-
1
-
-
60749125436
-
Epidermal homeostasis: a balancing act of stem cells in the skin
-
Blanpain C., Fuchs E. Epidermal homeostasis: a balancing act of stem cells in the skin. Nat. Rev. Mol. Cell Biol. 2009, 10:207-217.
-
(2009)
Nat. Rev. Mol. Cell Biol.
, vol.10
, pp. 207-217
-
-
Blanpain, C.1
Fuchs, E.2
-
2
-
-
79952682059
-
Keratin gene mutations in disorders of human skin and its appendages
-
Chamcheu J.C., et al. Keratin gene mutations in disorders of human skin and its appendages. Arch. Biochem. Biophys. 2011, 508:123-137.
-
(2011)
Arch. Biochem. Biophys.
, vol.508
, pp. 123-137
-
-
Chamcheu, J.C.1
-
3
-
-
77952717243
-
Identification of novel and known KRT5 and KRT14 mutations in 53 patients with epidermolysis bullosa simplex: correlation between genotype and phenotype
-
Arin M.J., et al. Identification of novel and known KRT5 and KRT14 mutations in 53 patients with epidermolysis bullosa simplex: correlation between genotype and phenotype. Br. J. Dermatol. 2010, 162:1365-1369.
-
(2010)
Br. J. Dermatol.
, vol.162
, pp. 1365-1369
-
-
Arin, M.J.1
-
4
-
-
84859495390
-
Expression signature of epidermolysis bullosa simplex
-
Bchetnia M., et al. Expression signature of epidermolysis bullosa simplex. Hum. Genet. 2012, 131:393-406.
-
(2012)
Hum. Genet.
, vol.131
, pp. 393-406
-
-
Bchetnia, M.1
-
5
-
-
77649204684
-
Overview of epidermolysis bullosa
-
Sawamura D., et al. Overview of epidermolysis bullosa. J. Dermatol. 2010, 37:214-219.
-
(2010)
J. Dermatol.
, vol.37
, pp. 214-219
-
-
Sawamura, D.1
-
6
-
-
84855265955
-
Targeted proteolysis of plectin isoform 1a accounts for hemidesmosome dysfunction in mice mimicking the dominant skin blistering disease EBS-Ogna
-
Walko G., et al. Targeted proteolysis of plectin isoform 1a accounts for hemidesmosome dysfunction in mice mimicking the dominant skin blistering disease EBS-Ogna. PLoS Genet. 2011, 7:e1002396.
-
(2011)
PLoS Genet.
, vol.7
-
-
Walko, G.1
-
7
-
-
79551487388
-
Expanding the keratin mutation database: novel and recurrent mutations and genotype-phenotype correlations in 28 patients with epidermolytic ichthyosis
-
Arin M.J., et al. Expanding the keratin mutation database: novel and recurrent mutations and genotype-phenotype correlations in 28 patients with epidermolytic ichthyosis. Br. J. Dermatol. 2011, 164:442-447.
-
(2011)
Br. J. Dermatol.
, vol.164
, pp. 442-447
-
-
Arin, M.J.1
-
8
-
-
84863091540
-
Deletion of K1/K10 does not impair epidermal stratification but affects desmosomal structure and nuclear integrity
-
Wallace L., et al. Deletion of K1/K10 does not impair epidermal stratification but affects desmosomal structure and nuclear integrity. J. Cell Sci. 2012, 125:1750-1758.
-
(2012)
J. Cell Sci.
, vol.125
, pp. 1750-1758
-
-
Wallace, L.1
-
9
-
-
77957371828
-
Mitotic recombination in patients with ichthyosis causes reversion of dominant mutations in KRT10
-
Choate K.A., et al. Mitotic recombination in patients with ichthyosis causes reversion of dominant mutations in KRT10. Science 2010, 330:94-97.
-
(2010)
Science
, vol.330
, pp. 94-97
-
-
Choate, K.A.1
-
10
-
-
41249083701
-
Inactivation of the calcium sensing receptor inhibits E-cadherin-mediated cell-cell adhesion and calcium-induced differentiation in human epidermal keratinocytes
-
Tu C-L., et al. Inactivation of the calcium sensing receptor inhibits E-cadherin-mediated cell-cell adhesion and calcium-induced differentiation in human epidermal keratinocytes. J. Biol. Chem. 2008, 283:3519-3528.
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 3519-3528
-
-
Tu, C.-L.1
-
11
-
-
84866372350
-
Ablation of the calcium-sensing receptor in keratinocytes impairs epidermal differentiation and barrier function
-
Tu C-L., et al. Ablation of the calcium-sensing receptor in keratinocytes impairs epidermal differentiation and barrier function. J. Invest. Dermatol. 2012, 132:2350-2359.
