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Volumn 4, Issue 6, 2012, Pages 665-674

Epigenetics of early-life lead exposure and effects on brain development

Author keywords

brain; development; environmental exposure; epigenetics; heavy metal; human; lead

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; DNA METHYLTRANSFERASE 1; LEAD; MESSENGER RNA; UNTRANSLATED RNA;

EID: 84871420816     PISSN: 17501911     EISSN: 1750192X     Source Type: Journal    
DOI: 10.2217/epi.12.58     Document Type: Review
Times cited : (107)

References (79)
  • 1
    • 84856490917 scopus 로고    scopus 로고
    • Panel advises tougher limits on lead exposure
    • Kuehn BM. Panel advises tougher limits on lead exposure. JAMA 307, 445 (2012).
    • (2012) JAMA , vol.307 , Issue.445
    • Kuehn, B.M.1
  • 5
    • 38149024924 scopus 로고    scopus 로고
    • Alzheimer's disease (AD)-like pathology in aged monkeys after infantile exposure to environmental metal lead (Pb): Evidence for a developmental origin and environmental link for AD
    • Wu J, Basha MR, Brock B et al. Alzheimer's disease (AD)-like pathology in aged monkeys after infantile exposure to environmental metal lead (Pb): evidence for a developmental origin and environmental link for AD. J. Neurosci. 28, 3-9 (2008).
    • (2008) J. Neurosci. , vol.28 , pp. 3-9
    • Wu, J.1    Basha, M.R.2    Brock, B.3
  • 6
    • 84861018468 scopus 로고    scopus 로고
    • Prenatal lead levels, plasma amyloid b levels, and gene expression in young adulthood
    • Mazumdar M, Xia W, Hofmann O et al. Prenatal lead levels, plasma amyloid b levels, and gene expression in young adulthood. Environ. Health Perspect. 120, 702-707 (2012).
    • (2012) Environ. Health Perspect. , vol.120 , pp. 702-707
    • Mazumdar, M.1    Xia, W.2    Hofmann, O.3
  • 7
    • 84861199523 scopus 로고    scopus 로고
    • Is lead exposure in early life an environmental risk factor for Schizophrenia? Neurobiological connections and testable hypotheses
    • Guilarte TR, Opler M, Pletnikov M. Is lead exposure in early life an environmental risk factor for Schizophrenia? Neurobiological connections and testable hypotheses. Neurotoxicology 33, 560-574 (2011).
    • (2011) Neurotoxicology , vol.33 , pp. 560-574
    • Guilarte, T.R.1    Opler, M.2    Pletnikov, M.3
  • 8
    • 12844273354 scopus 로고    scopus 로고
    • The fetal basis of amyloidogenesis: Exposure to lead and latent overexpression of amyloid precursor protein and β-amyloid in the aging brain
    • DOI 10.1523/JNEUROSCI.4335-04.2005
    • Basha MR, Wei W, Bakheet SA et al. The fetal basis of amyloidogenesis: exposure to lead and latent overexpression of amyloid precursor protein and b-amyloid in the aging brain. J. Neurosci. 25, 823-829 (2005). (Pubitemid 40170996)
    • (2005) Journal of Neuroscience , vol.25 , Issue.4 , pp. 823-829
    • Basha, M.R.1    Wei, W.2    Bakheet, S.A.3    Benitez, N.4    Siddiqi, H.K.5    Ge, Y.-W.6    Lahiri, D.K.7    Zawia, N.H.8
  • 9
    • 0033834727 scopus 로고    scopus 로고
    • Lead poisoning in a historical perspective
    • DOI 10.1002/1097-0274(200009)38:3<244::AID-AJIM3>3.0.CO;2-F
    • Hernberg S. Lead poisoning in a historical perspective. Am. J. Ind. Med. 38, 244-254 (2000). (Pubitemid 30648759)
    • (2000) American Journal of Industrial Medicine , vol.38 , Issue.3 , pp. 244-254
    • Hernberg, S.1
  • 10
    • 79960823853 scopus 로고    scopus 로고
    • The protean toxicities of lead: New chapters in a familiar story
    • Bellinger DC. The protean toxicities of lead: new chapters in a familiar story. Int. J. Environ. Res. Public Health 8, 2593-2628 (2011).
