Evaluating Drosophila p53 as a model system for studying cancer mutations

Journal of Biological Chemistry

Volumn 287, Issue 53, 2012, Pages 44330-44337

  Herzog, Gal ^a   Joerger, Andreas C ^b   Shmueli, Merav D ^a   Fersht, Alan R ^b   Gazit, Ehud ^a   Segal, Daniel ^a  

^a TEL AVIV UNIVERSITY   (Israel)

^b MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOTIC FUNCTION; CANCER-ASSOCIATED MUTATIONS; CONFORMATIONAL DIFFERENCES; DIFFERENT EFFECTS; DNA BINDING AFFINITY; DNA-BINDING DOMAIN; FULL-LENGTH PROTEINS; FUNCTIONAL RESPONSE; HOMOLOGY MODELING; HOT SPOT; HUMAN CANCER; MODEL SYSTEM; MUTANT PROTEINS; P53 FUNCTION; POINT MUTATIONS; SEQUENCE CONSERVATION; TUMOR SUPPRESSOR PROTEINS;

BINDING ENERGY; TRANSCRIPTION FACTORS;

DISEASES;

MUTANT PROTEIN; PROTEIN P53;

ARTICLE; BINDING AFFINITY; BINDING SITE; CONFORMATIONAL TRANSITION; DNA BINDING; DROSOPHILA; GENE TARGETING; GENETIC ASSOCIATION; GENETIC CONSERVATION; GENETIC MODEL; GENETIC STABILITY; MALIGNANT NEOPLASTIC DISEASE; MELTING POINT; POINT MUTATION; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN MOTIF; PROTEIN STABILITY; SEQUENCE ALIGNMENT; STRUCTURAL HOMOLOGY; STRUCTURE ACTIVITY RELATION; THERMODYNAMICS; THERMOSTABILITY; TUMOR SUPPRESSOR GENE;

AMINO ACID SEQUENCE; ANIMALS; DISEASE MODELS, ANIMAL; DROSOPHILA; DROSOPHILA PROTEINS; HUMANS; MOLECULAR SEQUENCE DATA; MUTATION; NEOPLASMS; PROTEIN STRUCTURE, TERTIARY; SEQUENCE ALIGNMENT; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84871745472     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.417980     Document Type: Article

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