Design, synthesis, and structure-activity correlations of novel dibenzo[b,d furan, dibenzo[b,d]thiophene, and N-methylcarbazole clubbed 1,2,3-triazoles as potent inhibitors of mycobacterium tuberculosis

Journal of Medicinal Chemistry

Volumn 55, Issue 8, 2012, Pages 3911-3922

  Patpi, Santhosh Reddy ^a   Pulipati, Lokesh ^a   Yogeeswari, Perumal ^b   Sriram, Dharmarajan ^b   Jain, Nishant ^c   Sridhar, Balasubramanian ^a   Murthy, Ramalinga ^c   Anjana Devi, T ^c   Kalivendi, Shasi Vardhan ^c   Kantevari, Srinivas ^a  

^a INDIAN INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

^b BIRLA INSTITUTE OF TECHNOLOGY AND SCIENCE   (India)

^c Chemical Biology Division   (India)

Author keywords

[No Author keywords available]

Indexed keywords

1 (1 (9 METHYL 9H CARBAZOL 3 YL)ETHYL) 1H 1,2,3 TRIAZOL 4 YL) METHANOL; 1 (9 METHYL 9H CARBAZOL 3 YL)ETHANOL; 1 (9 METHYL 9H CARBAZOL 3 YL)ETHANONE; 1 (DIBENZO[B,D]FURAN 2 YL)ETHANOL; 1 (DIBENZO[B,D]FURAN 2 YL)ETHANONE; 1 (DIBENZO[B,D]THIOPHEN 2 YL)ETHANOL; 1 (DIBENZO[B,D]THIOPHEN 2 YL)ETHANONE; 1,2,3 TRIAZOLE DERIVATIVE; 2 (1 AZIDOETHYL)DIBENZO[B,D]FURAN; 2 (1 AZIDOETHYL)DIBENZO[B,D]THIOPHENE; 3 (1 (4 BENZYLOXYMETHYL 1H 1,2,3 TRIAZOL 1 YL)ETHYL) 9 METHYL 9H CARBAZOLE; 3 (1 (4 HEXYL 1H 1,2,3 TRIAZOL 1 YL)ETHYL) 9 METHYL 9H CARBAZOLE; 3 (1 (4 PROPYL 1H 1,2,3 TRIAZOL 1 YL)ETHYL) 9 METHYL 9H CARBAZOLE; 3 (1 AZIDOETHYL) 9 METHYL 9H CARBAZOLE; 9 METHYL 3 (1 (4 PHENYL 1H 1,2,3 TRIAZOL 1 YL)ETHYL) 9H CARBAZOLE; 9 METHYL 3 (1 (4 PROPYL 1H 1,2,3 TRIAZOL 1 YL)ETHYL) 9H CARBAZOLE; BENZOFURAN SALICYLIC ACID; BENZOFUROBENZOPYRAN; CARBAZOLE DERIVATIVE; CLAUSINE K; DIBENZO[B,D]THIOPHENE; ETHAMBUTOL; ISONIAZID; MICROMELINE; OGLEMILAST; PYRAZINAMIDE; THIOPHENE DERIVATIVE; TUBERCULOSTATIC AGENT; UNCLASSIFIED DRUG; UNINDEXED DRUG; USNIC ACID;

ARTICLE; BACTERIAL STRAIN; CANCER CELL CULTURE; CLICK CHEMISTRY; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACTIVITY; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; MOLECULAR HYBRIDIZATION; MYCOBACTERIUM TUBERCULOSIS; STRUCTURE ACTIVITY RELATION; TUBERCULOSIS;

ANTITUBERCULAR AGENTS; BENZOFURANS; CARBAZOLES; CELL LINE, TUMOR; CLICK CHEMISTRY; CYTOSTATIC AGENTS; DRUG DESIGN; HUMANS; MYCOBACTERIUM TUBERCULOSIS; THIOPHENES; TRIAZOLES;

EID: 84860299081     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm300125e     Document Type: Article

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