Search for new pharmacophores for antimalarial activity. Part III: Synthesis and bioevaluation of new 6-thioureido-4-anilinoquinazolines

European Journal of Medicinal Chemistry

Volumn 44, Issue 11, 2009, Pages 4404-4412

  Mishra, A ^a   Srivastava, K ^a   Tripathi, R ^a   Puri, S K ^a   Batra, S ^a  

^a CENTRAL DRUG RESEARCH INSTITUTE   (India)

Author keywords

Antimalarial; In vitro; In vivo; Plasmodium falciparum; Quinazoline; Thiourea

Indexed keywords

ANTIMALARIAL AGENT; N (3 CHLOROPHENYL) N' [4 (3 METHOXYANILINO)QUINAZOLIN 6 YL]THIOUREA; N (3 CHLOROPHENYL) N' [4 [3 (TRIFLUOROMETHYL)ANILINO]QUINAZOLIN 6 YL]THIOUREA; N (3 CYANOPHENYL) N' [4 (3 METHOXYANILINO)QUINAZOLIN 6 YL]THIOUREA; N (3 FLUOROPHENYL) N' [4 (3 METHOXYANILINO)QUINAZOLIN 6 YL]THIOUREA; N (3 FLUOROPHENYL) N' [4 [3 (TRIFLUOROMETHYL)ANILINO]QUINAZOLIN 6 YL]THIOUREA; N (4 ANILINOQUINAZOLIN 6 YL) N' (2 NAPHTHYL)THIOUREA; N (4 ANILINOQUINAZOLIN 6 YL) N' (3 CHLOROPHENYL)THIOUREA; N (4 ANILINOQUINAZOLIN 6 YL) N' (3 CYANOPHENYL)THIOUREA; N (4 ANILINOQUINAZOLIN 6 YL) N' (3 FLUOROPHENYL)THIOUREA; N (4 ANILINOQUINAZOLIN 6 YL) N' (4 BROMOPHENYL)THIOUREA; N (4 ANILINOQUINAZOLIN 6 YL) N' (4 CHLOROPHENYL)THIOUREA; N (4 ANILINOQUINAZOLIN 6 YL) N' PHENYLTHIOUREA; N (4 BROMOPHENYL) N' [4 (3 CHLOROANILINO)QUINAZOLIN 6 YL]THIOUREA; N (4 BROMOPHENYL) N' [4 (3 METHOXYANILINO)QUINAZOLIN 6 YL]THIOUREA; N (4 BROMOPHENYL) N' [4 [3 (TRIFLUOROMETHYL)ANILINO]QUINAZOLIN 6 YL]THIOUREA; N (4 CHLOROPHENYL) N' [4 (3 METHOXYANILINO)QUINAZOLIN 6 YL]THIOUREA; N (4 CHLOROPHENYL) N' [4 [3 (TRIFLUOROMETHYL)ANILINO]QUINAZOLIN 6 YL]THIOUREA; N [4 (3 CHLOROANILINO)QUINAZOLIN 6 YL] N' (2 NAPHTHYL)THIOUREA; N [4 (3 CHLOROANILINO)QUINAZOLIN 6 YL] N' (3 CHLOROPHENYL)THIOUREA; N [4 (3 CHLOROANILINO)QUINAZOLIN 6 YL] N' (3 CYANOPHENYL)THIOUREA; N [4 (3 CHLOROANILINO)QUINAZOLIN 6 YL] N' (3 FLUOROPHENYL)THIOUREA; N [4 (3 CHLOROANILINO)QUINAZOLIN 6 YL] N' (4 CHLOROPHENYL)THIOUREA; N [4 (3 CHLOROANILINO)QUINAZOLIN 6 YL] N' PHENYLTHIOUREA; N [4 (3 METHOXYANILINO)QUINAZOLIN 6 YL] N' (2 NAPHTHYL)THIOUREA; N [4 (3 METHOXYANILINO)QUINAZOLIN 6 YL] N' PHENYLTHIOUREA; N [4 (3,4 DIMETHOXYANILINO)QUINAZOLIN 6 YL] N' PHENYLTHIOUREA; N [4 [3 (TRIFLUOROMETHYL)ANILINO]QUINAZOLIN 6 YL] N' (2 NAPHTHYL)THIOUREA; N PHENYL N' [4 [3 (TRIFLUOROMETHYL)ANILINO]QUINAZOLIN 6 YL]THIOUREA; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTIBIOTIC RESISTANCE; ANTIMALARIAL ACTIVITY; ARTICLE; DRUG STRUCTURE; DRUG SYNTHESIS; NONHUMAN; PHARMACOPHORE; PLASMODIUM FALCIPARUM; PLASMODIUM YOELII INFECTION;

ANIMALS; ANTIMALARIALS; CELL SURVIVAL; CERCOPITHECUS AETHIOPS; FEMALE; MALARIA; MALE; MICE; MOLECULAR STRUCTURE; PARASITIC SENSITIVITY TESTS; PLASMODIUM FALCIPARUM; PLASMODIUM YOELII; QUINAZOLINES; STRUCTURE-ACTIVITY RELATIONSHIP; THIOUREA; VERO CELLS;

EID: 70349780547     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2009.06.001     Document Type: Article

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