-
(2012)
J. Invest. Dermatol.
, vol.132
, pp. 2350-2359
-
-
Tu, C.-L.1
-
12
-
-
78650471794
-
Endoplasmic reticulum Ca2+ depletion activates XBP1 and controls terminal differentiation in keratinocytes and epidermis
-
Celli A., et al. Endoplasmic reticulum Ca2+ depletion activates XBP1 and controls terminal differentiation in keratinocytes and epidermis. Br. J. Dermatol. 2011, 164:16-25.
-
(2011)
Br. J. Dermatol.
, vol.164
, pp. 16-25
-
-
Celli, A.1
-
13
-
-
0032978357
-
Mutations in ATP2A2, encoding a Ca2+ pump, cause Darier disease
-
Sakuntabhai A., et al. Mutations in ATP2A2, encoding a Ca2+ pump, cause Darier disease. Nat. Genet. 1999, 21:271-277.
-
(1999)
Nat. Genet.
, vol.21
, pp. 271-277
-
-
Sakuntabhai, A.1
-
14
-
-
0033986288
-
Mutations in ATP2C1, encoding a calcium pump, cause Hailey-Hailey disease
-
Hu Z., et al. Mutations in ATP2C1, encoding a calcium pump, cause Hailey-Hailey disease. Nat. Genet. 2000, 24:61-65.
-
(2000)
Nat. Genet.
, vol.24
, pp. 61-65
-
-
Hu, Z.1
-
15
-
-
67349282678
-
Reevaluation of the normal epidermal calcium gradient, and analysis of calcium levels and ATP receptors in Hailey-Hailey and Darier epidermis
-
Leinonen P.T., et al. Reevaluation of the normal epidermal calcium gradient, and analysis of calcium levels and ATP receptors in Hailey-Hailey and Darier epidermis. J. Invest. Dermatol. 2009, 129:1379-1387.
-
(2009)
J. Invest. Dermatol.
, vol.129
, pp. 1379-1387
-
-
Leinonen, P.T.1
-
16
-
-
33645055383
-
Activity of the hSPCA1 Golgi Ca2+ pump is essential for Ca2+-mediated Ca2+ response and cell viability in Darier disease
-
Foggia L., et al. Activity of the hSPCA1 Golgi Ca2+ pump is essential for Ca2+-mediated Ca2+ response and cell viability in Darier disease. J. Cell Sci. 2006, 119:671-679.
-
(2006)
J. Cell Sci.
, vol.119
, pp. 671-679
-
-
Foggia, L.1
-
17
-
-
33749500948
-
Up-regulation of transient receptor potential canonical 1 (TRPC1) following sarco(endo)plasmic reticulum Ca2+ ATPase 2 gene silencing promotes cell survival: a potential role for TRPC1 in Darier's disease
-
Pani B., et al. Up-regulation of transient receptor potential canonical 1 (TRPC1) following sarco(endo)plasmic reticulum Ca2+ ATPase 2 gene silencing promotes cell survival: a potential role for TRPC1 in Darier's disease. Mol. Biol. Cell 2006, 17:4446-4458.
-
(2006)
Mol. Biol. Cell
, vol.17
, pp. 4446-4458
-
-
Pani, B.1
-
18
-
-
84858276574
-
SERCA2-controlled Ca2+-dependent keratinocyte adhesion and differentiation is mediated via the sphingolipid pathway: a therapeutic target for Darier's disease
-
Celli A., et al. SERCA2-controlled Ca2+-dependent keratinocyte adhesion and differentiation is mediated via the sphingolipid pathway: a therapeutic target for Darier's disease. J. Invest. Dermatol. 2012, 132:1188-1195.
-
(2012)
J. Invest. Dermatol.
, vol.132
, pp. 1188-1195
-
-
Celli, A.1
-
19
-
-
45449120119
-
K6PC-5, a direct activator of sphingosine kinase 1, promotes epidermal differentiation through intracellular Ca2+ signaling
-
Hong J.H., et al. K6PC-5, a direct activator of sphingosine kinase 1, promotes epidermal differentiation through intracellular Ca2+ signaling. J. Invest. Dermatol. 2008, 128:2166-2178.
-
(2008)
J. Invest. Dermatol.
, vol.128
, pp. 2166-2178
-
-
Hong, J.H.1
-
20
-
-
79957493955
-
Tight junctions in epidermis: from barrier to keratinization
-
Morita K., et al. Tight junctions in epidermis: from barrier to keratinization. Eur. J. Dermatol. 2011, 21:12-17.
-
(2011)
Eur. J. Dermatol.
, vol.21
, pp. 12-17
-
-
Morita, K.1
-
21
-
-
84555218069
-
Desmosomal genodermatoses
-
Petrof G., et al. Desmosomal genodermatoses. Br. J. Dermatol. 2012, 166:36-45.
-
(2012)
Br. J. Dermatol.
