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Volumn 2, Issue 2, 2010, Pages 913-954

Predictive and prognostic protein biomarkers in epithelial ovarian cancer: Recommendation for future studies

Author keywords

Gynecologic cancer; Immunohistochemistry; Outcome

Indexed keywords

BETA CATENIN; BRCA2 PROTEIN; CASPASE; CYCLIN D1; CYCLIN E; CYCLINE; DNA TOPOISOMERASE; EXCISION REPAIR CROSS COMPLEMENTING PROTEIN 1; FAS ANTIGEN; FAS LIGAND; HYPOXIA INDUCIBLE FACTOR; INHIBITOR OF APOPTOSIS PROTEIN; KI 67 ANTIGEN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PACLITAXEL; PLATINUM COMPLEX; PROTEIN BCL 2; PROTEIN DERIVATIVE; PROTEIN P16; PROTEIN P21; PROTEIN P27; PROTEIN P53; PROTEIN P57; REGULATOR PROTEIN; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND RECEPTOR; TYROSINE KINASE RECEPTOR; UNINDEXED DRUG; UVOMORULIN; VASCULOTROPIN;

EID: 79952264074     PISSN: None     EISSN: 20726694     Source Type: Journal    
DOI: 10.3390/cancers2020913     Document Type: Review
Times cited : (28)

References (288)
  • 1
    • 0035008525 scopus 로고    scopus 로고
    • Ovarian surface epithelium: Biology, endocrinology, and pathology
    • Auersperg, N.; Wong, A.S.; Choi, K.C.; Kang, S. K.; Leung, P.C. Ovarian surface epithelium: biology, endocrinology, and pathology. Endocr. Rev. 2001, 22, 255-288.
    • (2001) Endocr. Rev. , vol.22 , pp. 255-288
    • Auersperg, N.1    Wong, A.S.2    Choi, K.C.3    Kang, S.K.4    Leung, P.C.5
  • 2
    • 55949089955 scopus 로고    scopus 로고
    • New insights into the pathogenesis of serous ovarian cancer and its clinical impact
    • Levanon, K.; Crum, C.; Drapkin, R. New insights into the pathogenesis of serous ovarian cancer and its clinical impact. J. Clin. Oncol. 2008, 26, 5284-5293.
    • (2008) J. Clin. Oncol. , vol.26 , pp. 5284-5293
    • Levanon, K.1    Crum, C.2    Drapkin, R.3
  • 3
    • 63549096634 scopus 로고    scopus 로고
    • Hereditary ovarian carcinoma: Heterogeneity, molecular genetics, pathology, and management
    • Lynch, H.T.; Casey, M.J.; Snyder, C.L.; Bewtra, C.; Lynch, J.F.; Butts, M.; Godwin, A.K. Hereditary ovarian carcinoma: heterogeneity, molecular genetics, pathology, and management. Mol. Oncol. 2009, 3, 97-137.
    • (2009) Mol. Oncol. , vol.3 , pp. 97-137
    • Lynch, H.T.1    Casey, M.J.2    Snyder, C.L.3    Bewtra, C.4    Lynch, J.F.5    Butts, M.6    Godwin, A.K.7
  • 4
    • 68349155807 scopus 로고    scopus 로고
    • Ovarian carcinoma pathology and genetics: Recent advances
    • Gilks, C.B.; Prat, J. Ovarian carcinoma pathology and genetics: recent advances. Hum. Pathol. 2009, 40, 1213-1223.
    • (2009) Hum. Pathol. , vol.40 , pp. 1213-1223
    • Gilks, C.B.1    Prat, J.2
  • 7
    • 41349083323 scopus 로고    scopus 로고
    • Mechanisms of chemoresistance and poor prognosis in ovarian clear cell carcinoma
    • Itamochi, H.; Kigawa, J.; Terakawa, N. Mechanisms of chemoresistance and poor prognosis in ovarian clear cell carcinoma. Cancer Sci. 2008, 99, 653-658.
    • (2008) Cancer Sci , vol.99 , pp. 653-658
    • Itamochi, H.1    Kigawa, J.2    Terakawa, N.3
  • 9
    • 11244354859 scopus 로고    scopus 로고
    • Platinums: Extending their therapeutic spectrum
    • Muggia, F.M.; Fojo, T. Platinums: extending their therapeutic spectrum. J. Chemother. 2004, 16 (Suppl. 4), 77-82.
    • (2004) J. Chemother. , vol.16 , Issue.SUPPL. 4 , pp. 77-82
    • Muggia, F.M.1    Fojo, T.2
  • 10
    • 57649101120 scopus 로고    scopus 로고
    • Platinum compounds 30 years after the introduction of cisplatin: Implications for the treatment of ovarian cancer
    • Muggia, F. Platinum compounds 30 years after the introduction of cisplatin: implications for the treatment of ovarian cancer. Gynecol. Oncol. 2009, 112, 275-281.
    • (2009) Gynecol. Oncol. , vol.112 , pp. 275-281
    • Muggia, F.1
  • 12
    • 56449098987 scopus 로고    scopus 로고
    • Serum and tissue biomarkers as predictive and prognostic variables in epithelial ovarian cancer
    • Gadducci, A.; Cosio, S.; Tana, R.; Genazzani, A.R. Serum and tissue biomarkers as predictive and prognostic variables in epithelial ovarian cancer. Crit. Rev. Oncol. Hematol. 2009, 69, 12-27.
    • (2009) Crit. Rev. Oncol. Hematol. , vol.69 , pp. 12-27
    • Gadducci, A.1    Cosio, S.2    Tana, R.3    Genazzani, A.R.4
  • 15
    • 0034004365 scopus 로고    scopus 로고
    • Immunohistochemical detection of the Wilms' tumor gene (WT1) in epithelial ovarian tumors
    • Shimizu, M.; Toki, T.; Takagi, Y.; Konishi, I.; Fujii, S. Immunohistochemical detection of the Wilms' tumor gene (WT1) in epithelial ovarian tumors. Int. J. Gynecol Pathol. 2000, 19, 158-163.
    • (2000) Int. J. Gynecol Pathol. , vol.19 , pp. 158-163
    • Shimizu, M.1    Toki, T.2    Takagi, Y.3    Konishi, I.4    Fujii, S.5
  • 18
    • 34547137183 scopus 로고    scopus 로고
    • Expression level of Wilms tumor 1 (WT1) protein has limited prognostic value in epithelial ovarian cancer: From the Danish MALOVA ovarian cancer study
    • Hogdall, E.V.; Christensen, L.; Kjaer, S. K.; Blaakaer, J.; Christensen, I.J.; Gayther, S.; Jacobs, I.J.; Hogdall, C.K. Expression level of Wilms tumor 1 (WT1) protein has limited prognostic value in epithelial ovarian cancer: from the Danish MALOVA ovarian cancer study. Gynecol. Oncol. 2007, 106, 318-324.
    • (2007) Gynecol. Oncol. , vol.106 , pp. 318-324
    • Hogdall, E.V.1    Christensen, L.2    Kjaer, S.K.3    Blaakaer, J.4    Christensen, I.J.5    Gayther, S.6    Jacobs, I.J.7    Hogdall, C.K.8
  • 19
    • 33745067420 scopus 로고    scopus 로고
    • WT1 gene expression as a prognostic marker in advanced serous epithelial ovarian carcinoma: An immunohistochemical study
    • Netinatsunthorn, W.; Hanprasertpong, J.; Dechsukhum, C.; Leetanaporn, R.; Geater, A. WT1 gene expression as a prognostic marker in advanced serous epithelial ovarian carcinoma: an immunohistochemical study. BMC Cancer 2006, 6, 90.
    • (2006) BMC Cancer , vol.6 , pp. 90
    • Netinatsunthorn, W.1    Hanprasertpong, J.2    Dechsukhum, C.3    Leetanaporn, R.4    Geater, A.5
  • 20
    • 35748982942 scopus 로고    scopus 로고
    • Clinicopathological significance of WT1 expression in ovarian cancer: A possible accelerator of tumor progression in serous adenocarcinoma
    • Yamamoto, S.; Tsuda, H.; Kita, T.; Maekawa, K.; Fujii, K.; Kudoh, K.; Furuya, K.; Tamai, S.; Inazawa, J.; Matsubara, O. Clinicopathological significance of WT1 expression in ovarian cancer: a possible accelerator of tumor progression in serous adenocarcinoma. Virchows Arch. 2007, 451, 27-35.
    • (2007) Virchows Arch , vol.451 , pp. 27-35
    • Yamamoto, S.1    Tsuda, H.2    Kita, T.3    Maekawa, K.4    Fujii, K.5    Kudoh, K.6    Furuya, K.7    Tamai, S.8    Inazawa, J.9    Matsubara, O.10
  • 22
    • 34748858558 scopus 로고    scopus 로고
    • The clinical importance of Ki-67, p16, p14, and p57 expression in patients with advanced ovarian carcinoma
    • Khouja, M.H.; Baekelandt, M.; Nesland, J. M.; Holm, R. The clinical importance of Ki-67, p16, p14, and p57 expression in patients with advanced ovarian carcinoma. Int. J. Gynecol. Pathol. 2007, 26, 418-425.
    • (2007) Int. J. Gynecol. Pathol. , vol.26 , pp. 418-425
    • Khouja, M.H.1    Baekelandt, M.2    Nesland, J.M.3    Holm, R.4
  • 24
    • 12444346877 scopus 로고    scopus 로고
    • Prognostic significance of Ki-67 antigen immunostaining (MIB-1 monoclonal antibody) in ovarian cancer
    • Mita, S.; Nakai, A.; Maeda, S.; Takeshita, T. Prognostic significance of Ki-67 antigen immunostaining (MIB-1 monoclonal antibody) in ovarian cancer. J. Nippon Med. Sch. 2004, 71, 384-391.
    • (2004) J. Nippon Med. Sch. , vol.71 , pp. 384-391
    • Mita, S.1    Nakai, A.2    Maeda, S.3    Takeshita, T.4
  • 25
    • 48749085401 scopus 로고    scopus 로고
    • Immunohistochemical analysis of possible chemoresistance markers identified by micro-arrays on serous ovarian carcinomas
    • Tetu, B.; Popa, I.; Bairati, I.; L'Esperance, S.; Bachvarova, M.; Plante, M.; Harel, F.; Bachvarov, D. Immunohistochemical analysis of possible chemoresistance markers identified by micro-arrays on serous ovarian carcinomas. Mod. Pathol. 2008, 21, 1002-1010.
    • (2008) Mod. Pathol. , vol.21 , pp. 1002-1010
    • Tetu, B.1    Popa, I.2    Bairati, I.3    L'Esperance, S.4    Bachvarova, M.5    Plante, M.6    Harel, F.7    Bachvarov, D.8
  • 26
    • 0028905370 scopus 로고
    • Ki67 antigen immunostaining (MIB 1 monoclonal antibody) in serous ovarian tumors: Index of proliferative activity with prognostic significance
    • Garzetti, G.G.; Ciavattini, A.; Goteri, G.; De Nictolis, M.; Stramazzotti, D.; Lucarini, G.; Biagini, G. Ki67 antigen immunostaining (MIB 1 monoclonal antibody) in serous ovarian tumors: index of proliferative activity with prognostic significance. Gynecol. Oncol. 1995, 56, 169-174.
    • (1995) Gynecol. Oncol. , vol.56 , pp. 169-174
    • Garzetti, G.G.1    Ciavattini, A.2    Goteri, G.3    de Nictolis, M.4    Stramazzotti, D.5    Lucarini, G.6    Biagini, G.7
  • 27
    • 0026674241 scopus 로고
    • Assessment of proliferative activity in ovarian neoplasms by flow and static cytometry. Correlation with prognostic features
    • Huettner, P.C.; Weinberg, D.S.; Lage, J.M. Assessment of proliferative activity in ovarian neoplasms by flow and static cytometry. Correlation with prognostic features. Am. J. Pathol. 1992, 141, 699-706.
    • (1992) Am. J. Pathol. , vol.141 , pp. 699-706
    • Huettner, P.C.1    Weinberg, D.S.2    Lage, J.M.3
  • 28
    • 0033943585 scopus 로고    scopus 로고
    • [Comparative studies on the biological significance of the marker for proliferation Ki-67-Antigen and PCNA in primary ovarian carcinoma]
    • Reitmaier, M.; Rudlowski, C.; Biesterfeld, S.; Rath, W.; Schroder, W.[Comparative studies on the biological significance of the marker for proliferation Ki-67-Antigen and PCNA in primary ovarian carcinoma]. Zentralbl. Gynakol. 2000, 122, 361-367.
    • (2000) Zentralbl. Gynakol. , vol.122 , pp. 361-367
    • Reitmaier, M.1    Rudlowski, C.2    Biesterfeld, S.3    Rath, W.4    Schroder, W.5
  • 29
    • 27244438950 scopus 로고    scopus 로고
    • [Prognostic markers in ovarian carcinoma--retrospective study]
    • Tomsova, M.; Melichar, B.; Sedlakova, I.; Nova, M.[Prognostic markers in ovarian carcinoma--retrospective study]. Cesk. Patol. 2005, 41, 51-59.
    • (2005) Cesk. Patol. , vol.41 , pp. 51-59
    • Tomsova, M.1    Melichar, B.2    Sedlakova, I.3    Nova, M.4
  • 30
    • 0037377617 scopus 로고    scopus 로고
    • Expression and prognostic value of the cell-cycle regulatory proteins, Rb, p16MTS1, p21WAF1, p27KIP1, cyclin E, and cyclin D2, in ovarian cancer
    • Milde-Langosch, K.; Hagen, M.; Bamberger, A.M.; Loning, T. Expression and prognostic value of the cell-cycle regulatory proteins, Rb, p16MTS1, p21WAF1, p27KIP1, cyclin E, and cyclin D2, in ovarian cancer. Int. J. Gynecol. Pathol. 2003, 22, 168-174.
    • (2003) Int. J. Gynecol. Pathol. , vol.22 , pp. 168-174
    • Milde-Langosch, K.1    Hagen, M.2    Bamberger, A.M.3    Loning, T.4
  • 31
    • 33947514699 scopus 로고    scopus 로고
    • Prognostic value of PIK3CA and phosphorylated AKT expression in ovarian cancer
    • Woenckhaus, J.; Steger, K.; Sturm, K.; Munstedt, K.; Franke, F.E.; Fenic, I. Prognostic value of PIK3CA and phosphorylated AKT expression in ovarian cancer. Virchows Arch. 2007, 450, 387-395.
    • (2007) Virchows Arch , vol.450 , pp. 387-395
    • Woenckhaus, J.1    Steger, K.2    Sturm, K.3    Munstedt, K.4    Franke, F.E.5    Fenic, I.6
  • 32
    • 0035998397 scopus 로고    scopus 로고
    • The combined evaluation of p27Kip1 and Ki-67 expression provides independent information on overall survival of ovarian carcinoma patients
    • Korkolopoulou, P.; Vassilopoulos, I.; Konstantinidou, A.E.; Zorzos, H.; Patsouris, E.; Agapitos, E.; Davaris, P. The combined evaluation of p27Kip1 and Ki-67 expression provides independent information on overall survival of ovarian carcinoma patients. Gynecol. Oncol. 2002, 85, 404-414.
