-
1
-
-
79959463520
-
Regulation of HSF1 function in the heat stress response: implications in aging and disease
-
Anckar J, Sistonen L, (2011) Regulation of HSF1 function in the heat stress response: implications in aging and disease. Annu Rev Biochem 80: 1089-1115.
-
(2011)
Annu Rev Biochem
, vol.80
, pp. 1089-1115
-
-
Anckar, J.1
Sistonen, L.2
-
2
-
-
84882904778
-
The heat shock response and the stress of misfolded proteins
-
Bradshaw R, Dennis E, editors, San Diego: Elsevier, Inc
-
Morimoto RI, Westerheide SD, (2009) The heat shock response and the stress of misfolded proteins. In: Bradshaw R, Dennis E, editors. Handbook of Cell Signaling. San Diego: Elsevier, Inc. 2231-2239.
-
(2009)
Handbook of Cell Signaling
, pp. 2231-2239
-
-
Morimoto, R.I.1
Westerheide, S.D.2
-
3
-
-
0035913903
-
hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase
-
Vaziri H, Dessain SK, Ng Eaton E, Imai SI, Frye RA, et al. (2001) hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. Cell 107: 149-159.
-
(2001)
Cell
, vol.107
, pp. 149-159
-
-
Vaziri, H.1
Dessain, S.K.2
Ng Eaton, E.3
Imai, S.I.4
Frye, R.A.5
-
4
-
-
0035913911
-
Negative control of p53 by Sir2alpha promotes cell survival under stress
-
Luo J, Nikolaev AY, Imai S, Chen D, Su F, et al. (2001) Negative control of p53 by Sir2alpha promotes cell survival under stress. Cell 107: 137-148.
-
(2001)
Cell
, vol.107
, pp. 137-148
-
-
Luo, J.1
Nikolaev, A.Y.2
Imai, S.3
Chen, D.4
Su, F.5
-
5
-
-
14544282413
-
Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1
-
Rodgers JT, Lerin C, Haas W, Gygi SP, Spiegelman BM, et al. (2005) Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1. Nature 434: 113-118.
-
(2005)
Nature
, vol.434
, pp. 113-118
-
-
Rodgers, J.T.1
Lerin, C.2
Haas, W.3
Gygi, S.P.4
Spiegelman, B.M.5
-
6
-
-
37349110355
-
Metabolic adaptations through the PGC-1 alpha and SIRT1 pathways
-
Rodgers JT, Lerin C, Gerhart-Hines Z, Puigserver P, (2008) Metabolic adaptations through the PGC-1 alpha and SIRT1 pathways. Febs Letters 582: 46-53.
-
(2008)
Febs Letters
, vol.582
, pp. 46-53
-
-
Rodgers, J.T.1
Lerin, C.2
Gerhart-Hines, Z.3
Puigserver, P.4
-
7
-
-
20144372893
-
SIRT1 regulates HIV transcription via Tat deacetylation
-
Pagans S, Pedal A, North BJ, Kaehlcke K, Marshall BL, et al. (2005) SIRT1 regulates HIV transcription via Tat deacetylation. PLoS Biol 3: e41.
-
(2005)
PLoS Biol
, vol.3
-
-
Pagans, S.1
Pedal, A.2
North, B.J.3
Kaehlcke, K.4
Marshall, B.L.5
-
8
-
-
28844474597
-
SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-kappaB signaling
-
Chen J, Zhou Y, Mueller-Steiner S, Chen LF, Kwon H, et al. (2005) SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-kappaB signaling. J Biol Chem 280: 40364-40374.
-
(2005)
J Biol Chem
, vol.280
, pp. 40364-40374
-
-
Chen, J.1
Zhou, Y.2
Mueller-Steiner, S.3
Chen, L.F.4
Kwon, H.5
-
9
-
-
3242719545
-
Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase
-
Yeung F, Hoberg JE, Ramsey CS, Keller MD, Jones DR, et al. (2004) Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase. Embo Journal 23: 2369-2380.
