Rapid cytotoxicity screening platform for amyloid inhibitors using a membrane-potential sensitive fluorescent probe

Analytical Chemistry

Volumn 85, Issue 1, 2013, Pages 185-192

  Kim, Jihoon ^a,b   Sasaki, Yasuhiko ^a   Yoshida, Wataru ^a   Kobayashi, Natsuki ^a   Veloso, Anthony J ^c   Kerman, Kagan ^c   Ikebukuro, Kazunori ^a   Sode, Koji ^a  

^a TOKYO UNIVERSITY OF AGRICULTURE AND TECHNOLOGY   (Japan)

^b I SENS Inc   (South Korea)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ALZHEIMER'S; BAICALEIN; BIOLOGICAL TECHNIQUES; BIOSENSING SYSTEMS; CONCENTRATION-DEPENDENT; DRUG DISCOVERY; EPIGALLOCATECHIN-3-GALLATE; EVALUATION SYSTEM; FLUORESCENT DYES; FLUORESCENT PROBES; HIGH-THROUGHPUT SCREENING; LIPID BINDING; MEMBRANE POTENTIALS; MYRICETIN; PRION DISEASE; PYRROLOQUINOLINE QUINONE; SYNUCLEIN; UNDERLYING MECHANISM;

CELL CULTURE; CYTOTOXICITY; FLAVONOIDS; FLUORESCENCE; GLYCOPROTEINS; MOLECULAR INTERACTIONS; NEURODEGENERATIVE DISEASES; PROTEINS;

MEMBRANES;

ALPHA SYNUCLEIN; AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN (1 42); AMYLOID BETA-PROTEIN (1-42); ANTIOXIDANT; BAICALEIN; BARBITURIC ACID DERIVATIVE; BIS(1,3 DIBUTYLBARBITURIC ACID)TRIMETHINE OXONOL; BIS(1,3 DIETHYLTHIOBARBITURATE)TRIMETHINEOXONOL; BIS(1,3-DIBUTYLBARBITURATE)TRIMETHINE OXONOL; BIS(1,3-DIETHYLTHIOBARBITURATE)TRIMETHINEOXONOL; CATECHIN; DRUG DERIVATIVE; EPIGALLOCATECHIN GALLATE; FLAVANONE DERIVATIVE; FLUORESCENT DYE; ISOXAZOLE DERIVATIVE; PEPTIDE FRAGMENT; RECOMBINANT PROTEIN; THIOBARBITURIC ACID DERIVATIVE;

ARTICLE; BIOSYNTHESIS; CELL SURVIVAL; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; GENETIC PROCEDURES; GENETICS; HUMAN; METABOLISM; TUMOR CELL LINE;

ALPHA-SYNUCLEIN; AMYLOID BETA-PEPTIDES; ANTIOXIDANTS; BARBITURATES; BIOSENSING TECHNIQUES; CATECHIN; CELL LINE, TUMOR; CELL SURVIVAL; FLAVANONES; FLUORESCENT DYES; HUMANS; ISOXAZOLES; PEPTIDE FRAGMENTS; RECOMBINANT PROTEINS; THIOBARBITURATES;

EID: 84871779334     PISSN: 00032700     EISSN: 15206882     Source Type: Journal    
DOI: 10.1021/ac302442q     Document Type: Article

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