PPAR and LXR activators regulate ABCA12 expression in human keratinocytes

Journal of Investigative Dermatology

Volumn 128, Issue 1, 2008, Pages 104-109

  Jiang, Yan J ^a   Lu, Biao ^a   Kim, Peggy ^a   Paragh, Gyorgy ^b   Schmitz, Gerd ^b   Elias, Peter M ^a   Feingold, Kenneth R ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF REGENSBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ABC TRANSPORTER; ATP BINDING CASSETTE TRANSPORTER A12; LIVER X RECEPTOR; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; UNCLASSIFIED DRUG;

ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; CONTROLLED STUDY; HOMEOSTASIS; HUMAN; HUMAN CELL; KERATINOCYTE; LIPOGENESIS; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REAL TIME POLYMERASE CHAIN REACTION; UPREGULATION;

EID: 37049024066     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/sj.jid.5700944     Document Type: Article

References (30)

1. Akiyama M (2006) Pathomechanisms of Harlequin ichthyosis and ABCA transporters in human diseases. Arch Dermatol 142:914-8
2. Akiyama M, Sugiyama-Nakagiri Y, Sakai K, McMillan JR, Goto M, Arita K et al. (2005) Mutations in lipid transporter ABCA12 in Harlequin ichthyosis and functional recovery by corrective gene transfer. J Clin Invest 115:1777-84
3. Allikmets R, Gerrard B, Hutchinson A, Dean M (1996) Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database. Hum Mol Genet 5:1649-55
4. Allikmets R, Shroyer NF, Singh N, Seddon JM, Lewis RA, Bernstein PS et al. (1997) Mutation of the Stargardt disease gene (ABCR) in age-related macular degeneration. Science 277:1805-7
5. Borst P, Elferink RO (2002) Mammalian ABC transporters in health and disease. Annu Rev Biochem 71:537-92
6. Brooks-Wilson A, Marcil M, Clee SM, Zhang LH, Roomp K, van Dam M et al. (1999) Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency. Nat Genet 22:336-45
7. Dean M, Rzhetsky A, Allikmets R (2001) The human ATP-binding cassette (ABC) transporter superfamily. Genome Res 11:1156-66
8. Elias PM, Menon GK (1991) Structural and lipid biochemical correlates of the epidermal permeability barrier. Adv Lipid Res 24:1-26
9. Hanley K, Jiang Y, He SS, Friedman M, Elias PM, Bikle DD et al. (1998) Keratinocyte differentiation is stimulated by activators of the nuclear hormone receptor PPARalpha. J Invest Dermatol 110:368-75
10. Hanley K, Komuves LG, Bass NM, He SS, Jiang Y, Crumrine D et al. (1999) Fetal epidermal differentiation and barrier development In vivo is accelerated by nuclear hormone receptor activators. J Invest Dermatol 113:788-95
11. Hanley K, Komuves LG, Ng DC, Schoonjans K, He SS, Lau P et al. (2000a) Farnesol stimulates differentiation in epidermal keratinocytes via PPARalpha. J Biol Chem 275:11484-91
12. Hanley K, Ng DC, He SS, Lau P, Min K, Elias PM et al. (2000b) Oxysterols induce differentiation in human keratinocytes and increase Ap-1-dependent involucrin transcription. J Invest Dermatol 114:545-53
13. Jiang YJ, Kim P, Elias PM, Feingold KR (2005) LXR and PPAR activators stimulate cholesterol sulfotransferase type 2 isoform 1b in human keratinocytes. J Lipid Res 46:2657-66
14. Jiang YJ, Lu B, Kim P, Elias PM, Feingold KR (2006) Regulation of ABCA1 expression in human keratinocytes, murine epidermis. J Lipid Res 47:2248-58
