-
1
-
-
21844464054
-
Bax forms multispanning monomers that oligomerize to permeabilize membranes during apoptosis
-
Annis MG, Soucie EL, Dlugosz PJ, Cruz-Aguado JA, Penn LZ, Leber B, Andrews DW. 2005. Bax forms multispanning monomers that oligomerize to permeabilize membranes during apoptosis. EMBO J 24: 2096-2103.
-
(2005)
EMBO J
, vol.24
, pp. 2096-2103
-
-
Annis, M.G.1
Soucie, E.L.2
Dlugosz, P.J.3
Cruz-Aguado, J.A.4
Penn, L.Z.5
Leber, B.6
Andrews, D.W.7
-
2
-
-
9844257587
-
Inhibition of Bax channel-forming activity by Bcl-2
-
Antonsson B, Conti F, Ciavatta A, Montessuit S, Lewis S, Martinou I, Bernasconi L, Bernard A, Mermod JJ, Mazzei G, et al. 1997. Inhibition of Bax channel-forming activity by Bcl-2. Science 277: 370-372.
-
(1997)
Science
, vol.277
, pp. 370-372
-
-
Antonsson, B.1
Conti, F.2
Ciavatta, A.3
Montessuit, S.4
Lewis, S.5
Martinou, I.6
Bernasconi, L.7
Bernard, A.8
Mermod, J.J.9
Mazzei, G.10
-
3
-
-
15844375853
-
Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death
-
Baines CP, Kaiser RA, Purcell NH, Blair NS, Osinska H, Hambleton MA, Brunskill EW, Sayen MR, Gottlieb RA, Dorn GW, et al. 2005. Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death. Nature 434: 658-662.
-
(2005)
Nature
, vol.434
, pp. 658-662
-
-
Baines, C.P.1
Kaiser, R.A.2
Purcell, N.H.3
Blair, N.S.4
Osinska, H.5
Hambleton, M.A.6
Brunskill, E.W.7
Sayen, M.R.8
Gottlieb, R.A.9
Dorn, G.W.10
-
4
-
-
34247895697
-
Voltage-dependent anion channels are dispensable for mitochondrial-dependent cell death
-
Baines CP, Kaiser RA, Sheiko T, Craigen WJ, Molkentin JD. 2007. Voltage-dependent anion channels are dispensable for mitochondrial-dependent cell death. Nat Cell Biol 9: 550-555.
-
(2007)
Nat Cell Biol
, vol.9
, pp. 550-555
-
-
Baines, C.P.1
Kaiser, R.A.2
Sheiko, T.3
Craigen, W.J.4
Molkentin, J.D.5
-
5
-
-
0037147239
-
Bax-type apoptotic proteins porate pure lipid bilayers through a mechanism sensitive to intrinsic monolayer curvature
-
Basanez G, Sharpe JC, Galanis J, Brandt TB, Hardwick JM, Zimmerberg J. 2002. Bax-type apoptotic proteins porate pure lipid bilayers through a mechanism sensitive to intrinsic monolayer curvature. J Biol Chem 277: 49360-49365.
-
(2002)
J Biol Chem
, vol.277
, pp. 49360-49365
-
-
Basanez, G.1
Sharpe, J.C.2
Galanis, J.3
Brandt, T.B.4
Hardwick, J.M.5
Zimmerberg, J.6
-
6
-
-
45849112182
-
Bcl-XL inhibits membrane permeabilization by competing with Bax
-
Billen LP, Kokoski CL, Lovell JF, Leber B, AndrewsDW. 2008. Bcl-XL inhibits membrane permeabilization by competing with Bax. PLoS Biol 6: e147.
-
(2008)
PLoS Biol
, vol.6
-
-
Billen, L.P.1
Kokoski, C.L.2
Lovell, J.F.3
Leber, B.4
Andrews, D.W.5
-
7
-
-
77949897877
-
Molecular details of Bax activation, oligomerization, and membrane insertion
-
Bleicken S, Classen M, Padmavathi PV, Ishikawa T, Zeth K, Steinhoff HJ, Bordignon E. 2010. Molecular details of Bax activation, oligomerization, and membrane insertion. J Biol Chem 285: 6636-6647.
-
(2010)
J Biol Chem
, vol.285
, pp. 6636-6647
-
-
Bleicken, S.1
Classen, M.2
Padmavathi, P.V.3
Ishikawa, T.4
Zeth, K.5
Steinhoff, H.J.6
Bordignon, E.7
-
8
-
-
33646354381
-
Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members
-
Certo M, Del Gaizo Moore V, Nishino M, Wei G, Korsmeyer S, Armstrong SA, Letai A. 2006. Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members. Cancer Cell 9: 351-365.
-
(2006)
Cancer Cell
, vol.9
, pp. 351-365
-
-
Certo, M.1
Del Gaizo Moore, V.2
Nishino, M.3
Wei, G.4
Korsmeyer, S.5
Armstrong, S.A.6
Letai, A.7
-
9
-
-
19944432123
-
Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function
-
Chen L, Willis SN, Wei A, Smith BJ, Fletcher JI, Hinds MG, Colman PM, Day CL, Adams JM, Huang DC. 2005. Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function. Mol Cell 17: 393-403.
