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Volumn 14, Issue 1, 2013, Pages 640-673

Ovarian cancer: In search of better marker systems based on DNA repair defects

Author keywords

DNA repair errors; Early detection; Functional biomarker; Ovarian cancer risk; Prediction of therapeutic responsiveness

Indexed keywords

BIOLOGICAL MARKER; CARBOPLATIN; DOXORUBICIN; GEMCITABINE; INIPARIB; MESSENGER RNA; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; OLAPARIB; PACLITAXEL; BRCA1 PROTEIN; BRCA2 PROTEIN; PROTEIN BINDING; TUMOR MARKER;

EID: 84872178016     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms14010640     Document Type: Review
Times cited : (19)

References (171)
  • 1
    • 84857612237 scopus 로고    scopus 로고
    • Ovarian cancer: Etiology, risk factors, and epidemiology
    • Hunn, J.; Rodriguez, G.C. Ovarian cancer: Etiology, risk factors, and epidemiology. Clin. Obstet. Gynecol. 2012, 55, 3-23.
    • (2012) Clin. Obstet. Gynecol. , vol.55 , pp. 3-23
    • Hunn, J.1    Rodriguez, G.C.2
  • 8
    • 0038744296 scopus 로고    scopus 로고
    • Average risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutations detected in case series unselected for family history: A combined analysis of 22 studies
    • Antoniou, A.; Pharoah, P.D.; Narod, S.; Risch, H.A.; Eyfjord, J.E.; Hopper, J.L.; Loman, N.; Olsson, H.; Johannsson, O.; Borg, A.; et al. Average risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutations detected in case series unselected for family history: A combined analysis of 22 studies. Am. J. Hum. Genet. 2003, 72, 1117-1130.
    • (2003) Am. J. Hum. Genet. , vol.72 , pp. 1117-1130
    • Antoniou, A.1    Pharoah, P.D.2    Narod, S.3    Risch, H.A.4    Eyfjord, J.E.5    Hopper, J.L.6    Loman, N.7    Olsson, H.8    Johannsson, O.9    Borg, A.10
  • 10
    • 34248170114 scopus 로고    scopus 로고
    • Meta-analysis of BRCA1 and BRCA2 penetrance
    • 1329-1233
    • Chen, S.; Parmigiani, G. Meta-analysis of BRCA1 and BRCA2 penetrance. J. Clin. Oncol. 2007, 25, 1329-1233.
    • (2007) J. Clin. Oncol. , vol.25
    • Chen, S.1    Parmigiani, G.2
  • 13
    • 84856015503 scopus 로고    scopus 로고
    • Hereditary ovarian cancer: Beyond he usual suspects
    • Pennington, K.P.; Swisher, E.M. Hereditary ovarian cancer: Beyond he usual suspects. Gynecol. Oncol. 2012, 124, 347-353.
    • (2012) Gynecol. Oncol. , vol.124 , pp. 347-353
    • Pennington, K.P.1    Swisher, E.M.2
  • 14
    • 84866760278 scopus 로고    scopus 로고
    • Ovarian cancer: Emerging molecular-targeted therapies
    • Sourbier, C. Ovarian cancer: Emerging molecular-targeted therapies. Biologics 2012, 6, 147-154.
    • (2012) Biologics , vol.6 , pp. 147-154
    • Sourbier, C.1
  • 15
    • 84862486851 scopus 로고    scopus 로고
    • Screening women for ovarian cancer still does more harm than good
    • Slomski, A. Screening women for ovarian cancer still does more harm than good. JAMA 2012, 307, 2474-2475.
    • (2012) JAMA , vol.307 , pp. 2474-2475
    • Slomski, A.1
  • 17
  • 18
    • 84864053120 scopus 로고    scopus 로고
    • BRCAness: Finding the achilles heel in ovarian cancer
    • Rigakos, G.; Razis, E. BRCAness: Finding the achilles heel in ovarian cancer. Oncologist 2012, 17, 956-962.
    • (2012) Oncologist , vol.17 , pp. 956-962
    • Rigakos, G.1    Razis, E.2
  • 19
    • 0028793749 scopus 로고
    • Familial ovarian cancer. Update and clinical applications
    • Claus, E.B.; Schwartz, P.E. Familial ovarian cancer. Update and clinical applications. Cancer 1995, 76, 1998-2003.
    • (1995) Cancer , vol.76 , pp. 1998-2003
    • Claus, E.B.1    Schwartz, P.E.2
  • 20
    • 0037403380 scopus 로고    scopus 로고
    • Improved survival in women with BRCA-associated ovarian carcinoma
    • Cass, I.; Baldwin, R.L.; Varkey, T.; Moslehi, R.; Narod, S.A.; Karlan, B.Y. Improved survival in women with BRCA-associated ovarian carcinoma. Cancer 2003, 97, 2187-2195.
    • (2003) Cancer , vol.97 , pp. 2187-2195
    • Cass, I.1    Baldwin, R.L.2    Varkey, T.3    Moslehi, R.4    Narod, S.A.5    Karlan, B.Y.6
  • 21
    • 84864026311 scopus 로고    scopus 로고
    • BRCA mutation frequency and patterns of treatment response in BRCA mutation-positive women with ovarian cancer: A report from the Australian Ovarian Cancer Study Group
    • Alsop, K.; Fereday, S.; Meldrum, C.; deFazio, A.; Emmanuel, C.; George, J.; Dobrovic, A.; Birrer, M.J.; Webb, P.M.; Stewart, C.; et al. BRCA mutation frequency and patterns of treatment response in BRCA mutation-positive women with ovarian cancer: A report from the Australian Ovarian Cancer Study Group. J. Clin. Oncol. 2012, 30, 2654-2663.
    • (2012) J. Clin. Oncol. , vol.30 , pp. 2654-2663
    • Alsop, K.1    Fereday, S.2    Meldrum, C.3    deFazio, A.4    Emmanuel, C.5    George, J.6    Dobrovic, A.7    Birrer, M.J.8    Webb, P.M.9    Stewart, C.10
  • 22
    • 0030932869 scopus 로고    scopus 로고
    • Cancer-susceptibility genes. Gatekeepers and caretakers
    • Kinzler, K. W; Vogelstein, B. Cancer-susceptibility genes. Gatekeepers and caretakers. Nature 1997, 386, 761-763.
    • (1997) Nature , vol.386 , pp. 761-763
    • Kinzler, K.W.1    Vogelstein, B.2
  • 23
    • 14644391577 scopus 로고    scopus 로고
    • The Fanconi anemia pathway is required for the DNA replication stress response and for the regulation of common fragile site stability
    • Howlett, N.G.; Taniguchi, T.; Durkin, S.G.; D'Andrea, A.D.; Glover, T.W. The Fanconi anemia pathway is required for the DNA replication stress response and for the regulation of common fragile site stability. Hum. Mol. Genet. 2005, 14, 693-701.
    • (2005) Hum. Mol. Genet. , vol.14 , pp. 693-701
    • Howlett, N.G.1    Taniguchi, T.2    Durkin, S.G.3    D'Andrea, A.D.4    Glover, T.W.5
  • 24
    • 29144506137 scopus 로고    scopus 로고
    • The Fanconi anemia/BRCA pathway: New faces in the crowd
    • Kennedy, R.D.; D'Andrea, A.D. The Fanconi anemia/BRCA pathway: New faces in the crowd. Genes Dev. 2005, 19, 2925-2940.
