexed keywords

ATORVASTATIN; BEZAFIBRATE; CERIVASTATIN; CIPROFIBRATE; CLOFIBRATE; EZETIMIBE; FENOFIBRATE; FIBRIC ACID DERIVATIVE; GEMFIBROZIL; GLYCOSYLATED HEMOGLOBIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LIPID; LOW DENSITY LIPOPROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA AGONIST; PLACEBO; PRAVASTATIN; SIMVASTATIN; ANTILIPEMIC AGENT; CARDIOVASCULAR AGENT; CLOFIBRIC ACID;

EID: 50649089597     PISSN: 17434297     EISSN: 17434300     Source Type: Journal    
DOI: 10.1038/ncpcardio1278     Document Type: Review
Times cited : (148)

References (82)
  • 1
    • 27644466717 scopus 로고    scopus 로고
    • At the heart of statin benefit
    • LaRosa JC (2005) At the heart of statin benefit. J Am Coll Cardiol 46: 1863
    • (2005) J Am Coll Cardiol , vol.46 , pp. 1863
    • LaRosa, J.C.1
  • 2
    • 0029828488 scopus 로고    scopus 로고
    • Beyond LDL cholesterol reduction
    • Superko HR (1996) Beyond LDL cholesterol reduction. Circulation 94: 2351-2354
    • (1996) Circulation , vol.94 , pp. 2351-2354
    • Superko, H.R.1
  • 3
    • 11144355354 scopus 로고    scopus 로고
    • Intensive versus moderate lipid lowering with statins after acute coronary syndromes
    • Cannon CP et al. (2004) Intensive versus moderate lipid lowering with statins after acute coronary syndromes. N Engl J Med 350 1495-1504
    • (2004) N Engl J Med , vol.350 , pp. 1495-1504
    • Cannon, C.P.1
  • 4
    • 85047697297 scopus 로고    scopus 로고
    • The paradoxical nature of hunter-gatherer diets: Meat based, yet non-atherogenic
    • Cordain L et al. (2002) The paradoxical nature of hunter-gatherer diets: Meat based, yet non-atherogenic. Eur J Clin Nutr 56 (Suppl 1): S42-S52
    • (2002) Eur J Clin Nutr , vol.56 , Issue.SUPPL. 1
    • Cordain, L.1
  • 5
    • 0347623270 scopus 로고    scopus 로고
    • Cardiovascular disease resulting from a diet and lifestyle at odds with our Paleolithic genome: How to become a 21st century hunter-gatherer
    • O'Keefe JH and Cordain L (2004) Cardiovascular disease resulting from a diet and lifestyle at odds with our Paleolithic genome: How to become a 21st century hunter-gatherer. Mayo Clin Proc 70: 101-108
    • (2004) Mayo Clin Proc , vol.70 , pp. 101-108
    • O'Keefe, J.H.1    Cordain, L.2
  • 6
    • 27744522317 scopus 로고    scopus 로고
    • The forgotten majority: Unfinished business in cardiovascular risk reduction
    • Libby P (2005) The forgotten majority: Unfinished business in cardiovascular risk reduction. J Am Coll Cardiol 46: 1225-1228
    • (2005) J Am Coll Cardiol , vol.46 , pp. 1225-1228
    • Libby, P.1
  • 7
    • 32444444724 scopus 로고    scopus 로고
    • Mild to moderate muscular symptoms with high-dosage statin therapy in hyperlipidemic patients - the PRIMO study
    • Bruckert E et al. (2005) Mild to moderate muscular symptoms with high-dosage statin therapy in hyperlipidemic patients - the PRIMO study. Cardiovasc Drugs Ther 19: 403-414
    • (2005) Cardiovasc Drugs Ther , vol.19 , pp. 403-414
    • Bruckert, E.1
  • 8
    • 34447627450 scopus 로고    scopus 로고
    • Effect of the magnitude of lipid lowering on risk of elevated liver enzymes, rhabdomyolysis, and cancer
    • Alsheikh-Ali AA et al. (2007) Effect of the magnitude of lipid lowering on risk of elevated liver enzymes, rhabdomyolysis, and cancer. J Am Coll Cardiol 50: 409-418
    • (2007) J Am Coll Cardiol , vol.50 , pp. 409-418
    • Alsheikh-Ali, A.A.1
  • 9
    • 0037202476 scopus 로고    scopus 로고
    • Violi F et al.; MRC/BHF Heart Protection Study (2002) MRC/BHF Heart Protection Study. Lancet 360: 7-22
    • Violi F et al.; MRC/BHF Heart Protection Study (2002) MRC/BHF Heart Protection Study. Lancet 360: 7-22
  • 10
    • 4344683381 scopus 로고    scopus 로고
    • Colhoun HM et al.; CARDS Investigators (2004) Primary prevention of cardiovascular disease with atorvastatin in type 2 diabetes in the Collaborative Atorvastatin Diabetes Study (CARDS): Multicentre randomised placebo-controlled trial. Lancet 364: 685-696
    • Colhoun HM et al.; CARDS Investigators (2004) Primary prevention of cardiovascular disease with atorvastatin in type 2 diabetes in the Collaborative Atorvastatin Diabetes Study (CARDS): Multicentre randomised placebo-controlled trial. Lancet 364: 685-696
  • 11
    • 20944448451 scopus 로고    scopus 로고
    • Reduction in cardiovascular events with atorvastatin in 2,532 patients with type 2 diabetes: Anglo-Scandinavian Cardiac Outcomes Trial - lipid-lowering arm (ASCOT-LLA)