-
(2005)
Mol Cell
, vol.17
, pp. 393-403
-
-
Chen, L.1
Willis, S.N.2
Wei, A.3
Smith, B.J.4
Fletcher, J.I.5
Hinds, M.G.6
Colman, P.M.7
Day, C.L.8
Adams, J.M.9
Huang, D.C.10
-
10
-
-
0043204996
-
VDAC2 inhibits BAKactivation and mitochondrial apoptosis
-
Cheng EH, Sheiko TV, Fisher JK, Craigen WJ, Korsmeyer SJ. 2003. VDAC2 inhibits BAKactivation and mitochondrial apoptosis. Science 301: 513-517.
-
(2003)
Science
, vol.301
, pp. 513-517
-
-
Cheng, E.H.1
Sheiko, T.V.2
Fisher, J.K.3
Craigen, W.J.4
Korsmeyer, S.J.5
-
12
-
-
58149511987
-
Mechanism of apoptosis induction by inhibition of the anti-apoptotic BCL-2 proteins
-
Chipuk JE, Fisher JC, Dillon CP, Kriwacki RW, Kuwana T, Green DR. 2008. Mechanism of apoptosis induction by inhibition of the anti-apoptotic BCL-2 proteins. Proc Natl Acad Sci 105: 20327-20332.
-
(2008)
Proc Natl Acad Sci
, vol.105
, pp. 20327-20332
-
-
Chipuk, J.E.1
Fisher, J.C.2
Dillon, C.P.3
Kriwacki, R.W.4
Kuwana, T.5
Green, D.R.6
-
13
-
-
75949105922
-
The BCL-2 family reunion
-
Chipuk JE, Moldoveanu T, Llambi F, Parsons MJ, Green DR. 2010. The BCL-2 family reunion. Mol Cell 37: 299-310.
-
(2010)
Mol Cell
, vol.37
, pp. 299-310
-
-
Chipuk, J.E.1
Moldoveanu, T.2
Llambi, F.3
Parsons, M.J.4
Green, D.R.5
-
14
-
-
84857873334
-
Sphingolipid metabolism cooperates with BAK and BAX to promote the mitochondrial pathway of apoptosis
-
Chipuk JE, McStay GP, Bharti A, Kuwana T, Clarke CJ, Siskind LJ, Obeid LM, Green DR. 2012. Sphingolipid metabolism cooperates with BAK and BAX to promote the mitochondrial pathway of apoptosis. Cell 148: 988-1000.
-
(2012)
Cell
, vol.148
, pp. 988-1000
-
-
Chipuk, J.E.1
McStay, G.P.2
Bharti, A.3
Kuwana, T.4
Clarke, C.J.5
Siskind, L.J.6
Obeid, L.M.7
Green, D.R.8
-
15
-
-
0033535350
-
Bid-induced conformational change of Bax is responsible for mitochondrial cytochrome c release during apoptosis
-
Desagher S, Osen-Sand A, Nichols A, Eskes R, Montessuit S, Lauper S, Maundrell K, Antonsson B, Martinou JC. 1999. Bid-induced conformational change of Bax is responsible for mitochondrial cytochrome c release during apoptosis. J Cell Biol 144: 891-901.
-
(1999)
J Cell Biol
, vol.144
, pp. 891-901
-
-
Desagher, S.1
Osen-Sand, A.2
Nichols, A.3
Eskes, R.4
Montessuit, S.5
Lauper, S.6
Maundrell, K.7
Antonsson, B.8
Martinou, J.C.9
-
16
-
-
43049105074
-
To trigger apoptosis, Bak exposes its BH3 domain and homodimerizes via BH3: Groove interactions
-
Dewson G, Kratina T, Sim HW, Puthalakath H, Adams JM, Colman PM, Kluck RM. 2008. To trigger apoptosis, Bak exposes its BH3 domain and homodimerizes via BH3: groove interactions. Mol Cell 30: 369-380.
-
(2008)
Mol Cell
, vol.30
, pp. 369-380
-
-
Dewson, G.1
Kratina, T.2
Sim, H.W.3
Puthalakath, H.4
Adams, J.M.5
Colman, P.M.6
Kluck, R.M.7
-
17
-
-
70449941949
-
Bak activation for apoptosis involves oligomerization of dimers via their a6 helices
-
Dewson G, Kratina T, Czabotar P, Day CL, Adams JM, Kluck RM. 2009. Bak activation for apoptosis involves oligomerization of dimers via their a6 helices. Mol Cell 36: 696-703.
-
(2009)
Mol Cell
, vol.36
, pp. 696-703
-
-
Dewson, G.1
Kratina, T.2
Czabotar, P.3
Day, C.L.4
Adams, J.M.5
Kluck, R.M.6
-
18
-
-
33745755472
-
Bcl-2 changes conformation to inhibit Bax oligomerization
-
Dlugosz PJ, Billen LP, Annis MG, Zhu W, Zhang Z, Lin J, Leber B, AndrewsDW. 2006. Bcl-2 changes conformation to inhibit Bax oligomerization. EMBO J 25: 2287-2296.
-
(2006)
EMBO J
, vol.25
, pp. 2287-2296
-
-
Dlugosz, P.J.1
Billen, L.P.2
Annis, M.G.3
Zhu, W.4
Zhang, Z.5
Lin, J.6
Leber, B.7
Andrews, D.W.8
-
19
-
-
79953276389
-
Bcl-x(L) retrotranslocates Bax from the mitochondria into the cytosol
-
Edlich F, Banerjee S, Suzuki M, Cleland MM, Arnoult D, Wang C, Neutzner A, Tjandra N, Youle RJ. 2011. Bcl-x(L) retrotranslocates Bax from the mitochondria into the cytosol. Cell 145: 104-116.
