Fatty acid transport proteins, implications in physiology and disease

Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids

Volumn 1821, Issue 5, 2012, Pages 852-857

  Kazantzis, Melissa ^a   Stahl, Andreas ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Diabetes; Fatty acid uptake protein; Hepatosteatosis; Ichthyosis; Lipotoxicity; SLC27

Indexed keywords

BILE ACID; FATTY ACID TRANSPORTER; FATTY ACID TRANSPORTER 1; FATTY ACID TRANSPORTER 2; FATTY ACID TRANSPORTER 4; FATTY ACID TRANSPORTER 5; LONG CHAIN FATTY ACID; UNCLASSIFIED DRUG;

ADIPOCYTE; BILE ACID METABOLISM; CARDIOTOXICITY; CARDIOVASCULAR DISEASE; CELLULAR DISTRIBUTION; CHRONIC DISEASE; DIABETES MELLITUS; DISEASE PREDISPOSITION; ENDOTHELIUM CELL; FATTY ACID TRANSPORT; FATTY LIVER; GENE MUTATION; GENETIC POLYMORPHISM; HUMAN; ICHTHYOSIS; INSULIN RESISTANCE; LIPID LIVER LEVEL; LIPOTOXICITY; METABOLIC BALANCE; OVERNUTRITION; PRIORITY JOURNAL; REVIEW; THERMOGENESIS; TISSUE DISTRIBUTION;

ADIPOSE TISSUE; ENERGY METABOLISM; FATTY ACID TRANSPORT PROTEINS; FATTY ACIDS; FATTY LIVER; HUMANS; INSULIN RESISTANCE; LIVER; MUSCLE, SKELETAL; OBESITY; POLYMORPHISM, GENETIC;

EID: 84859157750     PISSN: 13881981     EISSN: 18792618     Source Type: Journal    
DOI: 10.1016/j.bbalip.2011.09.010     Document Type: Review

References (60)