    • Sever PS et al. (2005) Reduction in cardiovascular events with atorvastatin in 2,532 patients with type 2 diabetes: Anglo-Scandinavian Cardiac Outcomes Trial - lipid-lowering arm (ASCOT-LLA). Diabetes Care 28: 1151-1157
    • (2005) Diabetes Care , vol.28 , pp. 1151-1157
    • Sever, P.S.1
  • 12
    • 4644272251 scopus 로고    scopus 로고
    • Wanner C et al.; Deutsche Diabetes-Dialyse-Studie (4D) Study Group (2004) Randomized controlled trial on the efficacy and safety of atorvastatin in patients with type 2 diabetes on hemodialysis (4D study): Demographic and baseline characteristics. Kidney Blood Press Res 27: 259-266
    • Wanner C et al.; Deutsche Diabetes-Dialyse-Studie (4D) Study Group (2004) Randomized controlled trial on the efficacy and safety of atorvastatin in patients with type 2 diabetes on hemodialysis (4D study): Demographic and baseline characteristics. Kidney Blood Press Res 27: 259-266
  • 13
    • 33746431474 scopus 로고    scopus 로고
    • Efficacy and safety of atorvastatin in the prevention of cardiovascular end points in subjects with type 2 diabetes: The Atorvastatin Study for Prevention of Coronary Heart Disease Endpoints in non-insulin-dependent diabetes mellitus (ASPEN)
    • Knopp RH et al. (2006) Efficacy and safety of atorvastatin in the prevention of cardiovascular end points in subjects with type 2 diabetes: The Atorvastatin Study for Prevention of Coronary Heart Disease Endpoints in non-insulin-dependent diabetes mellitus (ASPEN). Diabetes Care 29: 1478-1485
    • (2006) Diabetes Care , vol.29 , pp. 1478-1485
    • Knopp, R.H.1
  • 14
    • 33646829645 scopus 로고    scopus 로고
    • Efficacy of lipid lowering drug treatment for diabetic and non-diabetic patients: Meta-analysis of randomised controlled trials
    • Costa J et al. (2006) Efficacy of lipid lowering drug treatment for diabetic and non-diabetic patients: Meta-analysis of randomised controlled trials. BMJ 332: 1115-1124
    • (2006) BMJ , vol.332 , pp. 1115-1124
    • Costa, J.1
  • 15
    • 0034641568 scopus 로고    scopus 로고
    • Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): Prospective observational study
    • Stratton IM et al. (2000) Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): Prospective observational study. BMJ 321: 405-412
    • (2000) BMJ , vol.321 , pp. 405-412
    • Stratton, I.M.1
  • 16
    • 0029838433 scopus 로고    scopus 로고
    • Plasma triglyceride level is a risk factor for cardiovascular disease independent of high-density lipoprotein cholesterol level: A meta-analysis of population-based prospective studies
    • Hokanson JE and Austin MA (1996) Plasma triglyceride level is a risk factor for cardiovascular disease independent of high-density lipoprotein cholesterol level: A meta-analysis of population-based prospective studies. J Cardiovasc Risk 3: 213-219
    • (1996) J Cardiovasc Risk , vol.3 , pp. 213-219
    • Hokanson, J.E.1    Austin, M.A.2
  • 17
    • 34447520136 scopus 로고    scopus 로고
    • Fasting compared with nonfasting triglycerides and risk of cardiovascular events in women
    • Bansal S et al. (2007) Fasting compared with nonfasting triglycerides and risk of cardiovascular events in women. JAMA 298: 309-316
    • (2007) JAMA , vol.298 , pp. 309-316
    • Bansal, S.1
  • 18
    • 34447523594 scopus 로고    scopus 로고
    • Triglycerides and risk for coronary heart disease
    • McBride PE (2007) Triglycerides and risk for coronary heart disease. JAMA 298: 336-338
    • (2007) JAMA , vol.298 , pp. 336-338
    • McBride, P.E.1
  • 19
    • 34547739110 scopus 로고    scopus 로고
    • Hypertriglyceridemia and cardiovascular risk reduction
    • Jacobson TA et al. (2007) Hypertriglyceridemia and cardiovascular risk reduction. Clin Ther 29: 763-777
    • (2007) Clin Ther , vol.29 , pp. 763-777
    • Jacobson, T.A.1
  • 20
    • 38949171001 scopus 로고    scopus 로고
    • Impact of triglyceride levels beyond low density lipoprotein cholesterol after an acute coronary syndrome in the PROVE IT-TIMI 22 trial
    • for the PROVE IT-TIMI 22 Investigators
    • Miller M et al.; for the PROVE IT-TIMI 22 Investigators (2008) Impact of triglyceride levels beyond low density lipoprotein cholesterol after an acute coronary syndrome in the PROVE IT-TIMI 22 trial. J Am Coll Cardiol 51: 724-730
    • (2008) J Am Coll Cardiol , vol.51 , pp. 724-730
    • Miller, M.1
  • 21
