Nuclear localization of protein kinase C-α induces thyroid hormone receptor-α1 expression in the cardiomyocyte

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 290, Issue 1, 2006, Pages

  Kenessey, Agnes ^a   Sullivan, Elizabeth Ann ^a   Ojamaa, Kaie ^a,b  

^a North Shore Long Island Jewish Health System ^*  (United States)

^b NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Adenovirus; Extracellular signal regulated kinase; Heart; Myosin heavy chain; Sarcoplasmic reticulum calcium activated adenosinetriphosphatase; Triiodothyronine

Indexed keywords

ADENOSINE TRIPHOSPHATASE; LIOTHYRONINE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MYOSIN HEAVY CHAIN; MYOSIN HEAVY CHAIN ALPHA; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN KINASE C ALPHA; THYROID HORMONE RECEPTOR ALPHA; THYROID HORMONE RECEPTOR ALPHA1; UNCLASSIFIED DRUG; ADENOSINE TRIPHOSPHATASE (CALCIUM); ATP2A2 PROTEIN, RAT; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE;

ADENOVIRUS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CYTOSOL; DRUG EFFECT; DRUG HALF LIFE; GENE EXPRESSION; GENE OVEREXPRESSION; GENE REPRESSION; GENE TRANSLOCATION; HEART VENTRICLE HYPERTROPHY; NONHUMAN; NUCLEAR LOCALIZATION SIGNAL; PHENOTYPE; PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; RAT; SARCOPLASMIC RETICULUM; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; WILD TYPE; ANIMAL; BIOSYNTHESIS; CELL NUCLEUS; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETIC TRANSDUCTION; GENETICS; HEART MUSCLE CELL; METABOLISM; NEWBORN; PHYSIOLOGY;

ADENOVIRIDAE; ANIMALS; ANIMALS, NEWBORN; CALCIUM-TRANSPORTING ATPASES; CELL NUCLEUS; GENE EXPRESSION REGULATION; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MYOCYTES, CARDIAC; MYOSIN HEAVY CHAINS; NUCLEAR LOCALIZATION SIGNALS; PHENOTYPE; PROTEIN KINASE C-ALPHA; RATS; SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES; TETRADECANOYLPHORBOL ACETATE; THYROID HORMONE RECEPTORS ALPHA; TRANSDUCTION, GENETIC; TRIIODOTHYRONINE;

EID: 33644802342     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00576.2005     Document Type: Article

References (43)

