메뉴 건너뛰기




Volumn 37, Issue 52, 1996, Pages 9267-9270

5-Formyl salicylaldehyde as a linker for the synthesis of benzofuran containing insulin sensitivity enhancer compounds

Author keywords

[No Author keywords available]

Indexed keywords

BENZOFURAN DERIVATIVE;

EID: 0030599686     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(97)82938-3     Document Type: Article
Times cited : (28)

References (29)
  • 7
    • 84889505348 scopus 로고
    • Eur. Pat. Appl. EP 283,035, 1988 and U.S. Pat. 4 824 833
    • 4. Iijima, I.; Ozeki, M.; Okumura, K.; Inamasu, M. Eur. Pat. Appl. EP 283,035, 1988 and U.S. Pat. 4 824 833; Chem. Abstr. 1989, 110, 57567p.
    • (1989) Chem. Abstr. , vol.110 , pp. 57567
    • Iijima, I.1    Ozeki, M.2    Okumura, K.3    Inamasu, M.4
  • 8
    • 4244059180 scopus 로고
    • Eur. Pat. Appl. EP 299,620, 1989
    • 5. (a) Haigh, D. B.; Hindley, R. M. Eur. Pat. Appl. EP 299,620, 1989; Chem. Abstr. 1989, 111, 7394a.
    • (1989) Chem. Abstr. , vol.111
    • Haigh, D.B.1    Hindley, R.M.2
  • 19
    • 84889517546 scopus 로고    scopus 로고
    • note
    • 2 (4 × 1865 mL), and the combined organic layers were concentrated to an oil. Addition of 135 mL of EtOH resulted in the crystallization of 2 as a light yellow solid, which was then washed with cold EtOH (2 × 50 mL), filtered, and dried to give 2 (56.64 g, 377 mmol) in 38.5% yield. The resultant filtrate was concentrated to a slurry, filtered, washed with EtOH (3 × 20 mL), and dried to give additional 2 (13.93 g, 93 mmol, 9.5% yield), which had a lower potency.
  • 20
    • 84889524173 scopus 로고    scopus 로고
    • note
    • 13C NMR, IR, and elemental analysis data were obtained for all reaction products.
  • 23
    • 84889517522 scopus 로고    scopus 로고
    • note
    • 2O/MeCN; 2:1 (2 × 1.5 L), MeCN (2 × 1.5 L), and then dried in vacuo at 50-60 °C overnight to give 7b (425 g, 1.42 mol) in 94% yield.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.