1. A. Schaffler, and J. Scholmerich Innate immunity and adipose tissue biology Trends Immunol. 31 2010 228 235
2. D.J. Beech, Y.M. Bahnasi, A.M. Dedman, and E. Al-Shawaf TRPC channel lipid specificity and mechanisms of lipid regulation Cell Calcium 45 2009 583 588
3. D.B. van Rossum, and R.L. Patterson PKC and PLA2: probing the complexities of the calcium network Cell Calcium 45 2009 535 545
4. A.B. Kohan, Y. Qing, H.A. Cyphert, P. Tso, and L.M. Salati Chylomicron remnants and nonesterified fatty acids differ in their ability to inhibit genes involved in lipogenesis in rats J. Nutr. 141 2011 171 176
5. M. Fantino Role of lipids in the control of food intake Curr. Opin. Clin. Nutr. Metab. Care 14 2011 138 144
6. L. Best, E. Jarman, and P.D. Brown A dual action of saturated fatty acids on electrical activity in rat pancreatic beta-cells. Role of volume-regulated anion channel and KATP channel currents J. Physiol. 589 2011 1307 1316
7. D.B. Jump Fatty acid regulation of hepatic lipid metabolism Curr. Opin. Clin. Nutr. Metab. Care 14 2011 115 120
8. P.A. Grimaldi Metabolic and nonmetabolic regulatory functions of peroxisome proliferator-activated receptor beta Curr. Opin. Lipidol. 21 2010 186 191
9. T. Vallim, and A.M. Salter Regulation of hepatic gene expression by saturated fatty acids Prostaglandins Leukot. Essent. Fatty Acids 82 2010 211 218
10. M. Guan, L. Qu, W. Tan, L. Chen, and C.W. Wong Hepatocyte nuclear factor-4 alpha regulates liver triglyceride metabolism in part through secreted phospholipase A(2) GXIIB Hepatology 53 2011 458 466
11. A. Kennedy, K. Martinez, C.C. Chuang, K. LaPoint, and M. McIntosh Saturated fatty acid-mediated inflammation and insulin resistance in adipose tissue: mechanisms of action and implications J. Nutr. 139 2009 1 4
12. G.V. Richieri, R.T. Ogata, and A.M. Kleinfeld Thermodynamics of fatty acid binding to fatty acid-binding proteins and fatty acid partition between water and membranes measured using the fluorescent probe ADIFAB J. Biol. Chem. 270 1995 15076 15084
13. A. Stahl, J.G. Evans, S. Pattel, D. Hirsch, and H.F. Lodish Insulin causes fatty acid transport protein translocation and enhanced fatty acid uptake in adipocytes Dev. Cell 2 2002 477 488
14. J.F. Glatz, J.J. Luiken, M. van Bilsen, and G.J. van der Vusse Cellular lipid binding proteins as facilitators and regulators of lipid metabolism Mol. Cell. Biochem. 239 2002 3 7
15. H. Huang, O. Starodub, A. McIntosh, A.B. Kier, and F. Schroeder Liver fatty acid-binding protein targets fatty acids to the nucleus. Real time confocal and multiphoton fluorescence imaging in living cells J. Biol. Chem. 277 2002 29139 29151
16. C.T. Coburn, T. Hajri, A. Ibrahimi, and N.A. Abumrad Role of CD36 in membrane transport and utilization of long-chain fatty acids by different tissues J. Mol. Neurosci. 16 2001 117 121 discussion 151-117
17. A. Stahl, R.E. Gimeno, L.A. Tartaglia, and H.F. Lodish Fatty acid transport proteins: a current view of a growing family Trends Endocrinol. Metab. 12 2001 266 273
18. J.E. Schaffer, and H.F. Lodish Expression cloning and characterization of a novel adipocyte long chain fatty acid transport protein Cell 79 1994 427 436
19. D. Hirsch, A. Stahl, and H.F. Lodish A family of fatty acid transporters conserved from mycobacterium to man Proc. Natl. Acad. Sci. U. S. A. 95 1998 8625 8629
20. T. Herrmann, F. Buchkremer, I. Gosch, A.M. Hall, D.A. Bernlohr, and W. Stremmel Mouse fatty acid transport protein 4 (FATP4): characterization of the gene and functional assessment as a very long chain acyl-CoA synthetase Gene 270 2001 31 40
21. Q. Wu, A.M. Ortegon, B. Tsang, H. Doege, K.R. Feingold, and A. Stahl FATP1 is an insulin-sensitive fatty acid transporter involved in diet-induced obesity Mol. Cell. Biol. 26 2006 3455 3467
22. Q. Wu, M. Kazantzis, H. Doege, A.M. Ortegon, B. Tsang, A. Falcon, and A. Stahl Fatty acid transport protein 1 is required for nonshivering thermogenesis in brown adipose tissue Diabetes 55 2006 3229 3237
23. A. Falcon, H. Doege, A. Fluitt, B. Tsang, N. Watson, M.A. Kay, and A. Stahl FATP2 is a hepatic fatty acid transporter and peroxisomal very long-chain acyl-CoA synthetase Am. J. Physiol. Endocrinol. Metab. 299 2010 E384 E393
24. A. Stahl, D.J. Hirsch, R.E. Gimeno, S. Punreddy, P. Ge, N. Watson, S. Patel, M. Kotler, A. Raimondi, L.A. Tartaglia, and H.F. Lodish Identification of the major intestinal fatty acid transport protein Mol. Cell 4 1999 299 308