-
(2004)
Embo Journal
, vol.23
, pp. 2369-2380
-
-
Yeung, F.1
Hoberg, J.E.2
Ramsey, C.S.3
Keller, M.D.4
Jones, D.R.5
-
10
-
-
40949123149
-
Activation of innate immunity system during aging: NF-kB signaling is the molecular culprit of inflamm-aging
-
Salminen A, Huuskonen J, Ojala J, Kauppinen A, Kaarniranta K, et al. (2008) Activation of innate immunity system during aging: NF-kB signaling is the molecular culprit of inflamm-aging. Ageing Res Rev 7: 83-105.
-
(2008)
Ageing Res Rev
, vol.7
, pp. 83-105
-
-
Salminen, A.1
Huuskonen, J.2
Ojala, J.3
Kauppinen, A.4
Kaarniranta, K.5
-
11
-
-
85042594546
-
Effect of short term calorie restriction on pro-inflammatory NF-kB and AP-1 in aged rat kidney
-
Jung KJ, Lee EK, Kim JY, Zou Y, Sung B, et al. (2009) Effect of short term calorie restriction on pro-inflammatory NF-kB and AP-1 in aged rat kidney. Inflammation Research 58: 143-150.
-
(2009)
Inflammation Research
, vol.58
, pp. 143-150
-
-
Jung, K.J.1
Lee, E.K.2
Kim, J.Y.3
Zou, Y.4
Sung, B.5
-
12
-
-
27644585190
-
A role for SIR-2.1 regulation of ER stress response genes in determining C. elegans life span
-
Viswanathan M, Kim SK, Berdichevsky A, Guarente L, (2005) A role for SIR-2.1 regulation of ER stress response genes in determining C. elegans life span. Dev Cell 9: 605-615.
-
(2005)
Dev Cell
, vol.9
, pp. 605-615
-
-
Viswanathan, M.1
Kim, S.K.2
Berdichevsky, A.3
Guarente, L.4
-
13
-
-
12144290563
-
Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase
-
Brunet A, Sweeney LB, Sturgill JF, Chua KF, Greer PL, et al. (2004) Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science 303: 2011-2015.
-
(2004)
Science
, vol.303
, pp. 2011-2015
-
-
Brunet, A.1
Sweeney, L.B.2
Sturgill, J.F.3
Chua, K.F.4
Greer, P.L.5
-
14
-
-
1342264308
-
Mammalian SIRT1 represses forkhead transcription factors
-
Motta MC, Divecha N, Lemieux M, Kamel C, Chen D, et al. (2004) Mammalian SIRT1 represses forkhead transcription factors. Cell 116: 551-563.
-
(2004)
Cell
, vol.116
, pp. 551-563
-
-
Motta, M.C.1
Divecha, N.2
Lemieux, M.3
Kamel, C.4
Chen, D.5
-
15
-
-
60749101582
-
Stress-inducible regulation of heat shock factor 1 by the deacetylase SIRT1
-
Westerheide SD, Anckar J, Stevens SM Jr, Sistonen L, Morimoto RI, (2009) Stress-inducible regulation of heat shock factor 1 by the deacetylase SIRT1. Science 323: 1063-1066.
-
(2009)
Science
, vol.323
, pp. 1063-1066
-
-
Westerheide, S.D.1
Anckar, J.2
Stevens Jr., S.M.3
Sistonen, L.4
Morimoto, R.I.5
-
16
-
-
33847035824
-
Phosphorylation of HuR by Chk2 regulates SIRT1 expression
-
Abdelmohsen K, Pullmann R Jr, Lal A, Kim HH, Galban S, et al. (2007) Phosphorylation of HuR by Chk2 regulates SIRT1 expression. Mol Cell 25: 543-557.
-
(2007)
Mol Cell
, vol.25
, pp. 543-557
-
-
Abdelmohsen, K.1
Pullmann Jr., R.2
Lal, A.3
Kim, H.H.4
Galban, S.5
-
17
-
-
3343024449
-
Substrate specificity and kinetic mechanism of the Sir2 family of NAD+-dependent histone/protein deacetylases
-
Borra MT, Langer MR, Slama JT, Denu JM, (2004) Substrate specificity and kinetic mechanism of the Sir2 family of NAD+-dependent histone/protein deacetylases. Biochemistry 43: 9877-9887.
