Rational inhibitor design and iterative screening in the identification of selective plasmodial cyclin dependent kinase inhibitors

Combinatorial Chemistry and High Throughput Screening

Volumn 8, Issue 1, 2005, Pages 27-38

  Keenan, Susan M ^a   Geyer, Jeanne A ^b   Welsh, William J ^a   Prigge, Sean T ^c   Waters, Norman C ^b  

^a RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^b WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

^c JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

CDK Pfmrk; In silico; Inhibitors; Malaria; Plasmodium falciparum; Rational drug design; Virtual screening

Indexed keywords

3 PHENYLQUINOLINONE; BUTYROLACTONE; CHLOROQUINE; CYCLIN DEPENDENT KINASE 7; CYCLIN DEPENDENT KINASE INHIBITOR; FLAVOPIRIDOL; INDIRUBIN; INDIRUBIN 3' MONOXIME; KENPAULLONE; OLOMOUCINE; OXINDOLE; PROTEIN PFMRK; PURVALANOL A; PURVALANOL B; QUINOLINE DERIVATIVE; QUINOLINOL DERIVATIVE; ROSCOVITINE; STAUROSPORINE; UNCLASSIFIED DRUG; WR 216174;

AMINO ACID COMPOSITION; CELL CYCLE; CRYSTALLOGRAPHY; DRUG DESIGN; DRUG POTENCY; DRUG TARGETING; ENZYME INHIBITION; INHIBITION KINETICS; MALARIA; MOLECULAR MODEL; PRIORITY JOURNAL; PROCESS DESIGN; REVIEW; SCREENING; SEQUENCE HOMOLOGY; VIRTUAL REALITY;

AMINO ACID SEQUENCE; ANIMALS; COMPUTER-AIDED DESIGN; CYCLIN-DEPENDENT KINASES; ENZYME INHIBITORS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PLASMODIUM FALCIPARUM; PROTEIN CONFORMATION; SEQUENCE HOMOLOGY, AMINO ACID;

MAMMALIA; PLASMODIUM FALCIPARUM;

EID: 12744281184     PISSN: 13862073     EISSN: None     Source Type: Journal    
DOI: 10.2174/1386207053328183     Document Type: Review

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