    • (2005) Genes Dev. , vol.19 , pp. 2925-2940
    • Kennedy, R.D.1    D'Andrea, A.D.2
  • 25
    • 33846850422 scopus 로고    scopus 로고
    • Ten genes for inherited breast cancer
    • Walsh, T.; King, M.C. Ten genes for inherited breast cancer. Cancer Cell 2007, 11, 103-105.
    • (2007) Cancer Cell , vol.11 , pp. 103-105
    • Walsh, T.1    King, M.C.2
  • 26
    • 5644277503 scopus 로고    scopus 로고
    • Mismatch repair proteins: Key regulators of genetic recombination
    • Surtees, J.A.; Argueso, J.L.; Alani, E. Mismatch repair proteins: Key regulators of genetic recombination. Cytogenet. Genome Res. 2004, 107, 146-159.
    • (2004) Cytogenet. Genome Res. , vol.107 , pp. 146-159
    • Surtees, J.A.1    Argueso, J.L.2    Alani, E.3
  • 27
    • 58149145579 scopus 로고    scopus 로고
    • Human Mlh1 monitors homologous recombination independently of mismatch repair and damage signaling
    • Siehler, S.Y.; Schrauder, M.; Gerischer, U.; Cantor, S.; Marra, G.; Wiesmüller, L. Human Mlh1 monitors homologous recombination independently of mismatch repair and damage signaling. DNA Repair 2009, 8, 242-252.
    • (2009) DNA Repair , vol.8 , pp. 242-252
    • Siehler, S.Y.1    Schrauder, M.2    Gerischer, U.3    Cantor, S.4    Marra, G.5    Wiesmüller, L.6
  • 28
    • 52449114574 scopus 로고    scopus 로고
    • Ataxia-telangiectasia: From a rare disorder to a paradigm for cell signalling and cancer
    • Lavin, M.F. Ataxia-telangiectasia: From a rare disorder to a paradigm for cell signalling and cancer. Nat. Rev. Mol. Cell Biol. 2008, 9, 759-769.
    • (2008) Nat. Rev. Mol. Cell Biol. , vol.9 , pp. 759-769
    • Lavin, M.F.1
  • 29
    • 33644927601 scopus 로고    scopus 로고
    • p53 in recombination and repair
    • Gatz, S.A.; Wiesmüller, L. p53 in recombination and repair. Cell Death Differ. 2006, 13, 1003-1006.
    • (2006) Cell Death Differ. , vol.13 , pp. 1003-1006
    • Gatz, S.A.1    Wiesmüller, L.2
  • 30
    • 67349107395 scopus 로고    scopus 로고
    • Cellular and molecular consequences of defective Fanconi anemia proteins in replication-coupled DNA repair: Mechanistic insights
    • Thompson, L.H.; Hinz, J.M. Cellular and molecular consequences of defective Fanconi anemia proteins in replication-coupled DNA repair: Mechanistic insights. Mutat. Res. 2009, 668, 54-72.
    • (2009) Mutat. Res. , vol.668 , pp. 54-72
    • Thompson, L.H.1    Hinz, J.M.2
  • 31
    • 33645322935 scopus 로고    scopus 로고
    • Signalling cell cycle arrest and cell death through the MMR system
    • O'Brien, V.; Brown, R. Signalling cell cycle arrest and cell death through the MMR system. Carcinogenesis 2006, 27, 682-692.
    • (2006) Carcinogenesis , vol.27 , pp. 682-692
    • O'Brien, V.1    Brown, R.2
  • 32
    • 54249084045 scopus 로고    scopus 로고
    • ATM and the Mre11-Rad50-Nbs1 complex respond to nucleoside analogue-induced stalled replication forks and contribute to drug resistance
    • Ewald, B.; Sampath, D.; Plunkett, W. ATM and the Mre11-Rad50-Nbs1 complex respond to nucleoside analogue-induced stalled replication forks and contribute to drug resistance. Cancer Res. 2008, 68, 7947-7955.
    • (2008) Cancer Res. , vol.68 , pp. 7947-7955
    • Ewald, B.1    Sampath, D.2    Plunkett, W.3
  • 33
    • 77951963106 scopus 로고    scopus 로고
    • A mitotic role for the DNA damage-responsive CHK2 kinase
    • Sato, K.; Ohta, T.; Venkitaraman, A.R. A mitotic role for the DNA damage-responsive CHK2 kinase. Nat. Cell Biol. 2010, 12, 424-425.
    • (2010) Nat. Cell Biol. , vol.12 , pp. 424-425
    • Sato, K.1    Ohta, T.2    Venkitaraman, A.R.3
  • 34
    • 84455194209 scopus 로고    scopus 로고
    • Mismatch repair, but not heteroduplex rejection, is temporally coupled to DNA replication
    • Hombauer, H.; Srivatsan, A.; Putnam, C.D.; Kolodner, R.D. Mismatch repair, but not heteroduplex rejection, is temporally coupled to DNA replication. Science 2011, 334, 1713-1716.
    • (2011) Science , vol.334 , pp. 1713-1716
    • Hombauer, H.1    Srivatsan, A.2    Putnam, C.D.3    Kolodner, R.D.4
  • 35
    • 84863753191 scopus 로고    scopus 로고
    • A distinct replication fork protection pathway connects Fanconi anemia tumor suppressors to RAD51-BRCA1/2
    • Schlacher, K.; Wu, H.; Jasin, M. A distinct replication fork protection pathway connects Fanconi anemia tumor suppressors to RAD51-BRCA1/2. Cancer Cell 2012, 22, 106-116.
    • (2012) Cancer Cell , vol.22 , pp. 106-116
    • Schlacher, K.1    Wu, H.2    Jasin, M.3
  • 36
    • 77950974130 scopus 로고    scopus 로고
    • Development of a functional assay for homologous recombination status in primary cultures of epithelial ovarian tumor and correlation with sensitivity to poly(ADP-ribose) polymerase inhibitors
    • Mukhopadhyay, A.; Elattar, A.; Cerbinskaite, A.; Wilkinson, S.J.; Drew, Y.; Kyle S.; Los, G.; Hostomsky, Z.; Edmondson, R.J.; Curtin, N.J. Development of a functional assay for homologous recombination status in primary cultures of epithelial ovarian tumor and correlation with sensitivity to poly(ADP-ribose) polymerase inhibitors. Clin. Cancer Res. 2010, 16, 2344-2351.
    • (2010) Clin. Cancer Res. , vol.16 , pp. 2344-2351
    • Mukhopadhyay, A.1    Elattar, A.2    Cerbinskaite, A.3    Wilkinson, S.J.4    Drew, Y.5    Kyle, S.6    Los, G.7    Hostomsky, Z.8    Edmondson, R.J.9    Curtin, N.J.10
  • 37
    • 0034650339 scopus 로고    scopus 로고
    • Induced micronucleus frequencies in peripheral lymphocytes as a screening test for carriers of a BRCA1 mutation in breast cancer families
    • Rothfuss, A.; Schütz, P.; Bochum, S.; Volm, T.; Eberhardt, E.; Kreienberg, R.; Vogel, W.; Speit, G. Induced micronucleus frequencies in peripheral lymphocytes as a screening test for carriers of a BRCA1 mutation in breast cancer families. Cancer Res. 2000, 60, 390-394.
