Protein kinases as targets for antiparasitic chemotherapy drugs

Current Drug Targets

Volumn 8, Issue 3, 2007, Pages 389-398

  Canduri, Fernanda ^a   Perez, Patrícia Cardoso ^b   Caceres, Rafael A ^b   de Azevedo Jr , Walter F ^b  

^a FEDERAL UNIVERSITY OF MATO GROSSO DO SUL   (Brazil)

^b PONTIFICAL CATHOLIC UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

Author keywords

Apicomplexa; Crystallography; Drug design; Kinases; Parasites

Indexed keywords

4 [2 (4 FLUOROPHENYL) 5 (1 METHYLPIPERIDINE 4 YL) 1H PYRROL 3 YL]PYRIDINE; ANTIMALARIAL AGENT; ANTIPARASITIC AGENT; CHLOROQUINE; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC GMP DEPENDENT PROTEIN KINASE; CYCLIN DEPENDENT KINASE 1; CYCLIN DEPENDENT KINASE INHIBITOR; CYCLINE; KT 5926; MEFLOQUINE; MITOGEN ACTIVATED PROTEIN KINASE; MQ15 RELATED KINASE; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; PHOSPHOTRANSFERASE; PROTEIN KINASE; PROTEIN KINASE 2; PROTEIN KINASE 5; PROTEIN KINASE 6; PROTEIN KINASE B; PROTEIN KINASE INHIBITOR; PYRROLE DERIVATIVE; REPLICATION PROTEIN A; ROSCOVITINE; SIGNAL PEPTIDE; STAUROSPORINE; TRYPTHANTHRIN; UNCLASSIFIED DRUG;

ANTIBIOTIC RESISTANCE; DEVELOPING COUNTRY; DRUG DESIGN; DRUG RESEARCH; DRUG TARGETING; EXPRESSED SEQUENCE TAG; GENE SEQUENCE; GENE STRUCTURE; GENETIC ANALYSIS; HUMAN; NONHUMAN; PLASMODIUM FALCIPARUM; PROTOZOAL INFECTION; PROTOZOON; PUBLIC HEALTH; REVIEW;

ANIMALS; ANTINEOPLASTIC AGENTS; ANTIPARASITIC AGENTS; DRUG DELIVERY SYSTEMS; HUMANS; NEOPLASMS; PROTEIN KINASE INHIBITORS; PROTEIN KINASES;

EID: 33847720940     PISSN: 13894501     EISSN: None     Source Type: Journal    
DOI: 10.2174/138945007780058979     Document Type: Review

References (126)