1. Alisi A, Spagnuolo S, Napoletano S, Spaziani A, and Leoni S. Thyroid hormones regulate DNA-synthesis and cell-cycle proteins by activation of PKCα and p42/44 MAPK in chick embryo hepatocytes. J Cell Physiol 201:259 -265, 2004.
2. 2+-sensitive isoforms in the failing human heart. Circulation 99: 384-391, 1999.
3. Braz JC, Bueno OF, De Windt LJ, and Molkentin JD. PKCα regulates the hypertrophic growth of cardiomyocytes through extracellular signal-regulated kinase 1/2 (ERK1/2). J Cell Biol 156: 905-919, 2002.
4. Braz JC, Gregary K, Pathak A, Zhao W, Sahin B, Klevitsky R, Kimball TF, Lorenz JN, Nairn AC, Liggett SB, Bodi I, Wang S, Schwartz A, Lakatta EG, DePaoli-Roach AA, Robbins J, Hewett TE, Bibb JA, Westfall MV, Kranias EG, and Molkentin JD. PKC-α regulates cardiac contractility and propensity toward heart failure. Nat Med 10: 248-254, 2004.
5. Cao X, Kambe F, Moeller LC, Refetoff S, and Seo H. Thyroid hormone induces rapid activation of Akt/protein kinase B-mammalian target of rapamycin-p70S6K cascade through phosphatidylinositol 3-kinase in human fibroblasts. Mol Endocrinol 19: 102-112, 2005.
6. Clerk A, Bogoyevitch MA, Fuller SJ, Lazou A, Parker PJ, and Sugden PH. Expression of protein kinase C isoforms during cardiac ventricular development. Am J Physiol Heart Circ Physiol 269: H1087-H1097, 1995.
7. D'Amati G, Di Gioia CRT, Mentuccia D, Pistilli D, Proietti-Pannunzi L, Miraldi F, Gallo P, and Celi FS. Increased expression of thyroid hormone receptor isoforms in end-stage human congestive heart failure. J Clin Endocrinol Metab 86: 2080-2084, 2001.
8. Davis PJ and Davis FB. Nongenomic actions of thyroid hormone on the heart. Thyroid 12: 459-466, 2002.
9. Davis PJ, Shih A, Lin HY, Martino LJ, and Davis FB. Thyroxine promotes association of mitogen-activated protein kinase and nuclear thyroid hormone receptor (TR) and causes serine phosphorylation of TR. J Biol Chem 275: 38032-38039, 2000.
10. Dean JLE, Sully G, Clark AR, and Saklatvala J. The involvement of AU-rich element-binding proteins in p38 mitogen-activated protein kinase pathway-mediated mRNA stabilization. Cell Signal 16: 1113-1121, 2004.
11. Decock JBJ, Gillespie-Brown J, Parker PJ, Sugden PH, and Fuller SJ. Classical, novel and atypical isoforms of PKC stimulate ANF- and TRE/AP-1-regulated-promoter activity in ventricular cardiomyocytes. FEBS Lett 356: 275-278, 1994.
12. Dorn IIGW and Force T. Protein kinase cascades in the regulation of cardiac hypertrophy. J Clin Invest 115: 527-537, 2005.
13. Dorn IIGW, Robbins J, and Sugden PH. Phenotyping hypertrophy. Eschew obfuscation. Circ Res 92: 1171-1175, 2003.
14. Friesema ECH, Ganguly S, Abdalla A, Fox JEM, Halestrap AP, and Visser TJ. Identification of monocarboxylate transporter 8 as a specific thyroid hormone transporter. J Biol Chem 278: 40128-40135, 2003.
15. Frodin M and Gammeltoft S. Role and regulation of 90-kDa ribosomal S6 kinase (RSK) in signal transduction. Mol Cell Endocrinol 151: 65-77, 1999.
16. Hahn HS, Marreez Y, Odley A, Sterbling A, Yussman MG, Hilty KC, Bodi I, Liggett SB, Schwartz A, and Dorn GW II. Protein kinase C-α negatively regulates systolic and diastolic function in pathological hypertrophy. Circ Res 93: 1111-1119, 2003.
17. Heidkamp MC, Bayer AL, Martin JL, and Samarel AM. Differential activation of mitogen-activated protein kinase cascades and apoptosis by protein kinase-C, -ε, and -δ in neonatal rat ventricular myocytes. Circ Res 89: 882-890, 2001.
18. Hu RM, Wu LM, Frank HJ, Pedram A, and Levin ER. Insulin stimulates thyroid hormone receptor-α gene expression in cultured bovine aortic endothelial cells. Mol Cell Endocrinol 103: 65-71, 1994.
19. Inagaki K, Chen L, Ikeno F, Lee FH, Imahashi K, Bouley DM, Rezaee M, Yock PG, Murphy E, and Mochley-Rosen D. Inhibition of δ-protein kinase C protects against reperfusion injury of the ischemic heart in vivo. Circulation 108: 2304-2307, 2003.
20. Kahaly GJ and Dillmann WH. Thyroid hormone action in the heart. Endocrinol Rev 26: 704-728, 2005.
21. Kenessey A and Ojamaa K. Ligand-mediated decrease of thyroid hormone receptor-α1 in cardiomyocytes by proteosome-dependent degradation and altered mRNA stability. Am J Physiol Heart Circ Physiol 288: H813-H821, 2005.
