Exploring the structural requirements for inhibition of the ubiquitin E3 ligase breast cancer associated protein 2 (BCA2) as a treatment for breast cancer

Journal of Medicinal Chemistry

Volumn 53, Issue 7, 2010, Pages 2757-2765

  Brahemi, Ghali ^a   Kona, Fathima R ^b   Fiasella, Annalisa ^a   Buac, Daniela ^b   Soukupová, Jitka ^a   Brancale, Andrea ^a   Burger, Angelika M ^b   Westwell, Andrew D ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 HYDROXYETHYLDIETHYLCARBAMO(DITHIOPEROXO)THIOATE; 4,4' DITHIODIMORPHOLINE; ALDEHYDE DEHYDROGENASE; ANTINEOPLASTIC AGENT; BENZISOTHIAZOLONE DERIVATIVE; BIS(DIALKYLTHIOCARBAMOYL)DISULFIDE; BIS(PIPERIDINYLTHIOCARBONYL)DISULFIDE; BIS(PYRROLIDINYLTHIOCARBONYL)DISULFIDE; BREAST CANCER ASSOCIATED PROTEIN 2; CARBAMO(DITHIOPEROXO)THIOATE DERIVATIVE; DISULFIRAM; DITHIO(PEROXO)THIOATE COMPOUND; DITHIOCARBAMIC ACID DERIVATIVE; DITHIODIMORPHOLINE; NSC 25953; NUCLEAR PROTEIN; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG; XEXYLDIETHYLCARBAMO(DITHIOPEROXO)THIOATE; ZINC;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; CONTROLLED STUDY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IC 50; PHARMACOPHORE; PROTEIN EXPRESSION; PROTEIN MOTIF; PROTEIN STABILITY; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; UBIQUITINATION;

ALDEHYDE DEHYDROGENASE; ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; CELL LINE, TUMOR; DISULFIRAM; ENZYME INHIBITORS; ENZYME STABILITY; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION; ZINC;

EID: 77950581975     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm901757t     Document Type: Article

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