-
(2011)
Cell
, vol.145
, pp. 104-116
-
-
Edlich, F.1
Banerjee, S.2
Suzuki, M.3
Cleland, M.M.4
Arnoult, D.5
Wang, C.6
Neutzner, A.7
Tjandra, N.8
Youle, R.J.9
-
20
-
-
55949137911
-
Membrane lysis during biological membrane fusion: Collateral damage by misregulated fusion machines
-
Engel A, Walter P. 2008. Membrane lysis during biological membrane fusion: Collateral damage by misregulated fusion machines. J Cell Biol 183: 181-186.
-
(2008)
J Cell Biol
, vol.183
, pp. 181-186
-
-
Engel, A.1
Walter, P.2
-
21
-
-
0033981577
-
Bid induces the oligomerization and insertion of Bax into the outer mitochondrial membrane
-
Eskes R, Desagher S, Antonsson B, Martinou JC. 2000. Bid induces the oligomerization and insertion of Bax into the outer mitochondrial membrane. Mol Cell Biol 20: 929-935.
-
(2000)
Mol Cell Biol
, vol.20
, pp. 929-935
-
-
Eskes, R.1
Desagher, S.2
Antonsson, B.3
Martinou, J.C.4
-
22
-
-
65349152495
-
Bax activation by the BH3-only protein Puma promotes cell dependence on antiapoptotic Bcl-2 family members
-
Gallenne T, Gautier F, Oliver L, Hervouet E, Noel B, Hickman JA, Geneste O, Cartron PF, Vallette FM, Manon S, et al. 2009. Bax activation by the BH3-only protein Puma promotes cell dependence on antiapoptotic Bcl-2 family members. J Cell Biol 185: 279-290.
-
(2009)
J Cell Biol
, vol.185
, pp. 279-290
-
-
Gallenne, T.1
Gautier, F.2
Oliver, L.3
Hervouet, E.4
Noel, B.5
Hickman, J.A.6
Geneste, O.7
Cartron, P.F.8
Vallette, F.M.9
Manon, S.10
-
23
-
-
34447255173
-
Pore formation by a Bax-derived peptide: Effect on the line tension of the membrane probed by AFM
-
Garcia-Saez AJ, Chiantia S, Salgado J, Schwille P. 2007. Pore formation by a Bax-derived peptide: Effect on the line tension of the membrane probed by AFM. Biophys J 93: 103-112.
-
(2007)
Biophys J
, vol.93
, pp. 103-112
-
-
Garcia-Saez, A.J.1
Chiantia, S.2
Salgado, J.3
Schwille, P.4
-
24
-
-
54549114986
-
BAX activation is initiated at a novel interaction site
-
Gavathiotis E, Suzuki M, Davis ML, Pitter K, Bird GH, Katz SG, Tu HC, Kim H, Cheng EH, Tjandra N, et al. 2008. BAX activation is initiated at a novel interaction site. Nature 455: 1076-1081.
-
(2008)
Nature
, vol.455
, pp. 1076-1081
-
-
Gavathiotis, E.1
Suzuki, M.2
Davis, M.L.3
Pitter, K.4
Bird, G.H.5
Katz, S.G.6
Tu, H.C.7
Kim, H.8
Cheng, E.H.9
Tjandra, N.10
-
25
-
-
78149449341
-
BH3-triggered structural reorganization drives the activation of proapoptotic BAX
-
Gavathiotis E, Reyna DE, Davis ML, Bird GH, Walensky LD. 2010. BH3-triggered structural reorganization drives the activation of proapoptotic BAX. Mol Cell 40: 481-492.
-
(2010)
Mol Cell
, vol.40
, pp. 481-492
-
-
Gavathiotis, E.1
Reyna, D.E.2
Davis, M.L.3
Bird, G.H.4
Walensky, L.D.5
-
26
-
-
34547629939
-
A three-helix homooligomerization domain containing BH3 and BH1 is responsible for the apoptotic activity of Bax
-
George NM, Evans JJ, Luo X. 2007. A three-helix homooligomerization domain containing BH3 and BH1 is responsible for the apoptotic activity of Bax. Genes Dev 21: 1937-1948.
-
(2007)
Genes Dev
, vol.21
, pp. 1937-1948
-
-
George, N.M.1
Evans, J.J.2
Luo, X.3
-
27
-
-
0031007644
-
Nonionic detergents induce dimerization among members of the Bcl-2 family
-
Hsu YT, Youle RJ. 1997. Nonionic detergents induce dimerization among members of the Bcl-2 family. J Biol Chem 272: 13829-13834.
-
(1997)
J Biol Chem
, vol.272
, pp. 13829-13834
-
-
Hsu, Y.T.1
Youle, R.J.2
-
28
-
-
0030963602
-
Cytosol-to-membrane redistribution of Bax and Bcl-X(L) during apoptosis
-
Hsu YT, Wolter KG, Youle RJ. 1997. Cytosol-to-membrane redistribution of Bax and Bcl-X(L) during apoptosis. Proc Natl Acad Sci 94: 3668-3672.
-
(1997)
Proc Natl Acad Sci
, vol.94
, pp. 3668-3672
-
-
Hsu, Y.T.1
Wolter, K.G.2
Youle, R.J.3
-
29
-
-
0037164813
-
Spatial and temporal association of Bax with mitochondrial fission sites, Drp1, and Mfn2 during apoptosis
-
Karbowski M, Lee YJ, Gaume B, Jeong SY, Frank S, Nechushtan A, Santel A, Fuller M, Smith CL, Youle RJ. 2002. Spatial and temporal association of Bax with mitochondrial fission sites, Drp1, and Mfn2 during apoptosis. J Cell Biol 159: 931-938.
