메뉴 건너뛰기




Volumn 24, Issue 7, 1996, Pages 799-806

Identification and characterization of human metabolites of CAI [5- amino-1-1(4'-chlorobenzoyl-3,5-dichlorobenzyl)-1,2,3-triazole-4-carboxamide)

Author keywords

[No Author keywords available]

Indexed keywords

3,5 DICHLORO 4 (4' CHLOROBENZOYL)BENZOIC ACID; 5 AMINO 1 (4' CHLOROBENZOYL 3,5 DICHLOROBENZYL) 1,2,3 TRIAZOLE 4 CARBOXAMIDE; ANTINEOPLASTIC AGENT; ARACHIDONIC ACID; BENZOPHENONE DERIVATIVE; BETA GLUCURONIDASE; CARBACHOL; DRUG METABOLITE; UNCLASSIFIED DRUG;

EID: 0030056717     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (165)

References (16)
  • 1
    • 0025012854 scopus 로고
    • L651582, a novel antiproliferative and antimetastasis agent
    • E. C. Kohn and L. A. Liotta: L651582, a novel antiproliferative and antimetastasis agent. J. Natl. Cancer Inst. 82, 54-50 (1990).
    • (1990) J. Natl. Cancer Inst. , vol.82 , pp. 54-150
    • Kohn, E.C.1    Liotta, L.A.2
  • 2
    • 0026740712 scopus 로고
    • In vivo efficacy of a novel inhibitor of selected signal transduction pathways including calcium, arachidonate, and inositol phosphates
    • E. C. Kohn, M. A. Sandeen, and L. A. Liotta: In vivo efficacy of a novel inhibitor of selected signal transduction pathways including calcium, arachidonate, and inositol phosphates. Cancer Res. 52, 3208-3212 (1992).
    • (1992) Cancer Res. , vol.52 , pp. 3208-3212
    • Kohn, E.C.1    Sandeen, M.A.2    Liotta, L.A.3
  • 4
    • 0028040432 scopus 로고
    • Calcium influx modulates expression of matrix metalloproteinase-2 (72 kDa type IV collagenase, gelatinase A) expression
    • E. C. Kohn, W. Jacobs, Y. S. Kim, R. Alessandro, W. G. Stetler-Stevenson, and L. A. Liotta: Calcium influx modulates expression of matrix metalloproteinase-2 (72 kDa type IV collagenase, gelatinase A) expression. J. Biol. Chem. 269, 21505-21511 (1994).
    • (1994) J. Biol. Chem. , vol.269 , pp. 21505-21511
    • Kohn, E.C.1    Jacobs, W.2    Kim, Y.S.3    Alessandro, R.4    Stetler-Stevenson, W.G.5    Liotta, L.A.6
  • 5
    • 0025772585 scopus 로고
    • The antiproliferative and antimetastatic compound L651582 inhibits muscarinic acetylcholine receptor-stimulated calcium influx and arachidonic acid release
    • C. C. Felder, A. L. Ma, L. A. Liotta, and E. C. Kohn: The antiproliferative and antimetastatic compound L651582 inhibits muscarinic acetylcholine receptor-stimulated calcium influx and arachidonic acid release. J. Pharmacol. Exp. Ther. 257, 967-971 (1991).
    • (1991) J. Pharmacol. Exp. Ther. , vol.257 , pp. 967-971
    • Felder, C.C.1    Ma, A.L.2    Liotta, L.A.3    Kohn, E.C.4
  • 6
    • 0027503305 scopus 로고
    • Muscarinic receptor-mediated tyrosine phosphorylation of phospholipase C-gamma: Alternative mechanism for cholinergic receptor-induced phosphoinositide breakdown
    • F. Gusovsky, J. E. Lueders, E. C. Kohn, and C. C. Felder: Muscarinic receptor-mediated tyrosine phosphorylation of phospholipase C-gamma: alternative mechanism for cholinergic receptor-induced phosphoinositide breakdown. J. Biol. Chem. 268, 7768-7772 (1993).
    • (1993) J. Biol. Chem. , vol.268 , pp. 7768-7772
