The effect of crocin and safranal, constituents of saffron, against subacute effect of diazinon on hematological and genotoxicity indices in rats

Phytomedicine

Volumn 18, Issue 6, 2011, Pages 499-504

  Hariri, Alireza Timcheh ^a   Moallem, Seyed Adel ^a   Mahmoudi, Mahmoud ^b   Hosseinzadeh, H ^a  

^a MASHHAD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b MASHHAD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Crocin; Crocus sativus; Diazinon; Genotoxicity; Hematological indices; Organophosphorus agents; Saffron; Safranal

Indexed keywords

ACETYLCHOLINESTERASE; ALPHA TOCOPHEROL; CROCIN; DIMPYLATE; HEMOGLOBIN; SAFRANAL; TERPENE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD TOXICITY; CONTROLLED STUDY; DRUG EFFECT; ENZYME INHIBITION; ERYTHROCYTE COUNT; GENOTOXICITY; HEMATOCRIT; HEMOGLOBIN BLOOD LEVEL; MALE; MEAN CORPUSCULAR HEMOGLOBIN; MEAN CORPUSCULAR VOLUME; MEDICINAL PLANT; MICRONUCLEUS TEST; MORNING DOSAGE; NONHUMAN; PRIORITY JOURNAL; RAT; RETICULOCYTE; RETICULOCYTE COUNT; SAFFRON; THROMBOCYTE COUNT;

CROCUS SATIVUS; RATTUS;

EID: 79954996502     PISSN: 09447113     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.phymed.2010.10.001     Document Type: Article

References (40)