-
(2004)
Biochemistry
, vol.43
, pp. 9877-9887
-
-
Borra, M.T.1
Langer, M.R.2
Slama, J.T.3
Denu, J.M.4
-
18
-
-
0347128279
-
Calorie restriction extends yeast life span by lowering the level of NADH
-
Lin SJ, Ford E, Haigis M, Liszt G, Guarente L, (2004) Calorie restriction extends yeast life span by lowering the level of NADH. Genes Dev 18: 12-16.
-
(2004)
Genes Dev
, vol.18
, pp. 12-16
-
-
Lin, S.J.1
Ford, E.2
Haigis, M.3
Liszt, G.4
Guarente, L.5
-
19
-
-
84856384698
-
The c-MYC oncoprotein, the NAMPT enzyme, the SIRT1-inhibitor DBC1, and the SIRT1 deacetylase form a positive feedback loop
-
Menssen A, Hydbring P, Kapelle K, Vervoorts J, Diebold J, et al. (2012) The c-MYC oncoprotein, the NAMPT enzyme, the SIRT1-inhibitor DBC1, and the SIRT1 deacetylase form a positive feedback loop. Proc Natl Acad Sci U S A 109: E187-196.
-
(2012)
Proc Natl Acad Sci U S A
, vol.109
-
-
Menssen, A.1
Hydbring, P.2
Kapelle, K.3
Vervoorts, J.4
Diebold, J.5
-
20
-
-
38749088678
-
DBC1 is a negative regulator of SIRT1
-
Kim JE, Chen J, Lou Z, (2008) DBC1 is a negative regulator of SIRT1. Nature 451: 583-586.
-
(2008)
Nature
, vol.451
, pp. 583-586
-
-
Kim, J.E.1
Chen, J.2
Lou, Z.3
-
21
-
-
38749132992
-
Negative regulation of the deacetylase SIRT1 by DBC1
-
Zhao W, Kruse JP, Tang Y, Jung SY, Qin J, et al. (2008) Negative regulation of the deacetylase SIRT1 by DBC1. Nature 451: 587-590.
-
(2008)
Nature
, vol.451
, pp. 587-590
-
-
Zhao, W.1
Kruse, J.P.2
Tang, Y.3
Jung, S.Y.4
Qin, J.5
-
22
-
-
35349011726
-
Active regulator of SIRT1 cooperates with SIRT1 and facilitates suppression of p53 activity
-
Kim EJ, Kho JH, Kang MR, Um SJ, (2007) Active regulator of SIRT1 cooperates with SIRT1 and facilitates suppression of p53 activity. Molecular Cell 28: 277-290.
-
(2007)
Molecular Cell
, vol.28
, pp. 277-290
-
-
Kim, E.J.1
Kho, J.H.2
Kang, M.R.3
Um, S.J.4
-
23
-
-
84855929223
-
SIRT1 protects against alpha-synuclein aggregation by activating molecular chaperones
-
Donmez G, Arun A, Chung CY, McLean PJ, Lindquist S, et al. (2012) SIRT1 protects against alpha-synuclein aggregation by activating molecular chaperones. J Neurosci 32: 124-132.
-
(2012)
J Neurosci
, vol.32
, pp. 124-132
-
-
Donmez, G.1
Arun, A.2
Chung, C.Y.3
McLean, P.J.4
Lindquist, S.5
-
24
-
-
0031760423
-
Inhibition of heat-shock protein 70 induction in intestinal cells overexpressing cyclooxygenase 2
-
Ethridge RT, Hellmich MR, DuBois RN, Evers BM, (1998) Inhibition of heat-shock protein 70 induction in intestinal cells overexpressing cyclooxygenase 2. Gastroenterology 115: 1454-1463.
-
(1998)
Gastroenterology
, vol.115
, pp. 1454-1463
-
-
Ethridge, R.T.1
Hellmich, M.R.2
DuBois, R.N.3
Evers, B.M.4
-
25
-
-
33751072349
-
Resveratrol improves health and survival of mice on a high-calorie diet
-
Baur JA, Pearson KJ, Price NL, Jamieson HA, Lerin C, et al. (2006) Resveratrol improves health and survival of mice on a high-calorie diet. Nature 444: 337-342.