25. H. Doege, D. Grimm, A. Falcon, B. Tsang, T.A. Storm, H. Xu, A.M. Ortegon, M. Kazantzis, M.A. Kay, and A. Stahl Silencing of hepatic fatty acid transporter protein 5 in vivo reverses diet-induced non-alcoholic fatty liver disease and improves hyperglycemia J. Biol. Chem. 283 2008 22186 22192
26. R.E. Gimeno, A.M. Ortegon, S. Patel, S. Punreddy, P. Ge, Y. Sun, H.F. Lodish, and A. Stahl Characterization of a heart-specific fatty acid transport protein J. Biol. Chem. 278 2003 16039 16044
27. H. Doege, R.A. Baillie, A.M. Ortegon, B. Tsang, Q. Wu, S. Punreddy, D. Hirsch, N. Watson, R.E. Gimeno, and A. Stahl Targeted deletion of FATP5 reveals multiple functions in liver metabolism: alterations in hepatic lipid homeostasis Gastroenterology 130 2006 1245 1258
28. R.E. Gimeno, D.J. Hirsch, S. Punreddy, Y. Sun, A.M. Ortegon, H. Wu, T. Daniels, A. Stricker-Krongrad, H.F. Lodish, and A. Stahl Targeted deletion of fatty acid transport protein-4 results in early embryonic lethality J. Biol. Chem. 278 2003 49512 49516
29. B. Hubbard, H. Doege, S. Punreddy, H. Wu, X. Huang, V.K. Kaushik, R.L. Mozell, J.J. Byrnes, A. Stricker-Krongrad, C.J. Chou, L.A. Tartaglia, H.F. Lodish, A. Stahl, and R.E. Gimeno Mice deleted for fatty acid transport protein 5 have defective bile acid conjugation and are protected from obesity Gastroenterology 130 2006 1259 1269
30. L. Ordovas, R. Roy, P. Zaragoza, and C. Rodellar Structural and functional characterization of the bovine solute carrier family 27 member 1 (SLC27A1) gene Cytogenet. Genome Res. 115 2006 115 122
31. J. Grzyb, D. Latowski, and K. Strzalka Lipocalins-a family portrait J. Plant Physiol. 163 2006 895 915
32. J. Storch, and L. McDermott Structural and functional analysis of fatty acid-binding proteins J. Lipid Res. 50 2009 S126 S131 (Suppl)
33. S.E. Lewis, L.L. Listenberger, D.S. Ory, and J.E. Schaffer Membrane topology of the murine fatty acid transport protein 1 J. Biol. Chem. 276 2001 37042 37050
34. M.R. Richards, L.L. Listenberger, A.A. Kelly, S.E. Lewis, D.S. Ory, and J.E. Schaffer Oligomerization of the murine fatty acid transport protein 1 J. Biol. Chem. 278 2003 10477 10483
35. S.J. Mihalik, S.J. Steinberg, Z. Pei, J. Park, G. Kim do, A.K. Heinzer, G. Dacremont, R.J. Wanders, D.A. Cuebas, K.D. Smith, and P.A. Watkins Participation of two members of the very long-chain acyl-CoA synthetase family in bile acid synthesis and recycling J. Biol. Chem. 277 2002 24771 24779
36. S.J. Steinberg, S.J. Mihalik, D.G. Kim, D.A. Cuebas, and P.A. Watkins The human liver-specific homolog of very long-chain acyl-CoA synthetase is cholate:CoA ligase J. Biol. Chem. 275 2000 15605 15608
37. M.R. Richards, J.D. Harp, D.S. Ory, and J.E. Schaffer Fatty acid transport protein 1 and long-chain acyl coenzyme A synthetase 1 interact in adipocytes J. Lipid Res. 47 2006 665 672
38. Z. Zou, C.C. DiRusso, V. Ctrnacta, and P.N. Black Fatty acid transport in Saccharomyces cerevisiae. Directed mutagenesis of FAT1 distinguishes the biochemical activities associated with Fat1p J. Biol. Chem. 277 2002 31062 31071
39. C.C. DiRusso, D. Darwis, T. Obermeyer, and P.N. Black Functional domains of the fatty acid transport proteins: studies using protein chimeras Biochim. Biophys. Acta 1781 2008 135 143
40. Z. Pei, P. Fraisl, J. Berger, Z. Jia, S. Forss-Petter, and P.A. Watkins Mouse very long-chain Acyl-CoA synthetase 3/fatty acid transport protein 3 catalyzes fatty acid activation but not fatty acid transport in MA-10 cells J. Biol. Chem. 279 2004 54454 54462
41. K. Milger, T. Herrmann, C. Becker, D. Gotthardt, J. Zickwolf, R. Ehehalt, P.A. Watkins, W. Stremmel, and J. Fullekrug Cellular uptake of fatty acids driven by the ER-localized acyl-CoA synthetase FATP4 J. Cell Sci. 119 2006 4678 4688
42. S.J. Mihalik, S.J. Steinberg, Z. Pei, J. Park, D.G. Kim, A.K. Heinzer, G. Dacremont, R.J. Wanders, D.A. Cuebas, K.D. Smith, and P.A. Watkins Participation of two members of the very long-chain acyl-CoA synthetase family in bile acid synthesis and recycling J. Biol. Chem. 277 2002 24771 24779
43. J.K. Kim, R.E. Gimeno, T. Higashimori, H.J. Kim, H. Choi, S. Punreddy, R.L. Mozell, G. Tan, A. Stricker-Krongrad, D.J. Hirsch, J.J. Fillmore, Z.X. Liu, J. Dong, G. Cline, A. Stahl, H.F. Lodish, and G.I. Shulman Inactivation of fatty acid transport protein 1 prevents fat-induced insulin resistance in skeletal muscle J. Clin. Invest. 113 2004 756 763