-
(2002)
J Cell Biol
, vol.159
, pp. 931-938
-
-
Karbowski, M.1
Lee, Y.J.2
Gaume, B.3
Jeong, S.Y.4
Frank, S.5
Nechushtan, A.6
Santel, A.7
Fuller, M.8
Smith, C.L.9
Youle, R.J.10
-
30
-
-
33751513394
-
Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies
-
Kim H, Rafiuddin-Shah M, Tu HC, Jeffers JR, Zambetti GP, Hsieh JJ, Cheng EH. 2006. Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies. Nat Cell Biol 8: 1348-1358.
-
(2006)
Nat Cell Biol
, vol.8
, pp. 1348-1358
-
-
Kim, H.1
Rafiuddin-Shah, M.2
Tu, H.C.3
Jeffers, J.R.4
Zambetti, G.P.5
Hsieh, J.J.6
Cheng, E.H.7
-
31
-
-
70449091753
-
Stepwise activation of BAX and BAK by tBID, BIM, and PUMA initiates mitochondrial apoptosis
-
Kim H, Tu HC, Ren D, Takeuchi O, Jeffers JR, Zambetti GP, Hsieh JJ, Cheng EH. 2009. Stepwise activation of BAX and BAK by tBID, BIM, and PUMA initiates mitochondrial apoptosis. Mol Cell 36: 487-499.
-
(2009)
Mol Cell
, vol.36
, pp. 487-499
-
-
Kim, H.1
Tu, H.C.2
Ren, D.3
Takeuchi, O.4
Jeffers, J.R.5
Zambetti, G.P.6
Hsieh, J.J.7
Cheng, E.H.8
-
32
-
-
0036850312
-
Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane
-
Kuwana T, Mackey MR, Perkins G, Ellisman MH, Latterich M, Schneiter R, Green DR, Newmeyer DD. 2002. Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane. Cell 111: 331-342.
-
(2002)
Cell
, vol.111
, pp. 331-342
-
-
Kuwana, T.1
McKey, M.R.2
Perkins, G.3
Ellisman, M.H.4
Latterich, M.5
Schneiter, R.6
Green, D.R.7
Newmeyer, D.D.8
-
33
-
-
13944277343
-
BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly
-
Kuwana T, Bouchier-Hayes L, Chipuk JE, Bonzon C, Sullivan BA, Green DR, Newmeyer DD. 2005. BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly. Mol Cell 17: 525-535.
-
(2005)
Mol Cell
, vol.17
, pp. 525-535
-
-
Kuwana, T.1
Bouchier-Hayes, L.2
Chipuk, J.E.3
Bonzon, C.4
Sullivan, B.A.5
Green, D.R.6
Newmeyer, D.D.7
-
34
-
-
34247497716
-
Embedded together: The life and death consequences of interaction of the Bcl-2 family with membranes
-
Leber B, Lin J, Andrews DW. 2007. Embedded together: The life and death consequences of interaction of the Bcl-2 family with membranes. Apoptosis 12: 897-911.
-
(2007)
Apoptosis
, vol.12
, pp. 897-911
-
-
Leber, B.1
Lin, J.2
Andrews, D.W.3
-
35
-
-
77957141008
-
Still embedded together binding to membranes regulates Bcl-2 protein interactions
-
Leber B, Lin J, Andrews DW. 2010. Still embedded together binding to membranes regulates Bcl-2 protein interactions. Oncogene 29: 5221-5230.
-
(2010)
Oncogene
, vol.29
, pp. 5221-5230
-
-
Leber, B.1
Lin, J.2
Andrews, D.W.3
-
36
-
-
0036728834
-
Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics
-
Letai A, Bassik MC, Walensky LD, Sorcinelli MD, Weiler S, Korsmeyer SJ. 2002. Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics. Cancer Cell 2: 183-192.
-
(2002)
Cancer Cell
, vol.2
, pp. 183-192
-
-
Letai, A.1
Bassik, M.C.2
Walensky, L.D.3
Sorcinelli, M.D.4
Weiler, S.5
Korsmeyer, S.J.6
-
37
-
-
33750347347
-
Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases
-
Lin MT, Beal MF. 2006. Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Nature 443: 787-795.
-
(2006)
Nature
, vol.443
, pp. 787-795
-
-
Lin, M.T.1
Beal, M.F.2
-
38
-
-
79952700828
-
Bcl-2 proteins and mitochondria-Specificity in membrane targeting for death
-
532-529
-
Lindsay J, EspostiMD, Gilmore AP. 2011. Bcl-2 proteins and mitochondria-Specificity in membrane targeting for death. Biochim Biophys Acta 1813: 532-529.
-
(2011)
Biochim Biophys Acta
, vol.1813
-
-
Lindsay, J.1
Esposti, M.D.2
Gilmore, A.P.3
-
39
-
-
79551620159
-
Apoptosis and oncogenesis: Give and take in the BCL-2 family
-
Llambi F, Green DR. 2011. Apoptosis and oncogenesis: Give and take in the BCL-2 family. Curr Opin Genet Dev 21: 12-20.
-
(2011)
Curr Opin Genet Dev
, vol.21
, pp. 12-20
-
-
Llambi, F.1
Green, D.R.2
-
40
-
-
81355146366
-
A unified model of mammalian BCL-2 protein family interactions at the mitochondria
-
Llambi F, Moldoveanu T, Tait SW, Bouchier-Hayes L, Temirov J, McCormick LL, Dillon CP, Green DR. 2011. A unified model of mammalian BCL-2 protein family interactions at the mitochondria. Mol Cell 44: 517-531.