    • (2002) Gynecol. Oncol. , vol.85 , pp. 404-414
    • Korkolopoulou, P.1    Vassilopoulos, I.2    Konstantinidou, A.E.3    Zorzos, H.4    Patsouris, E.5    Agapitos, E.6    Davaris, P.7
  • 33
    • 21744439937 scopus 로고    scopus 로고
    • Survival analysis in advanced epithelial ovarian carcinoma in relation to proliferative index of MIB-1 immunostaining
    • Kritpracha, K.; Hanprasertpong, J.; Chandeying, V.; Dechsukhum, C.; Geater, A. Survival analysis in advanced epithelial ovarian carcinoma in relation to proliferative index of MIB-1 immunostaining. J. Obstet. Gynaecol. Res. 2005, 31, 268-276.
    • (2005) J. Obstet. Gynaecol. Res. , vol.31 , pp. 268-276
    • Kritpracha, K.1    Hanprasertpong, J.2    Chandeying, V.3    Dechsukhum, C.4    Geater, A.5
  • 36
    • 0032125211 scopus 로고    scopus 로고
    • Oncogene expression: Long-term compared with short-term survival in patients with advanced epithelial ovarian cancer
    • Goff, B.A.; Muntz, H.G.; Greer, B.E.; Tamimi, H.K.; Gown, A.M. Oncogene expression: long-term compared with short-term survival in patients with advanced epithelial ovarian cancer. Obstet. Gynecol. 1998, 92, 88-93.
    • (1998) Obstet. Gynecol. , vol.92 , pp. 88-93
    • Goff, B.A.1    Muntz, H.G.2    Greer, B.E.3    Tamimi, H.K.4    Gown, A.M.5
  • 37
    • 38649121568 scopus 로고    scopus 로고
    • Contribution of immunohistochemistry in prognostic assessment of epithelial ovarian carcinoma --review of the literature I
    • Tomsova, M.; Melichar, B. Contribution of immunohistochemistry in prognostic assessment of epithelial ovarian carcinoma --review of the literature I. Acta Medica (Hradec Kralove) 2006, 49, 161-165.
    • (2006) Acta Medica (Hradec Kralove) , vol.49 , pp. 161-165
    • Tomsova, M.1    Melichar, B.2
  • 38
    • 67649624673 scopus 로고    scopus 로고
    • Intraepithelial T cells and tumor proliferation: Impact on the benefit from surgical cytoreduction in advanced serous ovarian cancer
    • Adams, S.F.; Levine, D.A.; Cadungog, M.G.; Hammond, R.; Facciabene, A.; Olvera, N.; Rubin, S.C.; Boyd, J.; Gimotty, P.A.; Coukos, G. Intraepithelial T cells and tumor proliferation: impact on the benefit from surgical cytoreduction in advanced serous ovarian cancer. Cancer 2009, 115, 2891-2902.
    • (2009) Cancer , vol.115 , pp. 2891-2902
    • Adams, S.F.1    Levine, D.A.2    Cadungog, M.G.3    Hammond, R.4    Facciabene, A.5    Olvera, N.6    Rubin, S.C.7    Boyd, J.8    Gimotty, P.A.9    Coukos, G.10
  • 40
    • 0031055966 scopus 로고    scopus 로고
    • Mib-1 evaluated proliferative activity in ovarian cancer with respect to prognostic significance
    • Marx, D.; Meden, H.; Brune, T.; Kron, M.; Korabiowska, M.; Kuhn, W.; Schauer, A. Mib-1 evaluated proliferative activity in ovarian cancer with respect to prognostic significance. Anticancer Res. 1997, 17, 775-780.
    • (1997) Anticancer Res , vol.17 , pp. 775-780
    • Marx, D.1    Meden, H.2    Brune, T.3    Kron, M.4    Korabiowska, M.5    Kuhn, W.6    Schauer, A.7
  • 43
    • 4143113738 scopus 로고    scopus 로고
    • Lack of relationship between EGFR-1 immunohistochemical expression and prognosis in a multicentre clinical trial of 93 patients with advanced primary ovarian epithelial cancer (GINECO group)
    • Elie, C.; Geay, J.F.; Morcos, M.; Le Tourneau, A.; Girre, V.; Broet, P.; Marmey, B.; Chauvenet, L.; Audouin, J.; Pujade-Lauraine, E.; Camilleri-Broet, S. Lack of relationship between EGFR-1 immunohistochemical expression and prognosis in a multicentre clinical trial of 93 patients with advanced primary ovarian epithelial cancer (GINECO group). Br. J. Cancer 2004, 91, 470-475.
    • (2004) Br. J. Cancer , vol.91 , pp. 470-475
    • Elie, C.1    Geay, J.F.2    Morcos, M.3    le Tourneau, A.4    Girre, V.5    Broet, P.6    Marmey, B.7    Chauvenet, L.8    Audouin, J.9    Pujade-Lauraine, E.10    Camilleri-Broet, S.11
  • 46
    • 33344460242 scopus 로고    scopus 로고
    • Angiotensin II type 1 receptor expression in ovarian cancer and its correlation with tumour angiogenesis and patient survival
    • Ino, K.; Shibata, K.; Kajiyama, H.; Yamamoto, E.; Nagasaka, T.; Nawa, A.; Nomura, S.; Kikkawa, F. Angiotensin II type 1 receptor expression in ovarian cancer and its correlation with tumour angiogenesis and patient survival. Br. J. Cancer 2006, 94, 552-560.
    • (2006) Br. J. Cancer , vol.94 , pp. 552-560
    • Ino, K.1    Shibata, K.2    Kajiyama, H.3    Yamamoto, E.4    Nagasaka, T.5    Nawa, A.6    Nomura, S.7    Kikkawa, F.8
  • 47
    • 0032876493 scopus 로고    scopus 로고
    • Expression and prognostic significance of proliferating cell nuclear antigen and Ki-67 in malignant ovarian germ cell tumors
    • Liu, F.S.; Chen, J.T.; Liu, S. C.; Shih, A.; Shih, R.T.; Ho, E.S. Expression and prognostic significance of proliferating cell nuclear antigen and Ki-67 in malignant ovarian germ cell tumors. Zhonghua Yi Xue Za Zhi (Taipei) 1999, 62, 695-702.
    • (1999) Zhonghua Yi Xue Za Zhi (Taipei) , vol.62 , pp. 695-702
    • Liu, F.S.1    Chen, J.T.2    Liu, S.C.3    Shih, A.4    Shih, R.T.5    Ho, E.S.6
  • 48
    • 0027730848 scopus 로고
    • [Importance of PCNA proliferating fraction and histomorphologic prognostic factors for survival in breast cancer]
    • Schonborn, I.; Minguillon, C.; Mohner, M.; Ebeling, K.[Importance of PCNA proliferating fraction and histomorphologic prognostic factors for survival in breast cancer]. Pathologe 1993, 14, 307-312.
    • (1993) Pathologe , vol.14 , pp. 307-312
    • Schonborn, I.1    Minguillon, C.2    Mohner, M.3    Ebeling, K.4
  • 49
    • 0026621263 scopus 로고
    • Proliferating cell nuclear antigen in epithelial ovarian cancer: Relation to results at second-look laparotomy and survival
    • Hartmann, L.C.; Sebo, T.J.; Kamel, N.A.; Podratz, K.C.; Cha, S.S.; Wieand, H.S.; Keeney, G.L.; Roche, P.C. Proliferating cell nuclear antigen in epithelial ovarian cancer: relation to results at second-look laparotomy and survival. Gynecol. Oncol. 1992, 47, 191-195.
    • (1992) Gynecol. Oncol. , vol.47 , pp. 191-195
    • Hartmann, L.C.1    Sebo, T.J.2    Kamel, N.A.3    Podratz, K.C.4    Cha, S.S.5    Wieand, H.S.6    Keeney, G.L.7    Roche, P.C.8
  • 52
    • 0030941961 scopus 로고    scopus 로고
    • Altered expression of gamma-glutamylcysteine synthetase, metallothionein and topoisomerase I or II during acquisition of drug resistance to cisplatin in human ovarian cancer cells
    • Kikuchi, Y.; Hirata, J.; Yamamoto, K.; Ishii, K.; Kita, T.; Kudoh, K.; Tode, T.; Nagata, I.; Taniguchi, K.; Kuwano, M. Altered expression of gamma-glutamylcysteine synthetase, metallothionein and topoisomerase I or II during acquisition of drug resistance to cisplatin in human ovarian cancer cells. Jpn. J. Cancer Res. 1997, 88, 213-217.
    • (1997) Jpn. J. Cancer Res. , vol.88 , pp. 213-217
    • Kikuchi, Y.1    Hirata, J.2    Yamamoto, K.3    Ishii, K.4    Kita, T.5    Kudoh, K.6    Tode, T.7    Nagata, I.8    Taniguchi, K.9    Kuwano, M.10
  • 53
    • 4644359804 scopus 로고    scopus 로고
    • Vascular endothelial growth factor expression in serous ovarian carcinoma: Relationship with topoisomerase II alpha and prognosis
    • Brustmann, H. Vascular endothelial growth factor expression in serous ovarian carcinoma: relationship with topoisomerase II alpha and prognosis. Gynecol. Oncol. 2004, 95, 16-22.
    • (2004) Gynecol. Oncol. , vol.95 , pp. 16-22
    • Brustmann, H.1
  • 56
    • 34548693895 scopus 로고    scopus 로고
    • Prognostic impact of KI67, p53, human epithelial growth factor receptor 2, topoisomerase IIalpha, epidermal growth factor receptor, and nm23 expression of ovarian carcinomas and disseminated tumor cells in the bone marrow
    • Schindlbeck, C.; Hantschmann, P.; Zerzer, M.; Jahns, B.; Rjosk, D.; Janni, W.; Rack, B.; Sommer, H.; Friese, K. Prognostic impact of KI67, p53, human epithelial growth factor receptor 2, topoisomerase IIalpha, epidermal growth factor receptor, and nm23 expression of ovarian carcinomas and disseminated tumor cells in the bone marrow. Int. J. Gynecol. Cancer 2007, 17, 1047-1055.
    • (2007) Int. J. Gynecol. Cancer , vol.17 , pp. 1047-1055
    • Schindlbeck, C.1    Hantschmann, P.2    Zerzer, M.3    Jahns, B.4    Rjosk, D.5    Janni, W.6    Rack, B.7    Sommer, H.8    Friese, K.9
  • 59
    • 0034791332 scopus 로고    scopus 로고
    • Implication of malignancy and prognosis of p27(kip1), Cyclin E, and Cdk2 expression in epithelial ovarian tumors
    • Sui, L.; Dong, Y.; Ohno, M.; Sugimoto, K.; Tai, Y.; Hando, T.; Tokuda, M. Implication of malignancy and prognosis of p27(kip1), Cyclin E, and Cdk2 expression in epithelial ovarian tumors. Gynecol. Oncol. 2001, 83, 56-63.
    • (2001) Gynecol. Oncol , vol.83 , pp. 56-63
    • Sui, L.1    Dong, Y.2    Ohno, M.3    Sugimoto, K.4    Tai, Y.5    Hando, T.6    Tokuda, M.7
  • 60
    • 0037444379 scopus 로고    scopus 로고
    • Cyclin E expression is a significant predictor of survival in advanced, suboptimally debulked ovarian epithelial cancers: A Gynecologic Oncology Group study
    • Farley, J.; Smith, L.M.; Darcy, K.M.; Sobel, E.; O'Connor, D.; Henderson, B.; Morrison, L.E.; Birrer, M.J. Cyclin E expression is a significant predictor of survival in advanced, suboptimally debulked ovarian epithelial cancers: a Gynecologic Oncology Group study. Cancer Res. 2003, 63, 1235-1241.
    • (2003) Cancer Res , vol.63 , pp. 1235-1241
    • Farley, J.1    Smith, L.M.2    Darcy, K.M.3    Sobel, E.4    O'Connor, D.5    Henderson, B.6    Morrison, L.E.7    Birrer, M.J.8
  • 61
    • 33646374432 scopus 로고    scopus 로고
    • Cyclin E expression is correlated with tumor progression and predicts a poor prognosis in patients with ovarian carcinoma
    • Rosen, D.G.; Yang, G.; Deavers, M.T.; Malpica, A.; Kavanagh, J.J.; Mills, G. B.; Liu, J. Cyclin E expression is correlated with tumor progression and predicts a poor prognosis in patients with ovarian carcinoma. Cancer 2006, 106, 1925-1932.
    • (2006) Cancer , vol.106 , pp. 1925-1932
    • Rosen, D.G.1    Yang, G.2    Deavers, M.T.3    Malpica, A.4    Kavanagh, J.J.5    Mills, G.B.6    Liu, J.7
  • 62
    • 34548080298 scopus 로고    scopus 로고
    • Cyclin E-associated kinase activity predicts response to platinum-based chemotherapy
    • Bedrosian, I.; Lee, C.; Tucker, S. L.; Palla, S.L.; Lu, K.; Keyomarsi, K. Cyclin E-associated kinase activity predicts response to platinum-based chemotherapy. Clin Cancer Res. 2007, 13, 4800-4806.
    • (2007) Clin Cancer Res , vol.13 , pp. 4800-4806
    • Bedrosian, I.1    Lee, C.2    Tucker, S.L.3    Palla, S.L.4    Lu, K.5    Keyomarsi, K.6
  • 63
    • 55949105520 scopus 로고    scopus 로고
    • Alteration of cell-cycle regulation in epithelial ovarian cancer
    • Nam, E.J.; Kim, Y.T. Alteration of cell-cycle regulation in epithelial ovarian cancer. Int. J. Gynecol. Cancer 2008, 18, 1169-1182.
    • (2008) Int. J. Gynecol. Cancer , vol.18 , pp. 1169-1182
    • Nam, E.J.1    Kim, Y.T.2
  • 64
    • 4143107930 scopus 로고    scopus 로고
    • Cyclin D1, p53, and p21Waf1/Cip1 expression is predictive of poor clinical outcome in serous epithelial ovarian cancer
    • Bali, A.; O'Brien, P.M.; Edwards, L.S.; Sutherland, R.L.; Hacker, N.F.; Henshall, S.M. Cyclin D1, p53, and p21Waf1/Cip1 expression is predictive of poor clinical outcome in serous epithelial ovarian cancer. Clin. Cancer Res. 2004, 10, 5168-5177.
    • (2004) Clin. Cancer Res , vol.10 , pp. 5168-5177
    • Bali, A.1    O'Brien, P.M.2    Edwards, L.S.3    Sutherland, R.L.4    Hacker, N.F.5    Henshall, S.M.6
  • 66
    • 3042592214 scopus 로고    scopus 로고
    • Overexpression of cyclin D1 is associated with poor survival in epithelial ovarian cancer
    • Barbieri, F.; Lorenzi, P.; Ragni, N.; Schettini, G.; Bruzzo, C.; Pedulla, F.; Alama, A. Overexpression of cyclin D1 is associated with poor survival in epithelial ovarian cancer. Oncology 2004, 66, 310-315.
    • (2004) Oncology , vol.66 , pp. 310-315
    • Barbieri, F.1    Lorenzi, P.2    Ragni, N.3    Schettini, G.4    Bruzzo, C.5    Pedulla, F.6    Alama, A.7
  • 67
    • 0032766778 scopus 로고    scopus 로고
    • Increased cyclin D1 expression is associated with features of malignancy and disease recurrence in ovarian tumors
    • Barbieri, F.; Cagnoli, M.; Ragni, N.; Foglia, G.; Bruzzo, C.; Pedulla, F.; Alama, A. Increased cyclin D1 expression is associated with features of malignancy and disease recurrence in ovarian tumors. Clin. Cancer Res. 1999, 5, 1837-1842.