1. F.I. Abdullaev Biological effects of saffron Biofactors 4 1993 83 86 (Pubitemid 23218839)
2. F.I. Abdullaev, L. Rivern-Negrete, H. Caballero-Ortega, J. Manuel Hernndez, I. Pérez-Lpez, R. Pereda-Miranda, and J.J. Espinosa-Aguirre Use of in vitro assays to assess the potential antigenotoxic and cytotoxic effects of saffron (Crocus sativus L.) Toxicol. In Vitro 17 2003 731 736 (Pubitemid 37352686)
3. K. Campbell Laboratory diagnosis and investigation of anaemia Nurs. Times 101 2005 36 39
4. J. Cao, L.P. Jiang, Y. Liu, G. Yang, X.F. Yao, and L.F. Zhong Curcumin-induced genotoxicity and antigenotoxicity in HepG2 cells Toxicon 49 2007 1219 1222 (Pubitemid 46802694)
5. W.C. Chang, Y.L. Lin, M.J. Lee, S.J. Shiow, and C.J. Wang Inhibitory effect of crocetin on benzo(a)pyrene genotoxicity and neoplastic transformation in C3H10T1/2 cells Anticancer Res. 765 1996 3603 3608
6. Y. Chen, H. Zhang, X. Tian, C. Zhao, L. Cai, Y. Liu, L. Jia, H.-X. Yin, and C. Chen Antioxidant potential of crocins and ethanol extracts of Gardenia jasminoides ELLIS and Crocus sativus L.: a relationship investigation between antioxidant activity and crocin contents Food Chem. 109 2008 484 492
7. G.L. Ellman, K.D. Courtney, V. Andres Jr., and R.M. Featherstone A new and rapid colorimetric determination of acetylcholinesterase activity Biochem. Pharmacol. 7 1961 88-90, IN81, 91-95
8. J.-A. Fernández Anticancer properties of saffron, Crocus sativus Linn M.T.H. Kahn, A. Ather, Lead Molecules from Natural Products 2006 Elsevier B.V. 313 330
9. S.J. Garfitt, K. Jones, H.J. Mason, and J. Cocker Exposure to the organophosphate diazinon: data from a human volunteer study with oral and dermal doses Toxicol. Lett. 134 2002 105 113 (Pubitemid 35007292)
10. R.D. Handy, H.A. Abd-El Samei, M.F.F. Bayomy, A.M. Mahran, A.M. Abdeen, and E.A. El-Elaimy Chronic diazinon exposure: pathologies of spleen, thymus, blood cells, and lymph nodes are modulated by dietary protein or lipid in the mouse Toxicology 172 2002 13 34 (Pubitemid 34159008)
11. M. Hayashi, T. Sofuni, and M. Ishidate Jr. An application of acridine orange fluorescent staining to the micronuclear test Mutat. Res. 120 1983 241 247 (Pubitemid 13103085)
12. A. Hazarika, S.N. Sarkar, S. Hajare, M. Kataria, and J.K. Malik Influence of malathion pretreatment on the toxicity of anilofos in male rats: a biochemical interaction study Toxicology 185 2003 1 8 (Pubitemid 36050725)
13. H. Hosseinzadeh, and J. Ghenaati Evaluation of the antitussive effect of stigma and petals of saffron (Crocus sativus L.) and its components, safranal and crocin in guinea pigs Fitoterapia 77 2006 446 448 (Pubitemid 44308375)
14. H. Hosseinzadeh, G. Karimi, and M. Niapoor Antidepressant effect of Crocus sativus L. stigma extracts and their constituents, crocin and safranal, in mice Acta Hort. 650 2004 435 445
15. H. Hosseinzadeh, and V. Khosravan Anticonvulsant effects of aqueous and ethanolic extracts of Crocus sativus L. stigmas in mice Arch. Iran Med. 5 2002 44 47 (Pubitemid 34591502)
16. H. Hosseinzadeh, M.H. Modaghegh, and Z. Saffari Crocus sativus L. (saffron) extract and its active constituents (crocin and safranal) on ischemia-reperfusion in rat skeletal muscle eCAM 6 2009 343 350
17. H. Hosseinzadeh, and N.B. Noraei Anxiolytic and hypnotic effect of Crocus sativus aqueous extract and its constituents, crocin and safranal, in mice Phytother. Res. 23 2009 768 774
18. H. Hosseinzadeh, H.R. Sadeghnia, T. Ziaee, and A. Danaee Protective effect of aqueous saffron extract (Crocus sativus L.) and crocin, its active constituent, on renal ischemia-reperfusion-induced oxidative damage in rats J. Pharm. Pharmacol. Sci. 8 2005 387 393 (Pubitemid 41529317)
19. H. Hosseinzadeh, and H.R. Sadeghnia Safranal, a constituent of Crocus sativus (saffron), attenuated cerebral ischemia induced oxidative damage in rat hippocampus J. Pharm. Pharm. Sci. 8 2005 394 399 (Pubitemid 41529318)
20. H. Hosseinzadeh, and H.R. Sadeghnia Protective effect of safranal on pentylenetetrazol-induced seizures in the rat: involvement of GABAergic and opioids systems Phytomedicine 14 2007 256 262 (Pubitemid 46386392)
21. H. Hosseinzadeh, F. Shamsaie, and S. Mehri Antioxidant activity of aqueous and ethanolic extracts of Crocus sativus L. stigma and its bioactive constituent, crocin and safranal Pharmacog. Mag. 5 2009 419 424