, vol.166
, pp. 36-45
-
-
Petrof, G.1
-
22
-
-
71649093068
-
Disadhesion of epidermal keratinocytes: a histologic clue to palmoplantar keratodermas caused by DSG1 mutations
-
Bergman R., et al. Disadhesion of epidermal keratinocytes: a histologic clue to palmoplantar keratodermas caused by DSG1 mutations. J. Am. Acad. Dermatol. 2010, 62:107-113.
-
(2010)
J. Am. Acad. Dermatol.
, vol.62
, pp. 107-113
-
-
Bergman, R.1
-
23
-
-
84858951977
-
Lack of plakoglobin in epidermis leads to keratoderma
-
Li D., et al. Lack of plakoglobin in epidermis leads to keratoderma. J. Biol. Chem. 2012, 287:10435-10443.
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 10435-10443
-
-
Li, D.1
-
24
-
-
80052608476
-
Lis1 is essential for cortical microtubule organization and desmosome stability in the epidermis
-
Sumigray K.D., et al. Lis1 is essential for cortical microtubule organization and desmosome stability in the epidermis. J. Cell Biol. 2011, 194:631-642.
-
(2011)
J. Cell Biol.
, vol.194
, pp. 631-642
-
-
Sumigray, K.D.1
-
25
-
-
77955579487
-
Mutations in PVRL4, encoding cell adhesion molecule nectin-4, cause ectodermal dysplasia-syndactyly syndrome
-
Brancati F., et al. Mutations in PVRL4, encoding cell adhesion molecule nectin-4, cause ectodermal dysplasia-syndactyly syndrome. Am. J. Hum. Genet. 2010, 87:265-273.
-
(2010)
Am. J. Hum. Genet.
, vol.87
, pp. 265-273
-
-
Brancati, F.1
-
26
-
-
80053917246
-
Mutations in CSTA, encoding cystatin A, underlie exfoliative ichthyosis and reveal a role for this protease inhibitor in cell-cell adhesion
-
Blaydon D.C., et al. Mutations in CSTA, encoding cystatin A, underlie exfoliative ichthyosis and reveal a role for this protease inhibitor in cell-cell adhesion. Am. J. Hum. Genet. 2011, 89:564-571.
-
(2011)
Am. J. Hum. Genet.
, vol.89
, pp. 564-571
-
-
Blaydon, D.C.1
-
28
-
-
84855918420
-
TCF/Lef1-mediated control of lipid metabolism regulates skin barrier function
-
Fehrenschild D., et al. TCF/Lef1-mediated control of lipid metabolism regulates skin barrier function. J. Invest. Dermatol. 2011, 132:337-345.
-
(2011)
J. Invest. Dermatol.
, vol.132
, pp. 337-345
-
-
Fehrenschild, D.1
-
29
-
-
33749524559
-
The Grainyhead-like epithelial transactivator Get-1/Grhl3 regulates epidermal terminal differentiation and interacts functionally with LMO4
-
Yu Z., et al. The Grainyhead-like epithelial transactivator Get-1/Grhl3 regulates epidermal terminal differentiation and interacts functionally with LMO4. Dev. Biol. 2006, 299:122-136.
-
(2006)
Dev. Biol.
, vol.299
, pp. 122-136
-
-
Yu, Z.1
-
30
-
-
0032813661
-
Klf4 is a transcription factor required for establishing the barrier function of the skin
-
Segre J.A., et al. Klf4 is a transcription factor required for establishing the barrier function of the skin. Nat. Genet. 1999, 22:356-360.
-
(1999)
Nat. Genet.
, vol.22
, pp. 356-360
-
-
Segre, J.A.1
-
32
-
-
77955842799
-
Psoriasis genetics: breaking the barrier
-
Roberson E.D.O., Bowcock A.M. Psoriasis genetics: breaking the barrier. Trends Genet. 2010, 26:415-423.
-
(2010)
Trends Genet.
, vol.26
, pp. 415-423
-
-
Roberson, E.D.O.1
Bowcock, A.M.2
-
33
-
-
66149155333
-
Autosomal recessive congenital ichthyosis
-
Fischer J. Autosomal recessive congenital ichthyosis. J. Invest. Dermatol. 2009, 129:1319-1321.
-
(2009)
J. Invest. Dermatol.
, vol.129
, pp. 1319-1321
-
-
Fischer, J.1
-
34
-
-
0034128648
-
Stratum corneum tryptic enzyme in normal epidermis: a missing link in the desquamation process?
-
Ekholm I.E., et al. Stratum corneum tryptic enzyme in normal epidermis: a missing link in the desquamation process?. J. Invest. Dermatol. 2000, 114:56-63.
