Synthesis and in vitro cytotoxic evaluation of novel 3,4,5-trimethoxyphenyl substituted β-carboline derivatives

European Journal of Medicinal Chemistry

Volumn 44, Issue 2, 2009, Pages 533-540

  Wu, Qifeng ^a   Cao, Rihui ^a   Feng, Manxiu ^a   Guan, Xiangdong ^a   Ma, Chunming ^a   Liu, Jinbing ^a   Song, Huacan ^a   Peng, Wenlie ^a  

^a SUN YAT SEN UNIVERSITY   (China)

Author keywords

Carboline; Antitumor; Cytotoxic activities; SARs; Synthesis

Indexed keywords

1 (3,4,5 TRIMETHOXY)PHENYL 3 HYDROXYMETHYL 9 ETHYL BETA CARBOLINE; 1 (3,4,5 TRIMETHOXY)PHENYL 3 HYDROXYMETHYL 9 METHYL BETA CARBOLINE; 1 (3,4,5 TRIMETHOXY)PHENYL 3 HYDROXYMETHYL 9 N BUTYL BETA CARBOLINE; 1 (3,4,5 TRIMETHOXY)PHENYL 3 HYDROXYMETHYL 9 PHENYLPROPYL BETA CARBOLINE; 1 (3,4,5 TRIMETHOXY)PHENYL 9 ETHYL BETA CARBOLINE; 1 (3,4,5 TRIMETHOXY)PHENYL 9 ETHYL BETA CARBOLINE 3 CARBOXALDEHYDE; 1 (3,4,5 TRIMETHOXY)PHENYL 9 ETHYL BETA CARBOLINE 3 CARBOXYLIC ACID; 1 (3,4,5 TRIMETHOXY)PHENYL 9 METHYL BETA CARBOLINE; 1 (3,4,5 TRIMETHOXY)PHENYL 9 METHYL BETA CARBOLINE 3 CARBOXALDEHYDE; 1 (3,4,5 TRIMETHOXY)PHENYL 9 METHYL BETA CARBOLINE 3 CARBOXYLIC ACID; 1 (3,4,5 TRIMETHOXY)PHENYL 9 N BUTYL BETA CARBOLINE; 1 (3,4,5 TRIMETHOXY)PHENYL 9 N BUTYL BETA CARBOLINE 3 CARBOXALDEHYDE; 1 (3,4,5 TRIMETHOXY)PHENYL 9 N BUTYL BETA CARBOLINE 3 CARBOXYLIC ACID; 1 (3,4,5 TRIMETHOXY)PHENYL 9 PHENYLPROPYL BETA CARBOLINE 3 CARBOXALDEHYDE; 1 (3,4,5 TRIMETHOXY)PHENYL BETA CARBOLINE; 3,4,5 TRIMETHOXYBENZALDEHYDE; ALDEHYDE DERIVATIVE; BETA CARBOLINE DERIVATIVE; ETHYL 1 (3,4,5 TRIMETHOXY)PHENYL 9 ETHYL BETA CARBOLINE 3 CARBOXYLATE; ETHYL 1 (3,4,5 TRIMETHOXY)PHENYL 9 METHYL BETA CARBOLINE 3 CARBOXYLATE; ETHYL 1 (3,4,5 TRIMETHOXY)PHENYL 9 N BUTYL BETA CARBOLINE 3 CARBOXYLATE; ETHYL 1 (3,4,5 TRIMETHOXY)PHENYL 9 PHENYLPROPYL BETA CARBOLINE 3 CARBOXYLATE; ETHYL 1 (3,4,5 TRIMETHOXY)PHENYL BETA CARBOLINE 3 CARBOXYLATE; N (2 HYDROXYETHYL) 1 (3,4,5 TRIMETHOXY)PHENYL 9 ETHYL BETA CARBOLINE 3 FORMAMIDE; N (2 HYDROXYETHYL) 1 (3,4,5 TRIMETHOXY)PHENYL 9 METHYL BETA CARBOLINE 3 FORMAMIDE; N (2 HYDROXYETHYL) 1 (3,4,5 TRIMETHOXY)PHENYL 9 N BUTYL BETA CARBOLINE 3 FORMAMIDE; TRYPTOPHAN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CELL ASSAY; CHEMICAL REACTION; CONFORMATIONAL TRANSITION; CYTOPATHOGENIC EFFECT; DRUG DESIGN; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; MOLECULAR INTERACTION; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

ANTINEOPLASTIC AGENTS; BENZALDEHYDES; CARBOLINES; CELL LINE, TUMOR; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; INHIBITORY CONCENTRATION 50; STRUCTURE-ACTIVITY RELATIONSHIP; TRYPTOPHAN;

EID: 60149096806     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2008.03.030     Document Type: Article

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