Synthesis and cytotoxic evaluation of N2-benzylated quaternary β-carboline amino acid ester conjugates

European Journal of Medicinal Chemistry

Volumn 45, Issue 4, 2010, Pages 1515-1523

  Ma, Chunming ^a   Cao, Rihui ^a   Shi, Buxi ^a   Li, Shaoxue ^a   Chen, Zhiyong ^a   Yi, Wei ^a   Peng, Wenlie ^a   Ren, Zhenhua ^a   Song, Huacan ^a  

^a SUN YAT SEN UNIVERSITY   (China)

Author keywords

Carboline; Amino acid; Cytotoxic activity; SARs; Synthesis

Indexed keywords

2 BENZYL 9 BUTYL 3 (CARBONYLMETHIONINE ETHYL ESTER) BETA CARBOLINIUM BROMIC ACID; 2 BENZYL 9 BUTYL 3 (CARBONYLPHENYLALANINE ETHYL ESTER) BETA CARBOLINIUM BROMIC ACID; 2 BENZYL 9 BUTYL 3 (CARBONYLVALINE ETHYL ESTER) BETA CARBOLINIUM BROMIC ACID; ANTINEOPLASTIC AGENT; BETA CARBOLINE; CISPLATIN; N (1 METHYL 9 BUTYL BETA CARBOLINE 3 CARBONYL)METHIONINE ETHYL ESTER; N (1 METHYL 9 BUTYL BETA CARBOLINE 3 CARBONYL)PHENYLALANINE ETHYL ESTER; N (9 BENZYL BETA CARBOLINE 3 CARBONYL)ALANINE METHYL ESTER; N (9 BENZYL BETA CARBOLINE 3 CARBONYL)METHIONINE; N (9 BENZYL BETA CARBOLINE 3 CARBONYL)METHIONINE ETHYL ESTER; N (9 BENZYL BETA CARBOLINE 3 CARBONYL)PHENYLALANINE ETHYL ESTER; N (9 BUTYL BETA CARBOLINE 3 CARBONYL)ALANINE METHYL ESTER; N (9 BUTYL BETA CARBOLINE 3 CARBONYL)METHIONINE; N (9 BUTYL BETA CARBOLINE 3 CARBONYL)METHIONINE ETHYL ESTER; N (9 BUTYL BETA CARBOLINE 3 CARBONYL)PHENYLALANINE; N (9 BUTYL BETA CARBOLINE 3 CARBONYL)PHENYLALANINE ETHYL ESTER; N (9 BUTYL BETA CARBOLINE 3 CARBONYL)PHENYLALANINE METHYL ESTER; N (9 BUTYL BETA CARBOLINE 3 CARBONYL)TYROSINE; N (9 BUTYL BETA CARBOLINE 3 CARBONYL)TYROSINE METHYL ESTER; N (9 BUTYL BETA CARBOLINE 3 CARBONYL)VALINE METHYL ESTER; N (9 PHENYLPROPYL BETA CARBOLINE 3 CARBONYL)ALANINE; N (9 PHENYLPROPYL BETA CARBOLINE 3 CARBONYL)METHIONINE; N (9 PHENYLPROPYL BETA CARBOLINE 3 CARBONYL)METHIONINE ETHYL ESTER; N (9 PHENYLPROPYL BETA CARBOLINE 3 CARBONYL)PHENYLALANINE; N (9 PHENYLPROPYL BETA CARBOLINE 3 CARBONYL)PHENYLALANINE ETHYL ESTER; N (9 PHENYLPROPYL BETA CARBOLINE 3 CARBONYL)VALINE; N (9 PHENYLPROPYL BETA CARBOLINE 3 CARBONYL)VALINE ETHYL ESTER; PACLITAXEL; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; CYTOTOXICITY; DRUG POTENCY; DRUG SOLUBILITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50;

AMINO ACIDS; BENZYL COMPOUNDS; CARBOLINES; CELL LINE, TUMOR; DRUG SCREENING ASSAYS, ANTITUMOR; ESTERS; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SPECTROPHOTOMETRY, INFRARED; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77349122062     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2009.12.060     Document Type: Article

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