1. Trouiller, P., Torreele E., Olliaro, P., White, N., Foster, S., Wirth, D. and Pecoul, B. (2001) Trop. Med. Int. Health, 6(11), 945-951.
2. Sinski, E. and Behnke, J.M. (2004) Pol. J. Microbiol., 53, 67-73.
3. Belli, S.I., Walker, R.A., and Flowers, S.A. (2005) Proteomics, 5(4), 918-924.
4. Ross-Macdonald, P.B., Graeser, R., Kappes, B., Franklin, R. and Williamson, DH. (1994) Eur. J. Biochem., 220(3), 693-701.
5. Doerig, C., Doerig, C., Horrocks, P., Coyle, J., Carlton, J., Sultan, A., Arnot, D. and Carter, R. (1995) Mol. Biochem. Parasitol., 70(1-2), 167-174.
6. Li, J.L., Robson, K.J.H., Chen, J.L., Targett, G.A.T. and Baker, D.A. (1996) Eur. J. Biochem., 241(3), 805-813.
7. Wastling, J.M. and Kinnaird, J.H. (1998) Mol. Biochem. Parasitol., 94(1), 143-148.
8. Khan, F., Tang, J., Qin, C.-L. and Kim, K. (2002) Mol. Microbiol., 45(2), 321-332.
9. Graeser, R., Wernli, B., Franklin, R.M. and Kappes, B. (1996) Mol. Biochem. Parasitol., 82(1), 37-49.
10. Kinnaird, J.H., Bumstead, J.M., Mann, D.J., Ryan, R., Shirley, M.W., Shiels, B.R. and Tomley, F.M. (2004) Int. J. Parasitol., 34(6), 683-92.
11. Gould, K.L. (2000) In Cyclin-dependent kinases in Protein Kinase Functions. Jim Woodgett Ed.; Frontiers in molecular biology. Oxford University Press: GreadBritain., p. 276-302.
12. Lohmann, S. M., Vaandrager, A. B., Smolenski, A., Walter, U. and De Jonge, H. R. (1997) Trends Biochem. Sci., 22(8), 307-312.
13. Gurnett, A.M., Liberator, P.A., Dulski, P.M., Salowe, S.P., Donald, R.G.K., Anderson, J.W., Wiltsie, J., Diaz, C.A., Harris, G., Chang, B. et al. (2002) J. Biol. Chem., 277(18), 15913-15922.
14. Donald, R.G.K. and Liberator, P.A. (2002) Mol. Biochem. Parasitol., 120(2), 165-175.
15. Deng, W. and Baker, D. A. (2002) Mol. Microbiol., 44(5), 1141-1151.
16. Diaz, C.A., Allocco, J., Powles, M.A., Yeung, L., Donald, R.G., Anderson, J.W. and Liberator, P.A. (2006) Mol. Biochem. Parasitol. 146(1), 78-88.
17. Deng, W., Parbhu-Patel, A., Meyer, D.J. and Baker, D.A. (2003) Biochem. J., 374, 559-65.
18. Wolfe, L., Corbin, J. D. and Francis, S. H. (1989) J. Biol. Chem., 264(13), 7734-7741.
19. Smith, J. A., Reed, R. B., Francis, S. H., Grimes, K. and Corbin, J. D. (2000) J. Biol. Chem., 275(1), 154-158.
20. Taylor, M. K. and Uhler, M. D. (2000) J. Biol. Chem., 275(36), 2805-2806.
21. Schneider, A.G. and Mercereau-Puijalon, O. (2005) BMC Genomics, 6(1), 30.
22. Vanhaesebroeck, B. and Alessi, D. R. (2000) Biochem. J., 346, 561-576.
23. Ridley, R. G. (2002) Nature (London), 415(6872), 686-693.
24. Kumar, A., Vaid, A., Syin, C. and Sharma, P. (2004) J. Biol. Chem., 279(23), 24255-64.
25. Carucci, D.J., Gardner, M.J., Tettelin, H., Cummings, L.M., Smith, H.O., Adams, M.D., Hoffman, S.L. and Venter, J.C. (1998) Expert Rev. Mol. Med., 1998, 1-9.
26. Doerig, C., Endicott, J. and Chakrabarti, D. (2002) Int. J. Parasitol., 32(13), 1575-1585.
27. Harmse, L., van Zyl, R., Gray, N., Schultz, P., Leclerc, S., Meijer, L., Doerig, C. and Havlik, I. (2001) Biochem. Pharmacol., 62(3), 341-348.