-
(2011)
Mol Cell
, vol.44
, pp. 517-531
-
-
Llambi, F.1
Moldoveanu, T.2
Tait, S.W.3
Bouchier-Hayes, L.4
Temirov, J.5
McCormick, L.L.6
Dillon, C.P.7
Green, D.R.8
-
41
-
-
57149135309
-
Membrane binding by tBid initiates an ordered series of events culminating in membrane permeabilization by Bax
-
Lovell JF, Billen LP, Bindner S, Shamas-Din A, Fradin C, Leber B, Andrews DW. 2008. Membrane binding by tBid initiates an ordered series of events culminating in membrane permeabilization by Bax. Cell 135: 1074-1084.
-
(2008)
Cell
, vol.135
, pp. 1074-1084
-
-
Lovell, J.F.1
Billen, L.P.2
Bindner, S.3
Shamas-Din, A.4
Fradin, C.5
Leber, B.6
Andrews, D.W.7
-
42
-
-
39449130146
-
Bax activation and stress-induced apoptosis delayed by the accumulation of cholesterol in mitochondrial membranes
-
Lucken-Ardjomande S, Montessuit S, Martinou JC. 2008a. Bax activation and stress-induced apoptosis delayed by the accumulation of cholesterol in mitochondrial membranes. Cell Death Differ 15: 484-493.
-
(2008)
Cell Death Differ
, vol.15
, pp. 484-493
-
-
Lucken-Ardjomande, S.1
Montessuit, S.2
Martinou, J.C.3
-
43
-
-
42149094346
-
Contributions to Bax insertion and oligomerization of lipids of the mitochondrial outer membrane
-
Lucken-Ardjomande S, Montessuit S, Martinou JC. 2008b. Contributions to Bax insertion and oligomerization of lipids of the mitochondrial outer membrane. Cell Death Differ 15: 929-937.
-
(2008)
Cell Death Differ
, vol.15
, pp. 929-937
-
-
Lucken-Ardjomande, S.1
Montessuit, S.2
Martinou, J.C.3
-
44
-
-
0034306169
-
Cardiolipin provides specificity for targeting of tBid to mitochondria
-
Lutter M, Fang M, Luo X, Nishijima M, Xie X, Wang X. 2000. Cardiolipin provides specificity for targeting of tBid to mitochondria. Nat Cell Biol 2: 754-761.
-
(2000)
Nat Cell Biol
, vol.2
, pp. 754-761
-
-
Lutter, M.1
Fang, M.2
Luo, X.3
Nishijima, M.4
Xie, X.5
Wang, X.6
-
45
-
-
18744374204
-
The pro-apoptotic Bcl-2 family member tBid localizes to mitochondrial contact sites
-
Lutter M, Perkins GA, Wang X. 2001. The pro-apoptotic Bcl-2 family member tBid localizes to mitochondrial contact sites. BMC Cell Biol 2: 22.
-
(2001)
BMC Cell Biol
, vol.2
, pp. 22
-
-
Lutter, M.1
Perkins, G.A.2
Wang, X.3
-
46
-
-
66449087483
-
Assembly of the mitochondrial apoptosis-induced channel, MAC
-
Martinez-Caballero S, Dejean LM, Kinnally MS, Oh KJ, Mannella CA, Kinnally KW. 2009. Assembly of the mitochondrial apoptosis-induced channel, MAC. J Biol Chem 284: 12235-12245.
-
(2009)
J Biol Chem
, vol.284
, pp. 12235-12245
-
-
Martinez-Caballero, S.1
Dejean, L.M.2
Kinnally, M.S.3
Oh, K.J.4
Mannella, C.A.5
Kinnally, K.W.6
-
47
-
-
79960230433
-
Mitochondria in apoptosis: Bcl-2 family members and mitochondrial dynamics
-
Martinou JC, Youle RJ. 2011. Mitochondria in apoptosis: Bcl-2 family members and mitochondrial dynamics. Dev Cell 21: 92-101.
-
(2011)
Dev Cell
, vol.21
, pp. 92-101
-
-
Martinou, J.C.1
Youle, R.J.2
-
48
-
-
33751544565
-
The X-ray structure of a BAK homodimer reveals an inhibitory zinc binding site
-
Moldoveanu T, Liu Q, Tocilj A, Watson M, Shore G, Gehring K. 2006. The X-ray structure of a BAK homodimer reveals an inhibitory zinc binding site. Mol Cell 24: 677-688.
-
(2006)
Mol Cell
, vol.24
, pp. 677-688
-
-
Moldoveanu, T.1
Liu, Q.2
Tocilj, A.3
Watson, M.4
Shore, G.5
Gehring, K.6
-
49
-
-
77956634444
-
Membrane remodeling induced by the dynamin-related protein Drp1 stimulates Bax oligomerization
-
Montessuit S, Somasekharan SP, Terrones O, Lucken-Ardjomande S, Herzig S, Schwarzenbacher R, Manstein DJ, Bossy-Wetzel E, Basanez G, Meda P, et al. 2010. Membrane remodeling induced by the dynamin-related protein Drp1 stimulates Bax oligomerization. Cell 142: 889-901.
