FPipTB, a benzimidazole derivative, induces chondrosarcoma cell apoptosis via endoplasmic reticulum stress and apoptosis signal-regulating kinase 1

Molecular Carcinogenesis

Volumn 51, Issue 4, 2012, Pages 315-326

  Liu, Ju Fang ^a   Chang, Chih Shiang ^a   Fong, Yi Chin ^a,b   Kuo, Sheng Chu ^a   Tang, Chih Hsin ^a  

^a CHINA MEDICAL UNIVERSITY   (Taiwan)

^b CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

ASK1; Benzimidazole; Chondrosarcoma; ER stress

Indexed keywords

2 (FURANYL) 5 (PIPERIDINYL) (3,4,5 TRIMETHOXYBENZYL) BENZIMIDAZOLE; ANTINEOPLASTIC AGENT; APOPTOSIS SIGNAL REGULATING KINASE 1; BENZIMIDAZOLE DERIVATIVE; CALCIUM; CYTOCHROME C; MITOGEN ACTIVATED PROTEIN KINASE KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE 6; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN BAX; PROTEIN P53; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CALCIUM CELL LEVEL; CANCER CELL CULTURE; CARTILAGE CELL; CHONDROSARCOMA; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOSOL; DRUG EFFECT; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; HUMAN; HUMAN CELL; INTRACELLULAR SIGNALING; MALE; MITOCHONDRION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN PHOSPHORYLATION; TRANSCRIPTION REGULATION; TUMOR CELL DESTRUCTION; TUMOR VOLUME; UPREGULATION;

ASK1; BENZIMIDAZOLE; CHONDROSARCOMA; ER STRESS;

ANIMALS; APOPTOSIS; BENZIMIDAZOLES; CALCIUM; CELL DEATH; CELL LINE, TUMOR; CHELATING AGENTS; CHONDROSARCOMA; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; FLOW CYTOMETRY; HUMANS; MALE; MAP KINASE KINASE KINASE 5; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MICE, INBRED BALB C; MICE, SCID; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ANIMALIA;

EID: 84858159124     PISSN: 08991987     EISSN: 10982744     Source Type: Journal    
DOI: 10.1002/mc.20787     Document Type: Article

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