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Volumn 207, Issue 2, 2013, Pages 346-357

Fatty acid transporters involved in the palmitate and oleate induced insulin resistance in primary rat hepatocytes

Author keywords

Ceramide; Diacylglycerols; FAT CD36; GLUT; Hepatocytes; Insulin resistance.

Indexed keywords

5 AMINO 4 IMIDAZOLECARBOXAMIDE RIBOSIDE; CD36 ANTIGEN; CERAMIDE; DIACYLGLYCEROL; FATTY ACID BINDING PROTEIN; FATTY ACID TRANSPORTER; FATTY ACID TRANSPORTER 2; GLUCOSE TRANSPORTER 1; GLUCOSE TRANSPORTER 2; GLYCOGEN SYNTHASE KINASE; INSULIN; OLEIC ACID; PALMITIC ACID; PHLORETIN; PROTEIN KINASE B; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

EID: 84872198700     PISSN: 17481708     EISSN: 17481716     Source Type: Journal    
DOI: 10.1111/apha.12022     Document Type: Article
Times cited : (64)

References (58)
  • 1
    • 83455246933 scopus 로고    scopus 로고
    • Increased FAT/CD36 cycling and lipid accumulation in myotubes derived from obese type 2 diabetic patients
    • Aguer, C., Foretz, M., Lantier, L., Hebrard, S., Viollet, B., Mercier, J. and Kitzmann, M. 2011. Increased FAT/CD36 cycling and lipid accumulation in myotubes derived from obese type 2 diabetic patients. PLoS ONE 6, e28981.
    • (2011) PLoS ONE , vol.6
    • Aguer, C.1    Foretz, M.2    Lantier, L.3    Hebrard, S.4    Viollet, B.5    Mercier, J.6    Kitzmann, M.7
  • 2
    • 0036330904 scopus 로고    scopus 로고
    • Plasma total and free fatty acids composition in human non-alcoholic steatohepatitis
    • de Almeida, I.T., Cortez-Pinto, H., Fidalgo, G., Rodrigues, D. and Camilo, M.E. 2002. Plasma total and free fatty acids composition in human non-alcoholic steatohepatitis. Clin Nutr 21, 219-223.
    • (2002) Clin Nutr , vol.21 , pp. 219-223
    • de Almeida, I.T.1    Cortez-Pinto, H.2    Fidalgo, G.3    Rodrigues, D.4    Camilo, M.E.5
  • 5
    • 80555124939 scopus 로고    scopus 로고
    • Ceramides as modulators of cellular and whole-body metabolism
    • Bikman, B.T. and Summers, S.A. 2011. Ceramides as modulators of cellular and whole-body metabolism. J Clin Invest 121, 4222-4230.
    • (2011) J Clin Invest , vol.121 , pp. 4222-4230
    • Bikman, B.T.1    Summers, S.A.2
  • 6
    • 33845261493 scopus 로고
    • A rapid method of total lipid extraction and purification
    • Bligh, E.G. and Dyer, W.J. 1959. A rapid method of total lipid extraction and purification. Can J Biochem Physiol 37, 911-917.
    • (1959) Can J Biochem Physiol , vol.37 , pp. 911-917
    • Bligh, E.G.1    Dyer, W.J.2
  • 7
    • 0037449380 scopus 로고    scopus 로고
    • Effects of free fatty acids on gluconeogenesis and glycogenolysis
    • Boden, G. 2003. Effects of free fatty acids on gluconeogenesis and glycogenolysis. Life Sci 72, 977-988.
    • (2003) Life Sci , vol.72 , pp. 977-988
    • Boden, G.1
  • 9
    • 70349617679 scopus 로고    scopus 로고
    • Cardiac and skeletal muscle fatty acid transport and transporters and triacylglycerol and fatty acid oxidation in lean and Zucker diabetic fatty rats
    • Bonen, A., Holloway, G.P., Tandon, N.N., Han, X.X., McFarlan, J., Glatz, J.F. and Luiken, J.J. 2009b. Cardiac and skeletal muscle fatty acid transport and transporters and triacylglycerol and fatty acid oxidation in lean and Zucker diabetic fatty rats. Am J Physiol Regul Integr Comp Physiol 297, R1202-R1212.