    • (2000) Cancer Res. , vol.60 , pp. 390-394
    • Rothfuss, A.1    Schütz, P.2    Bochum, S.3    Volm, T.4    Eberhardt, E.5    Kreienberg, R.6    Vogel, W.7    Speit, G.8
  • 40
    • 84555196106 scopus 로고    scopus 로고
    • BRCA1 and BRCA2: Different roles in a common pathway of genome protection
    • Roy, R.; Chun, J.; Powell, S.N. BRCA1 and BRCA2: Different roles in a common pathway of genome protection. Nat. Rev. Cancer 2011, 12, 68-78.
    • (2011) Nat. Rev. Cancer , vol.12 , pp. 68-78
    • Roy, R.1    Chun, J.2    Powell, S.N.3
  • 41
    • 78649778694 scopus 로고    scopus 로고
    • RAD51C: A novel cancer susceptibility gene is linked to FANconi anemia and breast cancer
    • Somyajit, K.; Subramanya, S.; Nagaraju, G. RAD51C: A novel cancer susceptibility gene is linked to FANconi anemia and breast cancer. Carcinogenesis 2010, 12, 2031-2038.
    • (2010) Carcinogenesis , vol.12 , pp. 2031-2038
    • Somyajit, K.1    Subramanya, S.2    Nagaraju, G.3
  • 42
    • 80055113946 scopus 로고    scopus 로고
    • Anticipation in lynch syndrome: Where we are where we go
    • Bozzao, C.; Lastella, P.; Stella, A. Anticipation in lynch syndrome: Where we are where we go. Curr. Genomics 2011, 12, 451-465.
    • (2011) Curr. Genomics , vol.12 , pp. 451-465
    • Bozzao, C.1    Lastella, P.2    Stella, A.3
  • 44
    • 0032853774 scopus 로고    scopus 로고
    • Mutant p53: Gain-of-function oncoproteins and wild-type p53 inactivators
    • Roemer, K. Mutant p53: Gain-of-function oncoproteins and wild-type p53 inactivators. Biol. Chem. 1999, 380, 879-887.
    • (1999) Biol. Chem. , vol.380 , pp. 879-887
    • Roemer, K.1
  • 45
    • 80053022230 scopus 로고    scopus 로고
    • Li-Fraumeni syndrome
    • Malkin, D. Li-Fraumeni syndrome. Genes Cancer 2011, 2, 475-484.
    • (2011) Genes Cancer , vol.2 , pp. 475-484
    • Malkin, D.1
  • 47
    • 2442477786 scopus 로고    scopus 로고
    • p53's double life: Transactivation-independent repression of homologous recombination
    • Bertrand, P.; Saintigny, Y.; Lopez, B.S. p53's double life: Transactivation-independent repression of homologous recombination. Trends Genet. 2004, 20, 235-243.
    • (2004) Trends Genet. , vol.20 , pp. 235-243
    • Bertrand, P.1    Saintigny, Y.2    Lopez, B.S.3
  • 48
    • 33845999615 scopus 로고    scopus 로고
    • Essential role for nuclear PTEN in maintaining chromosomal integrity
    • Shen, W.H.; Balajee, A.S.; Wang, J.; Wu, H.; Eng, C.; Pandolfi, P.P.; Yin, Y. Essential role for nuclear PTEN in maintaining chromosomal integrity. Cell 2007, 128, 157-170.
    • (2007) Cell , vol.128 , pp. 157-170
    • Shen, W.H.1    Balajee, A.S.2    Wang, J.3    Wu, H.4    Eng, C.5    Pandolfi, P.P.6    Yin, Y.7
  • 50
    • 39149123134 scopus 로고    scopus 로고
    • MEN1 and FANCD2 mediate distinct mechanisms of DNA crosslink repair
    • Marek, L.R.; Kottemann, M.C.; Glazer, P.M.; Bale, A.E. MEN1 and FANCD2 mediate distinct mechanisms of DNA crosslink repair. DNA Repair 2008, 7, 476-486.
    • (2008) DNA Repair , vol.7 , pp. 476-486
    • Marek, L.R.1    Kottemann, M.C.2    Glazer, P.M.3    Bale, A.E.4
  • 53
    • 0035902108 scopus 로고    scopus 로고
    • Genome maintenance mechanisms for preventing cancer
    • Hoeijmakers, J.H. Genome maintenance mechanisms for preventing cancer. Nature 2001, 411, 366-374.
    • (2001) Nature , vol.411 , pp. 366-374
    • Hoeijmakers, J.H.1
  • 54
    • 70350504453 scopus 로고    scopus 로고
    • The DNA-damage response in human biology and disease
    • Jackson, S.P.; Bartek, J. The DNA-damage response in human biology and disease. Nature 2009, 461, 1071-1078.
    • (2009) Nature , vol.461 , pp. 1071-1078
    • Jackson, S.P.1    Bartek, J.2
  • 55
    • 84891305522 scopus 로고    scopus 로고
    • DNA Repair
    • In, 1st ed.; Debatin, K.M., Fulda, S., Eds.; Wiley-VCH Verlag GmbH & Co. KGaA: Weinheim, Germany
    • Schrauder, M.; Wiesmüller, L. DNA Repair. In Apoptosis and Cancer Therapy, 1st ed.; Debatin, K.M., Fulda, S., Eds.; Wiley-VCH Verlag GmbH & Co. KGaA: Weinheim, Germany, 2006; Volume 2, pp. 822-846.
    • (2006) Apoptosis and Cancer Therapy , vol.2 , pp. 822-846
    • Schrauder, M.1    Wiesmüller, L.2
  • 56
    • 48249095920 scopus 로고    scopus 로고
    • Single-strand break repair and genetic disease
    • Caldecott, K.W. Single-strand break repair and genetic disease. Nat. Rev. Genet. 2008 9, 619-631.
    • (2008) Nat. Rev. Genet. , vol.9 , pp. 619-631
    • Caldecott, K.W.1
  • 57
    • 80054764341 scopus 로고    scopus 로고
    • PARP-1 enhances the mismatch-dependence of 5'-directed excision in human mismatch repair in vitro
    • Liu, Y.; Kadyrov, F.A.; Modrich, P. PARP-1 enhances the mismatch-dependence of 5'-directed excision in human mismatch repair in vitro. DNA Repair 2011, 10, 1145-1153.
    • (2011) DNA Repair , vol.10 , pp. 1145-1153
    • Liu, Y.1    Kadyrov, F.A.2    Modrich, P.3
  • 58
    • 77449086623 scopus 로고    scopus 로고
    • DNA resection in eukaryotes: Deciding how to fix the break
    • Huertas, P. DNA resection in eukaryotes: Deciding how to fix the break. Nat. Struct. Mol. Biol. 2010, 17, 11-16.