    • 0032912006 scopus 로고    scopus 로고
    • Influence of low HDL on progression of coronary artery disease and response to fluvastatin therapy
    • Ballantyne CM et al. (1999) Influence of low HDL on progression of coronary artery disease and response to fluvastatin therapy. Circulation 99: 736-443
    • (1999) Circulation , vol.99 , pp. 736-443
    • Ballantyne, C.M.1
  • 22
    • 0027435542 scopus 로고
    • The role of high-density lipoprotein and lipid-soluble antioxidant vitamins in inhibiting low-density lipoprotein oxidation
    • Mackness MI et al. (1993) The role of high-density lipoprotein and lipid-soluble antioxidant vitamins in inhibiting low-density lipoprotein oxidation. Biochem J 294: 829-834
    • (1993) Biochem J , vol.294 , pp. 829-834
    • Mackness, M.I.1
  • 23
    • 0028865357 scopus 로고
    • High-density lipoproteins inhibit cytokine-induced expression of endothelial cell adhesion molecules
    • Cockerill GW et al. (1995) High-density lipoproteins inhibit cytokine-induced expression of endothelial cell adhesion molecules. Arterioscler Thromb Vasc Biol 15: 1987-1994
    • (1995) Arterioscler Thromb Vasc Biol , vol.15 , pp. 1987-1994
    • Cockerill, G.W.1
  • 24
    • 33644608784 scopus 로고    scopus 로고
    • Antiatherogenic small, dense HDL-guardian angel of the arterial wall?
    • Kontush A and Chapman MJ (2006) Antiatherogenic small, dense HDL-guardian angel of the arterial wall? Nat Clin Pract Cardiovasc Med 3: 144-153
    • (2006) Nat Clin Pract Cardiovasc Med , vol.3 , pp. 144-153
    • Kontush, A.1    Chapman, M.J.2
  • 25
    • 0032838901 scopus 로고    scopus 로고
    • HDL metabolism in hypertriglyceridemic states: An overview
    • Lamarche B et al. (1999) HDL metabolism in hypertriglyceridemic states: An overview. Clin Chim Acta 286: 145-161
    • (1999) Clin Chim Acta , vol.286 , pp. 145-161
    • Lamarche, B.1
  • 26
    • 11844296800 scopus 로고    scopus 로고
    • Efficacy and safety of high-density lipoprotein cholesterol-increasing compounds: A meta-analysis of randomized controlled trials
    • Birjmohun RS et al. (2005) Efficacy and safety of high-density lipoprotein cholesterol-increasing compounds: A meta-analysis of randomized controlled trials. J Am Coll Cardiol 45: 185-197
    • (2005) J Am Coll Cardiol , vol.45 , pp. 185-197
    • Birjmohun, R.S.1
  • 27
    • 0035962077 scopus 로고    scopus 로고
    • Relation of gemfibrozil treatment and liAid levels with major coronary events: VA-HIT: a randomized controlled trial
    • Robins SJ et al. (2001) Relation of gemfibrozil treatment and liAid levels with major coronary events: VA-HIT: a randomized controlled trial. JAMA 285: 1585-1591
    • (2001) JAMA , vol.285 , pp. 1585-1591
    • Robins, S.J.1
  • 28
    • 33644652183 scopus 로고    scopus 로고
    • Sorting out the roles of PPAR alpha in energy metabolism and vascular homeostasis
    • Lefebvre et al. (2006) Sorting out the roles of PPAR alpha in energy metabolism and vascular homeostasis. J Clin Invest 116 571-680
    • (2006) J Clin Invest , vol.116 , pp. 571-680
    • Lefebvre1
  • 29
    • 13844272245 scopus 로고    scopus 로고
    • Effectiveness and tolerability of simvastatin plus fenofibrate for combined hyperlipidemia (the SAFARI trial)
    • Grundy SM et al. (2005) Effectiveness and tolerability of simvastatin plus fenofibrate for combined hyperlipidemia (the SAFARI trial). Am J Cardiol 95: 462-468
    • (2005) Am J Cardiol , vol.95 , pp. 462-468
    • Grundy, S.M.1
  • 30
    • 0032506273 scopus 로고    scopus 로고
    • Mechanisms of action fibrates on lipid and lipoprotein metabolism
    • Staels B et al. (1998) Mechanisms of action fibrates on lipid and lipoprotein metabolism. Circulation 98: 2088-2093
    • (1998) Circulation , vol.98 , pp. 2088-2093
    • Staels, B.1
  • 31
    • 0028864282 scopus 로고
    • Exercise-induced vasomotion of angiographically normal and stenotic coronary arteries improves after cholesterol-lowering drug therapy with bezafibrate
    • Seiler C et al. (1995) Exercise-induced vasomotion of angiographically normal and stenotic coronary arteries improves after cholesterol-lowering drug therapy with bezafibrate. J Am Coll Cardiol 26: 1615-1622
    • (1995) J Am Coll Cardiol , vol.26 , pp. 1615-1622
    • Seiler, C.1
  • 32
    • 19944379835 scopus 로고    scopus 로고
    • Beneficial effects of fenofibrate to improve endothelial dysfunction and raise adiponectin levels in patients with primary hypertriglyceridemia