    • (2011) Int. J. Environ. Res. Public Health , vol.8 , pp. 2593-2628
    • Bellinger, D.C.1
  • 11
    • 0025637288 scopus 로고
    • Transplacental transport of lead
    • Goyer R A. Transplacental transport of lead. Environ. Health Perspect. 89, 101-105 (1990).
    • (1990) Environ. Health Perspect. , vol.89 , pp. 101-105
    • Goyer, R.A.1
  • 12
    • 35649005511 scopus 로고    scopus 로고
    • Neuropsychological function in children with blood lead levels <10 μg/dL
    • DOI 10.1016/j.neuro.2007.07.007, PII S0161813X0700157X
    • Surkan PJ, Zhang A, Trachtenberg F, Daniel DB, McKinlay S, Bellinger DC. Neuropsychological function in children with blood lead levels <10 microg/dl. Neurotoxicology 28, 1170-1177 (2007). (Pubitemid 350027806)
    • (2007) NeuroToxicology , vol.28 , Issue.6 , pp. 1170-1177
    • Surkan, P.J.1    Zhang, A.2    Trachtenberg, F.3    Daniel, D.B.4    McKinlay, S.5    Bellinger, D.C.6
  • 14
    • 44449122269 scopus 로고    scopus 로고
    • Association of prenatal and childhood blood lead concentrations with criminal arrests in early adulthood
    • Wright JP, Dietrich KN, Ris MD et al. Association of prenatal and childhood blood lead concentrations with criminal arrests in early adulthood. PLoS Med. 5, e101 (2008).
    • (2008) PLoS Med. , vol.5
    • Wright, J.P.1    Dietrich, K.N.2    Ris, M.D.3
  • 15
    • 71949107413 scopus 로고    scopus 로고
    • Confirmation and extension of association of blood lead with attention-deficit/hyperactivity disorder (ADHD) and ADHD symptom domains at population-typical exposure levels
    • Nigg JT, Nikolas M, Mark Knottnerus G, Cavanagh K, Friderici K. Confirmation and extension of association of blood lead with attention-deficit/hyperactivity disorder (ADHD) and ADHD symptom domains at population-typical exposure levels. J. Child Psychol. Psychiatry 51, 58-65 (2010).
    • (2010) J. Child Psychol. Psychiatry , vol.51 , pp. 58-65
    • Nigg, J.T.1    Nikolas, M.2    Mark Knottnerus, G.3    Cavanagh, K.4    Friderici, K.5
  • 16
    • 33845346099 scopus 로고    scopus 로고
    • Exposures to environmental toxicants and attention deficit hyperactivity disorder in U.S. children
    • DOI 10.1289/ehp.9478
    • Braun JM, Kahn RS, Froehlich T, Auinger P, Lanphear BP. Exposures to environmental toxicants and attention deficit hyperactivity disorder in U.S. children. Environ. Health Perspect. 114, 1904-1909 (2006). (Pubitemid 44873693)
    • (2006) Environmental Health Perspectives , vol.114 , Issue.12 , pp. 1904-1909
    • Braun, J.M.1    Kahn, R.S.2    Froehlich, T.3    Auinger, P.4    Lanphear, B.P.5
  • 17
    • 71049119044 scopus 로고    scopus 로고
    • Altered myelination and axonal integrity in adults with childhood lead exposure: A diffusion tensor imaging study
    • Brubaker CJ, Schmithorst VJ, Haynes EM et al. Altered myelination and axonal integrity in adults with childhood lead exposure: a diffusion tensor imaging study. Neurotoxicology 30, 867-875 (2009).