-
(2010)
Cell
, vol.142
, pp. 889-901
-
-
Montessuit, S.1
Somasekharan, S.P.2
Terrones, O.3
Lucken-Ardjomande, S.4
Herzig, S.5
Schwarzenbacher, R.6
Manstein, D.J.7
Bossy-Wetzel, E.8
Basanez, G.9
Meda, P.10
-
50
-
-
5244224827
-
X-ray andNMRstructure of human Bcl-xL, an inhibitor of programmed cell death
-
Muchmore SW, Sattler M, Liang H, Meadows RP, Harlan JE, Yoon HS, Nettesheim D, Chang BS, Thompson CB, Wong SL, et al. 1996. X-ray andNMRstructure of human Bcl-xL, an inhibitor of programmed cell death. Nature 381: 335-341.
-
(1996)
Nature
, vol.381
, pp. 335-341
-
-
Muchmore, S.W.1
Sattler, M.2
Liang, H.3
Meadows, R.P.4
Harlan, J.E.5
Yoon, H.S.6
Nettesheim, D.7
Chang, B.S.8
Thompson, C.B.9
Wong, S.L.10
-
51
-
-
15844407874
-
Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death
-
Nakagawa T, Shimizu S, Watanabe T, Yamaguchi O, Otsu K, Yamagata H, Inohara H, Kubo T, Tsujimoto Y. 2005. Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death. Nature 434: 652-658.
-
(2005)
Nature
, vol.434
, pp. 652-658
-
-
Nakagawa, T.1
Shimizu, S.2
Watanabe, T.3
Yamaguchi, O.4
Otsu, K.5
Yamagata, H.6
Inohara, H.7
Kubo, T.8
Tsujimoto, Y.9
-
52
-
-
82255192310
-
Pretreatment mitochondrial priming correlates with clinical response to cytotoxic chemotherapy
-
Ni Chonghaile T, Sarosiek KA, Vo TT, Ryan JA, Tammareddi A, Moore Vdel G, Deng J, Anderson KC, Richardson P, Tai YT, et al. 2011. Pretreatment mitochondrial priming correlates with clinical response to cytotoxic chemotherapy. Science 334: 1129-1133.
-
(2011)
Science
, vol.334
, pp. 1129-1133
-
-
Ni Chonghaile, T.1
Sarosiek, K.A.2
Vo, T.T.3
Ryan, J.A.4
Tammareddi, A.5
Moore Vdel, G.6
Deng, J.7
Anderson, K.C.8
Richardson, P.9
Tai, Y.T.10
-
53
-
-
77956523192
-
Conformational changes in BAK, a pore-forming proapoptotic Bcl-2 family member, upon membrane insertion and direct evidence for the existence of BH3-BH3 contact interface in BAK homo-oligomers
-
Oh KJ, Singh P, Lee K, Foss K, Lee S, Park M, Aluvila S, Kim RS, Symersky J, Walters DE. 2010. Conformational changes in BAK, a pore-forming proapoptotic Bcl-2 family member, upon membrane insertion and direct evidence for the existence of BH3-BH3 contact interface in BAK homo-oligomers. J Biol Chem 285: 28924-28937.
-
(2010)
J Biol Chem
, vol.285
, pp. 28924-28937
-
-
Oh, K.J.1
Singh, P.2
Lee, K.3
Foss, K.4
Lee, S.5
Park, M.6
Aluvila, S.7
Kim, R.S.8
Symersky, J.9
Walters, D.E.10
-
55
-
-
17744396094
-
Rationale for Bcl-xL/Bad peptide complex formation from structure, mutagenesis, and biophysical studies
-
Petros AM, Nettesheim DG, Wang Y, Olejniczak ET, Meadows RP, Mack J, Swift K, Matayoshi ED, Zhang H, Thompson CB, et al. 2000. Rationale for Bcl-xL/Bad peptide complex formation from structure, mutagenesis, and biophysical studies. Protein Sci 9: 2528-2534.
-
(2000)
Protein Sci
, vol.9
, pp. 2528-2534
-
-
Petros, A.M.1
Nettesheim, D.G.2
Wang, Y.3
Olejniczak, E.T.4
Meadows, R.P.5
Mack, J.6
Swift, K.7
Matayoshi, E.D.8
Zhang, H.9
Thompson, C.B.10
-
56
-
-
56249132688
-
Structure of transmembrane pore induced by Bax-derived peptide: Evidence for lipidic pores
-
Qian S, Wang W, Yang L, Huang HW. 2008. Structure of transmembrane pore induced by Bax-derived peptide: Evidence for lipidic pores. Proc Natl Acad Sci 105: 17379-17383.
-
(2008)
Proc Natl Acad Sci
, vol.105
, pp. 17379-17383
-
-
Qian, S.1
Wang, W.2
Yang, L.3
Huang, H.W.4
-
57
-
-
0141768255
-
Real-time single cell analysis of Smac/DIABLO release during apoptosis
-
Rehm M, Dussmann H, Prehn JH. 2003. Real-time single cell analysis of Smac/DIABLO release during apoptosis. J Cell Biol 162: 1031-1043.
-
(2003)
J Cell Biol
, vol.162
, pp. 1031-1043
-
-
Rehm, M.1
Dussmann, H.2
Prehn, J.H.3
-
58
-
-
78649700978
-
BID, BIM, and PUMA are essential for activation of the BAXand BAK-dependent cell death program
-
Ren D, Tu HC, Kim H, Wang GX, Bean GR, Takeuchi O, Jeffers JR, Zambetti GP, Hsieh JJ, Cheng EH. 2010. BID, BIM, and PUMA are essential for activation of the BAXand BAK-dependent cell death program. Science 330: 1390-1393.