    • Koh KK et al. (2005) Beneficial effects of fenofibrate to improve endothelial dysfunction and raise adiponectin levels in patients with primary hypertriglyceridemia. Diabetes Care 28: 1419-1424
    • (2005) Diabetes Care , vol.28 , pp. 1419-1424
    • Koh, K.K.1
  • 33
    • 0038065548 scopus 로고    scopus 로고
    • Combined effect of coenzyme Q10 and fenofibrate on forearm microcirculatory function in type 2 diabetes
    • Playford DA et al. (2003) Combined effect of coenzyme Q10 and fenofibrate on forearm microcirculatory function in type 2 diabetes. Atherosclerosis 168: 169-179
    • (2003) Atherosclerosis , vol.168 , pp. 169-179
    • Playford, D.A.1
  • 34
    • 17944401657 scopus 로고    scopus 로고
    • Ciprofibrate therapy improves endothelial function and reduces postprandial lipemia and oxidative stress in type 2 diabetes mellitus
    • Evans M et al. (2000) Ciprofibrate therapy improves endothelial function and reduces postprandial lipemia and oxidative stress in type 2 diabetes mellitus. Circulation 101: 1773-1779
    • (2000) Circulation , vol.101 , pp. 1773-1779
    • Evans, M.1
  • 35
    • 0035017489 scopus 로고    scopus 로고
    • Effect of statin versus fibrate on postprandial endothelial dysfunction: Role of remnant-like particles
    • Wilmink HW et al. (2001) Effect of statin versus fibrate on postprandial endothelial dysfunction: Role of remnant-like particles. Cardiovasc Res 50: 577-582
    • (2001) Cardiovasc Res , vol.50 , pp. 577-582
    • Wilmink, H.W.1
  • 36
    • 0030612713 scopus 로고    scopus 로고
    • Effect of gemfibrozil +/- niacin +/- cholestyramine on endothelial function in patients with serum low-density lipoprotein cholesterol levels <60 mg/dl and high-density lipoprotein cholesterol levels <40 mg/dl
    • Andrews TC et al. (1997) Effect of gemfibrozil +/- niacin +/- cholestyramine on endothelial function in patients with serum low-density lipoprotein cholesterol levels <60 mg/dl and high-density lipoprotein cholesterol levels <40 mg/dl. Am J Cardiol 80: 831-835
    • (1997) Am J Cardiol , vol.80 , pp. 831-835
    • Andrews, T.C.1
  • 37
    • 1942484870 scopus 로고    scopus 로고
    • Myocardial fibrosis and diastolic dysfunction in deoxycorticosterone acetate-salt hypertensive rats is ameliorated by the peroxisome proliferator-activated receptor-alpha activator fenofibrate, partly by suppressing inflammatory responses associated with the nuclear factor-kappa-B pathway
    • Ogata T et al. (2004) Myocardial fibrosis and diastolic dysfunction in deoxycorticosterone acetate-salt hypertensive rats is ameliorated by the peroxisome proliferator-activated receptor-alpha activator fenofibrate, partly by suppressing inflammatory responses associated with the nuclear factor-kappa-B pathway. J Am Coll Cardiol 43: 1481-1488
    • (2004) J Am Coll Cardiol , vol.43 , pp. 1481-1488
    • Ogata, T.1
  • 38
    • 27444437661 scopus 로고    scopus 로고
    • Beneficial vascular and metabolic effects of peroxisome proliferator-activated receptor-alpha activators
    • Han SH et al. (2005) Beneficial vascular and metabolic effects of peroxisome proliferator-activated receptor-alpha activators. Hypertension 46: 1086-1092
    • (2005) Hypertension , vol.46 , pp. 1086-1092
    • Han, S.H.1
  • 39
    • 33646440029 scopus 로고    scopus 로고
    • Modulation of hepatic inflammatory risk markers of cardiovascular diseases by PPAR-alpha activators: Clinical and experimental evidence
    • Zambon A et al. (2006) Modulation of hepatic inflammatory risk markers of cardiovascular diseases by PPAR-alpha activators: Clinical and experimental evidence. Arterioscler Thromb Vasc Biol 26: 977-986
    • (2006) Arterioscler Thromb Vasc Biol , vol.26 , pp. 977-986
    • Zambon, A.1
  • 40
    • 18944381282 scopus 로고    scopus 로고
    • Additive beneficial effects of fenofibrate combined with atorvastatin in the treatment of combined hyperlipidemia
    • Koh et al. (2005) Additive beneficial effects of fenofibrate combined with atorvastatin in the treatment of combined hyperlipidemia. J Am Coll Cardiol 45: 1649-1653
    • (2005) J Am Coll Cardiol , vol.45 , pp. 1649-1653
    • Koh1
  • 41
    • 0034975586 scopus 로고    scopus 로고
    • Ciprofibrate versus gemfibrozil in the treatment of mixed hyperlipidemias: An open-label, multicenter study
    • Aguilar-Salinas CA et al. (2001) Ciprofibrate versus gemfibrozil in the treatment of mixed hyperlipidemias: An open-label, multicenter study. Metabolism 50: 729-733