    • (2009) Neurotoxicology , vol.30 , pp. 867-875
    • Brubaker, C.J.1    Schmithorst, V.J.2    Haynes, E.M.3
  • 18
    • 44449108593 scopus 로고    scopus 로고
    • Decreased brain volume in adults with childhood lead exposure
    • Cecil KM, Brubaker CJ, Adler CM et al. Decreased brain volume in adults with childhood lead exposure. PLoS Med. 5, e112 (2008).
    • (2008) PLoS Med. , vol.5
    • Cecil, K.M.1    Brubaker, C.J.2    Adler, C.M.3
  • 20
    • 78751638665 scopus 로고    scopus 로고
    • Lead dysregulates serine/threonine protein phosphatases in human neurons
    • Rahman A, Brew BJ, Guillemin GJ. Lead dysregulates serine/threonine protein phosphatases in human neurons. Neurochem. Res. 36, 195-204 (2011).
    • (2011) Neurochem. Res. , vol.36 , pp. 195-204
    • Rahman, A.1    Brew, B.J.2    Guillemin, G.J.3
  • 21
    • 1842583585 scopus 로고    scopus 로고
    • Lead
    • Bellinger DC. Lead. Pediatrics 113, 1016-1022 (2004). (Pubitemid 38443356)
    • (2004) Pediatrics , vol.113 , Issue.4 , pp. 1016-1022
    • Bellinger, D.C.1
  • 22
    • 67651102664 scopus 로고    scopus 로고
    • Gender specific differences in neurodevelopmental effects of prenatal exposure to very low-lead levels: The prospective cohort study in three-year olds
    • Jedrychowski W, Perera F, Jankowski J et al. Gender specific differences in neurodevelopmental effects of prenatal exposure to very low-lead levels: the prospective cohort study in three-year olds. Early Hum. Dev. 85, 503-510 (2009).
    • (2009) Early Hum. Dev. , vol.85 , pp. 503-510
    • Jedrychowski, W.1    Perera, F.2    Jankowski, J.3
  • 23
    • 33947303852 scopus 로고    scopus 로고
    • Environmental lead exposure during early life alters granule cell neurogenesis and morphology in the hippocampus of young adult rats
    • DOI 10.1016/j.neuroscience.2006.12.040, PII S0306452206017374
    • Verina T, Rohde CA, Guilarte TR. Environmental lead exposure during early life alters granule cell neurogenesis and morphology in the hippocampus of young adult rats. Neuroscience 145, 1037-1047 (2007). (Pubitemid 46441646)
    • (2007) Neuroscience , vol.145 , Issue.3 , pp. 1037-1047
    • Verina, T.1    Rohde, C.A.2    Guilarte, T.R.3
  • 24
    • 79951678616 scopus 로고    scopus 로고
    • Coordinated waves of gene expression during neuronal differentiation of embryonic stem cells as basis for novel approaches to developmental neurotoxicity testing
    • Zimmer B, Kuegler PB, Baudis B et al. Coordinated waves of gene expression during neuronal differentiation of embryonic stem cells as basis for novel approaches to developmental neurotoxicity testing. Cell Death Differ. 18, 383-395 (2011).
    • (2011) Cell Death Differ. , vol.18 , pp. 383-395
    • Zimmer, B.1    Kuegler, P.B.2    Baudis, B.3
  • 25
    • 84860151670 scopus 로고    scopus 로고
    • Dysregulation of BDNF-TrkB signaling in developing hippocampal neurons by Pb (2+): Implications for an environmental basis of neurodevelopmental disorders
    • Stansfield KH, Pilsner JR, Lu Q, Wright RO, Guilarte TR. Dysregulation of BDNF-TrkB signaling in developing hippocampal neurons by Pb(2+): implications for an environmental basis of neurodevelopmental disorders. Toxicol. Sci. 127, 277-295 (2012).
    • (2012) Toxicol. Sci. , vol.127 , pp. 277-295
    • Stansfield, K.H.1    Pilsner, J.R.2    Lu, Q.3    Wright, R.O.4    Guilarte, T.R.5
  • 26
    • 84865705867 scopus 로고    scopus 로고
    • Effects of developmental lead exposure on the hippocampal transcriptome: Influences of sex, developmental period, and lead exposure level
    • Schneider J, Anderson D, Talsania K, Mettil W, Vadigepalli R. Effects of developmental lead exposure on the hippocampal transcriptome: influences of sex, developmental period, and lead exposure level. Toxicol. Sci. 129(1), 108-125 (2012).