    • (2010) Nat. Struct. Mol. Biol. , vol.17 , pp. 11-16
    • Huertas, P.1
  • 59
    • 38049125555 scopus 로고    scopus 로고
    • The endless tale of non-homologous end-joining
    • Weterings, E.; Chen, D.J. The endless tale of non-homologous end-joining. Cell Res. 2008, 18, 114-124.
    • (2008) Cell Res. , vol.18 , pp. 114-124
    • Weterings, E.1    Chen, D.J.2
  • 60
    • 77953952646 scopus 로고    scopus 로고
    • BRCA1 and BRCA2: Breast/ovarian cancer susceptibility gene products and participants in DNA double-strand break repair
    • O'Donovan, P.J.; Livingston, D.M. BRCA1 and BRCA2: Breast/ovarian cancer susceptibility gene products and participants in DNA double-strand break repair. Carcinogenesis 2010, 31, 961-967.
    • (2010) Carcinogenesis , vol.31 , pp. 961-967
    • O'Donovan, P.J.1    Livingston, D.M.2
  • 61
    • 35348821296 scopus 로고    scopus 로고
    • A backup DNA repair pathway moves to the forefront
    • Nussenzweig, A.; Nussenzweig, M.C. A backup DNA repair pathway moves to the forefront. Cell 2007, 131, 223-225.
    • (2007) Cell , vol.131 , pp. 223-225
    • Nussenzweig, A.1    Nussenzweig, M.C.2
  • 64
    • 1942469352 scopus 로고    scopus 로고
    • Ovarian tumorigenesis: A proposed model based on morphological and molecular genetic analysis
    • Shih, I.; Kurman, R.J. Ovarian tumorigenesis: A proposed model based on morphological and molecular genetic analysis. Am. J. Pathol. 2004, 164, 1511-1518.
    • (2004) Am. J. Pathol. , vol.164 , pp. 1511-1518
    • Shih, I.1    Kurman, R.J.2
  • 66
    • 82955214537 scopus 로고    scopus 로고
    • Molecular pathogenesis of endometrial and ovarian cancer
    • Merritt, M.A.; Cramer, D.W. Molecular pathogenesis of endometrial and ovarian cancer. Cancer Biomarkers 2010, 9, 287-305.
    • (2010) Cancer Biomarkers , vol.9 , pp. 287-305
    • Merritt, M.A.1    Cramer, D.W.2
  • 68
    • 2442670288 scopus 로고    scopus 로고
    • Microsatellite instability and alteration of the expression of hMLH1 and hMSH2 in ovarian clear cell carcinoma
    • Cai, K.Q.; Albarracin, C.; Rosen, D.; Zhong, R.; Zheng, W.; Luthra, R.; Broaddus, R.; Liu, J. Microsatellite instability and alteration of the expression of hMLH1 and hMSH2 in ovarian clear cell carcinoma. Hum. Pathol. 2004, 35, 552-559.
    • (2004) Hum. Pathol. , vol.35 , pp. 552-559
    • Cai, K.Q.1    Albarracin, C.2    Rosen, D.3    Zhong, R.4    Zheng, W.5    Luthra, R.6    Broaddus, R.7    Liu, J.8
  • 71
    • 79958793918 scopus 로고    scopus 로고
    • The association with age, human tissue kallikreins 6 and 10 and hemostatic markers for survival outcome from epithelial ovarian cancer
    • Ovarian Cancer Research Consortium of SE Asia
    • Koh, S.C.; Razvi, K.; Chan, Y.H.; Narasimhan, K.; Ilancheran, A.; Low, J.J.; Choolani, M.; Ovarian Cancer Research Consortium of SE Asia. The association with age, human tissue kallikreins 6 and 10 and hemostatic markers for survival outcome from epithelial ovarian cancer. Arch. Gynecol. Obstet. 2011, 284, 183-190.
    • (2011) Arch. Gynecol. Obstet. , vol.284 , pp. 183-190
    • Koh, S.C.1    Razvi, K.2    Chan, Y.H.3    Narasimhan, K.4    Ilancheran, A.5    Low, J.J.6    Choolani, M.7
  • 72
  • 77
  • 82
    • 80055080310 scopus 로고    scopus 로고
    • Comparison of serum human epididymis protein 4 with cancer antigen 125 as a tumor marker in patients with malignant and nonmalignant diseases
    • Escudero J.M.; Auge, J.M.; Filella, X.; Torne, A.; Pahisa, J.; Molina, R. Comparison of serum human epididymis protein 4 with cancer antigen 125 as a tumor marker in patients with malignant and nonmalignant diseases. Clin. Chem. 2011, 57, 1534-1544.
    • (2011) Clin. Chem. , vol.57 , pp. 1534-1544
    • Escudero, J.M.1    Auge, J.M.2    Filella, X.3    Torne, A.4    Pahisa, J.5    Molina, R.6
  • 83
    • 84861494689 scopus 로고    scopus 로고
    • Two-marker combinations for preoperative discrimination of benign and malignant ovarian masses
    • Freydanck, M.K.; Laubender, R.P., Rack, B.; Schumacher, L.; Jeschke, U.; Scholz, C. Two-marker combinations for preoperative discrimination of benign and malignant ovarian masses. Anticancer Res. 2012, 32, 2003-2008.
    • (2012) Anticancer Res. , vol.32 , pp. 2003-2008
    • Freydanck, M.K.1    Laubender, R.P.2    Rack, B.3    Schumacher, L.4    Jeschke, U.5    Scholz, C.6
  • 85
    • 84858024838 scopus 로고    scopus 로고
    • Subjective assessment by ultrasound is superior to the risk of malignancy index (RMI) or the risk of ovarian malignancy algorithm (ROMA) in discriminating benign from malignant adnexal masses
    • Van Gorp, T.; Veldman, J.; van Calster, B.; Cadron, I.; Leunen, K.; Amant, F.; Timmermann, D.; Vergote, I. Subjective assessment by ultrasound is superior to the risk of malignancy index (RMI) or the risk of ovarian malignancy algorithm (ROMA) in discriminating benign from malignant adnexal masses. Eur. J. Cancer 2012, 48, 1649-1656.
    • (2012) Eur. J. Cancer , vol.48 , pp. 1649-1656
    • van Gorp, T.1    Veldman, J.2    van Calster, B.3    Cadron, I.4    Leunen, K.5    Amant, F.6    Timmermann, D.7    Vergote, I.8
  • 86
    • 84862292055 scopus 로고    scopus 로고
    • Does risk for ovarian malignancy algorithm excel human epididymis protein 4 and ca125 in predicting epithelial ovarian cancer. A meta-analysis
    • Li, F.; Tie, R.; Chang, K.; Wang, F.; Deng, S.; Lu, W.; Yu, L.; Chen, M. Does risk for ovarian malignancy algorithm excel human epididymis protein 4 and ca125 in predicting epithelial ovarian cancer. A meta-analysis. BMC Cancer 2012, 19, 258.
    • (2012) BMC Cancer , vol.19 , pp. 258
    • Li, F.1    Tie, R.2    Chang, K.3    Wang, F.4    Deng, S.5    Lu, W.6    Yu, L.7    Chen, M.8
  • 89
    • 84867397030 scopus 로고    scopus 로고
    • Immunohistochemical localization of HE4 in benign, borderline, and malignant lesions of the ovary
    • Georgakopoulos, P.; Mehmood, S.; Akalin, A.; Shroyer, K.R. Immunohistochemical localization of HE4 in benign, borderline, and malignant lesions of the ovary. Int. J. Gynecol. Pathol. 2012, 31, 517-523.
