3-(3-Phenoxybenzyl)amino-β-carboline: A novel antitumor drug targeting α-tubulin

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 16, 2011, Pages 4784-4787

  Ikeda, Reiko ^a   Kurosawa, Masaki ^a   Okabayashi, Takazumi ^a   Takei, Ayako ^a   Yoshiwara, Masamichi ^a   Kumakura, Tadashi ^a   Sakai, Norio ^a   Funatsu, Osamu ^a   Morita, Akinori ^a   Ikekita, Masahiko ^a   Nakaike, Yumi ^a   Konakahara, Takeo ^a  

^a TOKYO UNIVERSITY OF SCIENCE   (Japan)

Author keywords

Tubulin; Carboline; Antitumor drug; Apoptosis

Indexed keywords

3 (3 PHENOXYBENZYL)AMINO BETA CARBOLINE; ALPHA TUBULIN; ANTINEOPLASTIC AGENT; BETA CARBOLINE DERIVATIVE; CASPASE 3; UNCLASSIFIED DRUG;

AFFINITY CHROMATOGRAPHY; AGAR GEL ELECTROPHORESIS; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL DEATH; CELL POPULATION; CHROMATIN CONDENSATION; CONTROLLED STUDY; CYTOTOXICITY; DNA FRAGMENTATION; DRUG TARGETING; ENZYME ACTIVATION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; PROTEIN INTERACTION; WESTERN BLOTTING;

ANTINEOPLASTIC AGENTS; CELL DEATH; CELL LINE, TUMOR; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; HELA CELLS; HUMANS; MOLECULAR STRUCTURE; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TUBULIN;

EID: 79960899374     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.06.061     Document Type: Article

References (14)

1. Z.A. Stewart, M.D. Westfall, and J.A. Pietenpol Trends Pharmacol. Sci. 24 2003 139
2. J.B. Gibbs Science 287 2000 1969
3. M.A. Jordan Curr. Med. Chem. Anti-Cancer Agents 2 2002 1
4. K.W. Wood, W.D. Cornwell, and J.R. Jackson Curr. Opin. Pharmacol. 1 2001 370
5. C. Dumontet, and V.I. Sikic J. Clin. Oncol. 17 1999 1061
6. R. Cao, W. Peng, Z. Wang, and A. Xu Curr. Med. Chem. 14 2007 479
7. K. Hayashi, M. Nagao, and T. Sugimura Nucleic Acids Res. 4 1977 3679
8. J. Ishida, H.K. Wang, K.F. Bastow, C.Q. Hu, and K.H. Lee Bioorg. Med. Chem. Lett. 9 1999 3319
9. R. Cao, W. Peng, H. Chen, Y. Ma, X. Liu, X. Hou, H. Guan, and A. Xu Biochem. Biophys. Res. Commun. 338 2005 1557
10. T.J. Zhao, H.C. Rosenberg, and T.H. Chiu Eur. J. Pharmacol. 306 1996 61
11. M.D. Garcia, A.J. Wilson, D.P. Emmerson, and P.R. Jenkins Org. Biomol. Chem. 4 2006 4478
12. A.C. Castro, L.C. Dang, F.S. Soucy, and L. Grenier Bioorg. Med. Chem. Lett. 13 2003 2419
13. Konakahara, T.; Iida, T.; Iwaki, T.; Kumagai, M.; Sakai, N. JP2006321753.
14. B. Yohan, and C. Iain Bioorg. Med. Chem. Lett. 14 2004 5841