28. Holton, S., Merckx, A., Burgess, D., Doerig, C., Noble, M. and Endicott, J. (2003) Structure (Camb)., 11(11), 1329-37.
29. Keenan, S.M. and Welsh, W.J. (2004) J. Mol. Graph. Model, 22(3), 241-7.
30. Doerig, C., Endicott, J. and Chakrabarti, D. (2002) Int. J. Parasit., 32(13), 1575-1585.
31. Knighton, D.R., Zheng, J.H., Ten-Eyck, L.F., Ashford, V.A., Xuong, N.H., Taylor, S.S. and Sowadski, J.M., (1991) Science, 253(5018), 407-414.
32. De Bondt, H.L., Rosenblatt, J., Jancarik, J., Jones, H.D., Morgan, D.O. and Kim, S.H. (1993) Nature, 363(6430), 595-602.
33. Manhani, K.K., Arcuri, H.A., Silveira, N.J.F., Uchoa, H.B., de Azevedo Jr., W.F. and Canduri, F. (2005) J. Mol. Model, 12(1), 42-8.
34. Bracchi-Ricard, V., Barik, S., Delvecchio, C., Doerig, C., Chakrabarti, R. and Chakrabarti, D. (2000) Biochem. J., 347, 255-263.
35. Li, J.L., Robson, K.J., Chen, J.L., Targett, G.A. and Baker, D.A. (1996) Eur. J. Biochem., 241(3), 805-813.
36. Li, Z., Le Roch, K., Geyer, J.A., Woodard, C.L., Prigge, S.T., Koh, J., Doerig C. and Waters N.C. (2001) Biochem. Biophys. Res. Commun., 288(5), 1207-1211.
37. Chen, Y., Jirage, D., Caridha, D., Kathcart, A.K., Cortes, E.A., Dennull, R.A., Geyer, J.A., Prigge, S.T. and Waters, N.C. (2006) Mol. Biochem. Parasitol., 149(1), 48-57.
38. Rangarajan, R., Bei, A., Henry, N., Madamet, M., Parzy, D., Nivez, M.P., Doerig, C. and Sultan, A. (2006) Exp. Parasitol., 112(3), 202-7.
39. Vinkenoog, R., Veldhuisen, B., Speranca, M.A., del Portillo, H.A., Janse, C. and Waters, A.P. (1995) Mol. Biochem. Parasitol., 71(2), 233-241.
40. Syin, C., Parzy, D., Traincard, F., Boccaccio, I., Joshi, M.B., Lin, D.T., Yang, X.M., Assemat, K., Doerig, C. and Langsley, G. (2001) Eur. J. Biochem., 268(18), 4842-4849.
41. Gardner, M.J., Hall, N., Fung, E., White, O., Berriman, M., Hyman, R.W., Carlton, J.M., Pain, A., Nelson, K.E., Bowman, S., Paulsen, I.T., James, K., Eisen, J.A., Rutherford, K., Salzberg, S.L., Craig, A., Kyes, S., Chan, M.S., Nene, V., Shallom, S.J., Suh, B., Peterson, J., Angiuoli, S., Pertea, M., Allen, J., Selengut, J., Haft, D., Mather, M.W., Vaidya, A.B., Martin, D.M., Fairlamb, A.H., Fraunholz, M.J., Roos, D.S., Ralph, S.A., McFadden, G.I., Cummings, L.M., Subramanian, G.M., Mungall, C., Venter, J.C., Carucci, D.J., Hoffman, S.L., Newbold, C., Davis, R.W., Fraser, C.M. and Barrell, B. (2002) Nature, 419(6906), 498-511.
42. Aravind, L., Iyer, L.M., Wellems, T.E. and Miller, L.H. (2003) Cell, 115(7), 771-785.
43. Chandran, V., Stollar, E.J., Lindorff-Larsen, K., Harper, J.F., Chazin, W.J., Dobson, C.M., Luisi, B.F. and Christodoulou, J. (2006) J. Mol. Biol., 357(2), 400-10.
44. Hotta, C.T., Gazarini, M.L., Beraldo, F.H., Varotti, F.P., Lopes, C., Markus, R.P., Pozzan, T. and Garcia, C.R. (2000) Nat. Cell Biol., 2(7), 466-468.
45. Kawamoto, F., Alejo-Blanco, R., Fleck, S.L., Kawamoto, Y. and Sinden, R.E. (1990) Mol. Biochem. Parasitol., 42(1), 101-108.
