메뉴 건너뛰기




Volumn 54, Issue 23, 2006, Pages 8762-8768

Inhibitory activity on amyloid-β aggregation and antioxidant properties of Crocus sativus stigmas extract and its crocin constituents

Author keywords

Alzheimer's disease; Antioxidant; Crocin; Crocus sativus; Fibrillogenesis; Stigmas

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-40]; ANTIOXIDANT; CAROTENOID; CROCIN; PEPTIDE FRAGMENT; PLANT EXTRACT;

EID: 33751305217     PISSN: 00218561     EISSN: None     Source Type: Journal    
DOI: 10.1021/jf061932a     Document Type: Article
Times cited : (320)

References (33)
  • 1
    • 0029379605 scopus 로고
    • Processing of the β-amyloid precursor protein and its regulation in Alzheimer's disease
    • Checler, F. Processing of the β-amyloid precursor protein and its regulation in Alzheimer's disease. J. Neurochem. 1995, 65, 1431-1444.
    • (1995) J. Neurochem. , vol.65 , pp. 1431-1444
    • Checler, F.1
  • 2
    • 0006325405 scopus 로고    scopus 로고
    • Alzheimer's disease: A reexamination of the amyloid hypothesis
    • Neve, R. L.; Robakis, N. K. Alzheimer's disease: A reexamination of the amyloid hypothesis. Trends Neurosci. 1998, 21, 15-19.
    • (1998) Trends Neurosci. , vol.21 , pp. 15-19
    • Neve, R.L.1    Robakis, N.K.2
  • 4
    • 0034643895 scopus 로고    scopus 로고
    • Oxidative stress induces intracellular accumulation of amyloid β-protein (Aβ) in human neuroblastoma cells
    • Misonou, H.; Morishima-Kawashima, M.; Ihara, Y. Oxidative stress induces intracellular accumulation of amyloid β-protein (Aβ) in human neuroblastoma cells. Biochemistry 2000, 39, 6951-6959.
    • (2000) Biochemistry , vol.39 , pp. 6951-6959
    • Misonou, H.1    Morishima-Kawashima, M.2    Ihara, Y.3
  • 6
    • 0037272674 scopus 로고    scopus 로고
    • Plants with traditional uses and activities, relevant to the management of Alzheimer's disease and other cognitive disorders
    • Howes, M-JR.; Perry, N. S. L.; Houghton, P. J. Plants with traditional uses and activities, relevant to the management of Alzheimer's disease and other cognitive disorders. Phytother. Res. 2003, 17, 1-18.
    • (2003) Phytother. Res. , vol.17 , pp. 1-18
    • Howes, M.-J.R.1    Perry, N.S.L.2    Houghton, P.J.3
  • 7
    • 33244463729 scopus 로고    scopus 로고
    • Crocetin esters, picrocrocin and its related compounds present in Crocus sativus stigmas and Gardenia jasminoides fruits. Tentative identification of seven new compounds by LC-ESI-MS
    • Carmona, M.; Zalacain, A.; Sanchez, A. M.; Novella, J. L.; Alonso, G. L. Crocetin esters, picrocrocin and its related compounds present in Crocus sativus stigmas and Gardenia jasminoides fruits. Tentative identification of seven new compounds by LC-ESI-MS. J. Agric. Food Chem. 2006, 54, 973-979.
    • (2006) J. Agric. Food Chem. , vol.54 , pp. 973-979
    • Carmona, M.1    Zalacain, A.2    Sanchez, A.M.3    Novella, J.L.4    Alonso, G.L.5
  • 8
    • 0029066081 scopus 로고
    • Determination of saffron (Crocus sativus L) components in crude plant extract using high-performance liquid chromatography - UV - visible photodiode-array detection-mass spectrometry
    • Tarantilis, P. A.; Tsoupas, G.; Polissiou, M. Determination of saffron (Crocus sativus L) components in crude plant extract using high-performance liquid chromatography - UV - visible photodiode-array detection-mass spectrometry. J. Chromatogr. A 1995, 699, 107-118.
    • (1995) J. Chromatogr. A , vol.699 , pp. 107-118
    • Tarantilis, P.A.1    Tsoupas, G.2    Polissiou, M.3
  • 9
    • 0029036223 scopus 로고
    • The effects of ethanol and crocin on the induction of long-term potentiation in the CA1 region of rat hippocampal slices
    • Sugiura, M.; Shoyama, Y.; Saito, H.; Abe, K. The effects of ethanol and crocin on the induction of long-term potentiation in the CA1 region of rat hippocampal slices. Jpn. J. Pharmacol. 1995, 67, 395-397.
    • (1995) Jpn. J. Pharmacol. , vol.67 , pp. 395-397
