Novel dimeric aryldiketo containing inhibitors of HIV-1 integrase: Effects of the phenyl substituent and the linker orientation

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 16, 2008, Pages 7777-7787

  Zeng, Li Fan ^a   Jiang, Xiao Hua ^a   Sanchez, Tino ^b   Zhang, Hu Shan ^a   Dayam, Raveendra ^b   Neamati, Nouri ^b   Long, Ya Qiu ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

Aryl diketoacid; Conformationally constrained linker; Dimer; HIV 1 integrase inhibitors; Orientation; Strand transfer; Substitution effect

Indexed keywords

4 AMINO PIPERIDINE; ARYL DIKETOACID DERIVATIVE; BENZENE DERIVATIVE; DIAMINE DERIVATIVE; INTEGRASE; INTEGRASE INHIBITOR; MAGNESIUM; PIPERAZINE; PIPERIDIN 4 OL; PIPERIDINE DERIVATIVE; TRANS CYCLOHEXAN 1,2 DIAMINE; UNCLASSIFIED DRUG;

ARTICLE; DIMERIZATION; DRUG EFFECT; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN IMMUNODEFICIENCY VIRUS 1; SPATIAL ORIENTATION; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

DIMERIZATION; HIV INTEGRASE; HIV INTEGRASE INHIBITORS; HIV-1; KETO ACIDS; MASS SPECTROMETRY; MODELS, MOLECULAR; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; STRUCTURE-ACTIVITY RELATIONSHIP;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 49149122931     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.07.008     Document Type: Article

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