    • (2012) Toxicol. Sci. , vol.129 , Issue.1 , pp. 108-125
    • Schneider, J.1    Anderson, D.2    Talsania, K.3    Mettil, W.4    Vadigepalli, R.5
  • 27
    • 78650993109 scopus 로고    scopus 로고
    • Molecular neurobiology of lead (Pb(2+)): Effects on synaptic function
    • Neal AP, Guilarte TR. Molecular neurobiology of lead (Pb(2+)): effects on synaptic function. Mol. Neurobiol. 42, 151-160 (2010).
    • (2010) Mol. Neurobiol. , vol.42 , pp. 151-160
    • Neal, A.P.1    Guilarte, T.R.2
  • 28
    • 70349730228 scopus 로고    scopus 로고
    • Chronic lead exposure alters presynaptic calcium regulation and synaptic facilitation in Drosophila larvae
    • He T, Hirsch HV, Ruden DM, Lnenicka GA. Chronic lead exposure alters presynaptic calcium regulation and synaptic facilitation in Drosophila larvae. Neurotoxicology 30, 777-784 (2009).
    • (2009) Neurotoxicology , vol.30 , pp. 777-784
    • He, T.1    Hirsch, H.V.2    Ruden, D.M.3    Lnenicka, G.A.4
  • 29
    • 0028059976 scopus 로고
    • Effects of maternal lead exposure on functional plasticity in the visual cortex and hippocampus of immature rats
    • DOI 10.1016/0165-3806(94)90067-1
    • Altmann L, Gutowski M, Wiegand H. Effects of maternal lead exposure on functional plasticity in the visual cortex and hippocampus of immature rats. Brain Res. Dev. Brain Res. 81, 50-56 (1994). (Pubitemid 24246410)
    • (1994) Developmental Brain Research , vol.81 , Issue.1 , pp. 50-56
    • Altmann, L.1    Gutowski, M.2    Wiegand, H.3
  • 31
    • 40849130254 scopus 로고    scopus 로고
    • Low-level human equivalent gestational lead exposure produces sex-specific motor and coordination abnormalities and late-onset obesity in year-old mice
    • DOI 10.1289/ehp.10862
    • Leasure JL, Giddabasappa A, Chaney S et al. Low-level human equivalent gestational lead exposure produces sex-specific motor and coordination abnormalities and late-onset obesity in year-old mice. Environ. Health Perspect. 116, 355-361 (2008). (Pubitemid 351395604)
    • (2008) Environmental Health Perspectives , vol.116 , Issue.3 , pp. 355-361
    • Leasure, J.L.1    Giddabasappa, A.2    Chaney, S.3    Johnson Jr., J.E.4    Pothakos, K.5    Lau, Y.S.6    Fox, D.A.7
  • 32
    • 79960816743 scopus 로고    scopus 로고
    • Reframing sexual differentiation of the brain
    • McCarthy MM, Arnold AP. Reframing sexual differentiation of the brain. Nat. Neurosci. 14, 677-683 (2011).