    • (1999) Clin. Cancer Res , vol.5 , pp. 1837-1842
    • Barbieri, F.1    Cagnoli, M.2    Ragni, N.3    Foglia, G.4    Bruzzo, C.5    Pedulla, F.6    Alama, A.7
  • 71
    • 63449091651 scopus 로고    scopus 로고
    • Epithelial ovarian cancer: The role of cell cycle genes in the different histotypes
    • D'Andrilli, G.; Giordano, A.; Bovicelli, A. Epithelial ovarian cancer: the role of cell cycle genes in the different histotypes. Open. Clin. Cancer J. 2008, 2, 7-12.
    • (2008) Open. Clin. Cancer J , vol.2 , pp. 7-12
    • D'Andrilli, G.1    Giordano, A.2    Bovicelli, A.3
  • 73
    • 0035348561 scopus 로고    scopus 로고
    • Underexpression of cyclin-dependent kinase inhibitor p27 is associated with poor prognosis in serous ovarian carcinomas
    • Shigemasa, K.; Shiroyama, Y.; Sawasaki, T.; Fujii, T.; Nagai, N.; Parmley, T. H.; O'Brien, T.J.; Ohama, K. Underexpression of cyclin-dependent kinase inhibitor p27 is associated with poor prognosis in serous ovarian carcinomas. Int. J. Oncol. 2001, 18, 953-958.
    • (2001) Int. J. Oncol , vol.18 , pp. 953-958
    • Shigemasa, K.1    Shiroyama, Y.2    Sawasaki, T.3    Fujii, T.4    Nagai, N.5    Parmley, T.H.6    O'Brien, T.J.7    Ohama, K.8
  • 75
    • 0032943896 scopus 로고    scopus 로고
    • Expression of the cell cycle inhibitor p27KIP1 is a new prognostic marker associated with survival in epithelial ovarian tumors
    • Newcomb, E.W.; Sosnow, M.; Demopoulos, R.I.; Zeleniuch-Jacquotte, A.; Sorich, J.; Speyer, J.L. Expression of the cell cycle inhibitor p27KIP1 is a new prognostic marker associated with survival in epithelial ovarian tumors. Am. J. Pathol. 1999, 154, 119-125.
    • (1999) Am. J. Pathol , vol.154 , pp. 119-125
    • Newcomb, E.W.1    Sosnow, M.2    Demopoulos, R.I.3    Zeleniuch-Jacquotte, A.4    Sorich, J.5    Speyer, J.L.6
  • 77
    • 0034669625 scopus 로고    scopus 로고
    • Expression of apoptosis-related proteins is an independent determinant of patient prognosis in advanced ovarian cancer
    • Baekelandt, M.; Holm, R.; Nesland, J. M.; Trope, C.G.; Kristensen, G.B. Expression of apoptosis-related proteins is an independent determinant of patient prognosis in advanced ovarian cancer. J. Clin. Oncol. 2000, 18, 3775-3781.
    • (2000) J. Clin. Oncol , vol.18 , pp. 3775-3781
    • Baekelandt, M.1    Holm, R.2    Nesland, J.M.3    Trope, C.G.4    Kristensen, G.B.5
  • 79
  • 80
    • 0034077240 scopus 로고    scopus 로고
    • p53 and bcl-2 in epithelial ovarian carcinoma: Their value as prognostic indicators at a median follow-up of 60 months
    • Geisler, J.P.; Geisler, H.E.; Miller, G.A.; Wiemann, M.C.; Zhou, Z.; Crabtree, W. p53 and bcl-2 in epithelial ovarian carcinoma: their value as prognostic indicators at a median follow-up of 60 months. Gynecol. Oncol. 2000, 77, 278-282.
    • (2000) Gynecol. Oncol , vol.77 , pp. 278-282
    • Geisler, J.P.1    Geisler, H.E.2    Miller, G.A.3    Wiemann, M.C.4    Zhou, Z.5    Crabtree, W.6
  • 82
    • 34247880320 scopus 로고    scopus 로고
    • Expression of factors involved in regulation of DNA mismatch repair- and apoptosis pathways in ovarian cancer patients
    • Materna, V.; Surowiak, P.; Markwitz, E.; Spaczynski, M.; Drag-Zalesinska, M.; Zabel, M.; Lage, H. Expression of factors involved in regulation of DNA mismatch repair- and apoptosis pathways in ovarian cancer patients. Oncol. Rep. 2007, 17, 505-516.
    • (2007) Oncol. Rep , vol.17 , pp. 505-516
    • Materna, V.1    Surowiak, P.2    Markwitz, E.3    Spaczynski, M.4    Drag-Zalesinska, M.5    Zabel, M.6    Lage, H.7
  • 83
    • 0034071665 scopus 로고    scopus 로고
    • p21 (WAF1/CIP1) protein expression is associated with prolonged survival but not with p53 expression in epithelial ovarian carcinoma
    • Schmider, A.; Gee, C.; Friedmann, W.; Lukas, J.J.; Press, M.F.; Lichtenegger, W.; Reles, A. p21 (WAF1/CIP1) protein expression is associated with prolonged survival but not with p53 expression in epithelial ovarian carcinoma. Gynecol. Oncol. 2000, 77, 237-242.
    • (2000) Gynecol. Oncol , vol.77 , pp. 237-242
    • Schmider, A.1    Gee, C.2    Friedmann, W.3    Lukas, J.J.4    Press, M.F.5    Lichtenegger, W.6    Reles, A.7
  • 84
    • 0033883617 scopus 로고    scopus 로고
    • Evidence for a dose-response effect between p53 (but not p21WAF1/Cip1) protein concentrations, survival, and responsiveness in patients with epithelial ovarian cancer treated with platinum-based chemotherapy
    • Levesque, M.A.; Katsaros, D.; Massobrio, M.; Genta, F.; Yu, H.; Richiardi, G.; Fracchioli, S.; Durando, A.; Arisio, R.; Diamandis, E.P. Evidence for a dose-response effect between p53 (but not p21WAF1/Cip1) protein concentrations, survival, and responsiveness in patients with epithelial ovarian cancer treated with platinum-based chemotherapy. Clin. Cancer Res. 2000, 6, 3260-3270.
    • (2000) Clin. Cancer Res , vol.6 , pp. 3260-3270
    • Levesque, M.A.1    Katsaros, D.2    Massobrio, M.3    Genta, F.4    Yu, H.5    Richiardi, G.6    Fracchioli, S.7    Durando, A.8    Arisio, R.9    Diamandis, E.P.10
  • 85
    • 0035798438 scopus 로고    scopus 로고
    • Reduced expression of BAX is associated with poor prognosis in patients with epithelial ovarian cancer: A multifactorial analysis of TP53, p21, BAX and BCL-2
    • Schuyer, M.; van der Burg, M.E.; Henzen-Logmans, S.C.; Fieret, J.H.; Klijn, J.G.; Look, M.P.; Foekens, J.A.; Stoter, G.; Berns, E.M. Reduced expression of BAX is associated with poor prognosis in patients with epithelial ovarian cancer: a multifactorial analysis of TP53, p21, BAX and BCL-2. Br. J. Cancer 2001, 85, 1359-1367.
    • (2001) Br. J. Cancer , vol.85 , pp. 1359-1367
    • Schuyer, M.1    van der Burg, M.E.2    Henzen-Logmans, S.C.3    Fieret, J.H.4    Klijn, J.G.5    Look, M.P.6    Foekens, J.A.7    Stoter, G.8    Berns, E.M.9
  • 86
    • 0036827465 scopus 로고    scopus 로고
    • Expression of p57kip2 and its clinical relevance in epithelial ovarian tumors
    • Sui, L.; Dong, Y.; Ohno, M.; Watanabe, Y.; Sugimoto, K.; Tokuda, M. Expression of p57kip2 and its clinical relevance in epithelial ovarian tumors. Anticancer Res. 2002, 22, 3191-3196.
    • (2002) Anticancer Res , vol.22 , pp. 3191-3196
    • Sui, L.1    Dong, Y.2    Ohno, M.3    Watanabe, Y.4    Sugimoto, K.5    Tokuda, M.6
  • 87
    • 33846527856 scopus 로고    scopus 로고
    • Independent prognostic significance of cell cycle regulator proteins p16(INK4a) and pRb in advanced-stage ovarian carcinoma including optimally debulked patients: A translational research subprotocol of a randomised study of the Arbeitsgemeinschaft Gynaekologische Onkologie Ovarian Cancer Study Group
    • Kommoss, S.; du Bois, A.; Ridder, R.; Trunk, M.J.; Schmidt, D.; Pfisterer, J.; Kommoss, F. Independent prognostic significance of cell cycle regulator proteins p16(INK4a) and pRb in advanced-stage ovarian carcinoma including optimally debulked patients: a translational research subprotocol of a randomised study of the Arbeitsgemeinschaft Gynaekologische Onkologie Ovarian Cancer Study Group. Br. J. Cancer 2007, 96, 306-313.
    • (2007) Br. J. Cancer , vol.96 , pp. 306-313
    • Kommoss, S.1    du Bois, A.2    Ridder, R.3    Trunk, M.J.4    Schmidt, D.5    Pfisterer, J.6    Kommoss, F.7
  • 90
    • 39149133970 scopus 로고    scopus 로고
    • Human papilloma virus (HPV) status, p16INK4a, and p53 overexpression in epithelial malignant and borderline ovarian neoplasms
    • Giordano, G.; Azzoni, C.; D'Adda, T.; Rocco, A.; Gnetti, L.; Froio, E.; Merisio, C.; Melpignano, M. Human papilloma virus (HPV) status, p16INK4a, and p53 overexpression in epithelial malignant and borderline ovarian neoplasms. Pathol. Res. Pract. 2008, 204, 163-174.
    • (2008) Pathol. Res. Pract , vol.204 , pp. 163-174
    • Giordano, G.1    Azzoni, C.2    D'adda, T.3    Rocco, A.4    Gnetti, L.5    Froio, E.6    Merisio, C.7    Melpignano, M.8
  • 91
    • 0030955478 scopus 로고    scopus 로고
    • Increased expression of cyclin-dependent kinase inhibitor 2 (CDKN2A) gene product P16INK4A in ovarian cancer is associated with progression and unfavourable prognosis
    • Dong, Y.; Walsh, M.D.; McGuckin, M.A.; Gabrielli, B.G.; Cummings, M.C.; Wright, R.G.; Hurst, T.; Khoo, S. K.; Parsons, P.G. Increased expression of cyclin-dependent kinase inhibitor 2 (CDKN2A) gene product P16INK4A in ovarian cancer is associated with progression and unfavourable prognosis. Int. J. Cancer 1997, 74, 57-63.
    • (1997) Int. J. Cancer , vol.74 , pp. 57-63
    • Dong, Y.1    Walsh, M.D.2    McGuckin, M.A.3    Gabrielli, B.G.4    Cummings, M.C.5    Wright, R.G.6    Hurst, T.7    Khoo, S.K.8    Parsons, P.G.9
  • 93
    • 29344473740 scopus 로고    scopus 로고
    • Perturbation of the tumor necrosis factor--related apoptosis-inducing ligand cascade in ovarian cancer: Overexpression of FLIPL and deregulation of the functional receptors DR4 and DR5
    • Horak, P.; Pils, D.; Kaider, A.; Pinter, A.; Elandt, K.; Sax, C.; Zielinski, C.C.; Horvat, R.; Zeillinger, R.; Reinthaller, A.; Krainer, M. Perturbation of the tumor necrosis factor--related apoptosis-inducing ligand cascade in ovarian cancer: overexpression of FLIPL and deregulation of the functional receptors DR4 and DR5. Clin. Cancer Res. 2005, 11, 8585-8591.
    • (2005) Clin. Cancer Res , vol.11 , pp. 8585-8591
    • Horak, P.1    Pils, D.2    Kaider, A.3    Pinter, A.4    Elandt, K.5    Sax, C.6    Zielinski, C.C.7    Horvat, R.8    Zeillinger, R.9    Reinthaller, A.10    Krainer, M.11
  • 96
    • 0034024569 scopus 로고    scopus 로고
    • Expressions of Fas ligand and other apoptosis-related genes and their prognostic significance in epithelial ovarian neoplasms
    • Munakata, S.; Enomoto, T.; Tsujimoto, M.; Otsuki, Y.; Miwa, H.; Kanno, H.; Aozasa, K. Expressions of Fas ligand and other apoptosis-related genes and their prognostic significance in epithelial ovarian neoplasms. Br. J. Cancer 2000, 82, 1446-1452.
    • (2000) Br. J. Cancer , vol.82 , pp. 1446-1452
    • Munakata, S.1    Enomoto, T.2    Tsujimoto, M.3    Otsuki, Y.4    Miwa, H.5    Kanno, H.6    Aozasa, K.7
  • 97
    • 37449023100 scopus 로고    scopus 로고
    • Death receptor expression is associated with poor response to chemotherapy and shorter survival in metastatic ovarian carcinoma
    • Dong, H.P.; Kleinberg, L.; Silins, I.; Florenes, V.A.; Trope, C.G.; Risberg, B.; Nesland, J.M.; Davidson, B. Death receptor expression is associated with poor response to chemotherapy and shorter survival in metastatic ovarian carcinoma. Cancer 2008, 112, 84-93.
    • (2008) Cancer , vol.112 , pp. 84-93
    • Dong, H.P.1    Kleinberg, L.2    Silins, I.3    Florenes, V.A.4    Trope, C.G.5    Risberg, B.6    Nesland, J.M.7    Davidson, B.8
  • 98
  • 99
    • 0035032396 scopus 로고    scopus 로고
    • P53, bcl-2, and bax: Their relationship and effect on prognosis in early stage epithelial ovarian carcinoma
    • Skirnisdottir, I.; Sorbe, B.; Seidal, T. P53, bcl-2, and bax: their relationship and effect on prognosis in early stage epithelial ovarian carcinoma. Int. J. Gynecol. Cancer 2001, 11, 147-158.
    • (2001) Int. J. Gynecol. Cancer , vol.11 , pp. 147-158
    • Skirnisdottir, I.1    Sorbe, B.2    Seidal, T.3
  • 100
    • 0036077270 scopus 로고    scopus 로고
    • The prognostic importance of p53, bcl-2, and bax in early stage epithelial ovarian carcinoma treated with adjuvant chemotherapy
    • Skirnisdottir, I.; Seidal, T.; Gerdin, E.; Sorbe, B. The prognostic importance of p53, bcl-2, and bax in early stage epithelial ovarian carcinoma treated with adjuvant chemotherapy. Int. J. Gynecol. Cancer 2002, 12, 265-276.
    • (2002) Int. J. Gynecol. Cancer , vol.12 , pp. 265-276
    • Skirnisdottir, I.1    Seidal, T.2    Gerdin, E.3    Sorbe, B.4
  • 103
    • 0032794804 scopus 로고    scopus 로고
    • Bcl-2 as a predictor of chemosensitivity and prognosis in primary epithelial ovarian cancer
    • Mano, Y.; Kikuchi, Y.; Yamamoto, K.; Kita, T.; Hirata, J.; Tode, T.; Ishii, K.; Nagata, I. Bcl-2 as a predictor of chemosensitivity and prognosis in primary epithelial ovarian cancer. Eur. J. Cancer 1999, 35, 1214-1219.
    • (1999) Eur. J. Cancer , vol.35 , pp. 1214-1219
    • Mano, Y.1    Kikuchi, Y.2    Yamamoto, K.3    Kita, T.4    Hirata, J.5    Tode, T.6    Ishii, K.7    Nagata, I.8
  • 104
    • 0033024368 scopus 로고    scopus 로고
    • Clinical significance of apoptosis-related factors p53, Mdm2, and Bcl-2 in advanced ovarian cancer
    • Baekelandt, M.; Kristensen, G.B.; Nesland, J.M.; Trope, C.G.; Holm, R. Clinical significance of apoptosis-related factors p53, Mdm2, and Bcl-2 in advanced ovarian cancer. J. Clin. Oncol. 1999, 17, 2061.
