메뉴 건너뛰기




Volumn 26, Issue 3, 2012, Pages 381-386

Effects of saffron (Crocus sativus L.) and its active constituent, crocin, on recognition and spatial memory after chronic cerebral hypoperfusion in rats

Author keywords

Antioxidant; Chronic cerebral hypoperfusion; Crocin; Crocus sativus; Memory

Indexed keywords

CROCIN; CROCUS SATIVUS EXTRACT;

EID: 84858005351     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.3566     Document Type: Article
Times cited : (198)

References (37)
  • 1
    • 0034087334 scopus 로고    scopus 로고
    • Effects of saffron extract and its constituent crocin on learning behaviour and long-term potentiation
    • DOI 10.1002/(SICI)1099-1573(200005)14:3<149::AID-PTR665>3.0.CO;2-5
    • Abe K, Saito H. 2000. Effects of saffron extract and its constituent crocin on learning behaviour and long-term potentiation. Phytother Res 14: 149-152. (Pubitemid 30326004)
    • (2000) Phytotherapy Research , vol.14 , Issue.3 , pp. 149-152
    • Abe, K.1    Saito, H.2
  • 2
    • 0032536730 scopus 로고    scopus 로고
    • Crocin antagonizes ethanol inhibition of NMDA receptor-mediated responses in rat hippocampal neurons
    • DOI 10.1016/S0006-8993(97)01505-9, PII S0006899397015059
    • Abe K, Sugiura M, Shoyama Y et al. 1998. Crocin antagonizes ethanol inhibition of NMDA receptor-mediated responses in rat hippocampal neurons. Brain Res 787: 132-138. (Pubitemid 28279809)
    • (1998) Brain Research , vol.787 , Issue.1 , pp. 132-138
    • Abe, K.1    Sugiura, M.2    Shoyama, Y.3    Saito, H.4
  • 3
    • 10444231865 scopus 로고    scopus 로고
    • Comparison of Crocus sativus L. and imipramine in the treatment of mild to moderate depression: A pilot double-blind randomized trial [ISRCTN45683816]
    • Akhondzadeh S, Fallah-Pour H, Afkham K et al. 2004. Comparison of Crocus sativus L. and imipramine in the treatment of mild to moderate depression: a pilot double-blind randomized trial [ISRCTN45683816]. BMC Complement Altern Med 4: 12-16.
    • (2004) BMC Complement Altern Med , vol.4 , pp. 12-16
    • Akhondzadeh, S.1    Fallah-Pour, H.2    Afkham, K.3
  • 4
    • 77952881985 scopus 로고    scopus 로고
    • Potential of Crocus sativus (saffron) and its constituent, crocin, as hypolipidemic and antioxidant in rats
    • Asdaq SM, Inamdar MN. 2010. Potential of Crocus sativus (saffron) and its constituent, crocin, as hypolipidemic and antioxidant in rats. Appl Biochem Biotechnol 162: 358-372.
    • (2010) Appl Biochem Biotechnol , vol.162 , pp. 358-372
    • Asdaq, S.M.1    Inamdar, M.N.2
  • 5
    • 8744300045 scopus 로고    scopus 로고
    • Vascular factors in dementia: An overview
    • Decarli C. 2004. Vascular factors in dementia: an overview. J Neurol Sci 226: 19-23.