-
(2000)
J. Invest. Dermatol.
, vol.114
, pp. 56-63
-
-
Ekholm, I.E.1
-
35
-
-
78951479569
-
ABCA12 mutations and autosomal recessive congenital ichthyosis: a review of genotype/phenotype correlations and of pathogenetic conceptsa
-
Akiyama M. ABCA12 mutations and autosomal recessive congenital ichthyosis: a review of genotype/phenotype correlations and of pathogenetic conceptsa. Hum. Mutat. 2010, 31:1090-1096.
-
(2010)
Hum. Mutat.
, vol.31
, pp. 1090-1096
-
-
Akiyama, M.1
-
36
-
-
37049024066
-
PPAR and LXR activators regulate ABCA12 expression in human keratinocytes
-
Jiang Y.J., et al. PPAR and LXR activators regulate ABCA12 expression in human keratinocytes. J. Invest. Dermatol. 2007, 128:104-109.
-
(2007)
J. Invest. Dermatol.
, vol.128
, pp. 104-109
-
-
Jiang, Y.J.1
-
37
-
-
67650550792
-
Ceramide stimulates ABCA12 expression via peroxisome proliferator-activated receptor Δ in human keratinocytes
-
Jiang Y.J., et al. Ceramide stimulates ABCA12 expression via peroxisome proliferator-activated receptor Δ in human keratinocytes. J. Biol. Chem. 2009, 284:18942-18952.
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 18942-18952
-
-
Jiang, Y.J.1
-
38
-
-
25444473619
-
Targeted disruption of Smad4 in mouse epidermis results in failure of hair follicle cycling and formation of skin tumors
-
Yang L., et al. Targeted disruption of Smad4 in mouse epidermis results in failure of hair follicle cycling and formation of skin tumors. Cancer Res. 2005, 65:8671-8678.
-
(2005)
Cancer Res.
, vol.65
, pp. 8671-8678
-
-
Yang, L.1
-
39
-
-
48749122568
-
Keratinocyte-specific Smad2 ablation results in increased epithelial-mesenchymal transition during skin cancer formation and progression
-
Hoot K.E., et al. Keratinocyte-specific Smad2 ablation results in increased epithelial-mesenchymal transition during skin cancer formation and progression. J. Clin. Invest. 2008, 118:2722-2732.
-
(2008)
J. Clin. Invest.
, vol.118
, pp. 2722-2732
-
-
Hoot, K.E.1
-
40
-
-
0346497823
-
NF-kappaB RelA opposes epidermal proliferation driven by TNFR1 and JNK
-
Zhang J.Y., et al. NF-kappaB RelA opposes epidermal proliferation driven by TNFR1 and JNK. Genes Dev. 2004, 18:17-22.
-
(2004)
Genes Dev.
, vol.18
, pp. 17-22
-
-
Zhang, J.Y.1
-
41
-
-
0037309972
-
Keratinocyte-specific Pten deficiency results in epidermal hyperplasia, accelerated hair follicle morphogenesis and tumor formation
-
Suzuki A., et al. Keratinocyte-specific Pten deficiency results in epidermal hyperplasia, accelerated hair follicle morphogenesis and tumor formation. Cancer Res. 2003, 63:674-681.
-
(2003)
Cancer Res.
, vol.63
, pp. 674-681
-
-
Suzuki, A.1
-
42
-
-
67649304460
-
Epidermal Notch1 loss promotes skin tumorigenesis by impacting the stromal microenvironment
-
Demehri S., et al. Epidermal Notch1 loss promotes skin tumorigenesis by impacting the stromal microenvironment. Cancer Cell 2009, 16:55-66.
-
(2009)
Cancer Cell
, vol.16
, pp. 55-66
-
-
Demehri, S.1
-
43
-
-
33751230475
-
P63 regulates proliferation and differentiation of developmentally mature keratinocytes
-
Truong A.B., et al. p63 regulates proliferation and differentiation of developmentally mature keratinocytes. Genes Dev. 2006, 20:3185-3197.
-
(2006)
Genes Dev.
, vol.20
, pp. 3185-3197
-
-
Truong, A.B.1
-
44
-
-
67650461955
-
Rescue of key features of the p63-null epithelial phenotype by inactivation of Ink4a and Arf
-
Su X., et al. Rescue of key features of the p63-null epithelial phenotype by inactivation of Ink4a and Arf. EMBO J. 2009, 28:1904-1915.
-
(2009)
EMBO J.
, vol.28
, pp. 1904-1915
-
-
Su, X.1
-
45
-
-
77956880485
-
P63 in skin development and ectodermal dysplasias
-
Koster M.I. p63 in skin development and ectodermal dysplasias. J. Invest. Dermatol. 2010, 130:2352-2358.
-
(2010)
J. Invest. Dermatol.
, vol.130
, pp. 2352-2358
-
-
Koster, M.I.1
-
46
-
-
84863299509
-
Mutations in AEC syndrome skin reveal a role for p63 in basement membrane adhesion, skin barrier integrity and hair follicle biology
-
Clements S.E., et al. Mutations in AEC syndrome skin reveal a role for p63 in basement membrane adhesion, skin barrier integrity and hair follicle biology. Br. J. Dermatol. 2012, 167:134-144.