22. Kinugawa K, Jeong MY, Bristow MR, and Long CS. Thyroid hormone induces cardiac hypertrophy in a TRα1-specific manner that requires TAK1 and p38 MAPK. Mol Endocrinol 19: 1618-1628, 2005.
23. Kinugawa K, Minobe WA, Wood WM, Ridgway EC, Baxter JD, Ribeiro RCJ, Tawadrous MF, Lower BA, Long CS, and Bristow MR. Signaling pathways responsible for fetal gene induction in the failing human heart. Evidence for altered thyroid hormone receptor gene expression. Circulation 103: 1089-1094, 2001.
24. Kinugawa K, Yonekura K, Ribeiro RCJ, Eto Y, Aoyagi T, Baxter JD, Camacho SA, Bristow MR, Long CS, and Simpson PC. Regulation of thyroid hormone receptor isoforms in physiological and pathological cardiac hypertrophy. Circ Res 89: 591-598, 2001.
25. Klein I and Ojamaa K. Thyroid hormone and the cardiovascular system. N Engl J Med 344: 501-509, 2001.
26. Kotlyarov A and Gaestel M. Is MK2 (mitogen-activated protein kinase-activated protein kinase 2) the key for understanding posttranscriptional regulation of gene expression? Biochem Soc Trans 30: 959-963, 2002.
27. Laudet A, Vanacker JM, Adelmant G, Begue A, and Stehelin D. Characterization of a functional promoter for the human thyroid hormone receptor-α (c-erbA-1) gene. Oncogene 8: 975-982, 1993.
28. Lazar J, Desvergne B, Zimmerman EC, Zimmer DB, Magnuson MA, and Nikodem VM. A role for intronic sequences on expression of thyroid hormone receptor-α gene. J Biol Chem 269: 20352-20359, 1994.
29. Malhotra A, Kang BP, Opawumi D, Belizaire W, and Meggs LG. Molecular biology of protein kinase C signaling in cardiac myocytes. Mol Cell Biochem 225: 97-107, 2001.
30. Miyata S, Minobe W, Bristow MR, and Leinwand LA. Myosin heavy chain isoform expression in the failing and nonfailing human heart. Circ Res 86: 386-390, 2000.
31. Mochly-Rosen D, Wu G, Hahn H, Osinska H, Liron T, Lorenz JN, Yatani A, Robbins J, and Dorn GW II. Cardiotrophic effects of protein kinase Cε. Analysis by in vivo modulation of PKCε translocation. Circ Res 86: 1173-1179, 2000.
32. Morkin E, Ladenson P, Goldman S, and Adamson C. Thyroid hormone analogs for treatment of hypercholesterolemia and heart failure: past, present and future prospects. J Mol Cell Cardiol 37: 1137-1146, 2004.
33. Ojamaa K, Ascheim D, Hryniewicz K, and Klein I. Thyroid hormone therapy of cardiovascular disease. Cardiovasc Rev Rep 23: 20-26, 2002.
34. Ojamaa K, Kenessey A, Shenoy R, and Klein I. Thyroid hormone metabolism and cardiac gene expression after acute myocardial infarction in the rat. Am J Physiol Endocrinol Metab 279: E1319-E1324, 2000.
35. Rybin V and Steinberg SF. Thyroid hormone represses protein kinase C isoform expression and activity in rat cardiac myocytes. Circ Res 79: 388-398, 1996.
36. Sabri A and Steinberg SF. Protein kinase C isoform-selective signals that lead to cardiac hypertrophy and the progression of heart failure. Mol Cell Biochem 251: 97-101, 2003.
37. Steinberg SF, Goldberg M, and Rybin VO. Protein kinase C isoform diversity in the heart. J Mol Cell Cardiol 27: 141-153, 1995.
38. Strait JB III, Martin JL, Bayer A, Mestril R, Eble DM, and Samarel AM. Role of protein kinase C-ε in hypertrophy of cultured neonatal rat ventricular myocytes. Am J Physiol Heart Circ Physiol 280: H756-H766, 2001.
39. Sylven C, Jansson E, Sotonyi P, Waagstein F, Barkhem T, and Bronnegard M. Cardiac nuclear hormone receptor mRNA in heart failure in man. Life Sci 59: 1917-1922, 1996.
40. Tchen CR, Brook M, Saklatvala J, and Clark AR. The stability of tristetraprolin mRNA is regulated by mitogen-activated protein kinase p38 and by tristetraprolin itself. J Biol Chem 279: 32393-32400, 2004.
41. Vijayan K, Szotek EL, Martin JL, and Samarel AM. Protein kinase C-α-induced hypertrophy of neonatal rat ventricular myocytes. Am J Physiol Heart Circ Physiol 287: H2777-H2789, 2004.
42. Wang J, Liu X, Sentex E, Takeda M, and Dhalla NS. Increased expression of protein kinase C isoforms in heart failure due to myocardial infarction. Am J Physiol Heart Circ Physiol 284: H2277-H2287, 2003.
43. Wassen FWJS, Schiel AE, Kuiper GGJM, Kaptein E, Bakker O, Visser TJ, and Simonides WS. Induction of thyroid hormone-degrading deiodinase in cardiac hypertrophy and failure. Endocrinology 143: 2812-2815, 2002.