    • (2004) J Neurol Sci , vol.226 , pp. 19-23
    • Decarli, C.1
  • 6
    • 2442473297 scopus 로고    scopus 로고
    • Diazoxide and dimethyl sulphoxide prevent cerebral hypoperfusion-related learning dysfunction and brain damage after carotid artery occlusion
    • DOI 10.1016/j.brainres.2004.02.037, PII S0006899304003518
    • Farkas E, Institoris A, Domoki F et al. 2004. Diazoxide and dimethyl sulphoxide prevent cerebral hypoperfusion-related learning dysfunction and brain damage after carotid artery occlusion. Brain Res 1008: 252-260. (Pubitemid 38624056)
    • (2004) Brain Research , vol.1008 , Issue.2 , pp. 252-260
    • Farkas, E.1    Institoris, A.2    Domoki, F.3    Mihaly, A.4    Luiten, P.G.M.5    Bari, F.6
  • 7
    • 23844552880 scopus 로고    scopus 로고
    • Post-ischemic administration of diazoxide attenuates long-term microglial activation in the rat brain after permanent carotid artery occlusion
    • DOI 10.1016/j.neulet.2005.06.036, PII S0304394005007135
    • Farkas E, Timmer NM, Domoki F et al. 2005. Post-ischemic administration of diazoxide attenuates long-term microglial activation in the rat brain after permanent carotid artery occlusion. Neurosci Lett 387: 168-172. (Pubitemid 41160550)
    • (2005) Neuroscience Letters , vol.387 , Issue.3 , pp. 168-172
    • Farkas, E.1    Timmer, N.M.2    Domoki, F.3    Mihaly, A.4    Luiten, P.G.M.5    Bari, F.6
  • 8
    • 75249099832 scopus 로고    scopus 로고
    • Preventive effect of crocin of Crocus sativus on hemodynamic, biochemical, histopathological and ultrastuctural alterations in isoproterenol-induced cardiotoxicity in rats
    • Goyal SN, Arora S, Sharma AK et al. 2010. Preventive effect of crocin of Crocus sativus on hemodynamic, biochemical, histopathological and ultrastuctural alterations in isoproterenol-induced cardiotoxicity in rats. Phytomedicine 17: 227-232.
    • (2010) Phytomedicine , vol.17 , pp. 227-232
    • Goyal, S.N.1    Arora, S.2    Sharma, A.K.3
  • 9
    • 33746148924 scopus 로고    scopus 로고
    • Protections of pinocembrin on brain mitochondria contribute to cognitive improvement in chronic cerebral hypoperfused rats
    • Guang HM, Du GH. 2006. Protections of pinocembrin on brain mitochondria contribute to cognitive improvement in chronic cerebral hypoperfused rats. Eur J Pharmacol 542: 77-83.
    • (2006) Eur J Pharmacol , vol.542 , pp. 77-83
    • Guang, H.M.1    Du, G.H.2
  • 10
    • 77957274588 scopus 로고    scopus 로고
    • Extraction and purification of crocin from saffron stigmas employing a simple and efficient crystallization method
    • Hadizadeh F, Mohajeri SA, Seifi M. 2010. Extraction and purification of crocin from saffron stigmas employing a simple and efficient crystallization method. Pak J Biol Sci 13: 691-698.
    • (2010) Pak J Biol Sci , vol.13 , pp. 691-698
    • Hadizadeh, F.1    Mohajeri, S.A.2    Seifi, M.3
  • 11
    • 43049101090 scopus 로고    scopus 로고
    • Piracetam improves cognitive deficits caused by chronic cerebral hypoperfusion in rats
    • DOI 10.1007/s10571-007-9165-x
    • He Z, Liao Y, Zheng M et al. 2008. Piracetam improves cognitive deficits caused by chronic cerebral hypoperfusion in rats. Cell Mol Neurobiol 28: 613-627. (Pubitemid 351624502)
    • (2008) Cellular and Molecular Neurobiology , vol.28 , Issue.4 , pp. 613-627
    • He, Z.1    Liao, Y.2    Zheng, M.3    Zeng, F.-D.4    Guo, L.-J.5
  • 12
    • 15944399971 scopus 로고    scopus 로고
    • The effect of carbenoxolone on spatial learning in the Morris water maze task in rats
    • Hosseinzadeh H, Asl MN, Parvardeh S et al. 2005b. The effects of carbenoxolone on spatial learning in the Morris water maze task in rats. Med Sci Monit 11: BR88-BR94. (Pubitemid 40445978)
    • (2005) Medical Science Monitor , vol.11 , Issue.3
    • Hosseinzadeh, H.1    Asl, M.N.2    Parvardeh, S.3    Mansouri, S.M.T.4
  • 13
    • 27444432701 scopus 로고    scopus 로고
    • Antidepressant effect of Crocus sativus L. stigma extracts and their constituents, crocin and safranal, in mice
    • Hosseinzadeh H, Karimi G, Niapoor M. 2004. Antidepressant effect of Crocus sativus L. stigma extracts and their constituents, crocin and safranal, in mice. Acta Hort 650: 435-445.