-
(2012)
Br. J. Dermatol.
, vol.167
, pp. 134-144
-
-
Clements, S.E.1
-
47
-
-
84863229693
-
Mutant p63 causes defective expansion of ectodermal progenitor cells and impaired FGF signalling in AEC syndrome
-
Ferone G., et al. Mutant p63 causes defective expansion of ectodermal progenitor cells and impaired FGF signalling in AEC syndrome. EMBO Mol. Med. 2012, 4:192-205.
-
(2012)
EMBO Mol. Med.
, vol.4
, pp. 192-205
-
-
Ferone, G.1
-
48
-
-
33745574321
-
Seborrhea-like dermatitis with psoriasiform elements caused by a mutation in ZNF750, encoding a putative C2H2 zinc finger protein
-
Birnbaum R.Y., et al. Seborrhea-like dermatitis with psoriasiform elements caused by a mutation in ZNF750, encoding a putative C2H2 zinc finger protein. Nat. Genet. 2006, 38:749-751.
-
(2006)
Nat. Genet.
, vol.38
, pp. 749-751
-
-
Birnbaum, R.Y.1
-
49
-
-
45349104713
-
A promoter sequence variant of ZNF750 is linked with familial psoriasis
-
Yang C-F., et al. A promoter sequence variant of ZNF750 is linked with familial psoriasis. J. Invest. Dermatol. 2008, 128:1662-1668.
-
(2008)
J. Invest. Dermatol.
, vol.128
, pp. 1662-1668
-
-
Yang, C.-F.1
-
50
-
-
84858293792
-
ZNF750 is a p63 target gene that induces KLF4 to drive terminal epidermal differentiation
-
Sen G.L., et al. ZNF750 is a p63 target gene that induces KLF4 to drive terminal epidermal differentiation. Dev. Cell 2012, 22:669-677.
-
(2012)
Dev. Cell
, vol.22
, pp. 669-677
-
-
Sen, G.L.1
-
51
-
-
84866066605
-
Genomic profiling of a human organotypic model of AEC syndrome reveals ZNF750 as an essential downstream target of mutant TP63
-
Zarnegar B.J., et al. Genomic profiling of a human organotypic model of AEC syndrome reveals ZNF750 as an essential downstream target of mutant TP63. Am. J. Hum. Genet. 2012, 91:435-443.
-
(2012)
Am. J. Hum. Genet.
, vol.91
, pp. 435-443
-
-
Zarnegar, B.J.1
-
52
-
-
61749097816
-
Tgf-beta superfamily signaling in embryonic development and homeostasis
-
Wu M.Y., Hill C.S. Tgf-beta superfamily signaling in embryonic development and homeostasis. Dev. Cell 2009, 16:329-343.
-
(2009)
Dev. Cell
, vol.16
, pp. 329-343
-
-
Wu, M.Y.1
Hill, C.S.2
-
53
-
-
77954167982
-
Transcriptional crosstalk between TGF-β and stem cell pathways in tumor cell invasion: role of EMT promoting Smad complexes
-
Fuxe J., et al. Transcriptional crosstalk between TGF-β and stem cell pathways in tumor cell invasion: role of EMT promoting Smad complexes. Cell Cycle 2010, 9:2363-2374.
-
(2010)
Cell Cycle
, vol.9
, pp. 2363-2374
-
-
Fuxe, J.1
-
54
-
-
30544444184
-
Hair follicle defects and squamous cell carcinoma formation in Smad4 conditional knockout mouse skin
-
Qiao W., et al. Hair follicle defects and squamous cell carcinoma formation in Smad4 conditional knockout mouse skin. Oncogene 2006, 25:207-217.
-
(2006)
Oncogene
, vol.25
, pp. 207-217
-
-
Qiao, W.1
-
55
-
-
40649097065
-
IKKalpha is a critical coregulator of a Smad4-independent TGFbeta-Smad2/3 signaling pathway that controls keratinocyte differentiation
-
Descargues P., et al. IKKalpha is a critical coregulator of a Smad4-independent TGFbeta-Smad2/3 signaling pathway that controls keratinocyte differentiation. Proc. Natl. Acad. Sci. U.S.A. 2008, 105:2487-2492.
-
(2008)
Proc. Natl. Acad. Sci. U.S.A.
, vol.105
, pp. 2487-2492
-
-
Descargues, P.1
-
56
-
-
79953180846
-
Multiple self-healing squamous epithelioma is caused by a disease-specific spectrum of mutations in TGFBR1
-
Goudie D.R., et al. Multiple self-healing squamous epithelioma is caused by a disease-specific spectrum of mutations in TGFBR1. Nat. Genet. 2011, 43:365-369.