    • (2001) Metabolism , vol.50 , pp. 729-733
    • Aguilar-Salinas, C.A.1
  • 42
    • 0036941407 scopus 로고    scopus 로고
    • 2 mediated activation of transforming growth factor beta in human mesangial cells
    • 2 mediated activation of transforming growth factor beta in human mesangial cells. Antiox Redox Signal 4: 877-884
    • (2002) Antiox Redox Signal , vol.4 , pp. 877-884
    • Wilmer, W.A.1
  • 43
    • 33646508121 scopus 로고    scopus 로고
    • PPARα agonist fenofibrate improves diabetic nephropathy in db/db mice
    • Park CW et al. (2006) PPARα agonist fenofibrate improves diabetic nephropathy in db/db mice. Kidney Int 69: 1511-1517
    • (2006) Kidney Int , vol.69 , pp. 1511-1517
    • Park, C.W.1
  • 44
    • 33646156170 scopus 로고    scopus 로고
    • Renoprotective effects of fenofibrate in diabetic rats are achieved by suppressing kidney plasminogen activator inhibitor-1
    • Chen LL et al. (2006) Renoprotective effects of fenofibrate in diabetic rats are achieved by suppressing kidney plasminogen activator inhibitor-1. Vascul Pharmacol 44: 309-315
    • (2006) Vascul Pharmacol , vol.44 , pp. 309-315
    • Chen, L.L.1
  • 45
    • 33745313224 scopus 로고    scopus 로고
    • Accelerated diabetic nephropathy in mice lacking the peroxisome proliferator-activated receptor alpha
    • Park CW et al. (2006) Accelerated diabetic nephropathy in mice lacking the peroxisome proliferator-activated receptor alpha. Diabetes 55: 885-893
    • (2006) Diabetes , vol.55 , pp. 885-893
    • Park, C.W.1
  • 46
    • 0036287662 scopus 로고    scopus 로고
    • Identification of functions of peroxisome proliferator-activated receptor alpha in proximal tubules
    • Kamijo Y et al. (2002) Identification of functions of peroxisome proliferator-activated receptor alpha in proximal tubules. J Am Soc Nephrol 13: 16591-1702
    • (2002) J Am Soc Nephrol , vol.13 , pp. 16591-21702
    • Kamijo, Y.1
  • 47
    • 18944385230 scopus 로고    scopus 로고
    • Peroxisome proliferator activated receptor ligands and angiogenesis
    • Sato M (2005) Peroxisome proliferator activated receptor ligands and angiogenesis. Nippon Rinsho 63: 603-608
    • (2005) Nippon Rinsho , vol.63 , pp. 603-608
    • Sato, M.1
  • 48
    • 38949145780 scopus 로고    scopus 로고
    • PPARalpha agonist fenofibrate suppresses tumor growth through direct and indirect angiogenesis inhibition
    • Panigrahy D et al. (2008) PPARalpha agonist fenofibrate suppresses tumor growth through direct and indirect angiogenesis inhibition. Proc Natl Acad Sci USA 105: 985-990
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 985-990
    • Panigrahy, D.1
  • 49
    • 0343619443 scopus 로고    scopus 로고
    • Serum insulin-like growth factor-I level is independently associated with coronary artery disease progression in young male survivors of myocardial infarction: Beneficial effects of bszafibrate treatment
    • Ruotolo G et al. (2000) Serum insulin-like growth factor-I level is independently associated with coronary artery disease progression in young male survivors of myocardial infarction: Beneficial effects of bszafibrate treatment. J Am Coll Cardiol 35: 647-654
    • (2000) J Am Coll Cardiol , vol.35 , pp. 647-654
    • Ruotolo, G.1
  • 50
    • 33750550642 scopus 로고    scopus 로고
    • The role of growth hormone, insulin-like growth factor and somatostatin in diabetic retinopathy
    • Wilkinson-Berka JL et al. (2006) The role of growth hormone, insulin-like growth factor and somatostatin in diabetic retinopathy. Curr Med Chem 13: 3307-3317
    • (2006) Curr Med Chem , vol.13 , pp. 3307-3317
    • Wilkinson-Berka, J.L.1
  • 51
    • 0035873477 scopus 로고    scopus 로고
    • Plasma vascular endothelial growth factor and its receptor Flt-1 in patients with hyperlipidemia and atherosclerosis and the effects of fluvastatin or fenofibrate
    • Blann AD et al. (2001) Plasma vascular endothelial growth factor and its receptor Flt-1 in patients with hyperlipidemia and atherosclerosis and the effects of fluvastatin or fenofibrate. Am J Cardiol 15: 1160-1163
    • (2001) Am J Cardiol , vol.15 , pp. 1160-1163
    • Blann, A.D.1
  • 52
    • 34247108235 scopus 로고    scopus 로고
    • Fenofibrate regulates endothelial cell survival through the AMPK signal transduction pathway
    • Kim J et al. (2007) Fenofibrate regulates endothelial cell survival through the AMPK signal transduction pathway. Exp Eye Res 84: 886-893