    • (2004) Acta Hort , vol.650 , pp. 435-445
    • Hosseinzadeh, H.1    Karimi, G.2    Niapoor, M.3
  • 14
    • 68849096206 scopus 로고    scopus 로고
    • Crocus sativus L. (saffron) extract and its active constituents (crocin and safranal) on ischemia-reperfusion in rat skeletal muscle
    • Hosseinzadeh H, Modaghegh MH, Saffari Z. 2009. Crocus sativus L. (saffron) extract and its active constituents (crocin and safranal) on ischemia-reperfusion in rat skeletal muscle. Evid Based Complement Altern Med 6: 343-350.
    • (2009) Evid Based Complement Altern Med , vol.6 , pp. 343-350
    • Hosseinzadeh, H.1    Modaghegh, M.H.2    Saffari, Z.3
  • 15
    • 27444442382 scopus 로고    scopus 로고
    • Safranal, a constituent of Crocus sativus (saffron), attenuated cerebral ischemia induced oxidative damage in rat hippocampus
    • Hosseinzadeh H, Sadeghnia HR. 2005. Safranal, a constituent of Crocus sativus (saffron), attenuated cerebral ischemia induced oxidative damage in rat hippocampus. J Pharm Pharm Sci 8: 394-399. (Pubitemid 41529318)
    • (2005) Journal of Pharmacy and Pharmaceutical Sciences , vol.8 , Issue.3 , pp. 394-399
    • Hosseinzadeh, H.1    Sadeghnia, H.R.2
  • 16
    • 33847752592 scopus 로고    scopus 로고
    • Protective effect of safranal on pentylenetetrazol-induced seizures in the rat: Involvement of GABAergic and opioids systems
    • DOI 10.1016/j.phymed.2006.03.007, PII S0944711306000651
    • Hosseinzadeh H, Sadeghnia HR. 2007. Protective effect of safranal on pentylenetetrazol-induced seizures in the rat: involvement of GABAergic and opioids systems. Phytomedicine 14: 256-262. (Pubitemid 46386392)
    • (2007) Phytomedicine , vol.14 , Issue.4 , pp. 256-262
    • Hosseinzadeh, H.1    Sadeghnia, H.R.2
  • 17
    • 27444437828 scopus 로고    scopus 로고
    • Protective effect of aqueous saffron extract (Crocus sativus L.) and crocin, its active constituent, on renal ischemia-reperfusion-induced oxidative damage in rats
    • Hosseinzadeh H, Sadeghnia HR, Ziaee T et al. 2005a. Protective effect of aqueous saffron extract (Crocus sativus L.) and crocin, its active constituent, on renal ischemia-reperfusioninduced oxidative damage in rats. J Pharm Pharm Sci 8: 387-393. (Pubitemid 41529317)
    • (2005) Journal of Pharmacy and Pharmaceutical Sciences , vol.8 , Issue.3 , pp. 387-393
    • Hosseinzadeh, H.1    Sadeghnia, H.R.2    Ziaee, T.3    Danaee, A.4
  • 18
    • 27444447828 scopus 로고    scopus 로고
    • Anticonvulsant evaluation of safranal and crocin from Crocus sativus in mice
    • DOI 10.1016/j.fitote.2005.07.008, PII S0367326X05001991
    • Hosseinzadeh H, Talebzadeh F. 2005. Anticonvulsant evaluation of safranal and crocin from Crocus sativus in mice. Fitoterapia 76: 722-724. (Pubitemid 41688398)
    • (2005) Fitoterapia , vol.76 , Issue.7-8 , pp. 722-724
    • Hosseinzadeh, H.1    Talebzadeh, F.2
  • 19
    • 46149125926 scopus 로고    scopus 로고
