4-Dimethylamino-3′,4′-dimethoxychalcone downregulates iNOS expression and exerts anti-inflammatory effects

Free Radical Biology and Medicine

Volumn 30, Issue 1, 2001, Pages 43-50

  Herencia, Felipe ^a   Ferrándiz, Maria Luisa ^a   Ubeda, Amalia ^a   Guillén, Isabel ^a   Dominguez, José N ^b   Charris, Jaime E ^b   Lobo, Gricela M ^b   Alcaraz, Maria José ^a  

^a UNIVERSITY OF VALENCIA   (Spain)

^b UNIVERSIDAD CENTRAL DE VENEZUELA   (Venezuela)

Author keywords

Anti inflammatory; Chalcone; Free radicals; Inducible nitric oxide synthase; Leukocyte migration; Macrophage; Superoxide scavenger; TNF

Indexed keywords

4 DIMETHYLAMINO 3',4' DIMETHOXYCHALCONE; CH 11; CHALCONE DERIVATIVE; ICOSANOID; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRITE; NITROGEN; REACTIVE OXYGEN METABOLITE; SCAVENGER; SUPEROXIDE; TIRON; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ZYMOSAN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CHEMOLUMINESCENCE; CONTROLLED STUDY; CYTOKINE RELEASE; CYTOTOXICITY; DRUG ACTIVITY; DRUG EFFECT; DRUG MECHANISM; DRUG STRUCTURE; FEMALE; IN VITRO STUDY; IN VIVO STUDY; LEUKOCYTE MIGRATION; MALE; MOUSE; NONHUMAN; PAW EDEMA; PERITONEUM MACROPHAGE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CARRAGEENAN; CHALCONE; CHALCONES; CHEMILUMINESCENT MEASUREMENTS; EDEMA; ENZYME INHIBITORS; FEMALE; FREE RADICAL SCAVENGERS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; INFLAMMATION; MACROPHAGES, PERITONEAL; MICE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; OXIDATIVE STRESS; RESPIRATORY BURST; SUPEROXIDES; TIRON; ZYMOSAN;

TIRON;

EID: 0035180780     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0891-5849(00)00443-3     Document Type: Article

References (36)

1. Oxygen-dependent microbial killing by phagocytes (first of two parts)
2. New insights into the regulation of inducible nitric oxide synthesis
3. Nitric oxide in inflammation and immune response
4. Superoxide and peroxynitrite generation from inducible nitric oxide synthase in macrophages
5. Oxygen radicals, inflammation, and arthritis: Pathophysiological considerations and implications for treatment
6. Evidence for nitric oxide-mediated oxidative damage in chronic inflammation. Nitrotyrosine in serum and synovial fluid from rheumatoid patients
7. Oxidative chemistry of nitric oxide: The roles of superoxide, peroxynitrite, and carbon dioxide
8. Involvement of reactive oxygen species and nitric oxide in gastric ischemia-reperfusion injury in rats: Protective effect of tetrahydrobiopterin
9. The potential role of peroxynitrite in the vascular contractile and cellular energetic failure in endotoxic shock
10. Interactive role of nitric oxide and superoxide anion in neutrophil-mediated endothelial cell injury
11. Nitric oxide prevents leukocyte adherence: Role of superoxide
12. Superoxide anion scavengers restore NO-mediated pulmonary vasodilation after lung transplantation
13. Superoxide dismutase for therapeutic use: Clinical experience, dead ends, and hopes
14. A nonpeptidyl mimic of superoxide dismutase with therapeutic activity in rats
15. Synthesis and anti-inflammatory activity of chalcone derivatives
16. Novel anti-inflammatory chalcone derivatives inhibit the induction of nitric oxide synthase and cyclooxygenase-2 in mouse peritoneal macrophages
17. Bacterial lipopeptides induce nitric oxide synthase and promote apoptosis through nitric oxide-independent pathways in rat macrophages
18. Tetrahydrobiopterin synthesis. An absolute requirement for cytokine-induced nitric oxide generation by vascular smooth muscle
19. Detecting oxy radicals by chemiluminescence
20. A fluorometric assay for the measurement of nitrite in biological samples
21. Characterization of nitric oxide synthases in nonadrenergic noncholinergic nerve containing tissue from the rat anococcygeus muscle
22. 2 with anti-inflammatory activity
23. Anti-inflammatory testing methods: Comparative evaluation of mice and rats
24. Quantitative studies on the respiratory burst generated in peritoneal macrophages
25. Inducible nitric oxide: An autoregulatory feedback inhibitor of vascular inflammation
26. Repression of gene expression by oxidative stress
27. Role of transcription factor NF-κB/Rel in induction of nitric oxide synthase
28. Potentiation of nitric oxide synthase expression by superoxide in interleukin 1 β-stimulated rat mesangial cells
29. 2 by blocking induction of nitric oxide synthase: Role of superoxide
30. Superoxide enhances interleukin-1 β-mediated transcription of the hepatocyte-inducible nitric oxide synthase gene
31. Formation of free nitric oxide from 1-arginine by nitric oxide synthase: Direct enhancement of generation by superoxide dismutase
32. Hydrogen peroxide and superoxide modulate leukocyte adhesion molecule expression and leukocyte endothelial adhesion
33. Cytokine expression in chronic inflammatory disease
34. Superoxide production and signaling by endothelial nitric oxide synthase
35. Reactive oxygen intermediates as regulators of TNF-α production in rat lung, inflammation induced by silica
36. Evidence of peroxynitrite involvement in the carrageenan-induced rat paw edema