    • (2009) Am J Physiol Regul Integr Comp Physiol , vol.297
    • Bonen, A.1    Holloway, G.P.2    Tandon, N.N.3    Han, X.X.4    McFarlan, J.5    Glatz, J.F.6    Luiken, J.J.7
  • 11
    • 33644850802 scopus 로고    scopus 로고
    • Lipid metabolism and liver inflammation. I. Hepatic fatty acid uptake: possible role in steatosis
    • Bradbury, M.W. 2006. Lipid metabolism and liver inflammation. I. Hepatic fatty acid uptake: possible role in steatosis. Am J Physiol Gastrointest Liver Physiol 290, G194-G198.
    • (2006) Am J Physiol Gastrointest Liver Physiol , vol.290
    • Bradbury, M.W.1
  • 12
    • 12144273569 scopus 로고    scopus 로고
    • Effect of dietary fatty acids on the postprandial fatty acid composition of triacylglycerol-rich lipoproteins in healthy male subjects
    • Bysted, A., Hølmer, G., Lund, P., Sandström, B. and Tholstrup, T. 2005. Effect of dietary fatty acids on the postprandial fatty acid composition of triacylglycerol-rich lipoproteins in healthy male subjects. Eur J Clin Nutr 59, 24-34.
    • (2005) Eur J Clin Nutr , vol.59 , pp. 24-34
    • Bysted, A.1    Hølmer, G.2    Lund, P.3    Sandström, B.4    Tholstrup, T.5
  • 14
    • 84859159730 scopus 로고    scopus 로고
    • Not only accumulation, but also saturation status of intramuscular lipids is significantly affected by PPARγ activation
    • Chabowski, A., Zendzian-Piotrowska, M., Nawrocki, A. and Górski, J. 2011. Not only accumulation, but also saturation status of intramuscular lipids is significantly affected by PPARγ activation. Acta Physiol (Oxf) 205, 145-158.
    • (2011) Acta Physiol (Oxf) , vol.205 , pp. 145-158
    • Chabowski, A.1    Zendzian-Piotrowska, M.2    Nawrocki, A.3    Górski, J.4
  • 15
    • 0142164965 scopus 로고    scopus 로고
    • Characterizing the effects of saturated fatty acids on insulin signaling and ceramide and diacylglycerol accumulation in 3T3-L1 adipocytes and C2C12 myotubes
    • Chavez, J.A. and Summers, S.A. 2003. Characterizing the effects of saturated fatty acids on insulin signaling and ceramide and diacylglycerol accumulation in 3T3-L1 adipocytes and C2C12 myotubes. Arch Biochem Biophys 419, 101-109.
    • (2003) Arch Biochem Biophys , vol.419 , pp. 101-109
    • Chavez, J.A.1    Summers, S.A.2
  • 16
    • 76049095119 scopus 로고    scopus 로고
    • Lipid oversupply, selective insulin resistance, and lipotoxicity: molecular mechanisms
    • Chavez, J.A. and Summers, S.A. 2010. Lipid oversupply, selective insulin resistance, and lipotoxicity: molecular mechanisms. Biochim Biophys Acta 1801, 252-265.
    • (2010) Biochim Biophys Acta , vol.1801 , pp. 252-265
    • Chavez, J.A.1    Summers, S.A.2
  • 17
    • 0038532298 scopus 로고    scopus 로고
    • A role for ceramide, but not diacylglycerol, in the antagonism of insulin signal transduction by saturated fatty acids
    • Chavez, J.A., Knotts, T.A., Wang, L.P., Li, G., Dobrowsky, R.T., Florant, G.L. and Summers, S.A. 2003. A role for ceramide, but not diacylglycerol, in the antagonism of insulin signal transduction by saturated fatty acids. J Biol Chem 278, 10297-10303.