    • Improvement of cognitive deficit and neuronal damage in rats with chronic cerebral ischemia via relative long-term inhibition of rho-kinase
    • DOI 10.1007/s10571-007-9157-x
    • Huang L, He Z, Guo L et al. 2008. Improvement of cognitive deficit and neuronal damage in rats with chronic cerebral ischemia via relative long-term inhibition of rho-kinase. Cell Mol Neurobiol 28: 757-768. (Pubitemid 351905062)
    • (2008) Cellular and Molecular Neurobiology , vol.28 , Issue.5 , pp. 757-768
    • Huang, L.1    He, Z.2    Guo, L.3    Wang, H.4
  • 20
    • 10344254845 scopus 로고    scopus 로고
    • Centrophenoxine improves chronic cerebral ischemia induced cognitive deficit and neuronal degeneration in rats
    • Liao Y, Wang R, Tang XC. 2004. Centrophenoxine improves chronic cerebral ischemia induced cognitive deficit and neuronal degeneration in rats. Acta Pharmacol Sin 25: 1590-1596. (Pubitemid 39628025)
    • (2004) Acta Pharmacologica Sinica , vol.25 , Issue.12 , pp. 1590-1596
    • Liao, Y.1    Wang, R.2    Tang, X.-C.3
  • 22
    • 77955382371 scopus 로고    scopus 로고
    • Extraction of crocin from saffron (Crocus sativus) using molecularly imprinted polymer solid-phase extraction
    • Mohajeri SA, Hosseinzadeh H, Keyhanfar F et al. 2010. Extraction of crocin from saffron (Crocus sativus) using molecularly imprinted polymer solid-phase extraction. J Sep Sci 33: 2302-2309.
    • (2010) J Sep Sci , vol.33 , pp. 2302-2309
    • Mohajeri, S.A.1    Hosseinzadeh, H.2    Keyhanfar, F.3
  • 24
    • 33750500316 scopus 로고    scopus 로고
    • Crocus sativus L. (petal) in the treatment of mild-to-moderate depression: A double-blind, randomized and placebo-controlled trial
    • DOI 10.1016/j.phymed.2006.08.006, PII S0944711306001279
    • Moshiri E, Basti AA, Noorbala AA et al. 2006. Crocus sativus L. (petal) in the treatment of mild-to-moderate depression: a double-blind, randomized and placebo-controlled trial. Phytomedicine 13: 607-611. (Pubitemid 44666407)
    • (2006) Phytomedicine , vol.13 , Issue.9-10 , pp. 607-611
    • Moshiri, E.1    Basti, A.A.2    Noorbala, A.-A.3    Jamshidi, A.-H.4    Hesameddin, A.S.5    Akhondzadeh, S.6
  • 25
    • 77952093874 scopus 로고    scopus 로고
    • Protective effect of saffron extract and crocin on reactive oxygen species-mediated high glucose-induced toxicity in PC12 cells
    • Mousavi SH, Tayarani NZ, Parsaee H. 2010. Protective effect of saffron extract and crocin on reactive oxygen species-mediated high glucose-induced toxicity in PC12 cells. Cell Mol Neurobiol 30: 185-191.
    • (2010) Cell Mol Neurobiol , vol.30 , pp. 185-191
    • Mousavi, S.H.1    Tayarani, N.Z.2    Parsaee, H.3
  • 26
    • 38849095847 scopus 로고    scopus 로고
    • Vascular dementia: Clinical, neuroradiologic and neuropathologic aspects
    • Murray ME, Knopman DS, Dickson DW. 2007. Vascular dementia: clinical, neuroradiologic and neuropathologic aspects. Panminerva Med 49: 197-207.
