Halogen-enriched fragment libraries as leads for drug rescue of mutant p53

Journal of the American Chemical Society

Volumn 134, Issue 15, 2012, Pages 6810-6818

  Wilcken, Rainer ^a,b   Liu, Xiangrui ^b   Zimmermann, Markus O ^a   Rutherford, Trevor J ^b   Fersht, Alan R ^b   Joerger, Andreas C ^b   Boeckler, Frank M ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BIOPHYSICAL DATA; CENTRAL SCAFFOLD; CLASSICAL APPROACH; DRUG DISCOVERY; HALOGEN BONDING; HUMAN CANCER CELLS; KEY FEATURE; ROBUST BINDING; SMALL MOLECULES;

ACETYLENE; BINDING ENERGY; CELL CULTURE; CELL DEATH; IODINE;

LIBRARIES;

2 (AMINOMETHYL) 4 ETHYNYL 6 IODOPHENOL; CARBAZOLE DERIVATIVE; CARBONYL DERIVATIVE; HALOGEN; MUTANT PROTEIN; OXYGEN; PHENOL DERIVATIVE; PHIKAN 5116; PHIKAN 5174; PHIKAN 5196; PROTEIN P53; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; BINDING AFFINITY; CANCER CELL CULTURE; CHEMICAL STRUCTURE; CRYSTAL STRUCTURE; DIFFERENTIAL SCANNING FLUORIMETRY; DNA BINDING; DRUG DESIGN; DRUG TARGETING; FLUOROMETRY; GENE MUTATION; HALOGEN ENRICHED FRAGMENT LIBRARY; HUMAN; HUMAN CELL; HYDROGEN BOND; ISOTHERMAL TITRATION CALORIMETRY; LIGAND BINDING; MOLECULAR INTERACTION; MOLECULAR LIBRARY; MOLECULAR MODEL; MOLECULE; NITROGEN NUCLEAR MAGNETIC RESONANCE; PROTON NUCLEAR MAGNETIC RESONANCE; QUANTUM CHEMISTRY; STOMACH CANCER; SYNTHESIS; X RAY CRYSTALLOGRAPHY;

APOPTOSIS; CELL LINE, TUMOR; DRUG DISCOVERY; DRUG EVALUATION, PRECLINICAL; HALOGENS; HUMANS; MUTANT PROTEINS; MUTATION; PROTEIN STABILITY; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84859993146     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja301056a     Document Type: Article

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