46. Kawamoto, F., Fujioka, H., Murakami, R., Syafruddin, Hagiwara, M., Ishikawa, T. and Hidaka, H. (1993) Eur. J. Cell Biol., 60(1), 101-107.
47. Li, J.L., Baker, D.A. and Cox, L.S. (2000) Biochim. Biophys. Acta, 1491(1-3), 341-349.
48. Farber, P.M., Graeser, R., Franklin, R.M. and Kappes, B. (1997) Mol. Biochem. Parasitol., 87(2), 211-216.
49. Le Roch, K., Sestier, C., Dorin, D., Waters, N., Kappes, B., Chakrabarti, D., Meijer, L. and Doerig, C. (2000) J. Biol. Chem., 275(12), 8952-8958.
50. Garweg JG. (2005) Parasite Immunol., 27(3), 61-68.
51. Khan, F., Tang, J., Qin, C.L. and Kim, K. (2002) Mol. Microbiol., 45(2), 321-332.
52. Donald, R.G., Allocco, J., Singh, S.B., Nare, B., Salowe, S.P., Wiltsie, J. and Liberator, P.A. (2002) Eukaryot. Cell, 1(3), 317-328.
53. Pokholok, D.K., Zeitlinger, J., Hannett, N.M., Reynolds, D.B. and Young, R.A. (2006) Science, 313(5786), 533-6.
54. Roisin, M.P., Robert-Gangneux, F., Creuzet, C. and Dupouy-Camet, J. (2000) Parasitol. Res., 86(7), 588-598.
55. Brumlik, M.J., Wei, S., Finstad, K., Nesbit, J., Hyman, L.E., Lacey, M., Burow, M.E. and Curiel, T.J. (2004) Int. J. Parasitol., 34(11), 1245-54.
56. Wei, S., Marches, F., Daniel, B., Sonda, S., Heidenreich, K. and Curiel, T. (2002) Int. J. Parasitol., 32(8), 969-977.
57. Dorin, D., Alano, P., Boccaccio, I., Ciceron, L., Doerig, C., Sulpice R., Parzy, D. and Doerig, C. (1999) J. Biol. Chem., 274(42), 29912-29920.
58. Lin, D.T., Goldman, N.D. and Syin, C. (1996) Mol. Biochem. Parasitol., 78(1-2), 67-77.
59. Kieschnick, H., Wakefield, T., Narducci, C. A. and Beckers, C. (2001) J. Biol. Chem., 276(15), 12369-12377.
60. Moudy, R., Manning, T.J. and Beckers, C. (2001) J. Biol. Chem., 276(44), 41492-41501.
61. Nagamune, K. and Sibley, L.D. (2006) Mol. Biol. Evol. 23(8), 1613-27.
62. Billker, O., Dechamps, S., Tewari, R., Wenig, G., Franke-Fayard, B. and Brinkmann, V. (2004) Cell, 117(4), 503-514.
63. Tran, M.Q. (2005) Clin. Nephrol., 63(4), 305-309.
64. Okhuysen, P.C. and Chappell, C.L. (2002) Int. J. Parasitol., 32(5), 517-525.
65. Tzipori, S. and Griffiths, J.K. (1998) Adv. Parasitol., 40, 5-36.
66. Millership, J.J. and Zhu, G. (2002) Int. J. Parasitol., 32(12), 1477-1485.
67. Zhu, G., Marchewka, M.J. and Keithly, J.S. (1999) FEMS Microbiol. Lett., 176(2), 367-372.
68. Millership, J.J., Cai, X. and Zhu, G. (2004) Microbiology, 150(5), 1197-1205.
69. Henricksen, L.A., Carter, T., Dutta, A. and Wold, M.S. (1996) Nucleic Acids Res., 24(15), 3107-3112.
70. Treuner, K., Findeisen, M., Strausfeld, U. and Knippers, R. (1999) J. Biol. Chem., 274(22), 15556-15561.
71. Garcia-Echeverria, C., Traxler, P. and Evans, D. B. (2000) Med. Res. Rev., 20(1), 28-57.
72. Johnson, L. N. (2001) Ernst-Schering-Res-Found-Workshop, 34, 47-69.
73. Sridhar, R., Hanson-Painton, O. and Cooper, D. R. (2000) Pharmacol. Res., 17(11), 1345-1353.
74. Sibley, C.H. and Macreadie, I. (2001) IUBMB Life, 52(6), 285-289.
75. Winstanley, P. (2002) Int. J. Infect. Dis., 6(4), 246-252.
76. Haverkos, H.W. (1987) Am. J. Med., 82(5), 907-914.
77. Fung, H.B. and Kirschenbaum, H.L. (1996) Clin. Ther., 18(6), 1037-1056.