-
(2010)
Science
, vol.330
, pp. 1390-1393
-
-
Ren, D.1
Tu, H.C.2
Kim, H.3
Wang, G.X.4
Bean, G.R.5
Takeuchi, O.6
Jeffers, J.R.7
Zambetti, G.P.8
Hsieh, J.J.9
Cheng, E.H.10
-
59
-
-
84855729453
-
Interaction of the full-length Bax protein with biomimetic mitochondrial liposomes: A small-angle neutron scattering and fluorescence study
-
Satsoura D, Kucerka N, Shivakumar S, Pencer J, Griffiths C, Leber B, Andrews DW, Katsaras J, Fradin C. 2012. Interaction of the full-length Bax protein with biomimetic mitochondrial liposomes: A small-angle neutron scattering and fluorescence study. Biochim Biophys Acta 1818: 384-401.
-
(2012)
Biochim Biophys Acta
, vol.1818
, pp. 384-401
-
-
Satsoura, D.1
Kucerka, N.2
Shivakumar, S.3
Pencer, J.4
Griffiths, C.5
Leber, B.6
Andrews, D.W.7
Katsaras, J.8
Fradin, C.9
-
60
-
-
0030614915
-
Structure of Bcl-xL-Bak peptide complex: Recognition between regulators of apoptosis
-
Sattler M, Liang H, Nettesheim D, Meadows RP, Harlan JE, Eberstadt M, Yoon HS, Shuker SB, Chang BS, Minn AJ, et al. 1997. Structure of Bcl-xL-Bak peptide complex: Recognition between regulators of apoptosis. Science 275: 983-986.
-
(1997)
Science
, vol.275
, pp. 983-986
-
-
Sattler, M.1
Liang, H.2
Nettesheim, D.3
Meadows, R.P.4
Harlan, J.E.5
Eberstadt, M.6
Yoon, H.S.7
Shuker, S.B.8
Chang, B.S.9
Minn, A.J.10
-
61
-
-
65349136027
-
Mitochondrial outer membrane proteins assist Bid in Bax-mediated lipidic pore formation
-
Schafer B, Quispe J, Choudhary V, Chipuk JE, Ajero TG, Du H, Schneiter R, Kuwana T. 2009. Mitochondrial outer membrane proteins assist Bid in Bax-mediated lipidic pore formation. Mol Biol Cell 20: 2276-2285.
-
(2009)
Mol Biol Cell
, vol.20
, pp. 2276-2285
-
-
Schafer, B.1
Quispe, J.2
Choudhary, V.3
Chipuk, J.E.4
Ajero, T.G.5
Du, H.6
Schneiter, R.7
Kuwana, T.8
-
62
-
-
0030779846
-
Comparison of the ion channel characteristics of proapoptotic BAX and antiapoptotic BCL-2
-
Schlesinger PH, Gross A, Yin XM, Yamamoto K, Saito M, Waksman G, Korsmeyer SJ. 1997. Comparison of the ion channel characteristics of proapoptotic BAX and antiapoptotic BCL-2. Proc Natl Acad Sci 94: 11357-11362.
-
(1997)
Proc Natl Acad Sci
, vol.94
, pp. 11357-11362
-
-
Schlesinger, P.H.1
Gross, A.2
Yin, X.M.3
Yamamoto, K.4
Saito, M.5
Waksman, G.6
Korsmeyer, S.J.7
-
63
-
-
0033713002
-
Structure of Bax: Coregulation of dimer formation and intracellular localization
-
Suzuki M, Youle RJ, Tjandra N. 2000. Structure of Bax: Coregulation of dimer formation and intracellular localization. Cell 103: 645-654.
-
(2000)
Cell
, vol.103
, pp. 645-654
-
-
Suzuki, M.1
Youle, R.J.2
Tjandra, N.3
-
64
-
-
33744953583
-
Auto-activation of the apoptosis protein Bax increases mitochondrial membrane permeability and is inhibited by Bcl-2
-
Tan C, Dlugosz PJ, Peng J, Zhang Z, Lapolla SM, Plafker SM, Andrews DW, Lin J. 2006. Auto-activation of the apoptosis protein Bax increases mitochondrial membrane permeability and is inhibited by Bcl-2. J Biol Chem 281: 14764-14775.
-
(2006)
J Biol Chem
, vol.281
, pp. 14764-14775
-
-
Tan, C.1
Dlugosz, P.J.2
Peng, J.3
Zhang, Z.4
Lapolla, S.M.5
Plafker, S.M.6
Andrews, D.W.7
Lin, J.8
-
66
-
-
0037014586
-
Direct addition of BimL to mitochondria does not lead to cytochrome c release
-
Terradillos O, Montessuit S, Huang DC, Martinou JC. 2002. Direct addition of BimL to mitochondria does not lead to cytochrome c release. FEBS Lett 522: 29-34.
-
(2002)
FEBS Lett
, vol.522
, pp. 29-34
-
-
Terradillos, O.1
Montessuit, S.2
Huang, D.C.3
Martinou, J.C.4
-
67
-
-
3142746012
-
Lipidic pore formation by the concerted action of proapoptotic BAX and tBID
-
Terrones O, Antonsson B, Yamaguchi H, Wang HG, Liu J, Lee RM, Herrmann A, Basanez G. 2004. Lipidic pore formation by the concerted action of proapoptotic BAX and tBID. J Biol Chem 279: 30081-30091.