    • Sugiura, M.1    Shoyama, Y.2    Saito, H.3    Abe, K.4
  • 10
    • 0027184894 scopus 로고
    • Biological effects of saffron
    • Abdullaev, F. I. Biological effects of saffron. Biofactors 1993, 4, 83-86.
    • (1993) Biofactors , vol.4 , pp. 83-86
    • Abdullaev, F.I.1
  • 11
    • 10444231865 scopus 로고    scopus 로고
    • Comparison of Crocus sativus L. and imipramine in the treatment of mild to moderate depression: A pilot double-blind randomized trial [ISRCTN45683816]
    • Akhondzabeh, S.; Fallah-Pour, H.; Afkham, K.; Jamshidi, A. H.; Khalighi-Cigaroudi, F. Comparison of Crocus sativus L. and imipramine in the treatment of mild to moderate depression: A pilot double-blind randomized trial [ISRCTN45683816]. BMC Complement. Altern. Med. 2004, 4, 12-16.
    • (2004) BMC Complement. Altern. Med. , vol.4 , pp. 12-16
    • Akhondzabeh, S.1    Fallah-Pour, H.2    Afkham, K.3    Jamshidi, A.H.4    Khalighi-Cigaroudi, F.5
  • 12
    • 13544274008 scopus 로고    scopus 로고
    • Hydro-alcoholic extract of Crocus sativus L. versus fluoxetine in the treatment of mild to moderate depression: A double-blind, randomized pilot trial
    • Noorbala, A. A.; Akhondzadeh, S.; Tahmacebi-Pour, N.; Jamshidi, A. H. Hydro-alcoholic extract of Crocus sativus L. versus fluoxetine in the treatment of mild to moderate depression: A double-blind, randomized pilot trial. J. Ethnopharm. 2005, 97, 281-284.
    • (2005) J. Ethnopharm. , vol.97 , pp. 281-284
    • Noorbala, A.A.1    Akhondzadeh, S.2    Tahmacebi-Pour, N.3    Jamshidi, A.H.4
  • 13
    • 0032536730 scopus 로고    scopus 로고
    • Crocin antagonizes ethanol inhibition of NMDA receptor-mediated responses in rat hippocampal neurons
    • Abe, K.; Sugiura, M.; Shoyama, Y.; Saito, H. Crocin antagonizes ethanol inhibition of NMDA receptor-mediated responses in rat hippocampal neurons. Brain Res. 1998, 787, 132-138.
    • (1998) Brain Res. , vol.787 , pp. 132-138
    • Abe, K.1    Sugiura, M.2    Shoyama, Y.3    Saito, H.4
  • 14
    • 0034087334 scopus 로고    scopus 로고
    • Effects of saffron extract and its constituent crocin on learning behaviour and long-term potentiation
    • Abe, K.; Saito, H. Effects of saffron extract and its constituent crocin on learning behaviour and long-term potentiation. Phytother. Res. 2000, 14, 149-152.
    • (2000) Phytother. Res. , vol.14 , pp. 149-152
    • Abe, K.1    Saito, H.2
  • 15
    • 0035798068 scopus 로고    scopus 로고
    • Crocin suppresses tumour necrosis factor-α-induced cell death of neuronally differentiated PC12 cells
    • Soeda, S.; Ochiai, T.; Paopong, L.; Tanaka, H.; Shoyama, Y.; Shimeno, H. Crocin suppresses tumour necrosis factor-α-induced cell death of neuronally differentiated PC12 cells. Life Sci. 2001, 69, 2887-2898.
    • (2001) Life Sci. , vol.69 , pp. 2887-2898
    • Soeda, S.1    Ochiai, T.2    Paopong, L.3    Tanaka, H.4    Shoyama, Y.5    Shimeno, H.6
  • 18
    • 0346224735 scopus 로고    scopus 로고
    • FT-IR, FT-Raman spectroscopic study of carotenoids from saffron (Crocus sativus L.) and some derivatives
    • Tarantilis, P. A.; Beljebbar, A.; Manfait, M.; Polissiou, M. FT-IR, FT-Raman spectroscopic study of carotenoids from saffron (Crocus sativus L.) and some derivatives. Spectrochim. Acta A 1998, 54, 651-657.
    • (1998) Spectrochim. Acta A , vol.54 , pp. 651-657
    • Tarantilis, P.A.1    Beljebbar, A.2    Manfait, M.3    Polissiou, M.4
  • 20
    • 0030586361 scopus 로고    scopus 로고
    • The ferric reducing ability of plasma as a measure of "antioxidant power": The FRAP assay
    • Benzie, I. F.; Strain, J. J. The ferric reducing ability of plasma as a measure of "antioxidant power": The FRAP assay. Anal. Biochem. 1996, 239, 70-76.
    • (1996) Anal. Biochem. , vol.239 , pp. 70-76
    • Benzie, I.F.1    Strain, J.J.2
  • 21
    • 0242362596 scopus 로고    scopus 로고
    • β-Amyloid protein oligomers induced by metal ions and acid pH are distinct from those generated by slow spontaneous ageing at neutral pH