    • (2012) Int. J. Gynecol. Pathol. , vol.31 , pp. 517-523
    • Georgakopoulos, P.1    Mehmood, S.2    Akalin, A.3    Shroyer, K.R.4
  • 92
    • 78649265888 scopus 로고    scopus 로고
    • Ovarian cancer biomarkers for molecular biosensors and translational medicine
    • Suh, K.S.; Park S.W.; Castro, A.; Patel, H.; Blake, M.L.; Goy, A. Ovarian cancer biomarkers for molecular biosensors and translational medicine. Expert Rev. Mol. Diagn. 2010, 10, 1069-1083.
    • (2010) Expert Rev. Mol. Diagn. , vol.10 , pp. 1069-1083
    • Suh, K.S.1    Park, S.W.2    Castro, A.3    Patel, H.4    Blake, M.L.5    Goy, A.6
  • 94
    • 83655191714 scopus 로고    scopus 로고
    • Protein biomarkers of ovarian cancer: The forest and the trees
    • Nolen, B.M.; Lokshin, A.E. Protein biomarkers of ovarian cancer: The forest and the trees. Future Oncol. 2012, 8, 55-74.
    • (2012) Future Oncol. , vol.8 , pp. 55-74
    • Nolen, B.M.1    Lokshin, A.E.2
  • 95
    • 79952264074 scopus 로고    scopus 로고
    • Predictive and prognostic protein biomarkers in epithelial ovarian cancer: Recommendation for future studies
    • Le Page, C.; Huntsman, D.G.; Provencher, D.M.; Mes-Masson, A.-M. Predictive and prognostic protein biomarkers in epithelial ovarian cancer: Recommendation for future studies. Cancers 2010, 2, 913-954.
    • (2010) Cancers , vol.2 , pp. 913-954
    • Le Page, C.1    Huntsman, D.G.2    Provencher, D.M.3    Mes-Masson, A.-M.4
  • 99
    • 7044224620 scopus 로고    scopus 로고
    • Preoperative sensitivity and specificity for early-stage ovarian cancer when combining cancer antigen CA-125II, CA 15-3, CA 72-4, and macrophage colony-stimulating factor using mixtures of multivariate normal distributions
    • Skates, S.J.; Horick, N.; Yu, Y.; Xu, F.J.; Berchuck, A.; Havrilesky, L.J.; de Bruijn, H.W.; van der Zee, A.G.; Woolas, R.P.; Jacobs, I.J.; et al. Preoperative sensitivity and specificity for early-stage ovarian cancer when combining cancer antigen CA-125II, CA 15-3, CA 72-4, and macrophage colony-stimulating factor using mixtures of multivariate normal distributions. J. Clin. Oncol. 2004, 22, 4059-4066.
    • (2004) J. Clin. Oncol. , vol.22 , pp. 4059-4066
    • Skates, S.J.1    Horick, N.2    Yu, Y.3    Xu, F.J.4    Berchuck, A.5    Havrilesky, L.J.6    de Bruijn, H.W.7    van der Zee, A.G.8    Woolas, R.P.9    Jacobs, I.J.10
  • 101
  • 102
    • 79954672317 scopus 로고    scopus 로고
    • Genome structural variation discovery and genotyping
    • Alkan, C.; Bradley, P.C.; Eichler, E. Genome structural variation discovery and genotyping. Nat. Rev. 2011, 12, 363-376.
    • (2011) Nat. Rev. , vol.12 , pp. 363-376
    • Alkan, C.1    Bradley, P.C.2    Eichler, E.3
  • 103
    • 77949831756 scopus 로고    scopus 로고
    • Structural variation in the human genome and its role in disease
    • Stankiewicz, P.; Lupski, J.R. Structural variation in the human genome and its role in disease. Annu. Rev. Med. 2010, 61, 437-455.
    • (2010) Annu. Rev. Med. , vol.61 , pp. 437-455
    • Stankiewicz, P.1    Lupski, J.R.2
  • 106
    • 58149216953 scopus 로고    scopus 로고
    • Fanconi Anemia: Causes and Consequences of Genetic Instability
    • In, Volff, J.N., Ed.; Karger: Basel, Switzerland
    • Kalb, R.; Neveling, K.; Nanda, I.; Schindler, D.; Hoehn, H. Fanconi Anemia: Causes and Consequences of Genetic Instability. In Genome and Disease. Genome Dyn; Volff, J.N., Ed.; Karger: Basel, Switzerland, 2006; Volume 1, pp. 218-242.
    • (2006) Genome and Disease. Genome Dyn , vol.1 , pp. 218-242
    • Kalb, R.1    Neveling, K.2    Nanda, I.3    Schindler, D.4    Hoehn, H.5
  • 108
    • 46749157576 scopus 로고    scopus 로고
    • MLPA screening in the BRCA1 gene from 1506 German hereditary breast cancer cases: Novel deletions, frequent involvement of exon 17, and occurrence in single early-onset cases
    • Engert, S.; Wappenschmidt, B.; Betz, B.; Kast, K.; Kutsche, M.; Hellebrand, H.; Goecke, T.O.; Kiechle, M.; Niederacher, D.; Schmutzler, R.K.; et al. MLPA screening in the BRCA1 gene from 1506 German hereditary breast cancer cases: Novel deletions, frequent involvement of exon 17, and occurrence in single early-onset cases. Hum. Mutat. 2008, 29, 948-958.
    • (2008) Hum. Mutat. , vol.29 , pp. 948-958
    • Engert, S.1    Wappenschmidt, B.2    Betz, B.3    Kast, K.4    Kutsche, M.5    Hellebrand, H.6    Goecke, T.O.7    Kiechle, M.8    Niederacher, D.9    Schmutzler, R.K.10
  • 109
    • 79959838081 scopus 로고    scopus 로고
    • Integrated genomic analyses of ovarian carcinoma
    • The Cancer Genome Atlas Research Network
    • The Cancer Genome Atlas Research Network. Integrated genomic analyses of ovarian carcinoma. Nature 2011, 474, 609-615.
    • (2011) Nature , vol.474 , pp. 609-615
  • 114
    • 0037102445 scopus 로고    scopus 로고
    • Gene expression in ovarian cancer reflects both morphology and biological behavior, distinguishing clear cell from other poor-prognosis ovarian carcinomas
    • Schwartz, D.R.; Kardia, S.L.; Shedden, K.A.; Kuick, R.; Michailidis, G.; Taylor, J.M.; Misek, D.E.; Wu, R.; Zhai, Y.; Darrah, D.M.; et al. Gene expression in ovarian cancer reflects both morphology and biological behavior, distinguishing clear cell from other poor-prognosis ovarian carcinomas. Cancer Res. 2002, 62, 4722-4729.