    • (1999) J. Clin. Oncol , vol.17 , pp. 2061
    • Baekelandt, M.1    Kristensen, G.B.2    Nesland, J.M.3    Trope, C.G.4    Holm, R.5
  • 105
    • 0028862440 scopus 로고
    • Expression and prognostic significance of Bcl-2 in ovarian tumours
    • Henriksen, R.; Wilander, E.; Oberg, K. Expression and prognostic significance of Bcl-2 in ovarian tumours. Br. J. Cancer 1995, 72, 1324-1329.
    • (1995) Br. J. Cancer , vol.72 , pp. 1324-1329
    • Henriksen, R.1    Wilander, E.2    Oberg, K.3
  • 107
    • 0035653494 scopus 로고    scopus 로고
    • Prognostic importance of DNA ploidy and p53 in early stages of epithelial ovarian carcinoma
    • Skirnisdottir, I.; Sorbe, B.; Karlsson, M.; Seidal, T. Prognostic importance of DNA ploidy and p53 in early stages of epithelial ovarian carcinoma. Int. J. Oncol. 2001, 19, 1295-1302.
    • (2001) Int. J. Oncol , vol.19 , pp. 1295-1302
    • Skirnisdottir, I.1    Sorbe, B.2    Karlsson, M.3    Seidal, T.4
  • 108
    • 38649133581 scopus 로고    scopus 로고
    • Prognostic significance of CD3+ tumor-infiltrating lymphocytes in ovarian carcinoma
    • Tomsova, M.; Melichar, B.; Sedlakova, I.; Steiner, I. Prognostic significance of CD3+ tumor-infiltrating lymphocytes in ovarian carcinoma. Gynecol. Oncol. 2008, 108, 415-420.
    • (2008) Gynecol. Oncol , vol.108 , pp. 415-420
    • Tomsova, M.1    Melichar, B.2    Sedlakova, I.3    Steiner, I.4
  • 110
    • 0038457729 scopus 로고    scopus 로고
    • Survivin expression in ovarian carcinoma: Correlation with apoptotic markers and prognosis
    • Cohen, C.; Lohmann, C.M.; Cotsonis, G.; Lawson, D.; Santoianni, R. Survivin expression in ovarian carcinoma: correlation with apoptotic markers and prognosis. Mod. Pathol. 2003, 16, 574-583.
    • (2003) Mod. Pathol , vol.16 , pp. 574-583
    • Cohen, C.1    Lohmann, C.M.2    Cotsonis, G.3    Lawson, D.4    Santoianni, R.5
  • 111
    • 0034652598 scopus 로고    scopus 로고
    • Bcl-2: Bax and bcl-2: Bcl-x ratios by image cytometric quantitation of immunohistochemical expression in ovarian carcinoma: Correlation with prognosis
    • Lohmann, C.M.; League, A.A.; Clark, W.S.; Lawson, D.; DeRose, P.B.; Cohen, C. Bcl-2: bax and bcl-2: Bcl-x ratios by image cytometric quantitation of immunohistochemical expression in ovarian carcinoma: correlation with prognosis. Cytometry 2000, 42, 61-66.
    • (2000) Cytometry , vol.42 , pp. 61-66
    • Lohmann, C.M.1    League, A.A.2    Clark, W.S.3    Lawson, D.4    Derose, P.B.5    Cohen, C.6
  • 113
    • 69049099972 scopus 로고    scopus 로고
    • Expression and clinical role of antiapoptotic proteins of the bag, heat shock, and Bcl-2 families in effusions, primary tumors, and solid metastases in ovarian carcinoma
    • Elstrand, M.B.; Kleinberg, L.; Kohn, E. C.; Trope, C.G.; Davidson, B. Expression and clinical role of antiapoptotic proteins of the bag, heat shock, and Bcl-2 families in effusions, primary tumors, and solid metastases in ovarian carcinoma. Int. J. Gynecol. Pathol. 2009, 28, 211-221.
    • (2009) Int. J. Gynecol. Pathol , vol.28 , pp. 211-221
    • Elstrand, M.B.1    Kleinberg, L.2    Kohn, E.C.3    Trope, C.G.4    Davidson, B.5
  • 114
    • 12344266609 scopus 로고    scopus 로고
    • Expression of Bcl-xL in ovarian carcinoma is associated with chemoresistance and recurrent disease
    • Williams, J.; Lucas, P.C.; Griffith, K. A.; Choi, M.; Fogoros, S.; Hu, Y.Y.; Liu, J.R. Expression of Bcl-xL in ovarian carcinoma is associated with chemoresistance and recurrent disease. Gynecol. Oncol. 2005, 96, 287-295.
    • (2005) Gynecol. Oncol , vol.96 , pp. 287-295
    • Williams, J.1    Lucas, P.C.2    Griffith, K.A.3    Choi, M.4    Fogoros, S.5    Hu, Y.Y.6    Liu, J.R.7
  • 115
    • 0031829919 scopus 로고    scopus 로고
    • Expression and localization of Bcl-2 related proteins in human ovarian cancers
    • Witty, J.P.; Jensen, R.A.; Johnson, A.L. Expression and localization of Bcl-2 related proteins in human ovarian cancers. Anticancer Res. 1998, 18, 1223-1230.
    • (1998) Anticancer Res , vol.18 , pp. 1223-1230
    • Witty, J.P.1    Jensen, R.A.2    Johnson, A.L.3
  • 116
    • 0031807774 scopus 로고    scopus 로고
    • Gilks, C.B. Immunohistochemical analysis of bcl-2, bax, mcl-1, and bcl-X expression in ovarian surface epithelial tumors
    • Wehrli, B.M.; Krajewski, S.; Gascoyne, R.D.; Reed, J.C.; Gilks, C.B. Immunohistochemical analysis of bcl-2, bax, mcl-1, and bcl-X expression in ovarian surface epithelial tumors. Int. J. Gynecol. Pathol. 1998, 17, 255-260.
    • (1998) Int. J. Gynecol. Pathol , vol.17 , pp. 255-260
    • Wehrli, B.M.1    Krajewski, S.2    Gascoyne, R.D.3    Reed, J.C.4
  • 117
  • 118
    • 33846225572 scopus 로고    scopus 로고
    • Nuclear expression of survivin is associated with improved survival in metastatic ovarian carcinoma
    • Kleinberg, L.; Florenes, V.A.; Silins, I.; Haug, K.; Trope, C.G.; Nesland, J.M.; Davidson, B. Nuclear expression of survivin is associated with improved survival in metastatic ovarian carcinoma. Cancer 2007, 109, 228-238.
    • (2007) Cancer , vol.109 , pp. 228-238
    • Kleinberg, L.1    Florenes, V.A.2    Silins, I.3    Haug, K.4    Trope, C.G.5    Nesland, J.M.6    Davidson, B.7
  • 119
    • 0036673438 scopus 로고    scopus 로고
    • Survivin expression and its correlation with cell proliferation and prognosis in epithelial ovarian tumors
    • Sui, L.; Dong, Y.; Ohno, M.; Watanabe, Y.; Sugimoto, K.; Tokuda, M. Survivin expression and its correlation with cell proliferation and prognosis in epithelial ovarian tumors. Int. J. Oncol. 2002, 21, 315-320.
    • (2002) Int. J. Oncol , vol.21 , pp. 315-320
    • Sui, L.1    Dong, Y.2    Ohno, M.3    Watanabe, Y.4    Sugimoto, K.5    Tokuda, M.6
  • 120
    • 34147121608 scopus 로고    scopus 로고
    • Poly(adenosine diphosphate-ribose) polymerase expression in serous ovarian carcinoma: Correlation with p53, MIB-1, and outcome
    • Brustmann, H. Poly(adenosine diphosphate-ribose) polymerase expression in serous ovarian carcinoma: correlation with p53, MIB-1, and outcome. Int. J. Gynecol. Patho.l 2007, 26, 147-153.
    • (2007) Int. J. Gynecol. Patho.l , vol.26 , pp. 147-153
    • Brustmann, H.1
  • 121
    • 69449090272 scopus 로고    scopus 로고
    • The relationship of platinum resistance and ERCC1 protein expression in epithelial ovarian cancer
    • Steffensen, K.D.; Waldstrom, M.; Jakobsen, A. The relationship of platinum resistance and ERCC1 protein expression in epithelial ovarian cancer. Int. J. Gynecol. Cancer 2009, 19, 820-825.
    • (2009) Int. J. Gynecol. Cancer , vol.19 , pp. 820-825
    • Steffensen, K.D.1    Waldstrom, M.2    Jakobsen, A.3
  • 122
    • 51749115497 scopus 로고    scopus 로고
    • Protein expression levels of excision repair cross-complementation group 1 and xeroderma pigmentosum D correlate with response to platinum-based chemotherapy in the patients with advanced epithelial ovarian cancer
    • Lin, K.; Ye, D.; Xie, X. Protein expression levels of excision repair cross-complementation group 1 and xeroderma pigmentosum D correlate with response to platinum-based chemotherapy in the patients with advanced epithelial ovarian cancer. Int. J. Gynecol. Cancer 2008, 18, 1007-1012.
    • (2008) Int. J. Gynecol. Cancer , vol.18 , pp. 1007-1012
    • Lin, K.1    Ye, D.2    Xie, X.3
  • 127
    • 37849021868 scopus 로고    scopus 로고
    • Is It time to stratify for BRCA mutation status in therapeutic trials in ovarian cancer?
    • Kauff, N.D. Is It time to stratify for BRCA mutation status in therapeutic trials in ovarian cancer? J. Clin. Oncol. 2008, 26, 9-10.
    • (2008) J. Clin. Oncol , vol.26 , pp. 9-10
    • Kauff, N.D.1
  • 128
    • 33645359491 scopus 로고    scopus 로고
    • BRCA1 expression in a large series of sporadic ovarian carcinomas: A Gynecologic Oncology Group study
    • Thrall, M.; Gallion, H.H.; Kryscio, R.; Kapali, M.; Armstrong, D.K.; DeLoia, J.A. BRCA1 expression in a large series of sporadic ovarian carcinomas: a Gynecologic Oncology Group study. Int. J. Gynecol. Cancer 2006, 16 (Suppl. 1), 166-171.
    • (2006) Int. J. Gynecol. Cancer , vol.16 , Issue.SUPPL. 1 , pp. 166-171
    • Thrall, M.1    Gallion, H.H.2    Kryscio, R.3    Kapali, M.4    Armstrong, D.K.5    Deloia, J.A.6
  • 130
    • 34447499062 scopus 로고    scopus 로고
    • Novel approaches in advancing the treatment of epithelial ovarian cancer: The role of angiogenesis inhibition
    • Martin, L.; Schilder, R. Novel approaches in advancing the treatment of epithelial ovarian cancer: the role of angiogenesis inhibition. J. Clin. Oncol. 2007, 25, 2894-2901.
    • (2007) J. Clin. Oncol , vol.25 , pp. 2894-2901
    • Martin, L.1    Schilder, R.2
  • 133
    • 0026083903 scopus 로고
    • Tumor angiogenesis and metastasis--correlation in invasive breast carcinoma
    • Weidner, N.; Semple, J.P.; Welch, W. R.; Folkman, J. Tumor angiogenesis and metastasis--correlation in invasive breast carcinoma. N. Engl. J. Med. 1991, 324, 1-8.
    • (1991) N. Engl. J. Med , vol.324 , pp. 1-8
    • Weidner, N.1    Semple, J.P.2    Welch, W.R.3    Folkman, J.4
  • 134
    • 0031779574 scopus 로고    scopus 로고
    • Increased microvessel density in mucinous compared with malignant serous and benign tumours of the ovary
    • Orre, M.; Lotfi-Miri, M.; Mamers, P.; Rogers, P.A. Increased microvessel density in mucinous compared with malignant serous and benign tumours of the ovary. Br. J. Cancer 1998, 77, 2204-2209.
    • (1998) Br. J. Cancer , vol.77 , pp. 2204-2209
    • Orre, M.1    Lotfi-Miri, M.2    Mamers, P.3    Rogers, P.A.4
  • 138
    • 0031437089 scopus 로고    scopus 로고
    • Tumor angiogenesis as a prognostic factor in ovarian carcinoma: Quantification of endothelial immunoreactivity by image analysis
    • Schoell, W.M.; Pieber, D.; Reich, O.; Lahousen, M.; Janicek, M.; Guecer, F.; Winter, R. Tumor angiogenesis as a prognostic factor in ovarian carcinoma: quantification of endothelial immunoreactivity by image analysis. Cancer 1997, 80, 2257-2262.
    • (1997) Cancer , vol.80 , pp. 2257-2262
    • Schoell, W.M.1    Pieber, D.2    Reich, O.3    Lahousen, M.4    Janicek, M.5    Guecer, F.6    Winter, R.7
  • 140
    • 0037233629 scopus 로고    scopus 로고
    • Intratumoral microvessel density, response to chemotherapy and clinical outcome of patients with advanced ovarian carcinoma
    • Gadducci, A.; Viacava, P.; Cosio, S.; Fanelli, G.; Fanucchi, A.; Cecchetti, D.; Cristofani, R.; Genazzani, A.R. Intratumoral microvessel density, response to chemotherapy and clinical outcome of patients with advanced ovarian carcinoma. Anticancer Res. 2003, 23, 549-556.
    • (2003) Anticancer Res , vol.23 , pp. 549-556
    • Gadducci, A.1    Viacava, P.2    Cosio, S.3    Fanelli, G.4    Fanucchi, A.5    Cecchetti, D.6    Cristofani, R.7    Genazzani, A.R.8
  • 141
    • 10044250001 scopus 로고    scopus 로고
    • Prognostic factors responsible for survival in sex cord stromal tumors of the ovary--a multivariate analysis
    • Chan, J.K.; Zhang, M.; Kaleb, V.; Loizzi, V.; Benjamin, J.; Vasilev, S.; Osann, K.; Disaia, P.J. Prognostic factors responsible for survival in sex cord stromal tumors of the ovary--a multivariate analysis. Gynecol. Oncol. 2005, 96, 204-209.
    • (2005) Gynecol. Oncol , vol.96 , pp. 204-209
    • Chan, J.K.1    Zhang, M.2    Kaleb, V.3    Loizzi, V.4    Benjamin, J.5    Vasilev, S.6    Osann, K.7    Disaia, P.J.8
  • 142
    • 18844363423 scopus 로고    scopus 로고
    • The relationship of molecular markers of p53 function and angiogenesis to prognosis of stage I epithelial ovarian cancer
    • Goodheart, M.J.; Ritchie, J.M.; Rose, S.L.; Fruehauf, J.P.; De Young, B.R.; Buller, R.E. The relationship of molecular markers of p53 function and angiogenesis to prognosis of stage I epithelial ovarian cancer. Clin. Cancer Res. 2005, 11, 3733-3742.
    • (2005) Clin. Cancer Res , vol.11 , pp. 3733-3742
    • Goodheart, M.J.1    Ritchie, J.M.2    Rose, S.L.3    Fruehauf, J.P.4    de Young, B.R.5    Buller, R.E.6
  • 143
    • 0037039719 scopus 로고    scopus 로고
    • Prognostic significance of microvessel density, vascular cuffing and vascular endothelial growth factor expression in ovarian carcinoma: A special review for clear cell adenocarcinoma
    • Ogawa, S.; Kaku, T.; Kobayashi, H.; Hirakawa, T.; Ohishi, Y.; Kinukawa, N.; Nakano, H. Prognostic significance of microvessel density, vascular cuffing and vascular endothelial growth factor expression in ovarian carcinoma: a special review for clear cell adenocarcinoma. Cancer Lett. 2002, 176, 111-118.