22. H. Hosseinzadeh, and F. Talebzadeh Anticonvulsant evaluation of safranal and crocin from Crocus sativus in mice Fitoterapia 76 2005 722 724 (Pubitemid 41688398)
23. H. Hosseinzadeh, and T. Ziaei Effects of Crocus sativus stigma extract and its constituents, crocin and safranal, on intact memory and scopolamine-induced learning deficits in rats performing the Morris water maze task J. Med. Plants 5 2006 40 50
24. H. Hosseinzadeh, T. Ziaee, and A. Sadeghi Effect of saffron, Crocus sativus stigma, extract and its constituents, safranal and crocin on sexual behaviors of normal male rats Phytomedicine 15 2008 491 495 (Pubitemid 351783383)
25. H. Jacobsen, G. Østergaard, H.R. Lam, M.E. Poulsen, H. Frandsen, O. Ladefoged, and O. Meyer Repeated dose 28-day oral toxicity study in Wistar rats with a mixture of five pesticides often found as residues in food: alphacypermethrin, bromopropylate, carbendazim, chlorpyrifos and mancozeb Food Chem. Toxicol. 42 2004 1269 1277 (Pubitemid 38780874)
26. S.C. Joshi, R. Mathur, A. Gajraj, and T. Sharma Influence of methyl parathion on reproductive parameters in male rats Environ. Toxicol. Pharmacol. 14 2003 91 98 (Pubitemid 37338322)
27. S.S. Köprücü, K. Köprücü, M.S. Ural, N. Ispir, and M. Pala Acute toxicity of organophosphorous pesticide diazinon and its effects on behavior and some hematological parameters of fingerling European catfish (Silurus glanis L.) Pestic. Biochem. Physiol. 86 2006 99 105 (Pubitemid 44202544)
28. S. Kalender, A. Ogutcu, M. Uzunhisarcikli, F. Aikgoz, D. Durak, Y. Ulusoy, and Y. Kalender Diazinon-induced hepatotoxicity and protective effect of vitamin E on some biochemical indices and ultrastructural changes Toxicology 211 2005 197 206 (Pubitemid 40755254)
29. Y. Kalender, M. Uzunhisarcikli, A. Ogutcu, F. Acikgoz, and S. Kalender Effects of diazinon on pseudocholinesterase activity and haematological indices in rats: the protective role of Vitamin E Environ. Toxicol. Pharmacol. 22 2006 46 51
30. C.D. Kanakis, P.A. Tarantilis, C. Pappas, J. Bariyanga, H.A. Tajmir-Riahi, and M.G. Polissiou An overview of structural features of DNA and RNA complexes with saffron compounds: models and antioxidant activity J. Photochem. Photobiol. B: Biol. 95 2009 204 212
31. J.P. Kehrer, L.G. Lund, and T. Paraidathathu Pyridine nucleotides and the reduction of GSSG in hypoxic heart tissue exposed to diamide Free Radic. Biol. Med. 15 1993 520
32. C.C. Munari, J.M. Alves, J.K. Bastos, and D.C. Tavares Evaluation of the genotoxic and antigenotoxic potential of Baccharis dracunculifolia extract on V79 cells by the comet assay J. Appl. Toxicol. 30 2009 22 28
33. S.C. Nair, S.K. Kurumboor, and J.H. Hasegawa Saffron chemoprevention in biology and medicine: a review Cancer Biother. 10 1995 257 264
34. J.A. Patil, A.J. Patil, and S.P. Govindwar Biochemical effects of various pesticides on sprayers of grape gardens Indian J. Clin. Biochem. 18 2003 16 22 (Pubitemid 37039460)
35. G.A. Pascoe, K. Olafsdottir, and D.J. Reed Vitamin E protection against chemical-induced cell injury. I. Maintenance of cellular protein thiols as a cytoprotective mechanism Arch. Biochem. Biophys. 256 1987 150 158 (Pubitemid 17102994)
36. K. Premkumar, S.K. Abraham, S.T. Santhiya, P.M. Gopinath, and A. Ramesh Inhibition of genotoxicity by saffron (Crocus sativus L.) in mice Drug Chem. Toxicol. 24 2001 421 428 (Pubitemid 32959248)
37. J.L. Rios, M.C. Recio, R.M. Ginger, and S. Máñez An update review of saffron and its active constituents Phytother. Res. 10 1996 189 193 (Pubitemid 26164562)
38. M. Svoboda, V. Lusková, J. Drastichová, and V. Žlábek The effect of diazinon on haematological indices of common carp (Cyprinus carpio L.) Acta Vet. Brno. 70 2001 457 465 (Pubitemid 33799067)
39. J. Ueyama, D. Wang, T. Kondo, I. Saito, K. Takagi, K. Takagi, M. Kamijima, T. Nakajima, K.-I. Miyamoto, S. Wakusawa, and T. Hasegawa Toxicity of diazinon and its metabolites increases in diabetic rats Toxicol. Lett. 170 2007 229 237 (Pubitemid 46710274)
40. M.A.H. Yehia, S.G. El-Banna, and A.B. Okab Diazinon toxicity affects histophysiological and biochemical parameters in rabbits Exp. Toxicol. Pathol. 59 2007 215 225 (Pubitemid 350047537)