Nuclear targeting of Akt enhances ventricular function and myocyte contractility

Circulation Research

Volumn 97, Issue 12, 2005, Pages 1332-1341

  Rota, Marcello ^a   Boni, Alessandro ^a   Urbanek, Konrad ^a   Padin Iruegas, Maria Elena ^a   Kajstura, Tymoteusz J ^a   Fiore, Giuseppe ^a   Kubo, Hajime ^b   Sonnenblick, Edmund H ^a   Musso, Ezio ^a,d   Houser, Steve R ^b   Leri, Annarosa ^a   Sussman, Mark A ^c   Anversa, Piero ^a  

^a NEW YORK MEDICAL COLLEGE   (United States)

^b TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c SAN DIEGO STATE UNIVERSITY   (United States)

^d Tardini Olivetti Stem Cell Center   (Italy)

Author keywords

Akt; Myocyte mechanics; Myocyte size and number

Indexed keywords

ADENOSINE TRIPHOSPHATASE (CALCIUM); CALCIUM ION; CYCLIC AMP DEPENDENT PROTEIN KINASE; PHOSPHOLAMBAN; PHOSPHOPROTEIN PHOSPHATASE 1; PROTEIN KINASE B; REGULATOR PROTEIN; CALCIUM; CALCIUM BINDING PROTEIN; CALCIUM CHANNEL L TYPE; RYANODINE RECEPTOR; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE; SODIUM CALCIUM EXCHANGE PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CALCIUM METABOLISM; CALCIUM TRANSPORT; CARDIOMYOPATHY; CELL COUNT; CELL NUCLEUS; CELL VOLUME; CONTROLLED STUDY; CYTOPLASM; DIASTOLE; ELECTRIC ACTIVITY; ENZYME ACTIVITY; GENE OVEREXPRESSION; HEART MUSCLE CELL; HEART MUSCLE CONTRACTILITY; HEART SIZE; HEART VENTRICLE FUNCTION; HEART VENTRICLE HYPERTROPHY; HEART VENTRICLE PERFORMANCE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; PROTEIN TARGETING; SARCOPLASMIC RETICULUM; SYSTOLE; TRANSGENIC MOUSE; ANIMAL; CYTOLOGY; HEART CONTRACTION; METABOLISM; MICROFILAMENT; PHOSPHORYLATION; PHYSIOLOGY; SARCOMERE;

ANIMALS; CALCIUM; CALCIUM CHANNELS, L-TYPE; CALCIUM-BINDING PROTEINS; CALCIUM-TRANSPORTING ATPASES; CELL NUCLEUS; MICE; MICE, TRANSGENIC; MICROFILAMENTS; MYOCARDIAL CONTRACTION; MYOCYTES, CARDIAC; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RYANODINE RECEPTOR CALCIUM RELEASE CHANNEL; SARCOMERES; SARCOPLASMIC RETICULUM; SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES; SODIUM-CALCIUM EXCHANGER; VENTRICULAR FUNCTION;

EID: 33644699984     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.0000196568.11624.ae     Document Type: Article

References (39)