    • (2002) Cancer Res. , vol.62 , pp. 4722-4729
    • Schwartz, D.R.1    Kardia, S.L.2    Shedden, K.A.3    Kuick, R.4    Michailidis, G.5    Taylor, J.M.6    Misek, D.E.7    Wu, R.8    Zhai, Y.9    Darrah, D.M.10
  • 118
    • 84860214430 scopus 로고    scopus 로고
    • Meta-analysis of gene expression profiles associated with histological classification and survival in 829 ovarian cancer samples
    • Fekete, T.; Rásó, E.; Pete, I.; Tegze, B.; Liko, I.; Munkácsy, G.; Sipos, N.; Rigó, J., Jr.; Györffy, B. Meta-analysis of gene expression profiles associated with histological classification and survival in 829 ovarian cancer samples. Int. J. Cancer 2012, 131, 95-105.
    • (2012) Int. J. Cancer , vol.131 , pp. 95-105
    • Fekete, T.1    Rásó, E.2    Pete, I.3    Tegze, B.4    Liko, I.5    Munkácsy, G.6    Sipos, N.7    Rigó Jr., J.8    Györffy, B.9
  • 119
    • 84862188915 scopus 로고    scopus 로고
    • A DNA repair pathway-focused score for prediction of outcomes in ovarian cancer treated with platinum-based chemotherapy
    • Kang, J.; D'Andrea, A.D.; Kozono, D. A DNA repair pathway-focused score for prediction of outcomes in ovarian cancer treated with platinum-based chemotherapy. J. Natl. Cancer Inst. 2012, 104, 670-681.
    • (2012) J. Natl. Cancer Inst. , vol.104 , pp. 670-681
    • Kang, J.1    D'Andrea, A.D.2    Kozono, D.3
  • 121
    • 77954125830 scopus 로고    scopus 로고
    • Role of epigenomics in ovarian and endometrial cancers
    • Balch, C.; Matei, D.E.; Huang, T.H.; Nephew, K.P. Role of epigenomics in ovarian and endometrial cancers. Epigenomics 2010, 2, 419-447.
    • (2010) Epigenomics , vol.2 , pp. 419-447
    • Balch, C.1    Matei, D.E.2    Huang, T.H.3    Nephew, K.P.4
  • 122
    • 33847065486 scopus 로고    scopus 로고
    • The epigenomics of cancer
    • Jones, P.A.; Baylin, S.B. The epigenomics of cancer. Cell 2007, 128, 683-692.
    • (2007) Cell , vol.128 , pp. 683-692
    • Jones, P.A.1    Baylin, S.B.2
  • 123
    • 0034307160 scopus 로고    scopus 로고
    • BRCA1 promoter region hypermethylation in ovarian carcinoma: A population-based study
    • Baldwin, R.L.; Nemeth, E.; Tran, H.; Shvartsman, H.; Cass, I.; Narod, S.; Karlan, B.Y. BRCA1 promoter region hypermethylation in ovarian carcinoma: A population-based study. Cancer Res. 2000, 60, 5329-5333.
    • (2000) Cancer Res. , vol.60 , pp. 5329-5333
    • Baldwin, R.L.1    Nemeth, E.2    Tran, H.3    Shvartsman, H.4    Cass, I.5    Narod, S.6    Karlan, B.Y.7
  • 124
    • 0035099160 scopus 로고    scopus 로고
    • Primary ovarian carcinomas display multiple methylator phenotypes involving known tumor suppressor genes
    • Strathdee, G.; Appleton, K.; Illand, M.; Millan, D.W.; Sargent, J.; Paul, J.; Brown, R. Primary ovarian carcinomas display multiple methylator phenotypes involving known tumor suppressor genes. Am. J. Pathol. 2001, 158, 1121-1127.
    • (2001) Am. J. Pathol. , vol.158 , pp. 1121-1127
    • Strathdee, G.1    Appleton, K.2    Illand, M.3    Millan, D.W.4    Sargent, J.5    Paul, J.6    Brown, R.7
  • 129
    • 4944229642 scopus 로고    scopus 로고
    • Hallmarks of "BRCAness" in sporadic cancers
    • Turner, N.; Tutt, A.; Ashworth, A. Hallmarks of "BRCAness" in sporadic cancers. Nat. Rev. Cancer 2004, 4, 814-819.
    • (2004) Nat. Rev. Cancer , vol.4 , pp. 814-819
    • Turner, N.1    Tutt, A.2    Ashworth, A.3
  • 130
    • 79959825588 scopus 로고    scopus 로고
    • Translational application of epigenetic alterations: Ovarian cancer as a model
    • Maradeo, M.E.; Cairns, P. Translational application of epigenetic alterations: Ovarian cancer as a model. FEBS Lett. 2011, 585, 2112-2120.
    • (2011) FEBS Lett. , vol.585 , pp. 2112-2120
    • Maradeo, M.E.1    Cairns, P.2
  • 131
    • 84868354895 scopus 로고    scopus 로고
    • BRCA1 epigenetic inactivation predicts sensitivity to platinum-based chemotherapy in breast and ovarian cancer
    • Stefansson, O.A.; Villanueva, A.; Vidal, A.; Martí, L.; Esteller, M. BRCA1 epigenetic inactivation predicts sensitivity to platinum-based chemotherapy in breast and ovarian cancer. Epigenetics 2012, 7, 1225-1229.
    • (2012) Epigenetics , vol.7 , pp. 1225-1229
    • Stefansson, O.A.1    Villanueva, A.2    Vidal, A.3    Martí, L.4    Esteller, M.5
  • 132
    • 33847271255 scopus 로고    scopus 로고
    • Links between DNA double strand break repair and breast cancer: Accumulating evidence from both familial and nonfamilial cases
    • Ralhan, R.; Kaur, J.; Kreienberg, R.; Wiesmüller, L. Links between DNA double strand break repair and breast cancer: Accumulating evidence from both familial and nonfamilial cases. Cancer Lett. 2007, 248, 1-17.
    • (2007) Cancer Lett. , vol.248 , pp. 1-17
    • Ralhan, R.1    Kaur, J.2    Kreienberg, R.3    Wiesmüller, L.4
  • 133
    • 24944575242 scopus 로고    scopus 로고
    • BACH1 is critical for homologous recombination and appears to be the Fanconi anemia gene product FANCJ
    • Litman, R.; Peng, M.; Jin, Z.; Zhang, F.; Zhang, J.; Powell, S.; Andreassen, P.R.; Cantor, S.B. BACH1 is critical for homologous recombination and appears to be the Fanconi anemia gene product FANCJ. Cancer Cell 2005, 8, 255-265.
    • (2005) Cancer Cell , vol.8 , pp. 255-265
    • Litman, R.1    Peng, M.2    Jin, Z.3    Zhang, F.4    Zhang, J.5    Powell, S.6    Andreassen, P.R.7    Cantor, S.B.8
  • 134
    • 0024523360 scopus 로고
    • Kinetochore detection in micronuclei: An alternative method for measuring chromosome loss
    • Fenech, M.; Morley, A.A. Kinetochore detection in micronuclei: An alternative method for measuring chromosome loss. Mutagenesis 1989, 4, 98-104.
    • (1989) Mutagenesis , vol.4 , pp. 98-104
    • Fenech, M.1    Morley, A.A.2
  • 135
    • 0034693730 scopus 로고    scopus 로고
    • The in vitro micronucleus technique
    • Fenech, M. The in vitro micronucleus technique. Mutat. Res. 2000, 455, 81-95.