    • (2002) Cancer Lett , vol.176 , pp. 111-118
    • Ogawa, S.1    Kaku, T.2    Kobayashi, H.3    Hirakawa, T.4    Ohishi, Y.5    Kinukawa, N.6    Nakano, H.7
  • 149
    • 0034896068 scopus 로고    scopus 로고
    • Expression of hypoxia-inducible factor 1alpha in epithelial ovarian tumors: Its impact on prognosis and on response to chemotherapy
    • Birner, P.; Schindl, M.; Obermair, A.; Breitenecker, G.; Oberhuber, G. Expression of hypoxia-inducible factor 1alpha in epithelial ovarian tumors: its impact on prognosis and on response to chemotherapy. Clin. Cancer Res. 2001, 7, 1661-1668.
    • (2001) Clin. Cancer Res , vol.7 , pp. 1661-1668
    • Birner, P.1    Schindl, M.2    Obermair, A.3    Breitenecker, G.4    Oberhuber, G.5
  • 150
    • 14644422632 scopus 로고    scopus 로고
    • Expression of cyclooxygenase-2 in advanced stage ovarian serous carcinoma: Correlation with tumor cell proliferation, apoptosis, angiogenesis, and survival
    • Ali-Fehmi, R.; Morris, R.T.; Bandyopadhyay, S.; Che, M.; Schimp, V.; Malone, J.M., Jr.; Munkarah, A.R. Expression of cyclooxygenase-2 in advanced stage ovarian serous carcinoma: correlation with tumor cell proliferation, apoptosis, angiogenesis, and survival. Am. J. Obstet. Gynecol. 2005, 192, 819-825.
    • (2005) Am. J. Obstet. Gynecol , vol.192 , pp. 819-825
    • Ali-Fehmi, R.1    Morris, R.T.2    Bandyopadhyay, S.3    Che, M.4    Schimp, V.5    Malone Jr., J.M.6    Munkarah, A.R.7
  • 151
    • 3242749985 scopus 로고    scopus 로고
    • COX-2 status in relation to tumor microvessel density and VEGF expression: Analysis in ovarian carcinoma patients with low versus high survival rates
    • Raspollini, M.R.; Amunni, G.; Villanucci, A.; Boddi, V.; Baroni, G.; Taddei, A.; Taddei, G.L. COX-2 status in relation to tumor microvessel density and VEGF expression: analysis in ovarian carcinoma patients with low versus high survival rates. Oncol. Rep. 2004, 11, 309-313.
    • (2004) Oncol. Rep , vol.11 , pp. 309-313
    • Raspollini, M.R.1    Amunni, G.2    Villanucci, A.3    Boddi, V.4    Baroni, G.5    Taddei, A.6    Taddei, G.L.7
  • 153
    • 18144379214 scopus 로고    scopus 로고
    • Correlation of epidermal growth factor receptor expression with tumor microdensity vessels and with vascular endothelial growth factor expression in ovarian carcinoma
    • Raspollini, M.R.; Castiglione, F.; Garbini, F.; Villanucci, A.; Amunni, G.; Baroni, G.; Boddi, V.; Taddei, G.L. Correlation of epidermal growth factor receptor expression with tumor microdensity vessels and with vascular endothelial growth factor expression in ovarian carcinoma. Int. J. Surg. Pathol. 2005, 13, 135-142.
    • (2005) Int. J. Surg. Pathol , vol.13 , pp. 135-142
    • Raspollini, M.R.1    Castiglione, F.2    Garbini, F.3    Villanucci, A.4    Amunni, G.5    Baroni, G.6    Boddi, V.7    Taddei, G.L.8
  • 154
    • 0034046917 scopus 로고    scopus 로고
    • Prognostic significance of vascular endothelial growth factor expression in human ovarian carcinoma
    • Shen, G.H.; Ghazizadeh, M.; Kawanami, O.; Shimizu, H.; Jin, E.; Araki, T.; Sugisaki, Y. Prognostic significance of vascular endothelial growth factor expression in human ovarian carcinoma. Br. J. Cancer 2000, 83, 196-203.
    • (2000) Br. J. Cancer , vol.83 , pp. 196-203
    • Shen, G.H.1    Ghazizadeh, M.2    Kawanami, O.3    Shimizu, H.4    Jin, E.5    Araki, T.6    Sugisaki, Y.7
  • 156
    • 0030817612 scopus 로고    scopus 로고
    • Expression of vascular endothelial growth factor (VEGF) in epithelial ovarian neoplasms: Correlation with clinicopathology and patient survival, and analysis of serum VEGF levels
    • Yamamoto, S.; Konishi, I.; Mandai, M.; Kuroda, H.; Komatsu, T.; Nanbu, K.; Sakahara, H.; Mori, T. Expression of vascular endothelial growth factor (VEGF) in epithelial ovarian neoplasms: correlation with clinicopathology and patient survival, and analysis of serum VEGF levels. Br. J. Cancer 1997, 76, 1221-1227.
    • (1997) Br. J. Cancer , vol.76 , pp. 1221-1227
    • Yamamoto, S.1    Konishi, I.2    Mandai, M.3    Kuroda, H.4    Komatsu, T.5    Nanbu, K.6    Sakahara, H.7    Mori, T.8
  • 158
    • 0345711456 scopus 로고    scopus 로고
    • Expression of vascular endothelial growth factor related to 72-kilodalton metalloproteinase immunostaining in patients with serous ovarian tumors
    • Garzetti, G.G.; Ciavattini, A.; Lucarini, G.; Pugnaloni, A.; De Nictolis, M.; Amati, S.; Romanini, C.; Biagini, G. Expression of vascular endothelial growth factor related to 72-kilodalton metalloproteinase immunostaining in patients with serous ovarian tumors. Cancer 1999, 85, 2219-2225.
    • (1999) Cancer , vol.85 , pp. 2219-2225
    • Garzetti, G.G.1    Ciavattini, A.2    Lucarini, G.3    Pugnaloni, A.4    de Nictolis, M.5    Amati, S.6    Romanini, C.7    Biagini, G.8
  • 159
    • 34250304711 scopus 로고    scopus 로고
    • Co-expression of angiogenic markers and associations with prognosis in advanced epithelial ovarian cancer: A Gynecologic Oncology Group study
    • Secord, A.A.; Darcy, K.M.; Hutson, A.; Lee, P.S.; Havrilesky, L.J.; Grace, L.A.; Berchuck, A. Co-expression of angiogenic markers and associations with prognosis in advanced epithelial ovarian cancer: a Gynecologic Oncology Group study. Gynecol. Oncol. 2007, 106, 221-232.
    • (2007) Gynecol. Oncol , vol.106 , pp. 221-232
    • Secord, A.A.1    Darcy, K.M.2    Hutson, A.3    Lee, P.S.4    Havrilesky, L.J.5    Grace, L.A.6    Berchuck, A.7
  • 160
    • 0042624638 scopus 로고    scopus 로고
    • Vascular endothelial growth factor (VEGF) expression in primary tumors and peritoneal metastases from patients with advanced ovarian carcinoma
    • Gadducci, A.; Viacava, P.; Cosio, S.; Cecchetti, D.; Fanelli, G.; Fanucchi, A.; Teti, G.; Genazzani, A.R. Vascular endothelial growth factor (VEGF) expression in primary tumors and peritoneal metastases from patients with advanced ovarian carcinoma. Anticancer Res. 2003, 23, 3001-3008.
    • (2003) Anticancer Res , vol.23 , pp. 3001-3008
    • Gadducci, A.1    Viacava, P.2    Cosio, S.3    Cecchetti, D.4    Fanelli, G.5    Fanucchi, A.6    Teti, G.7    Genazzani, A.R.8
  • 161
  • 164
    • 45949084988 scopus 로고    scopus 로고
    • Prognostic significance of fascin expression in advanced poorly differentiated serous ovarian cancer
    • Daponte, A.; Kostopoulou, E.; Minas, M.; Koukoulis, G.; Messinis, I. E. Prognostic significance of fascin expression in advanced poorly differentiated serous ovarian cancer. Anticancer Res. 2008, 28, 1905-1910.
    • (2008) Anticancer Res , vol.28 , pp. 1905-1910
    • Daponte, A.1    Kostopoulou, E.2    Minas, M.3    Koukoulis, G.4    Messinis, I.E.5
  • 165
    • 34447619912 scopus 로고    scopus 로고
    • Over-expression of hypoxia-inducible factor 1 alpha in ovarian clear cell carcinoma
    • Lee, S.; Garner, E.I.; Welch, W.R.; Berkowitz, R.S.; Mok, S.C. Over-expression of hypoxia-inducible factor 1 alpha in ovarian clear cell carcinoma. Gynecol. Oncol. 2007, 106, 311-317.
    • (2007) Gynecol. Oncol , vol.106 , pp. 311-317
    • Lee, S.1    Garner, E.I.2    Welch, W.R.3    Berkowitz, R.S.4    Mok, S.C.5
  • 166
    • 34547838192 scopus 로고    scopus 로고
    • Expression of hypoxia-inducible factor 1alpha, hypoxia-inducible factor 2alpha, and von Hippel-Lindau protein in epithelial ovarian neoplasms and allelic loss of von Hippel-Lindau gene: Nuclear expression of hypoxia-inducible factor 1alpha is an independent prognostic factor in ovarian carcinoma
    • Osada, R.; Horiuchi, A.; Kikuchi, N.; Yoshida, J.; Hayashi, A.; Ota, M.; Katsuyama, Y.; Melillo, G.; Konishi, I. Expression of hypoxia-inducible factor 1alpha, hypoxia-inducible factor 2alpha, and von Hippel-Lindau protein in epithelial ovarian neoplasms and allelic loss of von Hippel-Lindau gene: nuclear expression of hypoxia-inducible factor 1alpha is an independent prognostic factor in ovarian carcinoma. Hum. Pathol. 2007, 38, 1310-1320.
    • (2007) Hum. Pathol , vol.38 , pp. 1310-1320
    • Osada, R.1    Horiuchi, A.2    Kikuchi, N.3    Yoshida, J.4    Hayashi, A.5    Ota, M.6    Katsuyama, Y.7    Melillo, G.8    Konishi, I.9
  • 167
    • 34247155290 scopus 로고    scopus 로고
    • Hypoxia inducible factor 1-alpha expression as a factor predictive of efficacy of taxane/platinum chemotherapy in advanced primary epithelial ovarian cancer
    • Nakai, H.; Watanabe, Y.; Ueda, H.; Hoshiai, H. Hypoxia inducible factor 1-alpha expression as a factor predictive of efficacy of taxane/platinum chemotherapy in advanced primary epithelial ovarian cancer. Cancer Lett. 2007, 251, 164-167.
    • (2007) Cancer Lett , vol.251 , pp. 164-167
    • Nakai, H.1    Watanabe, Y.2    Ueda, H.3    Hoshiai, H.4
  • 168
    • 0842311620 scopus 로고    scopus 로고
    • Elevated cyclooxygenase-2 expression is associated with altered expression of p53 and SMAD4, amplification of HER-2/neu, and poor outcome in serous ovarian carcinoma
    • Erkinheimo, T.L.; Lassus, H.; Finne, P.; van Rees, B.P.; Leminen, A.; Ylikorkala, O.; Haglund, C.; Butzow, R.; Ristimaki, A. Elevated cyclooxygenase-2 expression is associated with altered expression of p53 and SMAD4, amplification of HER-2/neu, and poor outcome in serous ovarian carcinoma. Clin. Cancer Res. 2004, 10, 538-545.
    • (2004) Clin. Cancer Res , vol.10 , pp. 538-545
    • Erkinheimo, T.L.1    Lassus, H.2    Finne, P.3    van Rees, B.P.4    Leminen, A.5    Ylikorkala, O.6    Haglund, C.7    Butzow, R.8    Ristimaki, A.9
  • 169
    • 1342321831 scopus 로고    scopus 로고
    • Expression of cyclooxygenase-2 in association with clinicopathological prognostic factors and molecular markers in epithelial ovarian cancer
    • Seo, S.S.; Song, Y.S.; Kang, D.H.; Park, I.A.; Bang, Y.J.; Kang, S.B.; Lee, H.P. Expression of cyclooxygenase-2 in association with clinicopathological prognostic factors and molecular markers in epithelial ovarian cancer. Gynecol. Oncol. 2004, 92, 927-935.
    • (2004) Gynecol. Oncol , vol.92 , pp. 927-935
    • Seo, S.S.1    Song, Y.S.2    Kang, D.H.3    Park, I.A.4    Bang, Y.J.5    Kang, S.B.6    Lee, H.P.7
  • 170
    • 0141675101 scopus 로고    scopus 로고
    • The effect of cyclooxygenase-2 expression on tumor vascularity in advanced stage ovarian serous carcinoma
    • Ali-Fehmi, R.; Che, M.; Khalifeh, I.; Malone, J.M.; Morris, R.; Lawrence, W.D.; Munkarah, A.R. The effect of cyclooxygenase-2 expression on tumor vascularity in advanced stage ovarian serous carcinoma. Cancer 2003, 98, 1423-1429.
    • (2003) Cancer , vol.98 , pp. 1423-1429
    • Ali-Fehmi, R.1    Che, M.2    Khalifeh, I.3    Malone, J.M.4    Morris, R.5    Lawrence, W.D.6    Munkarah, A.R.7
  • 171
    • 1642367845 scopus 로고    scopus 로고
    • Expression of Cox-2, CD34, Bcl-2, and p53 and survival in patients with primary peritoneal serous carcinoma and primary ovarian serous carcinoma
    • Khalifeh, I.; Munkarah, A. R.; Lonardo, F.; Malone, J. M.; Morris, R.; Lawrence, W.D.; Ali-Fehmi, R. Expression of Cox-2, CD34, Bcl-2, and p53 and survival in patients with primary peritoneal serous carcinoma and primary ovarian serous carcinoma. Int. J. Gynecol. Pathol. 2004, 23, 162-169.
    • (2004) Int. J. Gynecol. Pathol , vol.23 , pp. 162-169
    • Khalifeh, I.1    Munkarah, A.R.2    Lonardo, F.3    Malone, J.M.4    Morris, R.5    Lawrence, W.D.6    Ali-Fehmi, R.7
  • 172
    • 33645950085 scopus 로고    scopus 로고
    • Expression of metalloproteinases 2 and 9 and cyclooxygenase 2 in endometrial carcinoma
    • Raspollini, M.R.; Susini, T.; Taddei, G.L. Expression of metalloproteinases 2 and 9 and cyclooxygenase 2 in endometrial carcinoma. Int. J. Gynaecol. Obstet. 2006, 93, 64-66.
    • (2006) Int. J. Gynaecol. Obstet , vol.93 , pp. 64-66
    • Raspollini, M.R.1    Susini, T.2    Taddei, G.L.3
  • 174
    • 1342300679 scopus 로고    scopus 로고
    • Expression of inducible nitric oxide synthase and cyclooxygenase-2 in ovarian cancer: Correlation with clinical outcome
    • Raspollini, M.R.; Amunni, G.; Villanucci, A.; Boddi, V.; Baroni, G.; Taddei, A.; Taddei, G.L. Expression of inducible nitric oxide synthase and cyclooxygenase-2 in ovarian cancer: correlation with clinical outcome. Gynecol. Oncol. 2004, 92, 806-812.