15. Kelsell DP, Norgett EE, Unsworth H, Teh MT, Cullup T, Mein CA et al. (2005) Mutations in ABCA12 underlie the severe congenital skin disease Harlequin ichthyosis. Am J Hum Genet 76:794-803
16. Komuves LG, Hanley K, Jiang Y, Katagiri C, Elias PM, Williams ML et al. (1999) Induction of selected lipid metabolic enzymes and differentiation-linked structural proteins by air exposure in fetal rat skin explants. J Invest Dermatol 112:303-9
17. Komuves LG, Hanley K, Man MQ, Elias PM, Williams ML, Feingold KR (2000) Keratinocyte differentiation in hyperproliferative epidermis: topical application of PPARalpha activators restores tissue homeostasis. J Invest Dermatol 115:361-7
18. Komuves LG, Schmuth M, Fowler AJ, Elias PM, Hanley K, Man MQ et al. (2002) Oxysterol stimulation of epidermal differentiation is mediated by liver X receptor-beta in murine epidermis. J Invest Dermatol 118:25-34
19. Lefevre C, Audebert S, Jobard F, Bouadjar B, Lakhdar H, Boughdene-Stambouli O et al. (2003) Mutations in the transporter ABCA12 are associated with lamellar ichthyosis type 2. Hum Mol Genet 12:2369-78
20. Man MQ, Choi EH, Schmuth M, Crumrine D, Uchida Y, Elias PM et al. (2006) Basis for improved permeability barrier homeostasis induced by PPAR and LXR activators: liposensors stimulate lipid synthesis, lamellar body secretion, and post-secretory lipid processing. J Invest Dermatol 126:386-92
21. Mao-Qiang M, Fowler AJ, Schmuth M, Lau P, Chang S, Brown BE et al. (2004) Peroxisome-proliferator-activated receptor (PPAR)-gamma activation stimulates keratinocyte differentiation. J Invest Dermatol 123:305-12
22. Rassner U, Feingold KR, Crumrine DA, Elias PM (1999) Coordinate assembly of lipids and enzyme proteins into epidermal lamellar bodies. Tissue Cell 31:489-98
23. Schmitz G, Kaminski WE, Orso E (2000) ABC transporters in cellular lipid trafficking. Curr Opin Lipidol 11:493-501
24. Schmitz G, Langmann T (2005) Transcriptional regulatory networks in lipid metabolism control ABCA1 expression. Biochim Biophys Acta 1735:1-19
25. Schmuth M, Haqq CM, Cairns WJ, Holder JC, Dorsam S, Chang S et al. (2004) Peroxisome proliferator-activated receptor (PPAR)-beta/delta stimulates differentiation and lipid accumulation in keratinocytes. J Invest Dermatol 122:971-83
26. Shulenin S, Nogee LM, Annilo T, Wert SE, Whitsett JA, Dean M (2004) ABCA3 gene mutations in newborns with fatal surfactant deficiency. N Engl J Med 350:1296-303
27. Singaraja RR, Bocher V, James ER, Clee SM, Zhang LH, Leavitt BR et al. (2001) Human ABCA1 BAC transgenic mice show increased high density lipoprotein cholesterol and ApoAI-dependent efflux stimulated by an internal promoter containing liver X receptor response elements in intron 1. J Biol Chem 276:33969-79
28. Singaraja RR, James ER, Crim J, Visscher H, Chatterjee A, Hayden MR (2005) Alternate transcripts expressed in response to diet reflect tissue-specific regulation of ABCA1. J Lipid Res 46:2061-71
29. Uchida Y, Hara M, Nishio H, Sidransky E, Inoue S, Otsuka F et al. (2000) Epidermal sphingomyelins are precursors for selected stratum corneum ceramides. J Lipid Res 41:2071-82
30. Westergaard M, Henningsen J, Svendsen ML, Johansen C, Jensen UB, Schroder HD et al. (2001) Modulation of keratinocyte gene expression and differentiation by PPAR-selective ligands and tetradecylthioacetic acid. J Invest Dermatol 116:702-12