    • (2003) J Biol Chem , vol.278 , pp. 10297-10303
    • Chavez, J.A.1    Knotts, T.A.2    Wang, L.P.3    Li, G.4    Dobrowsky, R.T.5    Florant, G.L.6    Summers, S.A.7
  • 18
    • 0017303551 scopus 로고
    • Triacylglycerol synthesis in isolated fat cells. Studies on the microsomal diacylglycerol acyltransferase activity using ethanol-dispersed diacylglycerols
    • Coleman, R. and Bell, R.M. 1976. Triacylglycerol synthesis in isolated fat cells. Studies on the microsomal diacylglycerol acyltransferase activity using ethanol-dispersed diacylglycerols. J Biol Chem 251, 4537-4543.
    • (1976) J Biol Chem , vol.251 , pp. 4537-4543
    • Coleman, R.1    Bell, R.M.2
  • 20
    • 33845593356 scopus 로고    scopus 로고
    • Upregulation of liver VLDL receptor and FAT/CD36 expression in LDLR-/- apoB100/100 mice fed trans-10, cis-12 conjugated linoleic acid
    • Degrace, P., Moindrot, B., Mohamed, I., Gresti, J., Du, Z.Y., Chardigny, J.M., Sébédio, J.L. and Clouet, P. 2006. Upregulation of liver VLDL receptor and FAT/CD36 expression in LDLR-/- apoB100/100 mice fed trans-10, cis-12 conjugated linoleic acid. J Lipid Res 47, 2647-2655.
    • (2006) J Lipid Res , vol.47 , pp. 2647-2655
    • Degrace, P.1    Moindrot, B.2    Mohamed, I.3    Gresti, J.4    Du, Z.Y.5    Chardigny, J.M.6    Sébédio, J.L.7    Clouet, P.8
  • 22
    • 18244382304 scopus 로고    scopus 로고
    • Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease
    • Donnelly, K.L., Smith, C.I., Schwarzenberg, S.J., Jessurun, J., Boldt, M.D. and Parks, E.J. 2005. Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease. J Clin Invest 115, 1343-1351.
    • (2005) J Clin Invest , vol.115 , pp. 1343-1351
    • Donnelly, K.L.1    Smith, C.I.2    Schwarzenberg, S.J.3    Jessurun, J.4    Boldt, M.D.5    Parks, E.J.6
  • 23
    • 77950543816 scopus 로고    scopus 로고
    • Diacylglycerol-mediated insulin resistance
    • Erion, D.M. and Shulman, G.I. 2010. Diacylglycerol-mediated insulin resistance. Nat Med 16, 400-402.
    • (2010) Nat Med , vol.16 , pp. 400-402
    • Erion, D.M.1    Shulman, G.I.2
  • 24
    • 80455174428 scopus 로고    scopus 로고
    • Free fatty acid-induced PP2A hyperactivity selectively impairs hepatic insulin action on glucose metabolism
    • Galbo, T., Olsen, G.S., Quistorff, B. and Nishimura, E. 2011. Free fatty acid-induced PP2A hyperactivity selectively impairs hepatic insulin action on glucose metabolism. PLoS ONE 6, e27424.
    • (2011) PLoS ONE , vol.6
    • Galbo, T.1    Olsen, G.S.2    Quistorff, B.3    Nishimura, E.4
  • 25
    • 74949084316 scopus 로고    scopus 로고
    • Membrane fatty acid transporters as regulators of lipid metabolism: implications for metabolic disease
    • Glatz, J.F., Luiken, J.J. and Bonen, A. 2010. Membrane fatty acid transporters as regulators of lipid metabolism: implications for metabolic disease. Physiol Rev 90, 367-417.