-
(2011)
Nat. Genet.
, vol.43
, pp. 365-369
-
-
Goudie, D.R.1
-
57
-
-
17944378526
-
Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway
-
Senftleben U., et al. Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway. Science 2001, 293:1495-1499.
-
(2001)
Science
, vol.293
, pp. 1495-1499
-
-
Senftleben, U.1
-
58
-
-
0033537767
-
Abnormal morphogenesis but intact IKK activation in mice lacking the IKKalpha subunit of IkappaB kinase
-
Hu Y., et al. Abnormal morphogenesis but intact IKK activation in mice lacking the IKKalpha subunit of IkappaB kinase. Science 1999, 284:316-320.
-
(1999)
Science
, vol.284
, pp. 316-320
-
-
Hu, Y.1
-
59
-
-
33751217161
-
A critical role for I kappaB kinase alpha in the development of human and mouse squamous cell carcinomas
-
Liu B., et al. A critical role for I kappaB kinase alpha in the development of human and mouse squamous cell carcinomas. Proc. Natl. Acad. Sci. U.S.A. 2006, 103:17202-17207.
-
(2006)
Proc. Natl. Acad. Sci. U.S.A.
, vol.103
, pp. 17202-17207
-
-
Liu, B.1
-
60
-
-
34548844747
-
Epigenetic inactivation of IkappaB Kinase-alpha in oral carcinomas and tumor progression
-
Maeda G., et al. Epigenetic inactivation of IkappaB Kinase-alpha in oral carcinomas and tumor progression. Clin. Cancer Res. 2007, 13:5041-5047.
-
(2007)
Clin. Cancer Res.
, vol.13
, pp. 5041-5047
-
-
Maeda, G.1
-
61
-
-
35148897233
-
Reduction in IkappaB kinase alpha expression promotes the development of skin papillomas and carcinomas
-
Park E., et al. Reduction in IkappaB kinase alpha expression promotes the development of skin papillomas and carcinomas. Cancer Res. 2007, 67:9158-9168.
-
(2007)
Cancer Res.
, vol.67
, pp. 9158-9168
-
-
Park, E.1
-
62
-
-
33646528676
-
NEMO, NFkappaB signaling and incontinentia pigmenti
-
Nelson D.L. NEMO, NFkappaB signaling and incontinentia pigmenti. Curr. Opin. Genet. Dev. 2006, 16:282-288.
-
(2006)
Curr. Opin. Genet. Dev.
, vol.16
, pp. 282-288
-
-
Nelson, D.L.1
-
63
-
-
84871703852
-
Hypohidrotic ectodermal dysplasia and immunodeficiency with coincident NEMO and EDA mutations
-
Keller M.D., et al. Hypohidrotic ectodermal dysplasia and immunodeficiency with coincident NEMO and EDA mutations. Front. Immunol. 2011, 2:61.
-
(2011)
Front. Immunol.
, vol.2
, pp. 61
-
-
Keller, M.D.1
-
64
-
-
3442883360
-
Multiple familial trichoepithelioma caused by mutations in the cylindromatosis tumor suppressor gene
-
Salhi A., et al. Multiple familial trichoepithelioma caused by mutations in the cylindromatosis tumor suppressor gene. Cancer Res. 2004, 64:5113-5117.
-
(2004)
Cancer Res.
, vol.64
, pp. 5113-5117
-
-
Salhi, A.1
-
65
-
-
55749101603
-
New insights into cadherin function in epidermal sheet formation and maintenance of tissue integrity
-
Tinkle C.L., et al. New insights into cadherin function in epidermal sheet formation and maintenance of tissue integrity. Proc. Natl. Acad. Sci. U.S.A. 2008, 105:15405-15410.
-
(2008)
Proc. Natl. Acad. Sci. U.S.A.
, vol.105
, pp. 15405-15410
-
-
Tinkle, C.L.1
-
66
-
-
35348987509
-
Mutation in wnt10a is associated with an autosomal recessive ectodermal dysplasia: the Odonto-Onycho-Dermal dysplasia
-
Adaimy L., et al. Mutation in wnt10a is associated with an autosomal recessive ectodermal dysplasia: the Odonto-Onycho-Dermal dysplasia. Am. J. Hum. Genet. 2007, 81:821-828.
-
(2007)
Am. J. Hum. Genet.
, vol.81
, pp. 821-828
-
-
Adaimy, L.1
-
67
-
-
70450233732
-
WNT10A missense mutation associated with a complete Odonto-Onycho-Dermal Dysplasia syndrome
-
Nawaz S., et al. WNT10A missense mutation associated with a complete Odonto-Onycho-Dermal Dysplasia syndrome. Eur. J. Hum. Genet. 2009, 17:1600-1605.