    • (2000) Mutat. Res. , vol.455 , pp. 81-95
    • Fenech, M.1
  • 136
    • 0035024943 scopus 로고    scopus 로고
    • Hydrogen peroxide: Effects on DNA, chromosomes, cell cycle and apoptosis induction in Fanconi's anemia cell lines
    • Zunino, A.; Degan, P.; Vigo, T.; Abbondandolo, A. Hydrogen peroxide: Effects on DNA, chromosomes, cell cycle and apoptosis induction in Fanconi's anemia cell lines. Mutagenesis 2001, 16, 283-288.
    • (2001) Mutagenesis , vol.16 , pp. 283-288
    • Zunino, A.1    Degan, P.2    Vigo, T.3    Abbondandolo, A.4
  • 137
    • 0037419723 scopus 로고    scopus 로고
    • Use of the cytokinesis-block micronucleus assay to measure radiation-induced chromosome damage in lymphoblastoid cell lines
    • Gutiérrez-Enríquez, S.; Hall, J. Use of the cytokinesis-block micronucleus assay to measure radiation-induced chromosome damage in lymphoblastoid cell lines. Mutat. Res. 2003, 535, 1-13.
    • (2003) Mutat. Res. , vol.535 , pp. 1-13
    • Gutiérrez-Enríquez, S.1    Hall, J.2
  • 139
    • 84857048701 scopus 로고    scopus 로고
    • Role of micronucleus test in predicting breast cancer susceptibility: A systematic review and meta-analysis
    • Cardinale, F.; Bruzzi, P.; Bolognesi, C. Role of micronucleus test in predicting breast cancer susceptibility: A systematic review and meta-analysis. Br. J. Cancer 2012, 106, 780-790.
    • (2012) Br. J. Cancer , vol.106 , pp. 780-790
    • Cardinale, F.1    Bruzzi, P.2    Bolognesi, C.3
  • 141
    • 46049108550 scopus 로고    scopus 로고
    • A sensitive test for the detection of specific DSB repair defects in primary cells from breast cancer specimens
    • Keimling, M.; Kaur, J.; Bagadi, S.A.; Kreienberg, R.; Wiesmüller, L.; Ralhan, R. A sensitive test for the detection of specific DSB repair defects in primary cells from breast cancer specimens. Int. J. Cancer 2008, 123, 730-736.
    • (2008) Int. J. Cancer , vol.123 , pp. 730-736
    • Keimling, M.1    Kaur, J.2    Bagadi, S.A.3    Kreienberg, R.4    Wiesmüller, L.5    Ralhan, R.6
  • 142
    • 80355131376 scopus 로고    scopus 로고
    • Functional characterization connects individual patient mutations in ataxia telangiectasia mutated (ATM) with dysfunction of specific DNA double-strand break-repair signaling pathways
    • Keimling, M.; Volcic, M.; Csernok, A.; Wieland, B.; Dörk, T.; Wiesmüller, L. Functional characterization connects individual patient mutations in ataxia telangiectasia mutated (ATM) with dysfunction of specific DNA double-strand break-repair signaling pathways. FASEB J. 2011, 25, 3849-3860.
    • (2011) FASEB J. , vol.25 , pp. 3849-3860
    • Keimling, M.1    Volcic, M.2    Csernok, A.3    Wieland, B.4    Dörk, T.5    Wiesmüller, L.6
  • 143
    • 49249119415 scopus 로고    scopus 로고
    • A synthetic lethal therapeutic approach: Poly(ADP) ribose polymerase inhibitors for the treatment of cancers deficient in DNA double-strand break repair
    • Ashworth, A. A synthetic lethal therapeutic approach: Poly(ADP) ribose polymerase inhibitors for the treatment of cancers deficient in DNA double-strand break repair. J. Clin. Oncol. 2008, 26, 3785-3790.
    • (2008) J. Clin. Oncol. , vol.26 , pp. 3785-3790
    • Ashworth, A.1
  • 144
    • 84859378520 scopus 로고    scopus 로고
    • Minireview: Human ovarian cancer: Biology, current management, and paths to personalizing therapy
    • Romero, I.; Bast, R.C., Jr. Minireview: Human ovarian cancer: Biology, current management, and paths to personalizing therapy. Endocrinology 2012, 153, 1593-1602.
    • (2012) Endocrinology , vol.153 , pp. 1593-1602
    • Romero, I.1    Bast Jr., R.C.2
  • 146
    • 0036498788 scopus 로고    scopus 로고
    • Survival effect of maximal cytoreductive surgery for advanced ovarian carcinoma during paltinum era: A-meta analysis
    • Bristow, R.E.; Tomacruz, R.S.; Armstrong, D.K.; Trimble, E.L.; Montz, FJ. Survival effect of maximal cytoreductive surgery for advanced ovarian carcinoma during paltinum era: A-meta analysis. J. Clin. Oncol. 2002, 20, 1248-1259.
    • (2002) J. Clin. Oncol. , vol.20 , pp. 1248-1259
    • Bristow, R.E.1    Tomacruz, R.S.2    Armstrong, D.K.3    Trimble, E.L.4    Montz, F.J.5
  • 148
    • 24044456731 scopus 로고    scopus 로고
    • The role of surgery in ovarian cancer with special emphasis on cytoreductive surgery for recurrence
    • Harter, P.; du Bois, A. The role of surgery in ovarian cancer with special emphasis on cytoreductive surgery for recurrence. Curr. Opin. Oncol. 2005, 17, 505-514.
    • (2005) Curr. Opin. Oncol. , vol.17 , pp. 505-514
    • Harter, P.1    du Bois, A.2
  • 151
    • 0037125582 scopus 로고    scopus 로고
    • Paclitaxel plus carboplatin versus standard chemotherapy with either single-agent carboplatin or cyclophosphamide, doxorubicin, and cisplatin in women with ovarian cancer: The ICON3 randomised trial
    • International Collaborative Ovarian Neoplasm Group
    • International Collaborative Ovarian Neoplasm Group. Paclitaxel plus carboplatin versus standard chemotherapy with either single-agent carboplatin or cyclophosphamide, doxorubicin, and cisplatin in women with ovarian cancer: The ICON3 randomised trial. Lancet 2002, 360, 505-515.
    • (2002) Lancet , vol.360 , pp. 505-515
  • 153
    • 36349028594 scopus 로고    scopus 로고
    • Combination therapy with pegylated liposomal doxorubicin and carboplatin in gynecologic malignancies: A prospective phase II study of the Arbeitsgemeinschaft Gynäekologische Onkologie Studiengruppe Ovarialkarzinom (AGO-OVAR) and Kommission Uterus (AGO-K-Ut)
    • Du Bois, A.; Pfisterer, J.; Burchardi, N.; Loibl, S.; Huober, J.; Wimberger, P.; Burges, A.; Stähle, A.; Jackisch, C.; Kölbl, H.; et al. Combination therapy with pegylated liposomal doxorubicin and carboplatin in gynecologic malignancies: A prospective phase II study of the Arbeitsgemeinschaft Gynäekologische Onkologie Studiengruppe Ovarialkarzinom (AGO-OVAR) and Kommission Uterus (AGO-K-Ut). Gynecol. Oncol. 2007, 107, 518-525.
