Design, synthesis and 3D-QSAR of β-carboline derivatives as potent antitumor agents

European Journal of Medicinal Chemistry

Volumn 45, Issue 6, 2010, Pages 2503-2515

  Cao, Rihui ^a   Guan, Xiangdong ^a   Shi, Buxi ^a   Chen, Zhiyong ^a   Ren, Zhenhua ^a   Peng, Wenlie ^a   Song, Huacan ^a  

^a SUN YAT SEN UNIVERSITY   (China)

Author keywords

Carboline; 3D QSAR; Antitumor; Synthesis

Indexed keywords

7 (PERFLUOROBENZYLOXY) 2 BENZYL 9 ETHYL 1 METHYL BETA CARBOLINIUM BROMIDE; 7 BENZYLOXY 2 BENZYL 9 ISOBUTYL 1 METHYL BETA CARBOLINIUM BROMIDE; 7 ETHOXY 2 BENZYL 9 ETHYL 1 METHYL BETA CARBOLINIUM BROMIDE; 7 N BUTOXY 2 BENZYL 9 ISOBUTYL 1 METHYL BETA CARBOLINIUM BROMIDE; 7 OCTYLOXY 9 (3 PHENYLPROPYL) 2 BENZYL 1 METHYL BETA CARBOLINIUM BROMIDE; ANTINEOPLASTIC AGENT; BETA CARBOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; COMPARATIVE MOLECULAR FIELD ANALYSIS; COMPARATIVE MOLECULAR SIMILARITY INDICES ANALYSIS; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; PHARMACOPHORE; QUALITATIVE ANALYSIS; QUANTITATIVE STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; CARBOLINES; CELL LINE, TUMOR; DRUG DESIGN; HUMANS; INHIBITORY CONCENTRATION 50; MODELS, MOLECULAR; MOLECULAR CONFORMATION; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77950862722     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.02.036     Document Type: Article

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