MLPA screening in the BRCA1 gene from 1,506 German hereditary breast cancer cases: Novel deletions, frequent involvement of exon 17, and occurrence in single early-onset cases

Human Mutation

Volumn 29, Issue 7, 2008, Pages 948-958

  Engert, Stefanie ^a   Wappenschmidt, Barbara ^b   Betz, Beate ^c   Kast, Karin ^d   Kutsche, Michael ^e   Hellebrand, Heide ^a   Goecke, Timm O ^c   Kiechle, Marion ^a   Niederacher, Dieter ^c   Schmutzler, Rita K ^b   Meindl, Alfons ^a  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b TH Köln University of Applied Sciences   (Germany)

^c HEINRICH HEINE UNIVERSITY   (Germany)

^d DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^e Laboratory for Molecular Genetics   (Germany)

Author keywords

BRCA1 mutation spectra and prevalence; Hereditary breast and ovarian cancer; Large genomic rearrangements; Multiplex ligation dependent probe amplification

Indexed keywords

CHECKPOINT KINASE 2;

ARTICLE; BRCA2 GENE; BREAST CANCER; DIAGNOSTIC ACCURACY; EXON; EXON 17; FEMALE; GENE AMPLIFICATION; GENE DELETION; GENE FREQUENCY; GENE IDENTIFICATION; GENE REARRANGEMENT; GENETIC SCREENING; GERMANY; HIGH RISK PATIENT; HUMAN; HUMAN CELL; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; MALE BREAST; MULTIPLEX LIGATION DEPENDENT PROBE AMPLIFICATION; MUTATOR GENE; NUCLEOTIDE SEQUENCE; ONCOGENE; ONSET AGE; OVARY CANCER; PRIORITY JOURNAL;

AGE OF ONSET; BREAST NEOPLASMS; EXONS; FAMILY; FEMALE; GENE REARRANGEMENT; GENES, BRCA1; GENES, BRCA2; GENETIC SCREENING; GERMANY; HUMANS; MALE; OVARIAN NEOPLASMS; POLYMERASE CHAIN REACTION; SEQUENCE DELETION;

EID: 46749157576     PISSN: 10597794     EISSN: None     Source Type: Journal    
DOI: 10.1002/humu.20723     Document Type: Article

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