    • Klug, G. M. J. A.; Losic, D.; Subasinghe, S. S.; Aguilar, M. I.; Martin, L. L.; Small, D. H. β-Amyloid protein oligomers induced by metal ions and acid pH are distinct from those generated by slow spontaneous ageing at neutral pH. Eur. J. Biochem. 2003, 270, 4282-4293.
    • (2003) Eur. J. Biochem. , vol.270 , pp. 4282-4293
    • Klug, G.M.J.A.1    Losic, D.2    Subasinghe, S.S.3    Aguilar, M.I.4    Martin, L.L.5    Small, D.H.6
  • 25
    • 29244478599 scopus 로고    scopus 로고
    • Radical scavenging activity of Crocus sativus L., extracts and its bioactive constituents
    • Assimopoulou, A. N.; Sinakos, Z.; Papageorgiou, V. P. Radical scavenging activity of Crocus sativus L., extracts and its bioactive constituents. Phytother. Res. 2005, 19, 997-1000.
    • (2005) Phytother. Res. , vol.19 , pp. 997-1000
    • Assimopoulou, A.N.1    Sinakos, Z.2    Papageorgiou, V.P.3
  • 26
    • 2442604428 scopus 로고    scopus 로고
    • Crocin prevents the death of rat pheochromyctoma (PC-12) cells by its antioxidant effects stronger than those of alpha-tocopherol
    • Ochiai, T.; Ohno, S.; Soeda, S.; Tanaka, H.; Shoyama, Y.; Shimeno, H. Crocin prevents the death of rat pheochromyctoma (PC-12) cells by its antioxidant effects stronger than those of alpha-tocopherol. Neurosci. Lett. 2004, 362, 61-4.
    • (2004) Neurosci. Lett. , vol.362 , pp. 61-64
    • Ochiai, T.1    Ohno, S.2    Soeda, S.3    Tanaka, H.4    Shoyama, Y.5    Shimeno, H.6
  • 27
    • 0033849965 scopus 로고    scopus 로고
    • Studies on the in vitro assembly of Abeta 1-40: Implications for the search for Abeta fibril formation inhibitors
    • Goldsbury, C. S.; Wirtz, S.; Muller, S. A.; Sunderji, S.; Wicki, P.; Aebi, U.; Frey, P. Studies on the in vitro assembly of Abeta 1-40: Implications for the search for Abeta fibril formation inhibitors. J. Struct. Biol. 2000, 130, 217-231.
    • (2000) J. Struct. Biol. , vol.130 , pp. 217-231
    • Goldsbury, C.S.1    Wirtz, S.2    Muller, S.A.3    Sunderji, S.4    Wicki, P.5    Aebi, U.6    Frey, P.7
  • 28
    • 33745216323 scopus 로고    scopus 로고
    • Biology, biotechnology and biomedicine of saffron
    • Fernandez, J. A. Biology, biotechnology and biomedicine of saffron. Recent. Res. Dev. Plant Sci. 2004, 2, 127-159.
    • (2004) Recent. Res. Dev. Plant Sci. , vol.2 , pp. 127-159
    • Fernandez, J.A.1
  • 29
    • 4544227975 scopus 로고    scopus 로고
    • Vitamin A exhibits potent anti-amyloidogenic and fibril-destabilizing effects in vitro
    • Ono, K.; Yoshiike, Y.; Takashima, A.; Hasagawa, K.; Naiki, H.; Yamada, M. Vitamin A exhibits potent anti-amyloidogenic and fibril-destabilizing effects in vitro. Exp. Neurol. 2004, 189, 380-392.
    • (2004) Exp. Neurol. , vol.189 , pp. 380-392
    • Ono, K.1    Yoshiike, Y.2    Takashima, A.3    Hasagawa, K.4    Naiki, H.5    Yamada, M.6
  • 30
    • 24044483249 scopus 로고    scopus 로고
    • Trehalose differentially inhibits aggregation and neurotoxicity of beta-amyloid 40 and 42
    • Liu, R.; Barkhordarian, H.; Emadi, S.; Park, C. B.; Sierks, M. R. Trehalose differentially inhibits aggregation and neurotoxicity of beta-amyloid 40 and 42. Neurobiol. Dis. 2005, 20, 74-81.
    • (2005) Neurobiol. Dis. , vol.20 , pp. 74-81
    • Liu, R.1    Barkhordarian, H.2    Emadi, S.3    Park, C.B.4    Sierks, M.R.5
  • 31
    • 0141642253 scopus 로고    scopus 로고
    • Potent anti-amyloidogenic and fibril-destabilizing effects of polyphenols in vitro: Implications for the prevention and therapeutics of Alzheimer's disease
    • Ono, K.; Yoshiike, Y.; Takashima, A.; Hasagawa, K.; Naiki, H.; Yamada, M. Potent anti-amyloidogenic and fibril-destabilizing effects of polyphenols in vitro: Implications for the prevention and therapeutics of Alzheimer's disease. J. Neurochem. 2003, 87, 172-181.
    • (2003) J. Neurochem. , vol.87 , pp. 172-181
    • Ono, K.1    Yoshiike, Y.2    Takashima, A.3    Hasagawa, K.4    Naiki, H.5    Yamada, M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.