    • (2011) Nat. Neurosci. , vol.14 , pp. 677-683
    • McCarthy, M.M.1    Arnold, A.P.2
  • 33
    • 34249686014 scopus 로고    scopus 로고
    • Protective effect of 17-β-estradiol in human neurocellular models of lead exposure
    • DOI 10.1016/j.neuro.2006.03.012, PII S0161813X06000817, The 9th International Symposium on Neurobehavioral Methods and Effects in Occupational and Environmental Health
    • Chetty CS, Vemuri MC, Reddy GR, Suresh C. Protective effect of 17-b-estradiol in human neurocellular models of lead exposure. Neurotoxicology 28, 396-401 (2007). (Pubitemid 46843197)
    • (2007) NeuroToxicology , vol.28 , Issue.2 , pp. 396-401
    • Chetty, C.S.1    Vemuri, M.C.2    Reddy, G.R.3    Suresh, C.4
  • 34
    • 34147168824 scopus 로고    scopus 로고
    • Gender differences in the disposition and toxicity of metals
    • DOI 10.1016/j.envres.2006.08.003, PII S0013935106001745
    • Vahter M, Akesson A, Liden C, Ceccatelli S, Berglund M. Gender differences in the disposition and toxicity of metals. Environ. Res. 104, 85-95 (2007). (Pubitemid 46560490)
    • (2007) Environmental Research , vol.104 , Issue.1 , pp. 85-95
    • Vahter, M.1    Akesson, A.2    Liden, C.3    Ceccatelli, S.4    Berglund, M.5
  • 35
    • 0035200623 scopus 로고    scopus 로고
    • In vitro differentiation of transplantable neural precursors from human embryonic stem cells
    • DOI 10.1038/nbt1201-1129
    • Zhang SC, Wernig M, Duncan ID, Brustle O, Thomson JA. In vitro differentiation of transplantable neural precursors from human embryonic stem cells. Nat. Biotechnol. 19, 1129-1133 (2001). (Pubitemid 33115698)
    • (2001) Nature Biotechnology , vol.19 , Issue.12 , pp. 1129-1133
    • Zhang, S.-C.1    Wernig, M.2    Duncan, I.D.3    Brustle, O.4    Thomson, J.A.5
  • 36
    • 77953879152 scopus 로고    scopus 로고
    • Pluripotent stem cells in neurodegenerative and neurodevelopmental diseases
    • Marchetto MC, Winner B, Gage FH. Pluripotent stem cells in neurodegenerative and neurodevelopmental diseases. Hum. Mol. Genet. 19, R71-R76 (2010).
    • (2010) Hum. Mol. Genet. , vol.19
    • Marchetto, M.C.1    Winner, B.2    Gage, F.H.3
  • 37
    • 84857136772 scopus 로고    scopus 로고
    • Direct conversion of mouse fibroblasts to self-renewing, tripotent neural precursor cells
    • Lujan E, Chanda S, Ahlenius H, Sudhof TC, Wernig M. Direct conversion of mouse fibroblasts to self-renewing, tripotent neural precursor cells. Proc. Natl Acad. Sci. USA 109, 2527-2532 (2012).
    • (2012) Proc. Natl Acad. Sci. USA , vol.109 , pp. 2527-2532
    • Lujan, E.1    Chanda, S.2    Ahlenius, H.3    Sudhof, T.C.4    Wernig, M.5
  • 38
    • 79960854285 scopus 로고    scopus 로고
    • Induction of human neuronal cells by defined transcription factors
    • Pang ZP, Yang N, Vierbuchen T et al. Induction of human neuronal cells by defined transcription factors. Nature 476, 220-223 (2011).
    • (2011) Nature , vol.476 , pp. 220-223
    • Pang, Z.P.1    Yang, N.2    Vierbuchen, T.3
  • 39
    • 84869096444 scopus 로고    scopus 로고
    • DNA methylation and its basic function
    • doi:10.1038/npp.2012.112 Epub ahead of print
    • Moore LD, Le T, Fan G. DNA methylation and its basic function. Neuropsychopharmacology doi:10.1038/ npp.2012.112 (2012) (Epub ahead of print).
    • (2012) Neuropsychopharmacology
    • Moore, L.D.1    Le Fan T, G.2
  • 40
    • 79952534189 scopus 로고    scopus 로고
    • Regulation of chromatin by histone modifications
    • Bannister AJ, Kouzarides T. Regulation of chromatin by histone modifications. Cell Res. 21, 381-395 (2011).
    • (2011) Cell Res. , vol.21 , pp. 381-395
    • Bannister, A.J.1    Kouzarides, T.2
  • 41
    • 81355142141 scopus 로고    scopus 로고
    • Non-coding RNAs in human disease
    • Esteller M. Non-coding RNAs in human disease. Nat. Rev. Genet. 12, 861-874 (2011).