    • (2007) Gynecol. Oncol. , vol.107 , pp. 518-525
    • du Bois, A.1    Pfisterer, J.2    Burchardi, N.3    Loibl, S.4    Huober, J.5    Wimberger, P.6    Burges, A.7    Stähle, A.8    Jackisch, C.9    Kölbl, H.10
  • 155
    • 79251635492 scopus 로고    scopus 로고
    • A randomized Phase II/III trial of 3 weekly intraperitoneal versus intravenous carboplatin in combination with intravenous weekly dose-dense paclitaxel for newly diagnosed ovarian, fallopian tube and primary peritoneal cancer
    • Fujiwara, K.; Aotani, E.; Hamano, T.; Nagao, S.; Yoshikawa, H.; Sugiyama, T.; Kigawa, J.; Aoki, D.; Katsumata, N.; Takeuchi, M.; et al. A randomized Phase II/III trial of 3 weekly intraperitoneal versus intravenous carboplatin in combination with intravenous weekly dose-dense paclitaxel for newly diagnosed ovarian, fallopian tube and primary peritoneal cancer. Jpn. J. Clin. Oncol. 2011, 41, 278-282.
    • (2011) Jpn. J. Clin. Oncol. , vol.41 , pp. 278-282
    • Fujiwara, K.1    Aotani, E.2    Hamano, T.3    Nagao, S.4    Yoshikawa, H.5    Sugiyama, T.6    Kigawa, J.7    Aoki, D.8    Katsumata, N.9    Takeuchi, M.10
  • 157
    • 57149093237 scopus 로고    scopus 로고
    • "BRCAness" syndrome in ovarian cancer: A case-control study describing the clinical features and outcome of patients with epithelial ovarian cancer associated with BRCA1 and BRCA2 mutations
    • Tan, D.S.; Rothermundt, C.; Thomas, K.; Bancroft, E.; Eeles, R.; Shanley, S.; Ardern-Jones, A.; Norman, A.; Kaye, S.B.; Gore, M.E. "BRCAness" syndrome in ovarian cancer: A case-control study describing the clinical features and outcome of patients with epithelial ovarian cancer associated with BRCA1 and BRCA2 mutations. J. Clin. Oncol. 2008, 26, 5530-5536.
    • (2008) J. Clin. Oncol. , vol.26 , pp. 5530-5536
    • Tan, D.S.1    Rothermundt, C.2    Thomas, K.3    Bancroft, E.4    Eeles, R.5    Shanley, S.6    Ardern-Jones, A.7    Norman, A.8    Kaye, S.B.9    Gore, M.E.10
  • 158
    • 84866854042 scopus 로고    scopus 로고
    • Identification of DNA repair pathways that affect the survival of ovarian cancer cells treated with a PARP inhibitor in a novel drug combination
    • Huehls, A.M.; Wagner, J.M.; Huntoon, C.J.; Karnitz, L.M. Identification of DNA repair pathways that affect the survival of ovarian cancer cells treated with a PARP inhibitor in a novel drug combination. Mol. Pharmacol. 2012, 82, 767-776.
    • (2012) Mol. Pharmacol. , vol.82 , pp. 767-776
    • Huehls, A.M.1    Wagner, J.M.2    Huntoon, C.J.3    Karnitz, L.M.4
  • 159
    • 78149465125 scopus 로고    scopus 로고
    • Targeting poly(ADP-ribose)polymerase activity for cancer therapy
    • Mégnin-Chanet, F.; Bollet, M.A.; Hall, J. Targeting poly(ADP-ribose)polymerase activity for cancer therapy. Cell Mol. Life Sci. 2010, 67, 3649-3662.
    • (2010) Cell Mol. Life Sci. , vol.67 , pp. 3649-3662
    • Mégnin-Chanet, F.1    Bollet, M.A.2    Hall, J.3
  • 160
    • 79551587725 scopus 로고    scopus 로고
    • PARP inhibitor treatment in ovarian and breast cancer
    • Weil, M.K.; Chen, A.P. PARP inhibitor treatment in ovarian and breast cancer. Curr. Probl. Cancer 2012, 35, 7-50.
    • (2012) Curr. Probl. Cancer , vol.35 , pp. 7-50
    • Weil, M.K.1    Chen, A.P.2
  • 164
    • 77956657460 scopus 로고    scopus 로고
    • Poly (ADP-ribose) polymerase as a novel therapeutic target in cancer
    • Annunziata, C.M.; Shaughnessy, J. Poly (ADP-ribose) polymerase as a novel therapeutic target in cancer. Clin. Cancer Res. 2010, 16, 4517-4526.
    • (2010) Clin. Cancer Res. , vol.16 , pp. 4517-4526
    • Annunziata, C.M.1    Shaughnessy, J.2
  • 165
    • 80052243196 scopus 로고    scopus 로고
    • The role of poly adenosine diphosphate ribose polymerase inhibitors in breast and ovarian cancer: Current status and future directions
    • Chionh, F.; Mitchell, G.; Lindeman, G.J.; Friedlander, M.; Scott, C.L. The role of poly adenosine diphosphate ribose polymerase inhibitors in breast and ovarian cancer: Current status and future directions. Asia Pac. J. Clin. Oncol. 2011, 7, 197-211.
    • (2011) Asia Pac. J. Clin. Oncol. , vol.7 , pp. 197-211
    • Chionh, F.1    Mitchell, G.2    Lindeman, G.J.3    Friedlander, M.4    Scott, C.L.5
  • 170
    • 84869210797 scopus 로고    scopus 로고
    • Clinicopathological features of homologous recombination-deficient epithelial ovarian cancers: Sensitivity to PARP inhibitors, platinum, and survival
    • Mukhopadhyay, A.; Plummer, E.R.; Elattar, A.; Soohoo, S.; Uzir, B.; Quinn, J.E.; McCluggaga, W.G.; Maxwell, P.; Aneke, H.; Curtin, N.J.; et al. Clinicopathological features of homologous recombination-deficient epithelial ovarian cancers: Sensitivity to PARP inhibitors, platinum, and survival. Cancer Res. 2012, 15, 5675-5682.
    • (2012) Cancer Res. , vol.15 , pp. 5675-5682
    • Mukhopadhyay, A.1    Plummer, E.R.2    Elattar, A.3    Soohoo, S.4    Uzir, B.5    Quinn, J.E.6    McCluggaga, W.G.7    Maxwell, P.8    Aneke, H.9    Curtin, N.J.10
  • 171
    • 58249095937 scopus 로고    scopus 로고
    • BRCA1-associated protein 1 interferes with BRCA1/BARD1 RING heterodimer activity
    • Nishikawa, H.; Wu, W.; Koike, A.; Kojima, R.; Gomi, H.; Fukuda, M.; Ohta, T. BRCA1-associated protein 1 interferes with BRCA1/BARD1 RING heterodimer activity. Cancer Res. 2009, 69, 111-119.
    • (2009) Cancer Res. , vol.69 , pp. 111-119
    • Nishikawa, H.1    Wu, W.2    Koike, A.3    Kojima, R.4    Gomi, H.5    Fukuda, M.6    Ohta, T.7


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