-
(2004)
J Biol Chem
, vol.279
, pp. 30081-30091
-
-
Terrones, O.1
Antonsson, B.2
Yamaguchi, H.3
Wang, H.G.4
Liu, J.5
Lee, R.M.6
Herrmann, A.7
Basanez, G.8
-
68
-
-
67549141546
-
Different forms of cell death induced by putative BCL-2 inhibitors
-
Vogler M, Weber K, Dinsdale D, Schmitz I, Schulze-Osthoff K, Dyer MJS, Cohen GM. 2009. Different forms of cell death induced by putative BCL-2 inhibitors. Cell Death Differ 16: 1030-1039.
-
(2009)
Cell Death Differ
, vol.16
, pp. 1030-1039
-
-
Vogler, M.1
Weber, K.2
Dinsdale, D.3
Schmitz, I.4
Schulze-Osthoff, K.5
Dyer, M.J.S.6
Cohen, G.M.7
-
69
-
-
33749660845
-
A stapled BID BH3 helix directly binds and activates BAX
-
Walensky LD, Pitter K, Morash J, Oh KJ, Barbuto S, Fisher J, Smith E, Verdine GL, Korsmeyer SJ. 2006. A stapled BID BH3 helix directly binds and activates BAX. Mol Cell 24: 199-210.
-
(2006)
Mol Cell
, vol.24
, pp. 199-210
-
-
Walensky, L.D.1
Pitter, K.2
Morash, J.3
Oh, K.J.4
Barbuto, S.5
Fisher, J.6
Smith, E.7
Verdine, G.L.8
Korsmeyer, S.J.9
-
70
-
-
0035957653
-
Proapoptotic BAX and BAK: A requisite gateway to mitochondrial dysfunction and death
-
Wei MC, Zong WX, Cheng EH, Lindsten T, Panoutsakopoulou V, Ross AJ, Roth KA, MacGregor GR, Thompson CB, Korsmeyer SJ. 2001. Proapoptotic BAX and BAK: A requisite gateway to mitochondrial dysfunction and death. Science 292: 727-730.
-
(2001)
Science
, vol.292
, pp. 727-730
-
-
Wei, M.C.1
Zong, W.X.2
Cheng, E.H.3
Lindsten, T.4
Panoutsakopoulou, V.5
Ross, A.J.6
Roth, K.A.7
McGregor, G.R.8
Thompson, C.B.9
Korsmeyer, S.J.10
-
71
-
-
22244464818
-
Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins
-
Willis SN, Chen L, Dewson G, Wei A, Naik E, Fletcher JI, Adams JM, Huang DC. 2005. Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins. Genes Dev 19: 1294-1305.
-
(2005)
Genes Dev
, vol.19
, pp. 1294-1305
-
-
Willis, S.N.1
Chen, L.2
Dewson, G.3
Wei, A.4
Naik, E.5
Fletcher, J.I.6
Adams, J.M.7
Huang, D.C.8
-
72
-
-
33846964621
-
Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak
-
Willis SN, Fletcher JI, Kaufmann T, van Delft MF, Chen L, Czabotar PE, Ierino H, Lee EF, Fairlie WD, Bouillet P, et al. 2007. Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak. Science 315: 856-859.
-
(2007)
Science
, vol.315
, pp. 856-859
-
-
Willis, S.N.1
Fletcher, J.I.2
Kaufmann, T.3
van Delft, M.F.4
Chen, L.5
Czabotar, P.E.6
Ierino, H.7
Lee, E.F.8
Fairlie, W.D.9
Bouillet, P.10
-
73
-
-
37549048249
-
The BCL-2 protein family: Opposing activities that mediate cell death
-
Youle RJ, Strasser A. 2008. The BCL-2 protein family: Opposing activities that mediate cell death. Nat RevMol Cell Biol 9: 47-59.
-
(2008)
Nat RevMol Cell Biol
, vol.9
, pp. 47-59
-
-
Youle, R.J.1
Strasser, A.2
-
74
-
-
77953121576
-
MTCH2/MIMP is a major facilitator of tBID recruitment to mitochondria
-
Zaltsman Y, Shachnai L, Yivgi-Ohana N, Schwarz M, Maryanovich M, Houtkooper RH, Vaz FM, De Leonardis F, Fiermonte G, Palmieri F, et al. 2010. MTCH2/MIMP is a major facilitator of tBID recruitment to mitochondria. Nat Cell Biol 12: 553-562.
-
(2010)
Nat Cell Biol
, vol.12
, pp. 553-562
-
-
Zaltsman, Y.1
Shachnai, L.2
Yivgi-Ohana, N.3
Schwarz, M.4
Maryanovich, M.5
Houtkooper, R.H.6
Vaz, F.M.7
de Leonardis, F.8
Fiermonte, G.9
Palmieri, F.10
-
75
-
-
77952912800
-
Bax forms an oligomer via separate, yet interdependent, surfaces
-
Zhang Z, Zhu W, Lapolla SM, Miao Y, Shao Y, Falcone M, Boreham D, McFarlane N, Ding J, Johnson AE, et al. 2010. Bax forms an oligomer via separate, yet interdependent, surfaces. J Biol Chem 285: 17614-17627.
-
(2010)
J Biol Chem
, vol.285
, pp. 17614-17627
-
-
Zhang, Z.1
Zhu, W.2
Lapolla, S.M.3
Miao, Y.4
Shao, Y.5
Falcone, M.6
Boreham, D.7
McFarlane, N.8
Ding, J.9
Johnson, A.E.10
|