78. Chappell, C.L. and Okhuysen, P.C., (2002) Curr. Opin. Infect. Dis., 15(5), 523-527.
79. Mead, J.R. (2002) Drug Resist. Update, 5(1), 47-57.
80. Leav, B.A., Mackay, M. and Ward, H.D. (2003) Clin. Infect. Dis., 36(7), 903-908.
81. Wiersma, H.I., Galuska, S.E., Tomley, F.M., Sibley, L.D., Liberator, P.A. and Donald, R.G. (2004) Int. J. Parasitol., 34(3), 369-380.
82. Woodard, C.L., Li, Z., Kathcart, A.K., Terrell, J., Gerena, L., Lopez-Sanchez, M., Kyle, D.E., Bhattacharjee, A.K., Nichols, D.A., Ellis, W., Prigge, S.T., Geyer, J.A. and Waters, C. (2003) J. Med. Chem., 46(18), 3877-3882.
83. Doerig, C., Meijer, L. and Mottram, J. C. (2002) Trends Parasitol., 18(8), 366-371
84. Pattanaik, P., Raman, J. and Balaram, H. (2002) Curr. Top. Med. Chem., 2(5), 483-505.
85. Nare, B., Allocco, J.J., Liberator, P.A. and Donald, R.G. (2002) Antimicrob. Agents Chemother., 46(2), 300-307.
86. Ward, G.E., Fujioka, H., Aikawa, M. and Miller, L.H. (1994) Exp. Parasitol., 79(3), 480-487.
87. Dluzewski, A.R. and Garcia, C.R. (1996) Experientia, 52(6), 621-623.
88. Carruthers, V.B., Giddings, O.K. and Sibley, L.D. (1999) Cell Microbiol., 1(8), 225-235.
89. Brossier, F., Jewett, T.J., Lovett, J.L. and Sibley, L.D. (2003) J. Biol. Chem., 278(8), 6229-6234.
90. Huynh, M.H., Rabenau, K.E., Harper, J.M., Beatty, W.L., Sibley, L.D. and Carruthers, V.B. (2003) Eur. Mol. Biol. Org. J., 22(9), 2082-2090.
91. Sultan, A.A., Thathy, V., Frevert, U., Robson, K.J., Crisanti, A., Nussenzweig, V., Nussenzweig, R.S. and Menard, R. (1997) Cell, 90(3), 511-522.
92. Kappe, S., Bruderer, T., Gantt, S., Fujioka, H., Nussenzweig, V. and Menard, R. (1999) J. Cell Biol., 147(5), 937-944.
93. Dobrowolski, J.M., Carruthers, V.B. and Sibley, L.D. (1997) Mol. Microbiol., 26(1), 163-173.
94. Kieschnick, H., Wakefield, T., Narducci, C.A. and Beckers, C. (2001) J. Biol. Chem., 276(5), 12369-12377.
95. Vesely, J., Havlicek, L., Strnad, M., Blow, J. J., Donella-Deana, A., Pinna, L., Letham, D. S., Kato, J., Detivaud, L. and Leclerc, S. (1994) Eur. J. Biochem., 224(2), 771-786.
96. Schultz, C., Link, A., Leost, M., Zaharevitz, D. W., Gussio, R., Sausville, E. A., Meijer, L. and Kunick, C. (1999) J. Med. Chem., 42(15), 2909-2919.
97. Gray, N., Detivaud, L., Doerig, C. and Meijer, L. (1999) Curr. Med. Chem., 6(9), 859-875.
98. Schoepfer, J., Fretz, H., Chaudhuri, B., Muller, L., Seeber, E., Meijer, L., Lozach, O., Vangrevelinghe, E. and Furet, P. (2002) J. Med. Chem., 45(9), 1741-1747.
99. Legraverend, M., Tunnah, P., Noble, M., Ducrot, P., Ludwig, O., Grierson, D. S., Leost, M., Meijer, L. and Endicott, J. (2000) J. Med. Chem., 43(7), 1282-1292.
100. Noble, M. E. and Endicott, J. A. (1999) Pharmacol. Ther., 82(2-3), 269-278.
101. Hanks, S. K., Quinn, A. M. and Hunter, T. (1988) Science, 241(4861), 42-52.
102. Waters, N. C., Woodard, C. L. and Prigge, S. T. (2000) Mol. Biochem. Parasitol., 107(1), 45-55.
103. Xiao, Z., Waters, N. C., Woodard, C. L., Li, Z. and Li, P. K. (2001) Bioorg. Med. Chem. Lett., 11, 2875-2878.