    • (2010) Physiol Rev , vol.90 , pp. 367-417
    • Glatz, J.F.1    Luiken, J.J.2    Bonen, A.3
  • 27
    • 0036401857 scopus 로고    scopus 로고
    • Fatty acid transport across membranes: relevance to nutrition and metabolic pathology
    • Hajri, T. and Abumrad, N.A. 2002. Fatty acid transport across membranes: relevance to nutrition and metabolic pathology. Annu Rev Nutr 22, 383-415.
    • (2002) Annu Rev Nutr , vol.22 , pp. 383-415
    • Hajri, T.1    Abumrad, N.A.2
  • 28
    • 35848954991 scopus 로고    scopus 로고
    • Solution-state molecular structure of apo and oleate-liganded liver fatty acid-binding protein
    • He, Y., Yang, X., Wang, H., Estephan, R., Francis, F., Kodukula, S., Storch, J. and Stark, R.E. 2007. Solution-state molecular structure of apo and oleate-liganded liver fatty acid-binding protein. Biochemistry 46, 12543-12556.
    • (2007) Biochemistry , vol.46 , pp. 12543-12556
    • He, Y.1    Yang, X.2    Wang, H.3    Estephan, R.4    Francis, F.5    Kodukula, S.6    Storch, J.7    Stark, R.E.8
  • 32
    • 84859157750 scopus 로고    scopus 로고
    • Fatty acid transport proteins, implications in physiology and disease
    • Kazantzis, M. and Stahl, A. 2012. Fatty acid transport proteins, implications in physiology and disease. Biochim Biophys Acta 1821, 852-857.
    • (2012) Biochim Biophys Acta , vol.1821 , pp. 852-857
    • Kazantzis, M.1    Stahl, A.2
  • 33
    • 0034076660 scopus 로고    scopus 로고
    • Fuel selection in human skeletal muscle in insulin resistance: a reexamination
    • Kelley, D.E. and Mandarino, L.J. 2000. Fuel selection in human skeletal muscle in insulin resistance: a reexamination. Diabetes 49, 677-683.
    • (2000) Diabetes , vol.49 , pp. 677-683
    • Kelley, D.E.1    Mandarino, L.J.2
  • 34
    • 36849037401 scopus 로고    scopus 로고
    • Increased hepatic CD36 expression contributes to dyslipidemia associated with diet-induced obesity
    • Koonen, D.P., Jacobs, R.L., Febbraio, M., Young, M.E., Soltys, C.L., Ong, H., Vance, D.E. and Dyck, J.R. 2007. Increased hepatic CD36 expression contributes to dyslipidemia associated with diet-induced obesity. Diabetes 56, 2863-2871.
    • (2007) Diabetes , vol.56 , pp. 2863-2871
    • Koonen, D.P.1    Jacobs, R.L.2    Febbraio, M.3    Young, M.E.4    Soltys, C.L.5    Ong, H.6    Vance, D.E.7    Dyck, J.R.8
  • 36
    • 77952849224 scopus 로고    scopus 로고
    • Palmitate induces insulin resistance without significant intracellular triglyceride accumulation in HepG2 cells
    • Lee, J.Y., Cho, H.K. and Kwon, Y.H. 2010. Palmitate induces insulin resistance without significant intracellular triglyceride accumulation in HepG2 cells. Metabolism 59, 927-934.
    • (2010) Metabolism , vol.59 , pp. 927-934
    • Lee, J.Y.1    Cho, H.K.2    Kwon, Y.H.3
  • 37
    • 17444364801 scopus 로고    scopus 로고
    • Mitochondrial glycerol-3-phosphate acyltransferase-1 directs the metabolic fate of exogenous fatty acids in hepatocytes
    • Lewin, T.M., Wang, S., Nagle, C.A., Van Horn, C.G. and Coleman, R.A. 2005. Mitochondrial glycerol-3-phosphate acyltransferase-1 directs the metabolic fate of exogenous fatty acids in hepatocytes. Am J Physiol Endocrinol Metab 288, E835-E844.
