Double restriction-enzyme digestion improves the coverage and accuracy of genome-wide CpG methylation profiling by reduced representation bisulfite sequencing

BMC Genomics

Volumn 14, Issue 1, 2013, Pages

  Wang, Junwen ^a   Xia, Yudong ^a   Li, Lili ^b   Gong, Desheng ^a   Yao, Yu ^a   Luo, Huijuan ^a   Lu, Hanlin ^a   Yi, Na ^a   Wu, Honglong ^a   Zhang, Xiuqing ^a   Tao, Qian ^b   Gao, Fei ^a  

^a BGI SHENZHEN   (China)

^b CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

CpG coverage; DNA methylation; Double enzyme RRBS; Single enzyme RRBS

Indexed keywords

ACCURACY; ARTICLE; CANCER CELL CULTURE; COLORECTAL CANCER; COMPUTER MODEL; CONTROLLED STUDY; CPG ISLAND; DNA BASE COMPOSITION; DNA METHYLATION; DOUBLE ENZYME REDUCED REPRESENTATION BISULFITE SEQUENCING; ENZYMATIC DEGRADATION; GENETIC PROCEDURES; HUMAN; HUMAN CELL; PROCESS OPTIMIZATION; SINGLE ENZYME REDUCED REPRESENTATION BISULFITE SEQUENCING;

ANIMALS; CPG ISLANDS; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; DNA METHYLATION; GENE KNOCKOUT TECHNIQUES; GENOMICS; HCT116 CELLS; HUMANS; MICE; RESTRICTION MAPPING; SEQUENCE ANALYSIS, DNA; SULFITES;

EID: 84872175934     PISSN: None     EISSN: 14712164     Source Type: Journal    
DOI: 10.1186/1471-2164-14-11     Document Type: Article

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