Modulation of heme/substrate binding cleft of neuronal nitric-oxide synthase (nNOS) regulates binding of Hsp90 and Hsp70 proteins and nNOS ubiquitination

Journal of Biological Chemistry

Volumn 287, Issue 2, 2012, Pages 1556-1565

  Peng, Hwei Ming ^a   Morishima, Yoshihiro ^a   Pratt, William B ^a   Osawa, Yoichi ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING CLEFTS; CALCIUM IONOPHORE; CALMODULIN BINDING; HEK293 CELLS; LIGAND BINDING; NEURONAL NITRIC-OXIDE SYNTHASE (NNOS); NITRIC-OXIDE SYNTHASE; OVER-EXPRESSION; OXYGENASES; PROTEASOMAL DEGRADATION; SIGNALING PROTEINS; UBIQUITINATION;

AMINO ACIDS; CELLS; ENZYME ACTIVITY; MACHINERY;

CALMODULIN;

HEAT SHOCK PROTEIN 70; HEAT SHOCK PROTEIN 90; NEURONAL NITRIC OXIDE SYNTHASE;

ARTICLE; BINDING SITE; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME METABOLISM; GENE OVEREXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; PLASMID; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN CROSS LINKING; PROTEIN DEGRADATION; PROTEIN DOMAIN; SIGNAL TRANSDUCTION; UBIQUITINATION;

ANIMALS; CALCIMYCIN; CALCIUM IONOPHORES; CATALYTIC DOMAIN; HEK293 CELLS; HEME; HSP70 HEAT-SHOCK PROTEINS; HSP90 HEAT-SHOCK PROTEINS; HUMANS; NITRIC OXIDE SYNTHASE TYPE I; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN BINDING; PROTEOLYSIS; RATS; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION;

EID: 84855506364     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.323295     Document Type: Article

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