First-order rate-determining aggregation mechanism of p53 and its implications

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 34, 2012, Pages 13590-13595

  Wang, GuoZhen ^a   Fersht, Alan R ^a  

^a MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

Author keywords

Amyloid; Folding; Kinetics; Misfolding

Indexed keywords

EDETIC ACID; MONOMER; PROTEIN P53; THIOFLAVINE;

ALLELE; AMINO ACID SEQUENCE; ARTICLE; CANCER CELL; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN FOLDING; WILD TYPE;

BINDING SITES; CROSS-LINKING REAGENTS; EDETIC ACID; HUMANS; KINETICS; LIGHT; MUTATION; PROTEIN DENATURATION; PROTEIN FOLDING; PROTEIN STRUCTURE, TERTIARY; SCATTERING, RADIATION; TEMPERATURE; THIAZOLES; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84865293745     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1211557109     Document Type: Article

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