    • (2005) Am J Physiol Endocrinol Metab , vol.288
    • Lewin, T.M.1    Wang, S.2    Nagle, C.A.3    Van Horn, C.G.4    Coleman, R.A.5
  • 39
    • 0034796453 scopus 로고    scopus 로고
    • Electrostimulation enhances FAT/CD36-mediated long-chain fatty acid uptake by isolated rat cardiac myocytes
    • Luiken, J.J., Willems, J., van der Vusse, G.J. and Glatz, J.F. 2001b. Electrostimulation enhances FAT/CD36-mediated long-chain fatty acid uptake by isolated rat cardiac myocytes. Am J Physiol Endocrinol Metab 281, E704-E712.
    • (2001) Am J Physiol Endocrinol Metab , vol.281
    • Luiken, J.J.1    Willems, J.2    van der Vusse, G.J.3    Glatz, J.F.4
  • 40
    • 0032933114 scopus 로고    scopus 로고
    • Regulation of putative fatty acid transporters and Acyl-CoA synthetase in liver and adipose tissue in ob/ob mice
    • Memon, R.A., Fuller, J., Moser, A.H., Smith, P.J., Grunfeld, C. and Feingold, K.R. 1999. Regulation of putative fatty acid transporters and Acyl-CoA synthetase in liver and adipose tissue in ob/ob mice. Diabetes 48, 121-127.
    • (1999) Diabetes , vol.48 , pp. 121-127
    • Memon, R.A.1    Fuller, J.2    Moser, A.H.3    Smith, P.J.4    Grunfeld, C.5    Feingold, K.R.6
  • 43
    • 0018776250 scopus 로고
    • Sex differences in long chain fatty acid utilization and fatty acid binding protein concentration in rat liver
    • Ockner, R.K., Burnett, D.A., Lysenko, N. and Manning, J.A. 1979. Sex differences in long chain fatty acid utilization and fatty acid binding protein concentration in rat liver. J Clin Invest 64, 172-181.
    • (1979) J Clin Invest , vol.64 , pp. 172-181
    • Ockner, R.K.1    Burnett, D.A.2    Lysenko, N.3    Manning, J.A.4
  • 46
    • 0036295566 scopus 로고    scopus 로고
    • Protein kinase C and lipid-induced insulin resistance in skeletal muscle
    • Schmitz-Peiffer, C. 2002. Protein kinase C and lipid-induced insulin resistance in skeletal muscle. Ann N Y Acad Sci 967, 146-157.
    • (2002) Ann N Y Acad Sci , vol.967 , pp. 146-157
    • Schmitz-Peiffer, C.1
  • 47
    • 0033588253 scopus 로고    scopus 로고
    • Ceramide generation is sufficient to account for the inhibition of the insulin-stimulated PKB pathway in C2C12 skeletal muscle cells pretreated with palmitate
    • Schmitz-Peiffer, C., Craig, D.L. and Biden, T.J. 1999. Ceramide generation is sufficient to account for the inhibition of the insulin-stimulated PKB pathway in C2C12 skeletal muscle cells pretreated with palmitate. J Biol Chem 274, 24202-24210.
    • (1999) J Biol Chem , vol.274 , pp. 24202-24210
    • Schmitz-Peiffer, C.1    Craig, D.L.2    Biden, T.J.3
  • 48
    • 0017101039 scopus 로고
    • Preparation of isolated rat liver cells
    • Seglen, P.O. 1976. Preparation of isolated rat liver cells. Methods Cell Biol 13, 29-83.
    • (1976) Methods Cell Biol , vol.13 , pp. 29-83
    • Seglen, P.O.1
  • 49
    • 0016691920 scopus 로고
    • Fatty acid binding to plasma albumin
    • Spector, A.A. 1975. Fatty acid binding to plasma albumin. J Lipid Res 16, 165-179.