-
(2006)
Nature
, vol.444
, pp. 337-342
-
-
Baur, J.A.1
Pearson, K.J.2
Price, N.L.3
Jamieson, H.A.4
Lerin, C.5
-
27
-
-
53249121556
-
Sirtuins-novel therapeutic targets to treat age-associated diseases
-
Lavu S, Boss O, Elliott PJ, Lambert PD, (2008) Sirtuins-novel therapeutic targets to treat age-associated diseases. Nat Rev Drug Discov 7: 841-853.
-
(2008)
Nat Rev Drug Discov
, vol.7
, pp. 841-853
-
-
Lavu, S.1
Boss, O.2
Elliott, P.J.3
Lambert, P.D.4
-
29
-
-
19944426695
-
Celastrols as inducers of the heat shock response and cytoprotection
-
Westerheide SD, Bosman JD, Mbadugha BN, Kawahara TL, Matsumoto G, et al. (2004) Celastrols as inducers of the heat shock response and cytoprotection. J Biol Chem 279: 56053-56060.
-
(2004)
J Biol Chem
, vol.279
, pp. 56053-56060
-
-
Westerheide, S.D.1
Bosman, J.D.2
Mbadugha, B.N.3
Kawahara, T.L.4
Matsumoto, G.5
-
30
-
-
84865246956
-
Heat Shock and Caloric Restriction have a Synergistic Effect on the Heat Shock Response in a sir2.1-dependent Manner in Caenorhabditis elegans
-
Raynes R, Leckey BD, Jr., Nguyen K, Westerheide SD (2012) Heat Shock and Caloric Restriction have a Synergistic Effect on the Heat Shock Response in a sir2.1-dependent Manner in Caenorhabditis elegans. J Biol Chem.
-
(2012)
J Biol Chem.
-
-
Raynes, R.1
Leckey Jr., B.D.2
Nguyen, K.3
Westerheide, S.D.4
-
31
-
-
0345731468
-
Yeast life-span extension by calorie restriction is independent of NAD fluctuation
-
Anderson RM, Latorre-Esteves M, Neves AR, Lavu S, Medvedik O, et al. (2003) Yeast life-span extension by calorie restriction is independent of NAD fluctuation. Science 302: 2124-2126.
-
(2003)
Science
, vol.302
, pp. 2124-2126
-
-
Anderson, R.M.1
Latorre-Esteves, M.2
Neves, A.R.3
Lavu, S.4
Medvedik, O.5
-
32
-
-
79951790057
-
Multiple pathways regulating the calorie restriction response in yeast
-
Rahat O, Maoz N, Cohen HY, (2011) Multiple pathways regulating the calorie restriction response in yeast. J Gerontol A Biol Sci Med Sci 66: 163-169.
-
(2011)
J Gerontol A Biol Sci Med Sci
, vol.66
, pp. 163-169
-
-
Rahat, O.1
Maoz, N.2
Cohen, H.Y.3
-
33
-
-
11444252265
-
BCL11A-dependent recruitment of SIRT1 to a promoter template in mammalian cells results in histone deacetylation and transcriptional repression
-
Senawong T, Peterson VJ, Leid M, (2005) BCL11A-dependent recruitment of SIRT1 to a promoter template in mammalian cells results in histone deacetylation and transcriptional repression. Arch Biochem Biophys 434: 316-325.
-
(2005)
Arch Biochem Biophys
, vol.434
, pp. 316-325
-
-
Senawong, T.1
Peterson, V.J.2
Leid, M.3
-
34
-
-
47549088250
-
The NAD+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control
-
Nakahata Y, Kaluzova M, Grimaldi B, Sahar S, Hirayama J, et al. (2008) The NAD+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control. Cell 134: 329-340.
-
(2008)
Cell
, vol.134
, pp. 329-340
-
-
Nakahata, Y.1
Kaluzova, M.2
Grimaldi, B.3
Sahar, S.4
Hirayama, J.5
-
35
-
-
81055141345
-
High levels of nuclear heat-shock factor 1 (HSF1) are associated with poor prognosis in breast cancer
-
Santagata S, Hu R, Lin NU, Mendillo ML, Collins LC, et al. (2011) High levels of nuclear heat-shock factor 1 (HSF1) are associated with poor prognosis in breast cancer. Proceedings of the National Academy of Sciences of the United States of America 108: 18378-18383.