    • (2007) Exp Eye Res , vol.84 , pp. 886-893
    • Kim, J.1
  • 53
    • 0014519590 scopus 로고
    • A double-blind controlled trial of clofibrate in the treatment of diabetic retinopathy
    • Harrold BP et al. (1969) A double-blind controlled trial of clofibrate in the treatment of diabetic retinopathy. Diabetes 18: 285-291
    • (1969) Diabetes , vol.18 , pp. 285-291
    • Harrold, B.P.1
  • 54
    • 17744402260 scopus 로고
    • Exudative diabetic retinopathy. The use of clofibrate in the treatment of hard exudates using a reduced but prolonged dosage over several years
    • Dorne PA (1977) Exudative diabetic retinopathy. The use of clofibrate in the treatment of hard exudates using a reduced but prolonged dosage over several years. Arch Ophtalmol 37: 393-400
    • (1977) Arch Ophtalmol , vol.37 , pp. 393-400
    • Dorne, P.A.1
  • 55
    • 0342506477 scopus 로고
    • Prevention of the angiographic progression of coronary and vein-graft atherosclerosis by gemfibrozil after coronary bypass surgery in men with low levels of HDL cholesterol. Lopid Coronary Angiography Trial (LOCAT) Study Group
    • Frick MH et al. (1907) Prevention of the angiographic progression of coronary and vein-graft atherosclerosis by gemfibrozil after coronary bypass surgery in men with low levels of HDL cholesterol. Lopid Coronary Angiography Trial (LOCAT) Study Group. Circulation 96: 2137-2143
    • (1907) Circulation , vol.96 , pp. 2137-2143
    • Frick, M.H.1
  • 56
    • 0029982038 scopus 로고    scopus 로고
    • Angiographic assessment of effects of bezafibrate on progression of coronary artery disease in young male postinfarction patients
    • Ericsson CG et al. (1996) Angiographic assessment of effects of bezafibrate on progression of coronary artery disease in young male postinfarction patients. Lancet 347: 849-853
    • (1996) Lancet , vol.347 , pp. 849-853
    • Ericsson, C.G.1
  • 57
    • 0035941990 scopus 로고    scopus 로고
    • Effect of fenofibrate on progression of coronary-artery disease in type 2 diabetes: The Diabetes Atherosclerosis Intervention Study, a randomised study
    • DAIS investigators
    • DAIS investigators (2001) Effect of fenofibrate on progression of coronary-artery disease in type 2 diabetes: The Diabetes Atherosclerosis Intervention Study, a randomised study. Lancet 357: 905-910
    • (2001) Lancet , vol.357 , pp. 905-910
  • 58
    • 0033527030 scopus 로고    scopus 로고
    • Gemfibrozil for the secondary prevention of coronary heart disease in men with low levels of high-density lipoprotein cholesterol
    • Rubins HE et al. (1999) Gemfibrozil for the secondary prevention of coronary heart disease in men with low levels of high-density lipoprotein cholesterol. N Engl J Med 341: 410-418
    • (1999) N Engl J Med , vol.341 , pp. 410-418
    • Rubins, H.E.1
  • 59
    • 0035962077 scopus 로고    scopus 로고
    • Relation of gemfibrozil treatment and lipid levels with major coronary events. VA-HIT: A randomized controlled trial
    • Robins SJ et al. (2001) Relation of gemfibrozil treatment and lipid levels with major coronary events. VA-HIT: A randomized controlled trial. JAMA 285: 1585-1591
    • (2001) JAMA , vol.285 , pp. 1585-1591
    • Robins, S.J.1
  • 60
    • 0037049366 scopus 로고    scopus 로고
    • Diabetes, plasma insulin and cardiovascular disease: Subgroup analysis. from the Department of Veterans Affairs High-Density Lipoprotein Intervention Trial (VA-HIT)
    • Bloomfield-Rubins H et al. (2002) Diabetes, plasma insulin and cardiovascular disease: Subgroup analysis. from the Department of Veterans Affairs High-Density Lipoprotein Intervention Trial (VA-HIT). Arch Intern Med 162: 2597-2604
    • (2002) Arch Intern Med , vol.162 , pp. 2597-2604
    • Bloomfield-Rubins, H.1
  • 61
    • 0023232216 scopus 로고
    • Helsinki Heart Study: Primary-prevention trial with gemfibrozil in middle-aged men with dyslipidemia: Safety of treatment, changes in risk factors, and incidence of coronary heart disease
    • Frick MH et al. (1987) Helsinki Heart Study: Primary-prevention trial with gemfibrozil in middle-aged men with dyslipidemia: Safety of treatment, changes in risk factors, and incidence of coronary heart disease. N Engl J Med 317: 1237-1245
    • (1987) N Engl J Med , vol.317 , pp. 1237-1245
    • Frick, M.H.1
  • 62
    • 0029127208 scopus 로고