    • (1975) J Lipid Res , vol.16 , pp. 165-179
    • Spector, A.A.1
  • 52
    • 0037312745 scopus 로고    scopus 로고
    • Dietary fat, fatty acid composition in plasma and the metabolic syndrome
    • Vessby, B. 2003. Dietary fat, fatty acid composition in plasma and the metabolic syndrome. Curr Opin Lipidol 14, 15-19.
    • (2003) Curr Opin Lipidol , vol.14 , pp. 15-19
    • Vessby, B.1
  • 53
    • 0032497838 scopus 로고    scopus 로고
    • Diacylglycerol-when is it an intracellular messenger?
    • Wakelam, M.J. 1998. Diacylglycerol-when is it an intracellular messenger? Biochim Biophys Acta 1436, 117-126.
    • (1998) Biochim Biophys Acta , vol.1436 , pp. 117-126
    • Wakelam, M.J.1
  • 54
    • 2642561229 scopus 로고    scopus 로고
    • Palmitate, but not unsaturated fatty acids, induces the expression of interleukin-6 in human myotubes through proteasome-dependent activation of nuclear factor-kappaB
    • Weigert, C., Brodbeck, K., Staiger, H., Kausch, C., Machicao, F., Häring, H.U. and Schleicher, E.D. 2004. Palmitate, but not unsaturated fatty acids, induces the expression of interleukin-6 in human myotubes through proteasome-dependent activation of nuclear factor-kappaB. J Biol Chem 279, 23942-23952.
    • (2004) J Biol Chem , vol.279 , pp. 23942-23952
    • Weigert, C.1    Brodbeck, K.2    Staiger, H.3    Kausch, C.4    Machicao, F.5    Häring, H.U.6    Schleicher, E.D.7
  • 55
    • 75349098889 scopus 로고    scopus 로고
    • Chronic, in vivo, PPARalpha activation prevents lipid overload in rat liver induced by high fat feeding
    • Wierzbicki, M., Chabowski, A., Zendzian-Piotrowska, M., Harasim, E. and Górski, J. 2009. Chronic, in vivo, PPARalpha activation prevents lipid overload in rat liver induced by high fat feeding. Adv Med Sci 54, 59-65.
    • (2009) Adv Med Sci , vol.54 , pp. 59-65
    • Wierzbicki, M.1    Chabowski, A.2    Zendzian-Piotrowska, M.3    Harasim, E.4    Górski, J.5
  • 56
    • 0031716302 scopus 로고    scopus 로고
    • Quantitative analysis of ceramide molecular species by high performance liquid chromatography
    • Yano, M., Kishida, E., Muneyuki, Y. and Masuzawa, Y. 1998. Quantitative analysis of ceramide molecular species by high performance liquid chromatography. J Lipid Res 39, 2091-2098.
    • (1998) J Lipid Res , vol.39 , pp. 2091-2098
    • Yano, M.1    Kishida, E.2    Muneyuki, Y.3    Masuzawa, Y.4
  • 57
    • 33845984572 scopus 로고    scopus 로고
    • Aberrant hepatic expression of PPARgamma2 stimulates hepatic lipogenesis in a mouse model of obesity, insulin resistance, dyslipidemia, and hepatic steatosis
    • Zhang, Y.L., Hernandez-Ono, A., Siri, P., Weisberg, S., Conlon, D., Graham, M.J., Crooke, R.M., Huang, L.S. and Ginsberg, H.N. 2006. Aberrant hepatic expression of PPARgamma2 stimulates hepatic lipogenesis in a mouse model of obesity, insulin resistance, dyslipidemia, and hepatic steatosis. J Biol Chem 281, 37603-37615.
    • (2006) J Biol Chem , vol.281 , pp. 37603-37615
    • Zhang, Y.L.1    Hernandez-Ono, A.2    Siri, P.3    Weisberg, S.4    Conlon, D.5    Graham, M.J.6    Crooke, R.M.7    Huang, L.S.8    Ginsberg, H.N.9


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