Macroautophagy Abnormality in Essential Tremor

PLoS ONE

Volumn 7, Issue 12, 2012, Pages

  Kuo, Sheng Han ^a   Tang, Guomei ^a   Ma, Karen ^b   Babij, Rachel ^b   Cortes, Etty ^a,c   Vonsattel, Jean Paul G ^a,c   Faust, Phyllis L ^c   Sulzer, David ^a   Louis, Elan D ^a,b,d  

^a New York Presbyterian Columbia University Medical Center   (United States)

^b Vagelos College of Physicians and Surgeons   (United States)

^c Department of Medicine   (United States)

^d Department of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BECLIN 1; MICROTUBULE ASSOCIATED PROTEIN; MICROTUBULE ASSOCIATED PROTEIN LIGHT CHAIN 3 II; MITOCHONDRIAL PROTEIN; S6 KINASE; UNCLASSIFIED DRUG;

ARTICLE; CADAVER; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE DURATION; ENZYME PHOSPHORYLATION; ESSENTIAL TREMOR; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MACROAUTOPHAGY; MALE; MOLECULAR PATHOLOGY; PROTEIN ANALYSIS; PROTEIN FUNCTION; PURKINJE CELL; WESTERN BLOTTING;

AGED; AGED, 80 AND OVER; APOPTOSIS REGULATORY PROTEINS; AUTOPHAGY; CASE-CONTROL STUDIES; CEREBELLUM; ESSENTIAL TREMOR; FEMALE; HUMANS; MALE; MEMBRANE PROTEINS; MICROTUBULE-ASSOCIATED PROTEINS; MITOCHONDRIA; PHOSPHORYLATION; PURKINJE CELLS;

EID: 84871642898     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0053040     Document Type: Article

References (40)