    • (2004) Gynecol. Oncol , vol.92 , pp. 806-812
    • Raspollini, M.R.1    Amunni, G.2    Villanucci, A.3    Boddi, V.4    Baroni, G.5    Taddei, A.6    Taddei, G.L.7
  • 179
    • 0034902029 scopus 로고    scopus 로고
    • Thrombospondin-1 expression in epithelial ovarian carcinoma: Association with p53 status, tumor angiogenesis, and survival in platinum-treated patients
    • Alvarez, A.A.; Axelrod, J.R.; Whitaker, R.S.; Isner, P.D.; Bentley, R.C.; Dodge, R.K.; Rodriguez, G.C. Thrombospondin-1 expression in epithelial ovarian carcinoma: association with p53 status, tumor angiogenesis, and survival in platinum-treated patients. Gynecol. Oncol. 2001, 82, 273-278.
    • (2001) Gynecol. Oncol , vol.82 , pp. 273-278
    • Alvarez, A.A.1    Axelrod, J.R.2    Whitaker, R.S.3    Isner, P.D.4    Bentley, R.C.5    Dodge, R.K.6    Rodriguez, G.C.7
  • 180
    • 33645348277 scopus 로고    scopus 로고
    • Clinicopathologic study of vascular endothelial growth factor, thrombospondin-1, and microvessel density assessed by CD34 in patients with stage III ovarian carcinoma
    • Karavasilis, V.; Malamou-Mitsi, V.; Briasoulis, E.; Tsanou, E.; Kitsou, E.; Pavlidis, N. Clinicopathologic study of vascular endothelial growth factor, thrombospondin-1, and microvessel density assessed by CD34 in patients with stage III ovarian carcinoma. Int. J. Gynecol. Cancer 2006, 16 (Suppl. 1), 241-246.
    • (2006) Int. J. Gynecol. Cancer , vol.16 , Issue.SUPPL. 1 , pp. 241-246
    • Karavasilis, V.1    Malamou-Mitsi, V.2    Briasoulis, E.3    Tsanou, E.4    Kitsou, E.5    Pavlidis, N.6
  • 181
    • 0036512208 scopus 로고    scopus 로고
    • New functions for the matrix metalloproteinases in cancer progression
    • Egeblad, M.; Werb, Z. New functions for the matrix metalloproteinases in cancer progression. Nat. Rev. Cancer 2002, 2, 161-174.
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 161-174
    • Egeblad, M.1    Werb, Z.2
  • 185
    • 33748504131 scopus 로고    scopus 로고
    • Prognostic significance of matrix metalloproteinase-7 in epithelial ovarian cancer and its relation to beta-catenin expression
    • Sillanpaa, S.M.; Anttila, M.A.; Voutilainen, K.A.; Ropponen, K.M.; Sironen, R.K.; Saarikoski, S.V.; Kosma, V.M. Prognostic significance of matrix metalloproteinase-7 in epithelial ovarian cancer and its relation to beta-catenin expression. Int. J. Cancer 2006, 119, 1792-1799.
    • (2006) Int. J. Cancer , vol.119 , pp. 1792-1799
    • Sillanpaa, S.M.1    Anttila, M.A.2    Voutilainen, K.A.3    Ropponen, K.M.4    Sironen, R.K.5    Saarikoski, S.V.6    Kosma, V.M.7
  • 192
  • 193
    • 41149148789 scopus 로고    scopus 로고
    • The impact of T-cell immunity on ovarian cancer outcomes
    • B.H. The impact of T-cell immunity on ovarian cancer outcomes. Immunol. Rev. 2008, 222, 101-116.
    • (2008) Immunol. Rev , vol.222 , pp. 101-116
  • 194
    • 77956873287 scopus 로고    scopus 로고
    • Cell Density and Location Can Influence the Prognosis of Ovarian Cancer
    • doi: 10.1007/s12253-009-9230-5
    • Al-Attar, A.; Shehata, M.; Durrant, L.; Moseley, P.; Deen, S.; Chan, S. T Cell Density and Location Can Influence the Prognosis of Ovarian Cancer. Pathol. Oncol. Res. 2009, doi: 10.1007/s12253-009-9230-5.
    • (2009) Pathol. Oncol. Res
    • Al-Attar, A.1    Shehata, M.2    Durrant, L.3    Moseley, P.4    Deen, S.5    Chan, S.T.6
  • 195
    • 28544433483 scopus 로고    scopus 로고
    • The expression of the regulatory T cell-specific forkhead box transcription factor FoxP3 is associated with poor prognosis in ovarian cancer
    • Wolf, D.; Wolf, A.M.; Rumpold, H.; Fiegl, H.; Zeimet, A.G.; Muller-Holzner, E.; Deibl, M.; Gastl, G.; Gunsilius, E.; Marth, C. The expression of the regulatory T cell-specific forkhead box transcription factor FoxP3 is associated with poor prognosis in ovarian cancer. Clin. Cancer Res. 2005, 11, 8326-8331.
    • (2005) Clin. Cancer Res , vol.11 , pp. 8326-8331
    • Wolf, D.1    Wolf, A.M.2    Rumpold, H.3    Fiegl, H.4    Zeimet, A.G.5    Muller-Holzner, E.6    Deibl, M.7    Gastl, G.8    Gunsilius, E.9    Marth, C.10
  • 200
    • 68149141666 scopus 로고    scopus 로고
    • Systematic analysis of immune infiltrates in high-grade serous ovarian cancer reveals CD20, FoxP3 and TIA-1 as positive prognostic factors
    • Milne, K.; Kobel, M.; Kalloger, S.E.; Barnes, R.O.; Gao, D.; Gilks, C.B.; Watson, P.H.; Nelson, B.H. Systematic analysis of immune infiltrates in high-grade serous ovarian cancer reveals CD20, FoxP3 and TIA-1 as positive prognostic factors. PLoS One 2009, 4, e6412.
    • (2009) PLoS One , vol.4
    • Milne, K.1    Kobel, M.2    Kalloger, S.E.3    Barnes, R.O.4    Gao, D.5    Gilks, C.B.6    Watson, P.H.7    Nelson, B.H.8
  • 204
    • 34548798737 scopus 로고    scopus 로고
    • Relationship between B7-H4, regulatory T cells, and patient outcome in human ovarian carcinoma
    • Kryczek, I.; Wei, S.; Zhu, G.; Myers, L.; Mottram, P.; Cheng, P.; Chen, L.; Coukos, G.; Zou, W. Relationship between B7-H4, regulatory T cells, and patient outcome in human ovarian carcinoma. Cancer Res. 2007, 67, 8900-8905.
    • (2007) Cancer Res , vol.67 , pp. 8900-8905
    • Kryczek, I.1    Wei, S.2    Zhu, G.3    Myers, L.4    Mottram, P.5    Cheng, P.6    Chen, L.7    Coukos, G.8    Zou, W.9
  • 205
    • 0031150559 scopus 로고    scopus 로고
    • Overexpression of p53, EGFR, c-erbB2 and c-erbB3 in endometrioid carcinoma of the ovary
    • Leng, J.; Lang, J.; Shen, K.; Guo, L. Overexpression of p53, EGFR, c-erbB2 and c-erbB3 in endometrioid carcinoma of the ovary. Chin. Med. Sci. J. 1997, 12, 67-70.
    • (1997) Chin. Med. Sci. J , vol.12 , pp. 67-70
    • Leng, J.1    Lang, J.2    Shen, K.3    Guo, L.4
  • 207
    • 0035027576 scopus 로고    scopus 로고
    • The growth factor receptors HER-2/neu and EGFR, their relationship, and their effects on the prognosis in early stage (FIGO I-II) epithelial ovarian carcinoma
    • Skirnisdottir, I.; Sorbe, B.; Seidal, T. The growth factor receptors HER-2/neu and EGFR, their relationship, and their effects on the prognosis in early stage (FIGO I-II) epithelial ovarian carcinoma. Int. J. Gynecol. Cancer 2001, 11, 119-129.
    • (2001) Int. J. Gynecol. Cancer , vol.11 , pp. 119-129
    • Skirnisdottir, I.1    Sorbe, B.2    Seidal, T.3
  • 208
    • 1842732148 scopus 로고    scopus 로고
    • Interplay between EphB4 on tumor cells and vascular ephrin-B2 regulates tumor growth
    • Noren, N.K.; Lu, M.; Freeman, A.L.; Koolpe, M.; Pasquale, E. B. Interplay between EphB4 on tumor cells and vascular ephrin-B2 regulates tumor growth. Proc. Natl. Acad. Sci. USA 2004, 101, 5583-5588.
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 5583-5588
    • Noren, N.K.1    Lu, M.2    Freeman, A.L.3    Koolpe, M.4    Pasquale, E.B.5
  • 210
    • 33744910085 scopus 로고    scopus 로고
    • The prognostic impact of EphB2/B4 expression on patients with advanced ovarian carcinoma
    • Wu, Q.; Suo, Z.; Kristensen, G.B.; Baekelandt, M.; Nesland, J.M. The prognostic impact of EphB2/B4 expression on patients with advanced ovarian carcinoma. Gynecol. Oncol. 2006, 102, 15-21.
    • (2006) Gynecol. Oncol , vol.102 , pp. 15-21
    • Wu, Q.1    Suo, Z.2    Kristensen, G.B.3    Baekelandt, M.4    Nesland, J.M.5
  • 211
    • 39449101440 scopus 로고    scopus 로고
    • Coexpression of EphB4 and ephrinB2 in tumour advancement of ovarian cancers
    • Alam, S.M.; Fujimoto, J.; Jahan, I.; Sato, E.; Tamaya, T. Coexpression of EphB4 and ephrinB2 in tumour advancement of ovarian cancers. Br. J. Cancer 2008, 98, 845-851.
    • (2008) Br. J. Cancer , vol.98 , pp. 845-851
    • Alam, S.M.1    Fujimoto, J.2    Jahan, I.3    Sato, E.4    Tamaya, T.5
  • 212
    • 33745451273 scopus 로고    scopus 로고
    • Tissue array analysis of expression microarray candidates identifies markers associated with tumor grade and outcome in serous epithelial ovarian cancer
    • Ouellet, V.; Guyot, M.C.; Le Page, C.; Filali-Mouhim, A.; Lussier, C.; Tonin, P.N.; Provencher, D.M.; Mes-Masson, A.M. Tissue array analysis of expression microarray candidates identifies markers associated with tumor grade and outcome in serous epithelial ovarian cancer. Int. J. Cancer 2006, 119, 599-607.
    • (2006) Int. J. Cancer , vol.119 , pp. 599-607
    • Ouellet, V.1    Guyot, M.C.2    le Page, C.3    Filali-Mouhim, A.4    Lussier, C.5    Tonin, P.N.6    Provencher, D.M.7    Mes-Masson, A.M.8
  • 214
    • 56049094836 scopus 로고    scopus 로고
    • Increased staining for phosphorylated AKT and nuclear factor-kappaB p65 and their relationship with prognosis in epithelial ovarian cancer
    • Guo, R.X.; Qiao, Y.H.; Zhou, Y.; Li, L.X.; Shi, H.R.; Chen, K.S. Increased staining for phosphorylated AKT and nuclear factor-kappaB p65 and their relationship with prognosis in epithelial ovarian cancer. Pathol. Int. 2008, 58, 749-756.
    • (2008) Pathol. Int , vol.58 , pp. 749-756
    • Guo, R.X.1    Qiao, Y.H.2    Zhou, Y.3    Li, L.X.4    Shi, H.R.5    Chen, K.S.6
  • 216
    • 33750089285 scopus 로고    scopus 로고
    • Phosphorylated 4E binding protein 1: A hallmark of cell signaling that correlates with survival in ovarian cancer
    • Castellvi, J.; Garcia, A.; Rojo, F.; Ruiz-Marcellan, C.; Gil, A.; Baselga, J.; Ramon y Cajal, S. Phosphorylated 4E binding protein 1: a hallmark of cell signaling that correlates with survival in ovarian cancer. Cancer 2006, 107, 1801-1811.
    • (2006) Cancer , vol.107 , pp. 1801-1811
    • Castellvi, J.1    Garcia, A.2    Rojo, F.3    Ruiz-Marcellan, C.4    Gil, A.5    Baselga, J.6
  • 217
    • 75149175604 scopus 로고    scopus 로고
    • The Akt and ERK activation by platinum-based chemotherapy in ovarian cancer is associated with favorable patient outcome
    • Ohta, T.; Isobe, M.; Takahashi, T.; Saitoh-Sekiguchi, M.; Motoyama, T.; Kurachi, H. The Akt and ERK activation by platinum-based chemotherapy in ovarian cancer is associated with favorable patient outcome. Anticancer Res. 2009, 29, 4639-4647.
    • (2009) Anticancer Res , vol.29 , pp. 4639-4647
    • Ohta, T.1    Isobe, M.2    Takahashi, T.3    Saitoh-Sekiguchi, M.4    Motoyama, T.5    Kurachi, H.6
  • 219
    • 24144486962 scopus 로고    scopus 로고
    • Protein expression and prognostic value of genes in the erb-b signaling pathway in advanced ovarian carcinomas
    • Wang, Y.; Kristensen, G.B.; Helland, A.; Nesland, J.M.; Borresen-Dale, A.L.; Holm, R. Protein expression and prognostic value of genes in the erb-b signaling pathway in advanced ovarian carcinomas. Am. J. Clin. Pathol. 2005, 124, 392-401.
    • (2005) Am. J. Clin. Pathol , vol.124 , pp. 392-401
    • Wang, Y.1    Kristensen, G.B.2    Helland, A.3    Nesland, J.M.4    Borresen-Dale, A.L.5    Holm, R.6
  • 220
    • 6944238451 scopus 로고    scopus 로고
    • Prognostic value of E-cadherin immunoexpression in patients with primary ovarian carcinomas
    • Faleiro-Rodrigues, C.; Macedo-Pinto, I.; Pereira, D.; Lopes, C. S. Prognostic value of E-cadherin immunoexpression in patients with primary ovarian carcinomas. Ann. Oncol. 2004, 15, 1535-1542.
    • (2004) Ann. Oncol , vol.15 , pp. 1535-1542
    • Faleiro-Rodrigues, C.1    Macedo-Pinto, I.2    Pereira, D.3    Lopes, C.S.4
  • 221
    • 33645124691 scopus 로고    scopus 로고
    • Immunohistochemical study of the expression of adhesion molecules in ovarian serous neoplasms
    • Cho, E.Y.; Choi, Y.; Chae, S. W.; Sohn, J.H.; Ahn, G.H. Immunohistochemical study of the expression of adhesion molecules in ovarian serous neoplasms. Pathol. Int. 2006, 56, 62-70.
    • (2006) Pathol. Int , vol.56 , pp. 62-70
    • Cho, E.Y.1    Choi, Y.2    Chae, S.W.3    Sohn, J.H.4    Ahn, G.H.5
  • 222
    • 64049083106 scopus 로고    scopus 로고
    • Prognostic significance of paired epithelial cell adhesion molecule and E-cadherin in ovarian serous carcinoma
    • Shim, H.S.; Yoon, B.S.; Cho, N.H. Prognostic significance of paired epithelial cell adhesion molecule and E-cadherin in ovarian serous carcinoma. Hum. Pathol. 2009, 40, 693-698.
