Immunohistochemical localization of HE4 in benign, borderline, and malignant lesions of the ovary

International Journal of Gynecological Pathology

Volumn 31, Issue 6, 2012, Pages 517-523

  Georgakopoulos, Penelope ^a   Mehmood, Saira ^a   Akalin, Ali ^b   Shroyer, Kenneth R ^a  

^a STONY BROOK UNIVERSITY MEDICAL CENTER   (United States)

^b UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

Biomarkers; HE4; Immunohistochemistry; Ovarian carcinoma; WFDC2

Indexed keywords

HE4 PROTEIN; TUMOR MARKER; UNCLASSIFIED DRUG;

ARTICLE; CELLULAR DISTRIBUTION; CLEAR CELL CARCINOMA; CLEAR CELL OVARY CARCINOMA; COLLOID CARCINOMA; CONTROLLED STUDY; CYSTADENOMA; ENDOMETRIOID CARCINOMA; ENDOMETRIOSIS; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MESOTHELIUM; OVARY CANCER; OVARY TUMOR; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; UTERINE TUBE; UTERINE TUBE CARCINOMA;

ADENOCARCINOMA, CLEAR CELL; ADENOCARCINOMA, MUCINOUS; CARCINOMA, ENDOMETRIOID; CYSTADENOCARCINOMA, SEROUS; ENDOMETRIOSIS; FALLOPIAN TUBE NEOPLASMS; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; OVARIAN NEOPLASMS; PROTEINS;

EID: 84867397030     PISSN: 02771691     EISSN: 15387151     Source Type: Journal    
DOI: 10.1097/PGP.0b013e31824fe269     Document Type: Article

References (11)

1. Heintz AP, Odicino F, Maisonneuve P, et al. Carcinoma of the ovary. J Epidemiol Biostat 2001;6:107-38.
2. Pettersson F. Annual Report on the Results of Treatment in Gynecological Cancer, FIGO. Int J Gynaecol Obstet 1994;22:83-102.
3. Kurman RJ, Blaustein AU, eds. Blaustein's Pathology of the Female Genital Tract. 5th ed. New York, NY, London: Springer. xv; 2002:1391.
4. Ozols RF. Update on the management of ovarian cancer. Cancer J 2002;8:(SUPPL1): S22-S30.
5. American Cancer Society. Cancer Facts and Figures 2010. Atlanta: American Cancer Society; 2010.
6. Drapkin R, von Horsten HH, Lin Y, et al. Human epididymis protein 4 (HE4) is a secreted glycoprotein that is overexpressed by serous and endometrioid ovarian carcinomas. Cancer Res 2005;65:2162-9.
7. Clauss A, Lilja H, Lundwall A. A locus on human chromosome 20 contains several genes expressing protease inhibitor domains with homology to whey acidic protein. Biochem J 2002;368:(Part 1): 233-42.
8. Anastasi E, Marchei GG, Viggiani V, et al. HE4: A new potential early biomarker for the recurrence of ovarian cancer. Tumour Biol 2010;31:113-9.
9. Hellstrom I, Raycraft J, Hayden-Ledbetter M, et al. The HE4 (WFDC2) protein is a biomarker for ovarian carcinoma. Cancer Res 2003;63:3695-700.
10. Galgano MT, Hampton GM, Frierson HF, Jr. Comprehensive analysis of HE4 expression in normal and malignant human tissues. Mod Pathol 2006;19:847-53.
11. Tringler B, Liu W, Corral L, et al. B7-H4 overexpression in ovarian tumors. Gynecol Oncol 2006;100:44-52.