104. Vroman, J.A., Alvin-Gaston M. and Avery M.A. (1999) Curr. Pharm. Design, 5(2), 101-138.
105. Bhattacharjee A.K. and Karle. J.M. (1999) Chem. Res. Toxicol., 12(5), 422-428.
106. Baker W.R. and Mitscher L.A. (1995) U.S. Patent 5 441, 955.
107. Eguchi, S., Takeuchi H. and Matsushita Y. (1992) Heterocycles, 33(1), 153-156.
108. Honda G. and Tabata. M. (1979) Planta Medica, 36(1), 85-90.
109. Mitscher, L.A., Wong, W.C., DeMeulenaere, T., Sulko, J. and Drake, S. (1981) Heterocycles, 15(2), 1017-1021.
110. Pitzer, K.K., Kyle, D.E. and Gerena, L. (2001) Patent, 6 284 772.
111. Bhattacharjee, A.K., Hartell, M.G., Nichols, D.A., Hicks, R.P., Stanton, B., van Hamont, J.E. and Milhous, W.K. (2004) Eur. J. Med. Chem., 39(1), 59-67.
112. Keenan, S.M., Geyer, J.A., Welsh, W.J., Prigge, S.T. and Waters, N.C. (2005) Comb. Chem. High Throughput Screen., 8(1), 27-38.
113. De Azevedo, W.F.Jr.; Mueller-Dieckmann, H.J.; Schulze-Gahmen, U.; Worland, P.J.; Sausville, E. and Kim S.-H. (1996) Proc. Natl. Acad. Sci. USA., 93(7), 2735-2740.
114. Kim, S.-H.; Schulze-Gahmen, U.; Brandsen, J. and De Azevedo, W. F. Jr. (1996) Prog. Cell Cycle Res., 2, 137-145.
115. Canduri, F.; Uchoa, H.B. and de Azevedo, W.F.Jr. (2004) Biochem. Biophys. Res. Commun., 324(2), 661-666.
116. De Azevedo, W.F.Jr.; Canduri, F. and Silveira, N.J.F. (2002) Biochem. Biophys. Res. Commun., 293(1), 566-571.
117. De Azevedo, W.F.Jr.; Leclerc, S.; Meijer, L.; Havlicek, L.; Strnad, M. and Kim, S.-H. (1997) Eur. J. Biochem., 243(1-2), 518-526.
118. De Azevedo, W.F.Jr., Gaspar, R.T., Canduri, F.; Camera, J.C. Jr., and Silveira, N.J.F. (2002) Biochem. Biophys. Res. Commun., 297(5), 1154-1158.
119. De Azevedo, W. F. Jr., and Canduri, F. (2005) Curr. Comput. Aided Drug Design, 1, 53-64.
120. Zhang, B., Tan, V. B. C., Lim, K. M., Tay, T. E. and Zhuang, S. (2006) J. Mol. Model (In press).
121. Basso, L. A., da Silva, L. H. P., Fett-Neto, A. G., de Azevedo, W. F. Jr., Moreira, I. S., Palma, M. S., Calixto, J. B., Astolfi Filho, S., dos Santos, R. R., Soares, M. B. and Santos, D. S. (2005) Mem. Inst. Oswaldo Cruz, 100(6), 475-506.
122. De Azevedo, W. F., Canduri, F., Basso, L. A., Palma, M. S. and Santos, D. S. (2006) Cell Biochem. Biophys., 44(3), 405-411.
123. Oliveira, J. S., Pereira, J. H., Canduri, F.,Rodrigues, N. C., de Souza, O. N, de Azevedo Jr., W. F.,Basso, L. A. and Santos, D. S. (2006) J. Mol. Biol., 359(3), 646-666.
124. da Silveira, N. J., Uchoa, H. B., Canduri, F.,Pereira, J. H., Camera Jr., J. C., Basso, L. A., Palma, M. S., Santos, D. S. and de Azevedo Jr., W. F. (2004) Biochem. Biophys. Res. Commun., 322(1), 100-104.
125. Uchoa, H. B., Jorge, G. E., Freitas da Silveira, N. J., Camera J. C., Canduri, F. and De Azevedo, WF. (2004) Biochem. Biophys. Res. Commun., 325(4),1481-1486.
126. da Silveira, N. J. F., Bonalumi, C. A., Uchoa, H. B., Pereira, J. H., Canduri, F.,Pereira, J. H. and de Azevedo Jr., W. F. (2006) Cell Biochem. Biophys., 44, 366-374.