    • Some coronary risk factors related to the insulin resistance syndrome and treatment with gemfibrozil: Experience from the Helsinki Heart Study
    • Tenkanen L et al. (1995) Some coronary risk factors related to the insulin resistance syndrome and treatment with gemfibrozil: Experience from the Helsinki Heart Study. Circulation 92: 1779-1785
    • (1995) Circulation , vol.92 , pp. 1779-1785
    • Tenkanen, L.1
  • 63
    • 0034604225 scopus 로고    scopus 로고
    • Secondary prevention by raising HDL cholesterol and reducing triglycerides in patients with coronary artery disease: The Bezafibrate Infarction Prevention (BIP) study
    • The Bezafibrate Infarction Prevention study Group
    • The Bezafibrate Infarction Prevention study Group (2000) Secondary prevention by raising HDL cholesterol and reducing triglycerides in patients with coronary artery disease: The Bezafibrate Infarction Prevention (BIP) study. Circulation 102: 21-27
    • (2000) Circulation , vol.102 , pp. 21-27
  • 64
    • 38349138583 scopus 로고    scopus 로고
    • Secondary prevention with bezafibrate therapy for the treatment of dyslipidemia: An extended follow-up of the BIP trial
    • Goldenberg J et al. (2008) Secondary prevention with bezafibrate therapy for the treatment of dyslipidemia: An extended follow-up of the BIP trial. J Am Coll Cardiol 51: 459-465
    • (2008) J Am Coll Cardiol , vol.51 , pp. 459-465
    • Goldenberg, J.1
  • 65
    • 19344375593 scopus 로고    scopus 로고
    • Bezafibrate for the secondary prevention of myocardial infarction in patients with metabolic syndrome
    • Tenenbaum A et al. (2005) Bezafibrate for the secondary prevention of myocardial infarction in patients with metabolic syndrome. Arch Intern Med 165: 1154-1160
    • (2005) Arch Intern Med , vol.165 , pp. 1154-1160
    • Tenenbaum, A.1
  • 66
    • 28044452217 scopus 로고
    • FIELD study investigators (2005) Effects of long-term fenofibrate therapy on cardiovascular events in 9,795 people with type 2 diabetes mellitus (the FIELD study): Randomised controlled trial
    • Keech A et al.; FIELD study investigators (2005) Effects of long-term fenofibrate therapy on cardiovascular events in 9,795 people with type 2 diabetes mellitus (the FIELD study): Randomised controlled trial. Lancet 366: 1849-1861
    • (1849) Lancet , vol.366
    • Keech, A.1
  • 67
    • 50649104706 scopus 로고    scopus 로고
    • Scott R et al.; on behalf of the FIELD Investigators (2007) Features of metabolic syndrome identify individuals with type 2 diabetes mellitus at high risk for cardiovascular events and greater absolute benefits of fenofibrate [abstract]. Circulation 116: II_838
    • Scott R et al.; on behalf of the FIELD Investigators (2007) Features of metabolic syndrome identify individuals with type 2 diabetes mellitus at high risk for cardiovascular events and greater absolute benefits of fenofibrate [abstract]. Circulation 116: II_838
  • 68
    • 36049001784 scopus 로고    scopus 로고
    • Keech A et al.; FIELD study investigators (2007) Effect of fenofibrate on the need for laser treatment for diabetic retinopathy (FIELD study): A randomised controlled trial. Lancet 370: 1687-1697
    • Keech A et al.; FIELD study investigators (2007) Effect of fenofibrate on the need for laser treatment for diabetic retinopathy (FIELD study): A randomised controlled trial. Lancet 370: 1687-1697
  • 69
    • 34548488210 scopus 로고    scopus 로고
    • Long-term effects of fenofibrate on VLDL and HDL subspecies in participants with type 2 diabetes mellitus
    • Hiukka A et al. (2007) Long-term effects of fenofibrate on VLDL and HDL subspecies in participants with type 2 diabetes mellitus. Diabetologia 50: 2067-2075
    • (2007) Diabetologia , vol.50 , pp. 2067-2075
    • Hiukka, A.1
  • 70
    • 3142729178 scopus 로고    scopus 로고
    • Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III guidelines
    • Grundy SM et al. (2004) Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III guidelines. Circulation 110: 227-239
    • (2004) Circulation , vol.110 , pp. 227-239
    • Grundy, S.M.1
  • 71
    • 0036636769 scopus 로고    scopus 로고
    • Atorvastatin and micronized fenofibrate alone and in combination in type 2 diabetes with combined hypedipidemia
    • Athyros VG et al. (2002) Atorvastatin and micronized fenofibrate alone and in combination in type 2 diabetes with combined hypedipidemia. Diabetes Care 25: 1198-1202
    • (2002) Diabetes Care , vol.25 , pp. 1198-1202