    • (2009) Hum. Pathol , vol.40 , pp. 693-698
    • Shim, H.S.1    Yoon, B.S.2    Cho, N.H.3
  • 224
    • 19444384545 scopus 로고    scopus 로고
    • beta-catenin expression, DNA ploidy and clinicopathological features in ovarian cancer: A study in 253 patients
    • Kildal, W.; Risberg, B.; Abeler, V.M.; Kristensen, G.B.; Sudbo, J.; Nesland, J.M.; Danielsen, H.E. beta-catenin expression, DNA ploidy and clinicopathological features in ovarian cancer: a study in 253 patients. Eur. J. Cancer 2005, 41, 1127-1134.
    • (2005) Eur. J. Cancer , vol.41 , pp. 1127-1134
    • Kildal, W.1    Risberg, B.2    Abeler, V.M.3    Kristensen, G.B.4    Sudbo, J.5    Nesland, J.M.6    Danielsen, H.E.7
  • 228
    • 0037382283 scopus 로고    scopus 로고
    • Quantitative analysis of breast cancer tissue microarrays shows that both high and normal levels of HER2 expression are associated with poor outcome
    • Camp, R.L.; Dolled-Filhart, M.; King, B.L.; Rimm, D.L. Quantitative analysis of breast cancer tissue microarrays shows that both high and normal levels of HER2 expression are associated with poor outcome. Cancer Res. 2003, 63, 1445-1448.
    • (2003) Cancer Res , vol.63 , pp. 1445-1448
    • Camp, R.L.1    Dolled-Filhart, M.2    King, B.L.3    Rimm, D.L.4
  • 229
    • 57149117848 scopus 로고    scopus 로고
    • A decade of tissue microarrays: Progress in the discovery and validation of cancer biomarkers
    • Camp, R.L.; Neumeister, V.; Rimm, D.L. A decade of tissue microarrays: progress in the discovery and validation of cancer biomarkers. J. Clin. Oncol. 2008, 26, 5630-5637.
    • (2008) J. Clin. Oncol , vol.26 , pp. 5630-5637
    • Camp, R.L.1    Neumeister, V.2    Rimm, D.L.3
  • 232
    • 13444283596 scopus 로고    scopus 로고
    • Bias as a threat to the validity of cancer molecular-marker research
    • D.F. Bias as a threat to the validity of cancer molecular-marker research. Nat. Rev. Cancer 2005, 5, 142-149.
    • (2005) Nat. Rev. Cancer , vol.5 , pp. 142-149
  • 233
    • 35848962931 scopus 로고    scopus 로고
    • How to improve reliability and efficiency of research about molecular markers: Roles of phases, guidelines, and study design
    • Ransohoff, D.F. How to improve reliability and efficiency of research about molecular markers: roles of phases, guidelines, and study design. J. Clin. Epidemiol. 2007, 60, 1205-1219.
    • (2007) J. Clin. Epidemiol , vol.60 , pp. 1205-1219
    • Ransohoff, D.F.1
  • 234
    • 54049129625 scopus 로고    scopus 로고
    • Pivotal evaluation of the accuracy of a biomarker used for classification or prediction: Standards for study design
    • Pepe, M.; Feng, Z.; Janes, H.; Bossuyt, P.M.; Potter, J.D. Pivotal evaluation of the accuracy of a biomarker used for classification or prediction: standards for study design. J. Natl. Cancer Inst. 2008, 100, 1432-1438.
    • (2008) J. Natl. Cancer Inst , vol.100 , pp. 1432-1438
    • Pepe, M.1    Feng, Z.2    Janes, H.3    Bossuyt, P.M.4    Potter, J.D.5
  • 236
    • 73949159645 scopus 로고    scopus 로고
    • Does massively parallel DNA resequencing signify the end of histopathology as we know it?
    • Aparicio, S.A.; Huntsman, D.G. Does massively parallel DNA resequencing signify the end of histopathology as we know it? J. Pathol. 220, 307-315.
    • J. Pathol , vol.220 , pp. 307-315
    • Aparicio, S.A.1    Huntsman, D.G.2
  • 237
  • 238
    • 29144461054 scopus 로고    scopus 로고
    • Multidrug resistance-related phenotype and apoptosis-related protein expression in ovarian serous carcinomas
    • Yakirevich, E.; Sabo, E.; Naroditsky, I.; Sova, Y.; Lavie, O.; Resnick, M.B. Multidrug resistance-related phenotype and apoptosis-related protein expression in ovarian serous carcinomas. Gynecol. Oncol. 2006, 100, 152-159.
    • (2006) Gynecol. Oncol , vol.100 , pp. 152-159
    • Yakirevich, E.1    Sabo, E.2    Naroditsky, I.3    Sova, Y.4    Lavie, O.5    Resnick, M.B.6
  • 239
    • 1442351945 scopus 로고    scopus 로고
    • The prognostic significance of the immunohistochemical expression of p53, bcl-2, c-erb B-2 and cathepsin-D in ovarian cancer patients receiving platinum with cyclophosphamide or paclitaxel chemotherapy
    • Protopapas, A.; Diakomanolis, E.; Bamias, A.; Milingos, S.; Markaki, S.; Papadimitriou, C.; Dimopoulos, A.M.; Michalas, S. The prognostic significance of the immunohistochemical expression of p53, bcl-2, c-erb B-2 and cathepsin-D in ovarian cancer patients receiving platinum with cyclophosphamide or paclitaxel chemotherapy. Eur. J. Gynaecol. Oncol. 2004, 25, 225-229.
    • (2004) Eur. J. Gynaecol. Oncol , vol.25 , pp. 225-229
    • Protopapas, A.1    Diakomanolis, E.2    Bamias, A.3    Milingos, S.4    Markaki, S.5    Papadimitriou, C.6    Dimopoulos, A.M.7    Michalas, S.8
  • 242
    • 60449117723 scopus 로고    scopus 로고
    • Independent prognostic relevance of microvessel density in advanced epithelial ovarian cancer and associations between CD31, CD105, p53 status, and angiogenic marker expression: A Gynecologic Oncology Group study
    • Rubatt, J.M.; Darcy, K.M.; Hutson, A.; Bean, S.M.; Havrilesky, L.J.; Grace, L.A.; Berchuck, A.; Secord, A.A. Independent prognostic relevance of microvessel density in advanced epithelial ovarian cancer and associations between CD31, CD105, p53 status, and angiogenic marker expression: A Gynecologic Oncology Group study. Gynecol. Oncol. 2009, 112, 469-474.
    • (2009) Gynecol. Oncol , vol.112 , pp. 469-474
    • Rubatt, J.M.1    Darcy, K.M.2    Hutson, A.3    Bean, S.M.4    Havrilesky, L.J.5    Grace, L.A.6    Berchuck, A.7    Secord, A.A.8
  • 243
  • 245
    • 4544362792 scopus 로고    scopus 로고
    • Prognostic significance of microvessel density and vascular endothelial growth factor expression in advanced ovarian serous carcinoma
    • Raspollini, M.R.; Amunni, G.; Villanucci, A.; Baroni, G.; Boddi, V.; Taddei, G.L. Prognostic significance of microvessel density and vascular endothelial growth factor expression in advanced ovarian serous carcinoma. Int. J. Gynecol. Cancer 2004, 14, 815-823.
    • (2004) Int. J. Gynecol. Cancer , vol.14 , pp. 815-823
    • Raspollini, M.R.1    Amunni, G.2    Villanucci, A.3    Baroni, G.4    Boddi, V.5    Taddei, G.L.6
  • 246
    • 70350066161 scopus 로고    scopus 로고
    • Cox-2 immunohistochemical expression in epithelial ovarian carcinoma and platin sensitivity
    • Menczer, J.; Schreiber, L.; Kravtsov, V.; Berger, E.; Golan, A.; Levy, T. Cox-2 immunohistochemical expression in epithelial ovarian carcinoma and platin sensitivity. Eur. J. Gynaecol. Oncol. 2009, 30, 531-535.
    • (2009) Eur. J. Gynaecol. Oncol , vol.30 , pp. 531-535
    • Menczer, J.1    Schreiber, L.2    Kravtsov, V.3    Berger, E.4    Golan, A.5    Levy, T.6
  • 247
    • 50349096101 scopus 로고    scopus 로고
    • Epidermal growth factor receptor expression in serous ovarian carcinoma: An immunohistochemical study with galectin-3 and cyclin D1 and outcome
    • Brustmann, H. Epidermal growth factor receptor expression in serous ovarian carcinoma: an immunohistochemical study with galectin-3 and cyclin D1 and outcome. Int. J. Gynecol. Pathol. 2008, 27, 380-389.
    • (2008) Int. J. Gynecol. Pathol , vol.27 , pp. 380-389
    • Brustmann, H.1
  • 249
    • 0030761757 scopus 로고    scopus 로고
    • Expression of cadherins in benign, borderline, and malignant ovarian epithelial tumors: A clinicopathologic study of 60 cases
    • Darai, E.; Scoazec, J.Y.; Walker-Combrouze, F.; Mlika-Cabanne, N.; Feldmann, G.; Madelenat, P.; Potet, F. Expression of cadherins in benign, borderline, and malignant ovarian epithelial tumors: a clinicopathologic study of 60 cases. Hum. Pathol. 1997, 28, 922-928.
    • (1997) Hum. Pathol , vol.28 , pp. 922-928
    • Darai, E.1    Scoazec, J.Y.2    Walker-Combrouze, F.3    Mlika-Cabanne, N.4    Feldmann, G.5    Madelenat, P.6    Potet, F.7
  • 250
    • 23044511620 scopus 로고    scopus 로고
    • Phase II study of gefitinib in patients with relapsed or persistent ovarian or primary peritoneal carcinoma and evaluation of epidermal growth factor receptor mutations and immunohistochemical expression: A Gynecologic Oncology Group Study
    • Schilder, R.J.; Sill, M. W.; Chen, X.; Darcy, K.M.; Decesare, S.L.; Lewandowski, G.; Lee, R.B.; Arciero, C.A.; Wu, H.; Godwin, A.K. Phase II study of gefitinib in patients with relapsed or persistent ovarian or primary peritoneal carcinoma and evaluation of epidermal growth factor receptor mutations and immunohistochemical expression: a Gynecologic Oncology Group Study. Clin. Cancer Res. 2005, 11, 5539-5548.
    • (2005) Clin. Cancer Res , vol.11 , pp. 5539-5548
    • Schilder, R.J.1    Sill, M.W.2    Chen, X.3    Darcy, K.M.4    Decesare, S.L.5    Lewandowski, G.6    Lee, R.B.7    Arciero, C.A.8    Wu, H.9    Godwin, A.K.10
  • 252
    • 33746742412 scopus 로고    scopus 로고
    • Gene amplification, mutation, and protein expression of EGFR and mutations of ERBB2 in serous ovarian carcinoma
    • Lassus, H.; Sihto, H.; Leminen, A.; Joensuu, H.; Isola, J.; Nupponen, N.N.; Butzow, R. Gene amplification, mutation, and protein expression of EGFR and mutations of ERBB2 in serous ovarian carcinoma. J. Mol. Med. 2006, 84, 671-681.
    • (2006) J. Mol. Med , vol.84 , pp. 671-681
    • Lassus, H.1    Sihto, H.2    Leminen, A.3    Joensuu, H.4    Isola, J.5    Nupponen, N.N.6    Butzow, R.7
  • 253
    • 0031056372 scopus 로고    scopus 로고
    • EGFR and steroid receptors in ovarian carcinoma: Comparison with prognostic parameters and outcome of patients
    • Fischer-Colbrie, J.; Witt, A.; Heinzl, H.; Speiser, P.; Czerwenka, K.; Sevelda, P.; Zeillinger, R. EGFR and steroid receptors in ovarian carcinoma: comparison with prognostic parameters and outcome of patients. Anticancer Res. 1997, 17, 613-619.
    • (1997) Anticancer Res , vol.17 , pp. 613-619
    • Fischer-Colbrie, J.1    Witt, A.2    Heinzl, H.3    Speiser, P.4    Czerwenka, K.5    Sevelda, P.6    Zeillinger, R.7
  • 254
    • 0029156963 scopus 로고
    • Epidermal growth factor, oestrogen and progesterone receptor expression in primary ovarian cancer: Correlation with clinical outcome and response to chemotherapy
    • Scambia, G.; Benedetti-Panici, P.; Ferrandina, G.; Distefano, M.; Salerno, G.; Romanini, M.E.; Fagotti, A.; Mancuso, S. Epidermal growth factor, oestrogen and progesterone receptor expression in primary ovarian cancer: correlation with clinical outcome and response to chemotherapy. Br. J. Cancer 1995, 72, 361-366.
    • (1995) Br. J. Cancer , vol.72 , pp. 361-366
    • Scambia, G.1    Benedetti-Panici, P.2    Ferrandina, G.3    Distefano, M.4    Salerno, G.5    Romanini, M.E.6    Fagotti, A.7    Mancuso, S.8
  • 255
    • 61349160461 scopus 로고    scopus 로고
    • The expression of six biomarkers in the four most common ovarian cancers: Correlation with clinicopathological parameters
    • Lin, C.K.; Chao, T.K.; Yu, C.P.; Yu, M.H.; Jin, J.S. The expression of six biomarkers in the four most common ovarian cancers: correlation with clinicopathological parameters. APMIS 2009, 117, 162-175.
    • (2009) APMIS , vol.117 , pp. 162-175
    • Lin, C.K.1    Chao, T.K.2    Yu, C.P.3    Yu, M.H.4    Jin, J.S.5
  • 256
    • 10044232731 scopus 로고    scopus 로고
    • Prognostic significance of p53, Her-2, and EGFR overexpression in borderline and epithelial ovarian cancer
    • Nielsen, J.S.; Jakobsen, E.; Holund, B.; Bertelsen, K.; Jakobsen, A. Prognostic significance of p53, Her-2, and EGFR overexpression in borderline and epithelial ovarian cancer. Int. J. Gynecol. Cancer 2004, 14, 1086-1096.
    • (2004) Int. J. Gynecol. Cancer , vol.14 , pp. 1086-1096
    • Nielsen, J.S.1    Jakobsen, E.2    Holund, B.3    Bertelsen, K.4    Jakobsen, A.5
  • 257
    • 67649225203 scopus 로고    scopus 로고
    • Nuclear expression of epidermal growth factor receptor is a novel prognostic value in patients with ovarian cancer
    • Xia, W.; Wei, Y.; Du, Y.; Liu, J.; Chang, B.; Yu, Y.L.; Huo, L.F.; Miller, S.; Hung, M.C. Nuclear expression of epidermal growth factor receptor is a novel prognostic value in patients with ovarian cancer. Mol. Carcinog. 2009, 48, 610-617.
    • (2009) Mol. Carcinog , vol.48 , pp. 610-617
    • Xia, W.1    Wei, Y.2    Du, Y.3    Liu, J.4    Chang, B.5    Yu, Y.L.6    Huo, L.F.7    Miller, S.8    Hung, M.C.9
  • 258
    • 38049080500 scopus 로고    scopus 로고
    • Management of relapsed/refractory epithelial ovarian cancer: Current standards and novel approaches
    • Lin, H.; Changchien, C.C. Management of relapsed/refractory epithelial ovarian cancer: current standards and novel approaches. Taiwan J. Obstet. Gynecol. 2007, 46, 379-388.
    • (2007) Taiwan J. Obstet. Gynecol , vol.46 , pp. 379-388
    • Lin, H.1    Changchien, C.C.2
  • 259
    • 37349122779 scopus 로고    scopus 로고
    • ERCC1-immunoexpression does not predict platinum-resistance in ovarian cancer
    • Stadlmann, S.; Dirnhofer, S.; Guth, U.; Thies, S.; Singer, G. ERCC1-immunoexpression does not predict platinum-resistance in ovarian cancer. Gynecol. Oncol. 2008, 108, 252-253.