    • (2007) Panminerva Med , vol.49 , pp. 197-207
    • Murray, M.E.1    Knopman, D.S.2    Dickson, D.W.3
  • 27
    • 0030924490 scopus 로고    scopus 로고
    • The GABA(B) receptor antagonist CGP36742 attenuates the baclofen- and scopolamine-induced deficit in Morris water maze task in rats
    • DOI 10.1016/S0006-8993(97)00529-5, PII S0006899397005295
    • Nakagawa Y, Takashima T. 1997. The GABA(B) receptor antagonist CGP36742 attenuates the baclofen- and scopolamineinduced deficit in Morris water maze task in rats. Brain Res 766: 101-106. (Pubitemid 27431439)
    • (1997) Brain Research , vol.766 , Issue.1-2 , pp. 101-106
    • Nakagawa, Y.1    Takashima, T.2
  • 28
    • 2442604428 scopus 로고    scopus 로고
    • Crocin prevents the death of rat pheochromyctoma (PC-12) cells by its antioxidant effects stronger than those of alpha-tocopherol
    • DOI 10.1016/j.neulet.2004.02.067, PII S0304394004002629
    • Ochiai T, Ohno S, Soeda S et al. 2004. Crocin prevents the death of rat pheochromyctoma (PC-12) cells by its antioxidant effects stronger than those of alpha-tocopherol. Neurosci Lett 362: 61-64. (Pubitemid 38638385)
    • (2004) Neuroscience Letters , vol.362 , Issue.1 , pp. 61-64
    • Ochiai, T.1    Ohno, S.2    Soeda, S.3    Tanaka, H.4    Shoyama, Y.5    Shimeno, H.6
  • 31
    • 33750024445 scopus 로고    scopus 로고
    • Crocus sativus L. extracts antagonize memory impairments in different behavioural tasks in the rat
    • DOI 10.1016/j.bbr.2006.06.005, PII S016643280600307X
    • Pitsikas N, Sakellaridis N. 2006. Crocus sativus L. extracts antagonize memory impairments in different behavioural tasks in the rat. Behav Brain Res 173: 112-115. (Pubitemid 44572020)
    • (2006) Behavioural Brain Research , vol.173 , Issue.1 , pp. 112-115
    • Pitsikas, N.1    Sakellaridis, N.2
  • 33
    • 41949109036 scopus 로고    scopus 로고
    • Effect of ethanolic extract of root of Pongamia pinnata (L) Pierre on oxidative stress, behavioral and histopathological alterations induced by cerebral ischemia - Reperfusion and long-term hypoperfusion in rats
    • Raghavendra M, Trigunayat A, Singh RK et al. 2007. Effect of ethanolic extract of root of Pongamia pinnata (L) Pierre on oxidative stress, behavioral and histopathological alterations induced by cerebral ischemia - reperfusion and long-term hypoperfusion in rats. Indian J Exp Biol 45: 868-876.
    • (2007) Indian J Exp Biol , vol.45 , pp. 868-876
    • Raghavendra, M.1    Trigunayat, A.2    Singh, R.K.3
  • 35
    • 67649367539 scopus 로고    scopus 로고
    • Edaravone attenuates white matter lesions through endothelial protection in a rat chronic hypoperfusion model
    • Ueno Y, Zhang N, Miyamoto N et al. 2009. Edaravone attenuates white matter lesions through endothelial protection in a rat chronic hypoperfusion model. Neuroscience 162: 317-327.
    • (2009) Neuroscience , vol.162 , pp. 317-327
    • Ueno, Y.1    Zhang, N.2    Miyamoto, N.3
  • 36
    • 77954658826 scopus 로고    scopus 로고
    • Green tea polyphenols inhibit cognitive impairment induced by chronic cerebral hypoperfusion via modulating oxidative stress
    • Xu Y, Zhang JJ, Xiong L et al. 2010. Green tea polyphenols inhibit cognitive impairment induced by chronic cerebral hypoperfusion via modulating oxidative stress. J Nutr Biochem 21: 741-748.
    • (2010) J Nutr Biochem , vol.21 , pp. 741-748
    • Xu, Y.1    Zhang, J.J.2    Xiong, L.3
  • 37
    • 0028314443 scopus 로고
    • Effects of Crocus sativus L. on the ethanol-induced impairment of passive avoidance performances in mice
    • Zhang Y, Shoyama Y, SugiuraM et al. 1994. Effects of Crocus sativus L. on the ethanol-induced impairment of passive avoidance performances in mice. Biol Pharm Bull 17: 217-221. (Pubitemid 24112339)
    • (1994) Biological and Pharmaceutical Bulletin , vol.17 , Issue.2 , pp. 217-221
    • Zhang, Y.1    Shoyama, Y.2    Sugiura, M.3    Saito, H.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.