-
(2009)
Eur. J. Hum. Genet.
, vol.17
, pp. 1600-1605
-
-
Nawaz, S.1
-
68
-
-
33749065765
-
Tcf3 governs stem cell features and represses cell fate determination in skin
-
Nguyen H., et al. Tcf3 governs stem cell features and represses cell fate determination in skin. Cell 2006, 127:171-183.
-
(2006)
Cell
, vol.127
, pp. 171-183
-
-
Nguyen, H.1
-
69
-
-
70349554461
-
Tcf3 and Tcf4 are essential for long-term homeostasis of skin epithelia
-
Nguyen H., et al. Tcf3 and Tcf4 are essential for long-term homeostasis of skin epithelia. Nat. Genet. 2009, 41:1068-1075.
-
(2009)
Nat. Genet.
, vol.41
, pp. 1068-1075
-
-
Nguyen, H.1
-
70
-
-
77953878405
-
Adherens junctions: from molecules to morphogenesis
-
Harris T.J.C., Tepass U. Adherens junctions: from molecules to morphogenesis. Nat. Rev. Mol. Cell Biol. 2010, 11:502-514.
-
(2010)
Nat. Rev. Mol. Cell Biol.
, vol.11
, pp. 502-514
-
-
Harris, T.J.C.1
Tepass, U.2
-
71
-
-
0032953231
-
A common human skin tumour is caused by activating mutations in beta-catenin
-
Chan E.F., et al. A common human skin tumour is caused by activating mutations in beta-catenin. Nat. Genet. 1999, 21:410-413.
-
(1999)
Nat. Genet.
, vol.21
, pp. 410-413
-
-
Chan, E.F.1
-
72
-
-
41649089525
-
Cutaneous cancer stem cell maintenance is dependent on β-catenin signalling
-
Malanchi I., et al. Cutaneous cancer stem cell maintenance is dependent on β-catenin signalling. Nature 2008, 452:650-653.
-
(2008)
Nature
, vol.452
, pp. 650-653
-
-
Malanchi, I.1
-
73
-
-
79958735965
-
Actomyosin-mediated cellular tension drives increased tissue stiffness and β-catenin activation to induce epidermal hyperplasia and tumor growth
-
Samuel M.S., et al. Actomyosin-mediated cellular tension drives increased tissue stiffness and β-catenin activation to induce epidermal hyperplasia and tumor growth. Cancer Cell 2011, 19:776-791.
-
(2011)
Cancer Cell
, vol.19
, pp. 776-791
-
-
Samuel, M.S.1
-
74
-
-
41549166020
-
Epidermal Notch signalling: differentiation, cancer and adhesion
-
Watt F.M., et al. Epidermal Notch signalling: differentiation, cancer and adhesion. Curr. Opin. Cell Biol. 2008, 20:171-179.
-
(2008)
Curr. Opin. Cell Biol.
, vol.20
, pp. 171-179
-
-
Watt, F.M.1
-
75
-
-
53749106109
-
AP-2 factors act in concert with Notch to orchestrate terminal differentiation in skin epidermis
-
Wang X., et al. AP-2 factors act in concert with Notch to orchestrate terminal differentiation in skin epidermis. J. Cell Biol. 2008, 183:37-48.
-
(2008)
J. Cell Biol.
, vol.183
, pp. 37-48
-
-
Wang, X.1
-
76
-
-
67649304460
-
Epidermal Notch1 loss promotes skin tumorigenesis by impacting the stromal microenvironment
-
Demehri S., et al. Epidermal Notch1 loss promotes skin tumorigenesis by impacting the stromal microenvironment. Cancer Cell 2009, 16:55-66.
-
(2009)
Cancer Cell
, vol.16
, pp. 55-66
-
-
Demehri, S.1
-
77
-
-
81255210846
-
IRF6 is a mediator of Notch pro-differentiation and tumour suppressive function in keratinocytes
-
Restivo G., et al. IRF6 is a mediator of Notch pro-differentiation and tumour suppressive function in keratinocytes. EMBO J. 2011, 30:4571-4585.
-
(2011)
EMBO J.
, vol.30
, pp. 4571-4585
-
-
Restivo, G.1
-
78
-
-
80055092549
-
Loss-of-function mutations in Notch receptors in cutaneous and lung squamous cell carcinoma
-
Wang N.J., et al. Loss-of-function mutations in Notch receptors in cutaneous and lung squamous cell carcinoma. Proc. Natl. Acad. Sci. U.S.A. 2011, 108:17761-17766.
-
(2011)
Proc. Natl. Acad. Sci. U.S.A.
, vol.108
, pp. 17761-17766
-
-
Wang, N.J.1
-
79
-
-
34047129136
-
Mek1/2 MAPK kinases are essential for mammalian development, homeostasis, and Raf-Induced hyperplasia
-
Scholl F.A., et al. Mek1/2 MAPK kinases are essential for mammalian development, homeostasis, and Raf-Induced hyperplasia. Dev. Cell 2007, 12:615-629.