    • (2011) Nat. Rev. Genet. , vol.12 , pp. 861-874
    • Esteller, M.1
  • 42
    • 80755187797 scopus 로고    scopus 로고
    • Genomic imprinting: A mammalian epigenetic discovery model
    • Barlow DP. Genomic imprinting: a mammalian epigenetic discovery model. Annu. Rev. Genet. 45, 379-403 (2011).
    • (2011) Annu. Rev. Genet. , vol.45 , pp. 379-403
    • Barlow, D.P.1
  • 43
    • 80755176263 scopus 로고    scopus 로고
    • Chromosome silencing mechanisms in X chromosome inactivation: Unknown unknowns
    • Brockdorff N. Chromosome silencing mechanisms in X chromosome inactivation: unknown unknowns. Development 138, 5057-5065 (2011).
    • (2011) Development , vol.138 , pp. 5057-5065
    • Brockdorff, N.1
  • 44
    • 66149146320 scopus 로고    scopus 로고
    • Conversion of 5 methylcytosine to 5 hydroxymethylcytosine in mammalian DNA by MLL partner TET1
    • Tahiliani M, Koh KP, Shen Y et al. Conversion of 5 methylcytosine to 5 hydroxymethylcytosine in mammalian DNA by MLL partner TET1. Science 324, 930-935 (2009).
    • (2009) Science , vol.324 , pp. 930-935
    • Tahiliani, M.1    Koh, K.P.2    Shen, Y.3
  • 45
    • 34247469843 scopus 로고    scopus 로고
    • Epigenetic regulation of neural gene expression and neuronal function
    • DOI 10.1203/pdr.0b013e3180457635
    • Feng J, Fouse S, Fan G. Epigenetic regulation of neural gene expression and neuronal function. Pediatr. Res. 61, 58R-63R (2007). (Pubitemid 46653070)
    • (2007) Pediatric Research , vol.61 , Issue.5 PART 2
    • Feng, J.1    Fouse, S.2    Fan, G.3
  • 46
    • 84860608341 scopus 로고    scopus 로고
    • Genetic variation in the epigenetic machinery and mental health
    • Murgatroyd C, Spengler D. Genetic variation in the epigenetic machinery and mental health. Curr. Psychiatry Rep. 14, 138-149 (2012).
    • (2012) Curr. Psychiatry Rep. , vol.14 , pp. 138-149
    • Murgatroyd, C.1    Spengler, D.2
  • 47
    • 84862208827 scopus 로고    scopus 로고
    • Crosstalk among epigenetic pathways regulates neurogenesis
    • Jobe EM, McQuate AL, Zhao X. Crosstalk among epigenetic pathways regulates neurogenesis. Front. Neurosci. 6, 59 (2012).
    • (2012) Front. Neurosci. , vol.6 , Issue.59
    • Jobe, E.M.1    McQuate, A.L.2    Zhao, X.3
  • 48
    • 0026708177 scopus 로고
    • Targeted mutation of the DNA methyltransferase gene results in embryonic lethality
    • Li E, Bestor TH, Jaenisch R. Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell 69, 915-926 (1992).
    • (1992) Cell , vol.69 , pp. 915-926
    • Li, E.1    Bestor, T.H.2    Jaenisch, R.3
  • 49
    • 79960842090 scopus 로고    scopus 로고
    • Loss of activity-induced phosphorylation of MeCP2 enhances synaptogenesis, LTP and spatial memory
    • Li H, Zhong X, Chau KF, Williams EC, Chang Q. Loss of activity-induced phosphorylation of MeCP2 enhances synaptogenesis, LTP and spatial memory. Nat. Neurosci. 14, 1001-1008 (2011).