-
(2011)
Proceedings of the National Academy of Sciences of the United States of America
, vol.108
, pp. 18378-18383
-
-
Santagata, S.1
Hu, R.2
Lin, N.U.3
Mendillo, M.L.4
Collins, L.C.5
-
36
-
-
0037093346
-
Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence
-
Langley E, Pearson M, Faretta M, Bauer UM, Frye RA, et al. (2002) Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence. Embo Journal 21: 2383-2396.
-
(2002)
Embo Journal
, vol.21
, pp. 2383-2396
-
-
Langley, E.1
Pearson, M.2
Faretta, M.3
Bauer, U.M.4
Frye, R.A.5
-
37
-
-
0028296414
-
Molecular cloning and functional analysis of the adenovirus E1A-associated 300-kD protein (p300) reveals a protein with properties of a transcriptional adaptor
-
Eckner R, Ewen ME, Newsome D, Gerdes M, DeCaprio JA, et al. (1994) Molecular cloning and functional analysis of the adenovirus E1A-associated 300-kD protein (p300) reveals a protein with properties of a transcriptional adaptor. Genes Dev 8: 869-884.
-
(1994)
Genes Dev
, vol.8
, pp. 869-884
-
-
Eckner, R.1
Ewen, M.E.2
Newsome, D.3
Gerdes, M.4
DeCaprio, J.A.5
-
38
-
-
0031467707
-
HSF1 granules: a novel stress-induced nuclear compartment of human cells
-
Cotto J, Fox S, Morimoto R, (1997) HSF1 granules: a novel stress-induced nuclear compartment of human cells. Journal of Cell Science 110 (Pt 23): 2925-2934.
-
(1997)
Journal of Cell Science
, vol.110
, Issue.Pt 23
, pp. 2925-2934
-
-
Cotto, J.1
Fox, S.2
Morimoto, R.3
-
39
-
-
17844386323
-
Phosphorylation of serine 230 promotes inducible transcriptional activity of heat shock factor 1
-
Holmberg CI, Hietakangas V, Mikhailov A, Rantanen JO, Kallio M, et al. (2001) Phosphorylation of serine 230 promotes inducible transcriptional activity of heat shock factor 1. Embo Journal 20: 3800-3810.
-
(2001)
Embo Journal
, vol.20
, pp. 3800-3810
-
-
Holmberg, C.I.1
Hietakangas, V.2
Mikhailov, A.3
Rantanen, J.O.4
Kallio, M.5
-
40
-
-
0034913587
-
CIITA coordinates multiple histone acetylation modifications at the HLA-DRA promoter
-
Beresford GW, Boss JM, (2001) CIITA coordinates multiple histone acetylation modifications at the HLA-DRA promoter. Nat Immunol 2: 652-657.
-
(2001)
Nat Immunol
, vol.2
, pp. 652-657
-
-
Beresford, G.W.1
Boss, J.M.2
-
41
-
-
11144337833
-
Quantitative real-time PCR protocol for analysis of nuclear receptor signaling pathways
-
Bookout AL, Mangelsdorf DJ, (2003) Quantitative real-time PCR protocol for analysis of nuclear receptor signaling pathways. Nucl Recept Signal 1: e012.
-
(2003)
Nucl Recept Signal
, vol.1
-
-
Bookout, A.L.1
Mangelsdorf, D.J.2
-
42
-
-
33646900838
-
Triptolide, an inhibitor of the human heat shock response that enhances stress-induced cell death
-
Westerheide SD, Kawahara TL, Orton K, Morimoto RI, (2006) Triptolide, an inhibitor of the human heat shock response that enhances stress-induced cell death. J Biol Chem 281: 9616-9622.
-
(2006)
J Biol Chem
, vol.281
, pp. 9616-9622
-
-
Westerheide, S.D.1
Kawahara, T.L.2
Orton, K.3
Morimoto, R.I.4
|