-
(2007)
Dev. Cell
, vol.12
, pp. 615-629
-
-
Scholl, F.A.1
-
80
-
-
78651330430
-
COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer
-
Forbes S.A., et al. COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer. Nucleic Acids Res. 2010, 39:D945-D950.
-
(2010)
Nucleic Acids Res.
, vol.39
-
-
Forbes, S.A.1
-
81
-
-
84862982298
-
Postzygotic HRAS and KRAS mutations cause nevus sebaceous and Schimmelpenning syndrome
-
Groesser L., et al. Postzygotic HRAS and KRAS mutations cause nevus sebaceous and Schimmelpenning syndrome. Nat. Genet. 2012, 44:783-787.
-
(2012)
Nat. Genet.
, vol.44
, pp. 783-787
-
-
Groesser, L.1
-
82
-
-
68649121646
-
The RASopathies: developmental syndromes of Ras/MAPK pathway dysregulation
-
Tidyman W., Rauen K. The RASopathies: developmental syndromes of Ras/MAPK pathway dysregulation. Curr. Opin. Genet. Dev. 2009, 19:230-236.
-
(2009)
Curr. Opin. Genet. Dev.
, vol.19
, pp. 230-236
-
-
Tidyman, W.1
Rauen, K.2
-
83
-
-
38349094750
-
Germline mutations of MEK in cardio-facio-cutaneous syndrome are sensitive to MEK and RAF inhibition: implications for therapeutic options
-
Senawong T., et al. Germline mutations of MEK in cardio-facio-cutaneous syndrome are sensitive to MEK and RAF inhibition: implications for therapeutic options. Hum. Mol. Genet. 2008, 17:419-430.
-
(2008)
Hum. Mol. Genet.
, vol.17
, pp. 419-430
-
-
Senawong, T.1
-
84
-
-
67649857201
-
Kinase-activating and kinase-impaired cardio-facio-cutaneous syndrome alleles have activity during zebrafish development and are sensitive to small molecule inhibitors
-
Anastasaki C., et al. Kinase-activating and kinase-impaired cardio-facio-cutaneous syndrome alleles have activity during zebrafish development and are sensitive to small molecule inhibitors. Hum. Mol. Genet. 2009, 18:2543-2554.
-
(2009)
Hum. Mol. Genet.
, vol.18
, pp. 2543-2554
-
-
Anastasaki, C.1
-
85
-
-
33644629727
-
Germline KRAS and BRAF mutations in cardio-facio-cutaneous syndrome
-
Niihori T., et al. Germline KRAS and BRAF mutations in cardio-facio-cutaneous syndrome. Nat. Genet. 2006, 38:294-296.
-
(2006)
Nat. Genet.
, vol.38
, pp. 294-296
-
-
Niihori, T.1
-
86
-
-
45749098853
-
A mouse model for Costello syndrome reveals an Ang II-mediated hypertensive condition
-
Schuhmacher A.J., et al. A mouse model for Costello syndrome reveals an Ang II-mediated hypertensive condition. J. Clin. Invest. 2008, 118:2169-2179.
-
(2008)
J. Clin. Invest.
, vol.118
, pp. 2169-2179
-
-
Schuhmacher, A.J.1
-
87
-
-
25444466556
-
Phosphoinositide 3-kinase signaling to akt promotes keratinocyte differentiation versus death
-
Calautti E., et al. Phosphoinositide 3-kinase signaling to akt promotes keratinocyte differentiation versus death. J. Biol. Chem. 2005, 280:32856-32865.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 32856-32865
-
-
Calautti, E.1
-
88
-
-
81255205360
-
Targeting of the tumor suppressor GRHL3 by a miR-21-dependent proto-oncogenic network results in PTEN Loss and tumorigenesis
-
Darido C., et al. Targeting of the tumor suppressor GRHL3 by a miR-21-dependent proto-oncogenic network results in PTEN Loss and tumorigenesis. Cancer Cell 2011, 20:635-648.
-
(2011)
Cancer Cell
, vol.20
, pp. 635-648
-
-
Darido, C.1
-
89
-
-
46249113172
-
Fos cooperation with PTEN loss elicits keratoacanthoma not carcinoma, owing to p53/p21WAF-induced differentiation triggered by GSK3β inactivation and reduced AKT activity
-
Yao D., et al. Fos cooperation with PTEN loss elicits keratoacanthoma not carcinoma, owing to p53/p21WAF-induced differentiation triggered by GSK3β inactivation and reduced AKT activity. J. Cell Sci. 2008, 121:1758-1769.
-
(2008)
J. Cell Sci.
, vol.121
, pp. 1758-1769
-
-
Yao, D.1
|