1. Webster KA. Aktion in the nucleus. Circ Res. 2004;94:856-859.
2. Jessup M, Brozena S. Heart failure. N Engl J Med. 2003;348:2007-2018.
3. Morisco C, Zebrowski D, Condorelli G, Tsichlis P, Vatner SF, Sadoshima J. The Akt-glycogensynthase kinase 3β pathway regulates transcription of atrial natriuretic factor induced by β-adrenergic receptor stimulation in cardiac myocytes. J Biol Chem. 2000;275:14466-14475.
4. Shioi T, Kang PM, Douglas PS, Hampe J, Yballe CM, Lawitts J, Cantley LC, Izumo S. The conserved phosphoinositide 3-kinase pathway determines heart size in mice. EMBO J. 2000;19:2537-2548.
5. Shioi T, McMullen JR, Kang PM, Douglas PS, Obata T, Franke TF, Cantley LC, Izumo S. Akt/protein kinase B promotes organ growth in transgenic mice. Mol Cell Biol. 2002;22:2799-27809.
6. Matsui T, Li L, Wu JC, Cook SA, Nagoshi T, Picard MH, Liao R, Rosenzweig A. Phenotypic spectrum caused by transgenic overexpression of activated Akt in the heart. J Biol Chem. 2002;277:22896-22901.
7. Condorelli G, Drusco A, Stassi G, Bellacosa A, Roncarati R, Iaccarino G, Russo MA, Gu Y, Dalton N, Chung C, Latronico MV, Napoli C, Sadoshima J, Croce CM, Ross J Jr. Akt induces enhanced myocardial contractility and cell size in vivo in transgenic mice. Proc Natl Acad Sci U S A. 2002;99:12333-12338.
8. Shiraishi I, Melendez J, Ahn Y, Skavdahl M, Murphy E, Welch S, Schaefer E, Walsh K, Rosenzweig A, Torella D, Nurzynska D, Kajstura J, Leri A, Anversa P, Sussman MA. Nuclear targeting of Akt enhances kinase activity and survival of cardiomyocytes. Circ Res. 2004;94:884-891.
9. Takaishi H, Konishi H, Matsuzaki H, Ono Y, Shirai Y, Saito N, Kitamura T, Ogawa W, Kasuga M, Kikkawa U, Nishizuka Y. Regulation of nuclear translocation of forkhead transcription factor AFX by protein kinase B. Proc Natl Acad Sci U S A. 1999;96:11836-11841.
10. Koh H, Jee K, Lee B, Kim J, Kim D, Yun YH, Kim JW, Choi HS, Chung J. Cloning and characterization of a nuclear S6 kinase, S6 kinase-related kinase (SRK): a novel nuclear target of Akt. Oncogene. 1999;18:5115-5119.
11. Du K, Montminy M. CREB is a regulatory target for the protein kinase Akt/PKB. J Biol Chem. 1998;273:32377-32379.
12. Kim YK, Kim SJ, Yatani A, Huang Y, Castelli G, Vatner DE, Liu J, Zhang Q, Diaz G, Zieba R, Thaisz J, Drusco A, Croce C, Sadoshima J, Condorelli G, Vatner SF. Mechanism of enhanced cardiac function in mice with hypertrophy induced by overexpression Akt. J Biol Chem. 2003;278:47622-47628.
13. Benjamin EJ, Levy D. Why is left ventricular hypertrophy so predictive of morbidity and mortality? Am J Med Sci. 1999;317:168-175.
14. Limana F, Urbanek K, Chimenti S, Quaini F, Leri A, Kajstura J, Nadal-Ginard B, Izumo S, Anversa P. bcl-2 overexpression promotes myocyte proliferation. Proc Natl Acad Sci U S A. 2002;99:6257-6262.
15. Beltrami AP, Barlucchi L, Torella D, Baker M, Limana F, Chimenti S, Kasahara H, Rota M, Musso E, Urbanek K, Leri A, Kajstura J, Nadal-Ginard B, Anversa P. Adult cardiac stem cells are multipotent and support myocardial regeneration. Cell. 2003;114:763-776.
16. Torella D, Rota M, Nurzynska D, Musso E, Monsen A, Shiraishi I, Zias E, Walsh K, Rosenzweig A, Sussman MA, Urbanek K, Nadal-Ginard B, Kajstura J, Anversa P, Leri A. Cardiac stem cell and myocyte aging, heart failure, and insulin-like growth factor-1 overexpression. Circ Res. 2004;94:514-524.
17. Bers DM. Cardiac excitation-contraction coupling. Nature. 2002;415:198-205.
18. i transients in mouse ventricular myocytes. J Physiol. 2002;543:889-898.
19. Fabiato A. Calcium-induced release of calcium from the cardiac sarcoplasmic reticulum. Am J Physiol. 1983;245:C1-C14.
20. Rota M, Vassalle M. Patch-clamp analysis in canine cardiac Purkinje cells of a novel sodium component in the pacemaker range. J Physiol. 2003;548:147-165.
21. MacLennan DH, Kranias EG. Phospholamban: a crucial regulator of cardiac contractility. Nat Rev Mol Cell Biol. 2003;4:566-577.