1. Louis ED, Ferreira JJ, (2010) How common is the most common adult movement disorder? Update on the worldwide prevalence of essential tremor. Mov Disord 25: 534-541.
2. Axelrad JE, Louis ED, Honig LS, Flores I, Ross GW, et al. (2008) Reduced Purkinje cell number in essential tremor: a postmortem study. Arch Neurol 65: 101-107.
3. Louis ED, Faust PL, Vonsattel JP, Honig LS, Rajput A, et al. (2007) Neuropathological changes in essential tremor: 33 cases compared with 21 controls. Brain 130: 3297-3307.
4. Erickson-Davis CR, Faust PL, Vonsattel JP, Gupta S, Honig LS, et al. (2010) "Hairy baskets" associated with degenerative Purkinje cell changes in essential tremor. J Neuropathol Exp Neurology 69: 262-271.
5. Kuo SH, Erickson-Davis C, Gillman A, Faust PL, Vonsattel JP, et al. (2011) Increased number of heterotopic Purkinje cells in essential tremor. J Neurol Neurosurg Psychiatry 82: 1038-1040.
6. Louis ED, Vonsattel JP, Honig LS, Ross GW, Lyons KE, et al. (2006) Neuropathologic findings in essential tremor. Neurology 66: 1756-1759.
7. Kuo SH, Faust PL, Vonsattel JP, Ma K, Louis ED, (2011) Parallel fiber counts and parallel fiber integrated density are similar in essential tremor cases and controls. Acta Neuropathol 121: 287-289.
8. Louis ED, (2009) Essential tremors: a family of neurodegenerative disorders? Arch Neurol 66: 1202-1208.
9. Dusart I, Guenet JL, Sotelo C, (2006) Purkinje cell death: differences between developmental cell death and neurodegenerative death in mutant mice. Cerebellum 5: 163-173.
10. Wong E, Cuervo AM, (2010) Autophagy gone awry in neurodegenerative diseases. Nat Neurosci 13: 805-811.
11. Hara T, Nakamura K, Matsui M, Yamamoto A, Nakahara Y, et al. (2006) Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice. Nature 441: 885-889.
12. Komatsu M, Waguri S, Chiba T, Murata S, Iwata J, et al. (2006) Loss of autophagy in the central nervous system causes neurodegeneration in mice. Nature 441: 880-884.
13. Lee JH, Yu WH, Kumar A, Lee S, Mohan PS, et al. (2010) Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations. Cell 141: 1146-1158.
14. Martinez-Vicente M, Talloczy Z, Wong E, Tang G, Koga H, et al. (2010) Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease. Nat Neurosci 13: 567-576.
15. Crews L, Spencer B, Desplats P, Patrick C, Paulino A, et al. (2010) Selective molecular alterations in the autophagy pathway in patients with Lewy body disease and in models of alpha-synucleinopathy. PloS One 5: e9313.
16. Spencer B, Potkar R, Trejo M, Rockenstein E, Patrick C, et al. (2009) Beclin 1 gene transfer activates autophagy and ameliorates the neurodegenerative pathology in alpha-synuclein models of Parkinson's and Lewy body diseases. J Neurosci 29: 13578-13588.
17. Narendra DP, Jin SM, Tanaka A, Suen DF, Gautier CA, et al. (2010) PINK1 is selectively stabilized on impaired mitochondria to activate Parkin. PLoS Biol 8: e1000298.
18. Louis ED, Borden S, Moskowitz CB, (2005) Essential tremor centralized brain repository: diagnostic validity and clinical characteristics of a highly selected group of essential tremor cases. Mov Disord 20: 1361-1365.
19. Vonsattel JP, Del Amaya MP, Keller CE, (2008) Twenty-first century brain banking. Processing brains for research: the Columbia University methods. Acta Neuropathol 115: 509-532.
20. Yu WH, Dorado B, Figueroa HY, Wang L, Planel E, et al. (2009) Metabolic activity determines efficacy of macroautophagic clearance of pathological oligomeric alpha-synuclein. Am J Pathol 175: 736-747.
21. Chu CT, Plowey ED, Dagda RK, Hickey RW, Cherra SJ 3rd, et al. (2009) Autophagy in neurite injury and neurodegeneration: in vitro and in vivo models. Methods Enzymol 453: 217-249.
22. Chakrabarti L, Eng J, Ivanov N, Garden GA, La Spada AR, (2009) Autophagy activation and enhanced mitophagy characterize the Purkinje cells of pcd mice prior to neuronal death. Mol Brain 29: 24.
23. Klionsky DJ, Abeliovich H, Agostinis P, Agrawal DK, Aliev G, et al. (2008) Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy 4: 151-175.
24. Shirendeb UP, Calkins MJ, Manczak M, Anekonda V, Dufour B, et al. (2012) Mutant huntingtin's interaction with mitochondrial protein Drp1 impairs mitochondrial biogenesis and causes defective axonal transport and synaptic degeneration in Huntington's disease. Hum Mol Genet 21: 406-420.
25. Yang Z, Klionsky DJ, (2010) Mammalian autophagy: core molecular machinery and signaling regulation. Curr Opin Cell Biol 22: 124-131.
26. Sosunov AA, Wu X, Weiner HL, Mikell CB, Goodman RR, et al. (2008) Tuberous sclerosis: a primary pathology of astrocytes? Epilepsia 49 Suppl 2: 53-62.
27. Menzies FM, Huebener J, Renna M, Bonin M, Riess O, et al. (2010) Autophagy induction reduces mutant ataxin-3 levels and toxicity in a mouse model of spinocerebellar ataxia type 3. Brain 133: 93-104.
28. Alvarez-Erviti L, Rodriguez-Oroz MC, Cooper JM, Caballero C, Ferrer I, et al. (2010) Chaperone-mediated autophagy markers in Parkinson disease brains. Arch Neurol 67: 1464-1472.
29. Boland B, Kumar A, Lee S, Platt FM, Wegiel J, et al. (2008) Autophagy induction and autophagosome clearance in neurons: relationship to autophagic pathology in Alzheimer's disease. J Neurosci 28: 6926-6937.
30. Higashi S, Moore DJ, Minegishi M, Kasanuki K, Fujishiro H, et al. (2011) Localization of MAP1-LC3 in vulnerable neurons and Lewy bodies in brains of patients with dementia with Lewy bodies. J Neuropathol Exp Neurol 70: 264-280.
31. Pickford F, Masliah E, Britschgi M, Lucin K, Narashimhan R, et al. (2008) The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice. J Clin Invest 118: 2190-2199.
32. Nascimento-Ferreira I, Santos-Ferreira T, Sousa-Ferreira L, Auregan G, Onofre I, et al. (2011) Overexpression of the autophagic beclin-1 protein clears mutant ataxin-3 and alleviates Machado-Joseph disease. Brain 134: 1400-1415.
33. Shibata M, Lu T, Furuya T, Degterev A, Mizushima N, et al. (2006) Regulation of intracellular accumulation of mutant Huntingtin by Beclin 1. J Biol Chem 281: 14474-14485.
34. Yue Z, Horton A, Bravin M, DeJager PL, Selimi F, et al. (2002) A novel protein complex linking the delta 2 glutamate receptor and autophagy: implications for neurodegeneration in lurcher mice. Neuron 35: 921-933.
35. Nakatogawa H, Suzuki K, Kamada Y, Ohsumi Y, (2009) Dynamics and diversity in autophagy mechanisms: lessons from yeast. Nature reviews Mol Cell Biol 10: 458-467.
36. Komatsu M, Wang QJ, Holstein GR, Fredrich VL Jr, Iwata J, et al. (2007) Essential role for autophagy protein Atg7 in the maintenance of axonal homeostasis and the prevention of axonal degeneration. Proc Natl Acad Sci U S A 104: 14489-14494.
37. Nishiyama J, Miura E, Mizushima N, Watanabe M, Yuzaki M, (2007) Aberrant membranes and double-membrane structures accumulate in the axons of Atg5-null Purkinje cells before neuronal death. Autophagy 3: 591-596.
38. Dehay B, Bove J, Rodriguez-Muela N, Perier C, Recasens A, et al. (2010) Pathogenic lysosomal depletion in Parkinson's disease. J Neurosci 30: 12535-12544.
39. Jeong H, Then F, Melia TJ Jr, Mazzulli JR, Cui L, et al. (2009) Acetylation targets mutant huntingtin to autophagosomes for degradation. Cell 137: 60-72.
40. Louis ED, Yi H, Erickson-Davis C, Vonsattel JP, Faust PL, (2009) Structural study of Purkinje cell axonal torpedoes in essential tremor. Neurosci Lett 450: 287-291.