Method for screening of solid dispersion formulations of low-solubility compounds-Miniaturization and automation of solvent casting and dissolution testing

International Journal of Pharmaceutics

Volumn 351, Issue 1-2, 2008, Pages 209-218

  Shanbhag, Anant ^a   Rabel, Shelley ^a   Nauka, Ewa ^a   Casadevall, Gemma ^a   Shivanand, Padmaja ^a   Eichenbaum, Gary ^a   Mansky, Paul ^a  

^a ALZA CORPORATION   (United States)

Author keywords

Bioavailability; Dissolution; High throughput; Solid dispersions; Solubility; Surfactants

Indexed keywords

2 PYRROLIDONE DERIVATIVE; ALPHA TOCOPHEROL; CREMOPHOR; CRODESTA; DODECYL SULFATE SODIUM; EUDRAGIT; EUDRAGIT RS; EXCIPIENT; HYDROXYPROPYLCELLULOSE; HYDROXYPROPYLMETHYLCELLULOSE PHTHALATE; JNJ 25894934; POLOXAMER; POLYMER; POLYOXYETHYLENE OLEYL ETHER; POLYSORBATE 80; POVIDONE; SOLVENT; SURFACTANT; TERNARY COMPLEX FACTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; AQUEOUS SOLUTION; AREA UNDER THE CURVE; ARTICLE; AUTOMATION; CONTROLLED STUDY; DISPERSION; DISSOLUTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG FORMULATION; DRUG POTENTIATION; DRUG SCREENING; DRUG SOLUBILITY; ELECTRONICS; IN VIVO STUDY; INTESTINE FLUID; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; RAT; SIMULATION; SOLID; TIME TO MAXIMUM PLASMA CONCENTRATION;

ANIMALS; AUTOMATION; BIOLOGICAL AVAILABILITY; CHEMISTRY, PHARMACEUTICAL; EXCIPIENTS; MALE; MINIATURIZATION; PHARMACEUTICAL PREPARATIONS; POLYMERS; RATS; RATS, SPRAGUE-DAWLEY; SOLUBILITY; SOLVENTS; SURFACE-ACTIVE AGENTS; TECHNOLOGY, PHARMACEUTICAL;

EID: 38749130125     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2007.09.042     Document Type: Article

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