Structure determination of glycogen synthase kinase-3 from Leishmania major and comparative inhibitor structure-activity relationships with Trypanosoma brucei GSK-3

Molecular and Biochemical Parasitology

Volumn 176, Issue 2, 2011, Pages 98-108

  Ojo, Kayode K ^a   Arakaki, Tracy L ^a,b   Napuli, Alberto J ^a,b   Inampudi, Krishna K ^a,c   Keyloun, Katelyn R ^a   Zhang, Li ^a,b   Hol, Wim G J ^a,b   Verlinde, Christophe L M J ^a,b   Merritt, Ethan A ^a,b   Van Voorhis, Wesley C ^a,b  

^a UNIVERSITY OF WASHINGTON   (United States)

^b Medical Structural Genomics of Pathogenic Protozoa Consortium ^*  (United States)

^c Seattle BioMed   (United States)

Author keywords

African sleeping sickness; Drug development; Glycogen synthase kinase 3; Leishmania spp.; Protein kinase; Trypanosoma brucei

Indexed keywords

3 [1 (3 AMINOPROPYL) 3 INDOLYL] 4 (1 METHYL 3 INDOLYL) 1H PYRROLE 2,5 DIONE; ADENOSINE TRIPHOSPHATE; ALSTERPAULLONE; ANGIOGENESIS INHIBITOR; CYCLIN DEPENDENT KINASE INHIBITOR; ENZYME VARIANT; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3 INHIBITOR; GW 8510; HYMENIALDISINE; INDIRUBIN 3' MONOXIME 5 SULPHONIC ACID; JANUS KINASE 3 INHIBITOR; SU 9516; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; BINDING SITE; CONTROLLED STUDY; LEISHMANIA INFANTUM; LEISHMANIA MAJOR; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; TRYPANOSOMA BRUCEI; VISCERAL LEISHMANIASIS;

AMINO ACID MOTIFS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; ESCHERICHIA COLI; GENE EXPRESSION; GLYCOGEN SYNTHASE KINASE 3; HUMANS; KINETICS; LEISHMANIA INFANTUM; LEISHMANIA MAJOR; LEISHMANIASIS, CUTANEOUS; LEISHMANIASIS, VISCERAL; MODELS, MOLECULAR; MUTATION; PROTEIN BINDING; PROTEIN ISOFORMS; PROTEIN KINASE INHIBITORS; RECOMBINANT PROTEINS; SPECIES SPECIFICITY; STRUCTURE-ACTIVITY RELATIONSHIP; TRYPANOSOMA BRUCEI BRUCEI;

EUKARYOTA; LEISHMANIA INFANTUM; LEISHMANIA MAJOR; TRYPANOSOMA BRUCEI; TRYPANOSOMATIDAE;

EID: 79951678683     PISSN: 01666851     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molbiopara.2010.12.009     Document Type: Article

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