    • Gusovsky, F.1    Lueders, J.E.2    Kohn, E.C.3    Felder, C.C.4
  • 7
    • 0028205812 scopus 로고
    • Structure function analysis of signal and growth inhibition by carboxyamido-triazole, CAI
    • E. C. Kohn, C. C. Felder, W. Jacobs, K. A. Holmes, A. F. Day, R. Freer, and L. A. Liotta: Structure function analysis of signal and growth inhibition by carboxyamido-triazole, CAI. Cancer Res. 54, 935-942 (1994).
    • (1994) Cancer Res. , vol.54 , pp. 935-942
    • Kohn, E.C.1    Felder, C.C.2    Jacobs, W.3    Holmes, K.A.4    Day, A.F.5    Freer, R.6    Liotta, L.A.7
  • 10
    • 0027518744 scopus 로고
    • Quantitation of plasma levels of a novel anticancer drug, carboxyamidotriazole (CAI) by high pressure liquid chromatography
    • K. A. Holmes, C. Chaffins, B. Osborne, L. A. Liotta, and E. C. Kohn: Quantitation of plasma levels of a novel anticancer drug, carboxyamidotriazole (CAI) by high pressure liquid chromatography. J. Chrom. Biomed. Appl. 613, 317-325 (1993).
    • (1993) J. Chrom. Biomed. Appl. , vol.613 , pp. 317-325
    • Holmes, K.A.1    Chaffins, C.2    Osborne, B.3    Liotta, L.A.4    Kohn, E.C.5
  • 11
    • 0028945544 scopus 로고
    • Similarity of metabolism for CAI (NSC 609974) in human liver tissue in vitro and in humans in vivo
    • L. K. Ludden, J. M. Strong, E. C. Kohn, and J. M. Collins: Similarity of metabolism for CAI (NSC 609974) in human liver tissue in vitro and in humans in vivo. Clin. Cancer Res. 1, 399-405 (1995).
    • (1995) Clin. Cancer Res. , vol.1 , pp. 399-405
    • Ludden, L.K.1    Strong, J.M.2    Kohn, E.C.3    Collins, J.M.4
  • 12
    • 0025975978 scopus 로고
    • Isolation and characterization of a novel quaternary ammonium-liked glucuronide of lamotrigne
    • M. W. Sinz and R. P. Remmel: Isolation and characterization of a novel quaternary ammonium-liked glucuronide of lamotrigne. Drug Metab. Dispos. 19, 149-153 (1991).
    • (1991) Drug Metab. Dispos. , vol.19 , pp. 149-153
    • Sinz, M.W.1    Remmel, R.P.2
  • 13
    • 0021895138 scopus 로고
    • 2+ indicators with greatly improved fluorescence properties
    • 2+ indicators with greatly improved fluorescence properties. J. Biol. Chem. 260, 3440-3450 (1985).
    • (1985) J. Biol. Chem. , vol.260 , pp. 3440-3450
    • Grynkiewicz, G.1    Poenie, M.2    Tsien, R.Y.3
  • 15
    • 0026750647 scopus 로고
    • The human hepatic cytochromes P450 involved in drug metabolism
    • S. A. Wrighton and J. C. Stevens: The human hepatic cytochromes P450 involved in drug metabolism. Crit. Rev. Toxicol. 22, 1-21 (1992).
    • (1992) Crit. Rev. Toxicol. , vol.22 , pp. 1-21
    • Wrighton, S.A.1    Stevens, J.C.2
  • 16
    • 0026568284 scopus 로고
    • Glucuronidation of the dopamine D-1 receptor antagonists NNC 0756 and NNC 0772 in liver microsomes
    • T. K. Hansen, K. F. Thomsen, and H. Bundagaard: Glucuronidation of the dopamine D-1 receptor antagonists NNC 0756 and NNC 0772 in liver microsomes. Drug Metab. Dispos. 20, 172-178 (1992).
    • (1992) Drug Metab. Dispos. , vol.20 , pp. 172-178
    • Hansen, T.K.1    Thomsen, K.F.2    Bundagaard, H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.