44. H.M. Feldmann, V. Golozoubova, B. Cannon, and J. Nedergaard UCP1 ablation induces obesity and abolishes diet-induced thermogenesis in mice exempt from thermal stress by living at thermoneutrality Cell Metab. 9 2009 203 209
45. A. Bartelt, O.T. Bruns, R. Reimer, H. Hohenberg, H. Ittrich, K. Peldschus, M.G. Kaul, U.I. Tromsdorf, H. Weller, C. Waurisch, A. Eychmuller, P.L. Gordts, F. Rinninger, K. Bruegelmann, B. Freund, P. Nielsen, M. Merkel, and J. Heeren Brown adipose tissue activity controls triglyceride clearance Nat. Med. 17 2011 200 205
46. H.C. Chiu, A. Kovacs, R.M. Blanton, X. Han, M. Courtois, C.J. Weinheimer, K.A. Yamada, S. Brunet, H. Xu, J.M. Nerbonne, M.J. Welch, N.M. Fettig, T.L. Sharp, N. Sambandam, K.M. Olson, D.S. Ory, and J.E. Schaffer Transgenic expression of fatty acid transport protein 1 in the heart causes lipotoxic cardiomyopathy Circ. Res. 96 2005 225 233
47. W. Stremmel, L. Pohl, A. Ring, and T. Herrmann A new concept of cellular uptake and intracellular trafficking of long-chain fatty acids Lipids 36 2001 981 989
48. C.E. Hagberg, A. Falkevall, X. Wang, E. Larsson, J. Huusko, I. Nilsson, L.A. van Meeteren, E. Samen, L. Lu, M. Vanwildemeersch, J. Klar, G. Genove, K. Pietras, S. Stone-Elander, L. Claesson-Welsh, S. Yla-Herttuala, P. Lindahl, and U. Eriksson Vascular endothelial growth factor B controls endothelial fatty acid uptake Nature 464 2010 917 921
49. D.M. Muoio Metabolism and vascular fatty acid transport N. Engl. J. Med. 363 2010 291 293
50. R.W. Mitchell, N.H. On, M.R. Del Bigio, D.W. Miller, and G.M. Hatch Fatty acid transport protein expression in human brain and potential role in fatty acid transport across human brain microvessel endothelial cells J. Neurochem. 117 2011 735 746
51. T. Herrmann, F. Van Der Hoeven, H.J. Grone, A.F. Stewart, L. Langbein, I. Kaiser, G. Liebisch, I. Gosch, F. Buchkremer, W. Drobnik, G. Schmitz, and W. Stremmel Mice with targeted disruption of the fatty acid transport protein 4 (Fatp 4, Slc27a4) gene show features of lethal restrictive dermopathy J. Cell Biol. 161 2003 1105 1115
52. C.L. Moulson, M.H. Lin, J.M. White, E.P. Newberry, N.O. Davidson, and J.H. Miner Keratinocyte-specific expression of fatty acid transport protein 4 rescues the wrinkle-free phenotype in Slc27a4/Fatp4 mutant mice J. Biol. Chem. 282 2007 15912 15920
53. T. Herrmann, H.J. Grone, L. Langbein, I. Kaiser, I. Gosch, U. Bennemann, D. Metzger, P. Chambon, A.F. Stewart, and W. Stremmel Disturbed epidermal structure in mice with temporally controlled fatp4 deficiency J. Invest. Dermatol. 125 2005 1228 1235
54. M. Schmuth, A.M. Ortegon, M. Mao-Qiang, P.M. Elias, K.R. Feingold, and A. Stahl Differential expression of fatty acid transport proteins in epidermis and skin appendages J. Invest. Dermatol. 125 2005 1174 1181
55. M. Sobol, N. Dahl, J. Klar, FATP4 missense and nonsense mutations cause similar features in Ichthyosis Prematurity Syndrome, BMC Res Notes, 4 90.
56. J. Klar, M. Schweiger, R. Zimmerman, R. Zechner, H. Li, H. Torma, A. Vahlquist, B. Bouadjar, N. Dahl, and J. Fischer Mutations in the fatty acid transport protein 4 gene cause the ichthyosis prematurity syndrome Am. J. Hum. Genet. 85 2009 248 253
57. A. Meirhaeghe, G. Martin, M. Nemoto, S. Deeb, D. Cottel, J. Auwerx, P. Amouyel, and N. Helbecque Intronic polymorphism in the fatty acid transport protein 1 gene is associated with increased plasma triglyceride levels in a French population Arterioscler. Thromb. Vasc. Biol. 20 2000 1330 1334
58. K. Gertow, C. Skoglund-Andersson, P. Eriksson, S. Boquist, K. Orth-Gomer, K. Schenck-Gustafsson, A. Hamsten, and R.M. Fisher A common polymorphism in the fatty acid transport protein-1 gene associated with elevated post-prandial lipaemia and alterations in LDL particle size distribution Atherosclerosis 167 2003 265 273
59. K. Gertow, K.H. Pietilainen, H. Yki-Jarvinen, J. Kaprio, A. Rissanen, P. Eriksson, A. Hamsten, and R.M. Fisher Expression of fatty-acid-handling proteins in human adipose tissue in relation to obesity and insulin resistance Diabetologia 47 2004 1118 1125
60. A. Auinger, L. Valenti, M. Pfeuffer, U. Helwig, J. Herrmann, A.L. Fracanzani, P. Dongiovanni, S. Fargion, J. Schrezenmeir, and D. Rubin A promoter polymorphism in the liver-specific fatty acid transport protein 5 is associated with features of the metabolic syndrome and steatosis Horm. Metab. Res. 42 2010 854 859