    • Athyros, V.G.1
  • 72
    • 0037339775 scopus 로고    scopus 로고
    • Differential regulation of lipoprotein kinetics by atorvastatin and fenofibrate in subjects with the metabolic syndrome
    • Watts GF (2003) Differential regulation of lipoprotein kinetics by atorvastatin and fenofibrate in subjects with the metabolic syndrome. Diabetes 52: 803-811
    • (2003) Diabetes , vol.52 , pp. 803-811
    • Watts, G.F.1
  • 73
    • 33846199963 scopus 로고    scopus 로고
    • Efficacy and safety of the coadministration of ezetimibe/simvastatin with fenofibrate in patients with mixed hyperlipidemia
    • Farnier M et al. (2007) Efficacy and safety of the coadministration of ezetimibe/simvastatin with fenofibrate in patients with mixed hyperlipidemia. Am Heart J 153: 335-338
    • (2007) Am Heart J , vol.153 , pp. 335-338
    • Farnier, M.1
  • 74
    • 0032617597 scopus 로고    scopus 로고
    • Fenofibrate increases blood creatinine, but does not change the glomerular filtration rate in patients with mild renal insufficiency
    • Hottelart C et al. (1999) Fenofibrate increases blood creatinine, but does not change the glomerular filtration rate in patients with mild renal insufficiency. Nephrologie 20: 41-44
    • (1999) Nephrologie , vol.20 , pp. 41-44
    • Hottelart, C.1
  • 75
    • 1442301511 scopus 로고    scopus 로고
    • Fenofibrate increases homocysteinemia through a PPARα-mediated mechanism
    • Luc G et al. (2004) Fenofibrate increases homocysteinemia through a PPARα-mediated mechanism. J Cardiovasc Pharmacol 43 452-453
    • (2004) J Cardiovasc Pharmacol , vol.43 , pp. 452-453
    • Luc, G.1
  • 76
    • 1842477680 scopus 로고    scopus 로고
    • Effect of fenofibrate-mediated increase in plasma homocysteine on the progression of coronary artery disease in type 2 diabetes mellitus
    • Genest J et al. (2004) Effect of fenofibrate-mediated increase in plasma homocysteine on the progression of coronary artery disease in type 2 diabetes mellitus. Am J Cardiol 93: 848-853
    • (2004) Am J Cardiol , vol.93 , pp. 848-853
    • Genest, J.1
  • 77
    • 30344436628 scopus 로고    scopus 로고
    • Statin/fibrate combination in patients with metabolic syndrome or diabetes: Evaluating the risks of pharmacokinetic drug interactions
    • Davidson MH et al. (2006) Statin/fibrate combination in patients with metabolic syndrome or diabetes: Evaluating the risks of pharmacokinetic drug interactions. Expert Opin Drug Saf 5: 145-156
    • (2006) Expert Opin Drug Saf , vol.5 , pp. 145-156
    • Davidson, M.H.1
  • 78
    • 33947110940 scopus 로고    scopus 로고
    • Safety considerations with fibrate therapy
    • Davidson MH et al. (2007) Safety considerations with fibrate therapy. Am J Cardiol 99 (Suppl): 3C-18C
    • (2007) Am J Cardiol , vol.99 , Issue.SUPPL.
    • Davidson, M.H.1
  • 79
    • 0036843479 scopus 로고    scopus 로고
    • Effect of fibrates on metabolism of statins in human hepatocytes
    • Prueksaritanont T et al. (2002) Effect of fibrates on metabolism of statins in human hepatocytes. Drug Metab Dispos 30: 1280-1287
    • (2002) Drug Metab Dispos , vol.30 , pp. 1280-1287
    • Prueksaritanont, T.1
  • 80
    • 33748672081 scopus 로고    scopus 로고
    • Selective PPAR modulators, dual and pan PPAR agonists: Multimodal drugs for the treatment of type 2 diabetes and atherosclerosis
    • Pourcet B et al. (2006) Selective PPAR modulators, dual and pan PPAR agonists: Multimodal drugs for the treatment of type 2 diabetes and atherosclerosis. Expert Opin Emerg Drugs 111: 379-401
    • (2006) Expert Opin Emerg Drugs , vol.111 , pp. 379-401
    • Pourcet, B.1
  • 81
    • 20044396568 scopus 로고    scopus 로고
    • Regulation of human apo A-I by gemfibrozil and fenofibrate through selective PPAR-α modulation
    • Duez H et al. (2005) Regulation of human apo A-I by gemfibrozil and fenofibrate through selective PPAR-α modulation. Arteriosder Thromb Vasc Biol 25: 585-591
    • (2005) Arteriosder Thromb Vasc Biol , vol.25 , pp. 585-591
    • Duez, H.1
  • 82
    • 34250785602 scopus 로고    scopus 로고
    • ACCORD Study Group; Buse JB et al. (2007) Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial: Design and methods. Am J Cardiol 99 (Suppl): 21i-33i
    • ACCORD Study Group; Buse JB et al. (2007) Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial: Design and methods. Am J Cardiol 99 (Suppl): 21i-33i


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