22. 2+)-ATPase. J Biol Chem. 1991;266:11270-11275.
23. Le Peuch CJ, Haiech J, Demaille JG. Concerted regulation of cardiac sarcoplasmic reticulum calcium transport by cyclic adenosine monophosphate dependent and calcium-calmodulin-dependent phosphorylations. Biochemistry. 1979;18:5150-5157.
24. Macdougal LK, Jones LR, Cohen P. Identification of the major protein phosphatases in mammalian cardiac muscle which dephosphorylate phospholamban. Eur J Biochem. 1991;196:725-734.
25. Braz JC, Gregory K, Pathak A, Zhou W, Sahin B, Klevitsky R, Kimball TF, Lorenz JN, Nairn AC, Liggett SB, Bodi I, Wang S, Schwartz A, Lakatta EG, DePaoli-Roach AA, Robbins J, Hewitt TE, Bibb JA, Westfall MV, Kranias EG, Molkentin JD. PKC-alpha regulates cardiac contractility and propensity toward heart failure. Nat Med. 2004;10:248-254.
26. Morano I. Effects of different expression and posttranslational modifications of myosin light chains on contractility of skinned human cardiac fibers. Basic Res Cardiol. 1992;87:129-141.
27. 2+- stimulated actomyosin MgATPase activity. Biochem Biophys Res Commun. 1993;193:254-260.
28. Reiss K, Cheng W, Ferber A, Kajstura J, Li P, Li B, Olivetti G, Homey CJ, Baserga R, Anversa P. Overexpression of insulin-like growth factor-1 in the heart is coupled with myocyte proliferation in transgenic mice. Proc Natl Acad Sci U S A. 1996;93:8630-8635.
29. Musaro A, Giacinti C, Borsellino G, Dobrowolny G, Pelosi L, Cairns L, Ottolenghi S, Cossu G, Bernardi G, Battistini L, Molinaro M, Rosenthal N. Stem cell-mediated muscle regeneration is enhanced by local isoform of insulin-like growth factor 1. Proc Natl Acad Sci U S A. 2004;101:1206-1210.
30. Shiojima I, Yefremashvili M, Luo Z, Kureishi Y, Takahashi A, Tao J, Rosenzweig A, Kahn CR, Abel ED, Walsh K. Akt signaling mediates postnatal heart growth in response to insulin and nutritional status. J Biol Chem. 2002;277:37670-37677.
31. Wehrens XHT, Lehnart SE, Reiken SR, Deng SX, Vest JA, Cervantes D, Coromilas J, Landry DW, Marks AR. Protection from cardiac arrhythmia through ryanodine receptor-stabilizing protein calstabin2. Science. 2004;304:292-296.
32. Piacentino V 3rd, Weber CR, Chen X, Weisser-Thomas J, Margulies KB, Bers DM, Houser SR. Cellular basis of abnormal calcium transients of failing human ventricular myocytes. Circ Res. 2003;92:651-658.
33. Redaelli G, Malhorta A, Li B, Li P, Sonnenblick EH, Hofmann PA, Anversa P. Effects of constitutive overexpression of insulin-like growth factor-1 on the mechanical characteristics and molecular properties of ventricular myocytes. Circ Res. 1998;82:594-603.
34. Communal C, Singh K, Pimentel DR, Colucci WS. Norepinephrine stimulates apoptosis in adult rat ventricular myocytes by activation of the β-adrenergic pathway. Circulation. 1998;98:1329-1334.
35. Ahmet I, Krawczyk M, Heller P, Moon C, Lakatta EG, Talan MI. Beneficial effects of chronic pharmacological manipulation of beta-adre-noreceptor subtype signaling in rodent dilated ischemic cardiomyopathy. Circulation. 2004;110:1083-1090.
36. Satwani S, Dec GW, Narula J. Beta-adrenergic blockers in heart failure: review of mechanisms of action and clinical outcomes. J Cardiovasc Pharmacol Ther. 2004;9:243-255.
37. Hasenfuss G, Pieske B. Calcium cycling in congestive heart failure. J Mol Cell Cardiol. 2002;34:951-969.
38. Furuya Y, Lundmo P, Short AD, Gill DL, Isaacs JT. The role of calcium, pH, and cell proliferation in the programmed (apoptotic) death of androgen-independent prostatic cancer cells induced by thapsigargin. Cancer Res. 1994;54:6167-6175.
39. Kajstura J, Fiordaliso F, Andreoli AM, Li B, Chimenti S, Medow MS, Limana F, Nadal-Ginard B, Leri A, Anversa P. IGF-1 overexpression inhibits the development of diabetic cardiomyopathy and angiotensin II-mediated oxidative stress. Diabetes. 2001;50:1414-1424.