    • (2008) Gynecol. Oncol , vol.108 , pp. 252-253
    • Stadlmann, S.1    Dirnhofer, S.2    Guth, U.3    Thies, S.4    Singer, G.5
  • 262
    • 33745148925 scopus 로고    scopus 로고
    • Ephrin B expression in epithelial ovarian neoplasms correlates with tumor differentiation and angiogenesis
    • Castellvi, J.; Garcia, A.; de la Torre, J.; Hernandez, J.; Gil, A.; Xercavins, J.; Ramon y Cajal, S. Ephrin B expression in epithelial ovarian neoplasms correlates with tumor differentiation and angiogenesis. Hum. Pathol. 2006, 37, 883-889.
    • (2006) Hum. Pathol , vol.37 , pp. 883-889
    • Castellvi, J.1    Garcia, A.2    de la Torre, J.3    Hernandez, J.4    Gil, A.5    Xercavins, J.6
  • 263
    • 0027407511 scopus 로고
    • Prognostic significance of HER-2/neu expression in advanced epithelial ovarian cancer: A multivariate analysis
    • Rubin, S.C.; Finstad, C.L.; Wong, G.Y.; Almadrones, L.; Plante, M.; Lloyd, K.O. Prognostic significance of HER-2/neu expression in advanced epithelial ovarian cancer: a multivariate analysis. Am. J. Obstet. Gynecol. 1993, 168, 162-169.
    • (1993) Am. J. Obstet. Gynecol , vol.168 , pp. 162-169
    • Rubin, S.C.1    Finstad, C.L.2    Wong, G.Y.3    Almadrones, L.4    Plante, M.5    Lloyd, K.O.6
  • 265
    • 0038340769 scopus 로고    scopus 로고
    • Distribution of HER-2 overexpression in ovarian carcinoma tissue and its prognostic value in patients with ovarian carcinoma: From the Danish MALOVA Ovarian Cancer Study
    • Hogdall, E.V.; Christensen, L.; Kjaer, S.K.; Blaakaer, J.; Bock, J.E.; Glud, E.; Norgaard-Pedersen, B.; Hogdall, C.K. Distribution of HER-2 overexpression in ovarian carcinoma tissue and its prognostic value in patients with ovarian carcinoma: from the Danish MALOVA Ovarian Cancer Study. Cancer 2003, 98, 66-73.
    • (2003) Cancer , vol.98 , pp. 66-73
    • Hogdall, E.V.1    Christensen, L.2    Kjaer, S.K.3    Blaakaer, J.4    Bock, J.E.5    Glud, E.6    Norgaard-Pedersen, B.7    Hogdall, C.K.8
  • 266
    • 33845876631 scopus 로고    scopus 로고
    • Effect of HER-2/neu overexpression on chemoresistance and prognosis in ovarian carcinoma
    • Sasaki, N.; Kudoh, K.; Kita, T.; Tsuda, H.; Furuya, K.; Kikuchi, Y. Effect of HER-2/neu overexpression on chemoresistance and prognosis in ovarian carcinoma. J. Obstet. Gynaecol. Res. 2007, 33, 17-23.
    • (2007) J. Obstet. Gynaecol. Res , vol.33 , pp. 17-23
    • Sasaki, N.1    Kudoh, K.2    Kita, T.3    Tsuda, H.4    Furuya, K.5    Kikuchi, Y.6
  • 267
    • 23844485690 scopus 로고    scopus 로고
    • HER2/neu oncoprotein overexpression in epithelial ovarian cancer: Evaluation of its prevalence and prognostic significance. Clinical study
    • Verri, E.; Guglielmini, P.; Puntoni, M.; Perdelli, L.; Papadia, A.; Lorenzi, P.; Rubagotti, A.; Ragni, N.; Boccardo, F. HER2/neu oncoprotein overexpression in epithelial ovarian cancer: evaluation of its prevalence and prognostic significance. Clinical study. Oncology 2005, 68, 154-161.
    • (2005) Oncology , vol.68 , pp. 154-161
    • Verri, E.1    Guglielmini, P.2    Puntoni, M.3    Perdelli, L.4    Papadia, A.5    Lorenzi, P.6    Rubagotti, A.7    Ragni, N.8    Boccardo, F.9
  • 269
    • 65649119661 scopus 로고    scopus 로고
    • Prognostic value of human epidermal growth factor receptor 2 (Her-2)/neu in patients with advanced ovarian cancer treated with platinum/paclitaxel as first-line chemotherapy: A retrospective evaluation of the AGO-OVAR 3 Trial by the AGO OVAR Germany
    • Pfisterer, J.; Du Bois, A.; Bentz, E.K.; Kommoss, F.; Harter, P.; Huober, J.; Schmalfeldt, B.; Burchardi, N.; Arnold, N.; Hilpert, F. Prognostic value of human epidermal growth factor receptor 2 (Her-2)/neu in patients with advanced ovarian cancer treated with platinum/paclitaxel as first-line chemotherapy: a retrospective evaluation of the AGO-OVAR 3 Trial by the AGO OVAR Germany. Int. J. Gynecol. Cancer 2009, 19, 109-115.
    • (2009) Int. J. Gynecol. Cancer , vol.19 , pp. 109-115
    • Pfisterer, J.1    du Bois, A.2    Bentz, E.K.3    Kommoss, F.4    Harter, P.5    Huober, J.6    Schmalfeldt, B.7    Burchardi, N.8    Arnold, N.9    Hilpert, F.10
  • 271
    • 0038377853 scopus 로고    scopus 로고
    • Expression of heat-shock proteins hsp27, hsp70 and hsp90 in malignant epithelial tumour of the ovaries
    • Elpek, G.O.; Karaveli, S.; Simsek, T.; Keles, N.; Aksoy, N.H. Expression of heat-shock proteins hsp27, hsp70 and hsp90 in malignant epithelial tumour of the ovaries. APMIS 2003, 111, 523-530.
    • (2003) APMIS , vol.111 , pp. 523-530
    • Elpek, G.O.1    Karaveli, S.2    Simsek, T.3    Keles, N.4    Aksoy, N.H.5
  • 272
    • 22344446260 scopus 로고    scopus 로고
    • Prognostic value of immunohistochemical estimation of CD24 and Ki67 expression in cisplatin and paclitaxel treated ovarian carcinoma patients
    • Surowiak, P.; Materna, V.; Klak, K.; Spaczynski, M.; Dietel, M.; Kristiansen, G.; Lage, H.; Zabel, M. Prognostic value of immunohistochemical estimation of CD24 and Ki67 expression in cisplatin and paclitaxel treated ovarian carcinoma patients. Pol. J. Pathol. 2005, 56, 69-74.
    • (2005) Pol. J. Pathol , vol.56 , pp. 69-74
    • Surowiak, P.1    Materna, V.2    Klak, K.3    Spaczynski, M.4    Dietel, M.5    Kristiansen, G.6    Lage, H.7    Zabel, M.8
  • 273
    • 30944436435 scopus 로고    scopus 로고
    • Prognostic factors in ovarian carcinoma stage III patients. Can biomarkers improve the prediction of short- and long-term survivors?
    • Kaern, J.; Aghmesheh, M.; Nesland, J.M.; Danielsen, H.E.; Sandstad, B.; Friedlander, M.; Trope, C. Prognostic factors in ovarian carcinoma stage III patients. Can biomarkers improve the prediction of short- and long-term survivors? Int. J. Gynecol. Cancer 2005, 15, 1014-1022.
    • (2005) Int. J. Gynecol. Cancer , vol.15 , pp. 1014-1022
    • Kaern, J.1    Aghmesheh, M.2    Nesland, J.M.3    Danielsen, H.E.4    Sandstad, B.5    Friedlander, M.6    Trope, C.7
  • 274
    • 0141455143 scopus 로고    scopus 로고
    • The impact of p53 protein core domain structural alteration on ovarian cancer survival. Clin
    • Rose, S.L.; Robertson, A.D.; Goodheart, M.J.; Smith, B.J.; DeYoung, B.R.; Buller, R.E. The impact of p53 protein core domain structural alteration on ovarian cancer survival. Clin. Cancer Res. 2003, 9, 4139-4144.
    • (2003) Cancer Res , vol.9 , pp. 4139-4144
    • Rose, S.L.1    Robertson, A.D.2    Goodheart, M.J.3    Smith, B.J.4    Deyoung, B.R.5    Buller, R.E.6
  • 276
    • 0033763955 scopus 로고    scopus 로고
    • p53 mutations in epithelial ovarian cancers: Possible role in predicting chemoresistance
    • Laframboise, S.; Chapman, W.; McLaughlin, J.; Andrulis, I.L. p53 mutations in epithelial ovarian cancers: possible role in predicting chemoresistance. Cancer J. 2000, 6, 302-308.
    • (2000) Cancer J , vol.6 , pp. 302-308
    • Laframboise, S.1    Chapman, W.2    McLaughlin, J.3    Andrulis, I.L.4
  • 277
    • 0028177368 scopus 로고
    • Oberg, K. p53 expression in epithelial ovarian neoplasms: Relationship to clinical and pathological parameters, Ki-67 expression and flow cytometry
    • Henriksen, R.; Strang, P.; Wilander, E.; Backstrom, T.; Tribukait, B.; Oberg, K. p53 expression in epithelial ovarian neoplasms: relationship to clinical and pathological parameters, Ki-67 expression and flow cytometry. Gynecol. Oncol. 1994, 53, 301-306.
    • (1994) Gynecol. Oncol , vol.53 , pp. 301-306
    • Henriksen, R.1    Strang, P.2    Wilander, E.3    Backstrom, T.4    Tribukait, B.5
  • 278
    • 0028898748 scopus 로고
    • Mutant p53 protein overexpression is associated with poor outcome in patients with well or moderately differentiated ovarian carcinoma
    • Levesque, M.A.; Katsaros, D.; Yu, H.; Zola, P.; Sismondi, P.; Giardina, G.; Diamandis, E.P. Mutant p53 protein overexpression is associated with poor outcome in patients with well or moderately differentiated ovarian carcinoma. Cancer 1995, 75, 1327-1338.
    • (1995) Cancer , vol.75 , pp. 1327-1338
    • Levesque, M.A.1    Katsaros, D.2    Yu, H.3    Zola, P.4    Sismondi, P.5    Giardina, G.6    Diamandis, E.P.7
  • 279
    • 0030807593 scopus 로고    scopus 로고
    • p53 overexpression is not an independent prognostic factor for patients with primary ovarian epithelial cancer
    • Eltabbakh, G.H.; Belinson, J.L.; Kennedy, A.W.; Biscotti, C.V.; Casey, G.; Tubbs, R.R.; Blumenson, L.E. p53 overexpression is not an independent prognostic factor for patients with primary ovarian epithelial cancer. Cancer 1997, 80, 892-898.
    • (1997) Cancer , vol.80 , pp. 892-898
    • Eltabbakh, G.H.1    Belinson, J.L.2    Kennedy, A.W.3    Biscotti, C.V.4    Casey, G.5    Tubbs, R.R.6    Blumenson, L.E.7
  • 280
    • 36249031994 scopus 로고    scopus 로고
    • Actinin-4 expression in ovarian cancer: A novel prognostic indicator independent of clinical stage and histological type
    • Yamamoto, S.; Tsuda, H.; Honda, K.; Kita, T.; Takano, M.; Tamai, S.; Inazawa, J.; Yamada, T.; Matsubara, O. Actinin-4 expression in ovarian cancer: a novel prognostic indicator independent of clinical stage and histological type. Mod. Pathol. 2007, 20, 1278-1285.
    • (2007) Mod. Pathol , vol.20 , pp. 1278-1285
    • Yamamoto, S.1    Tsuda, H.2    Honda, K.3    Kita, T.4    Takano, M.5    Tamai, S.6    Inazawa, J.7    Yamada, T.8    Matsubara, O.9
  • 281
    • 0028982390 scopus 로고
    • p53 protein detected by immunohistochemistry as a prognostic factor in patients with epithelial ovarian carcinoma
    • Klemi, P.J.; Pylkkanen, L.; Kiilholma, P.; Kurvinen, K.; Joensuu, H. p53 protein detected by immunohistochemistry as a prognostic factor in patients with epithelial ovarian carcinoma. Cancer 1995, 76, 1201-1208.
    • (1995) Cancer , vol.76 , pp. 1201-1208
    • Klemi, P.J.1    Pylkkanen, L.2    Kiilholma, P.3    Kurvinen, K.4    Joensuu, H.5
  • 282
    • 0034332322 scopus 로고    scopus 로고
    • The prognostic significance of p53 tumor suppressor gene alterations in ovarian carcinoma
    • Shahin, M.S.; Hughes, J.H.; Sood, A. K.; Buller, R.E. The prognostic significance of p53 tumor suppressor gene alterations in ovarian carcinoma. Cancer 2000, 89, 2006-2017.
    • (2000) Cancer , vol.89 , pp. 2006-2017
    • Shahin, M.S.1    Hughes, J.H.2    Sood, A.K.3    Buller, R.E.4
  • 285
    • 0028122005 scopus 로고
    • Immunohistochemical detection of p185 product, p21 product, and proliferating cell nuclear antigen (PCNA) in formalin-fixed, paraffin-embedded tissues from ovarian carcinomas. Preliminary data
    • Gadducci, A.; Ciancia, E.M.; Campani, D.; Malagnino, G.; De Luca, F.; Facchini, V.; Pingitore, R.; Fioretti, P. Immunohistochemical detection of p185 product, p21 product, and proliferating cell nuclear antigen (PCNA) in formalin-fixed, paraffin-embedded tissues from ovarian carcinomas. Preliminary data. Eur. J. Gynaecol. Oncol. 1994, 15, 359-368.
    • (1994) Eur. J. Gynaecol. Oncol , vol.15 , pp. 359-368
    • Gadducci, A.1    Ciancia, E.M.2    Campani, D.3    Malagnino, G.4    de Luca, F.5    Facchini, V.6    Pingitore, R.7    Fioretti, P.8
  • 287
    • 0029812713 scopus 로고    scopus 로고
    • Gene expression of DNA topoisomerases I, II alpha and II beta and response to cisplatin-based chemotherapy in advanced ovarian carcinoma
    • Cornarotti, M.; Capranico, G.; Bohm, S.; Oriana, S.; Spatti, G.B.; Mariani, L.; Ballabio, G.; Zunino, F. Gene expression of DNA topoisomerases I, II alpha and II beta and response to cisplatin-based chemotherapy in advanced ovarian carcinoma. Int. J. Cancer 1996, 67, 479-484.
    • (1996) Int. J. Cancer , vol.67 , pp. 479-484
    • Cornarotti, M.1    Capranico, G.2    Bohm, S.3    Oriana, S.4    Spatti, G.B.5    Mariani, L.6    Ballabio, G.7    Zunino, F.8
  • 288
    • 0033922173 scopus 로고    scopus 로고
    • Topoisomerase II alpha: Prognostic predictor and cell cycle marker in surface epithelial neoplasms of the ovary and peritoneum
    • Costa, M.J.; Hansen, C.L.; Holden, J.A.; Guinee, D., Jr. Topoisomerase II alpha: prognostic predictor and cell cycle marker in surface epithelial neoplasms of the ovary and peritoneum. Int. J. Gynecol. Pathol. 2000, 19, 248-257.
    • (2000) Int. J. Gynecol. Pathol , vol.19 , pp. 248-257
    • Costa, M.J.1    Hansen, C.L.2    Holden, J.A.3    Guinee Jr., D.4


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