    • (2011) Nat. Neurosci. , vol.14 , pp. 1001-1008
    • Li, H.1    Zhong, X.2    Chau, K.F.3    Williams, E.C.4    Chang, Q.5
  • 51
    • 82255192294 scopus 로고    scopus 로고
    • 5-hmC-mediated epigenetic dynamics during postnatal neurodevelopment and aging
    • Szulwach KE, Li X, Li Y et al. 5-hmC-mediated epigenetic dynamics during postnatal neurodevelopment and aging. Nat. Neurosci. 14, 1607-1616 (2011).
    • (2011) Nat. Neurosci. , vol.14 , pp. 1607-1616
    • Szulwach, K.E.1    Li, X.2    Li, Y.3
  • 54
    • 0036897351 scopus 로고    scopus 로고
    • Histone deacetylase activity is necessary for oligodendrocyte lineage progression
    • Marin-Husstege M, Muggironi M, Liu A, Casaccia-Bonnefil P. Histone deacetylase activity is necessary for oligodendrocyte lineage progression. J. Neurosci. 22, 10333-10345 (2002). (Pubitemid 35416871)
    • (2002) Journal of Neuroscience , vol.22 , Issue.23 , pp. 10333-10345
    • Marin-Husstege, M.1    Muggironi, M.2    Liu, A.3    Casaccia-Bonnefil, P.4
  • 56
    • 84860388339 scopus 로고    scopus 로고
    • MicroRNAs in neuronal function and dysfunction
    • Im HI, Kenny PJ. MicroRNAs in neuronal function and dysfunction. Trends Neurosci. 35, 325-334 (2012).
    • (2012) Trends Neurosci. , vol.35 , pp. 325-334
    • Im, H.I.1    Kenny, P.J.2
  • 58
    • 77949357100 scopus 로고    scopus 로고
    • Histone methylation regulates memory formation
    • Gupta S, Kim SY, Artis S et al. Histone methylation regulates memory formation. J. Neurosci. 30, 3589-3599 (2010).
    • (2010) J. Neurosci. , vol.30 , pp. 3589-3599
    • Gupta, S.1    Kim, S.Y.2    Artis, S.3
  • 59
    • 84864000264 scopus 로고    scopus 로고
    • Epigenetic targets of some toxicologically relevant metals: A review of the literature
    • Cheng TF, Choudhuri S, Muldoon-Jacobs K. Epigenetic targets of some toxicologically relevant metals: a review of the literature. J. Appl. Toxicol. 32(9), 643-653 (2012).
    • (2012) J. Appl. Toxicol. , vol.32 , Issue.9 , pp. 643-653
    • Cheng, T.F.1    Choudhuri, S.2    Muldoon-Jacobs, K.3
  • 61
    • 79960112920 scopus 로고    scopus 로고
    • Environmental epigenetics in metal exposure
    • Martinez-Zamudio R, Ha HC. Environmental epigenetics in metal exposure. Epigenetics 6, 820-827 (2011).
    • (2011) Epigenetics , vol.6 , pp. 820-827
    • Martinez-Zamudio, R.1    Ha, H.C.2
  • 62
    • 84863338135 scopus 로고    scopus 로고
    • Environmental chemical exposures and human epigenetics
    • Hou L, Zhang X, Wang D, Baccarelli A. Environmental chemical exposures and human epigenetics. Int. J. Epidemiol. 41, 79-105 (2012).
    • (2012) Int. J. Epidemiol. , vol.41 , pp. 79-105
    • Hou, L.1    Zhang, X.2    Wang, D.3    Baccarelli, A.4
  • 63
    • 69949103740 scopus 로고    scopus 로고
    • Influence of prenatal lead exposure on genomic methylation of cord blood DNA. Environ
    • Pilsner JR, Hu H, Ettinger A et al. Influence of prenatal lead exposure on genomic methylation of cord blood DNA. Environ. Health Perspect. 117, 1466-1471 (2009).
    • (2009) Health Perspect. , vol.117 , pp. 1466-1471
    • Pilsner, J.R.1    Hu, H.2    Ettinger, A.3
  • 66
    • 77953281055 scopus 로고    scopus 로고
    • Biomarkers of lead exposure and DNA methylation within retrotransposons
    • Wright RO, Schwartz J, Wright RJ et al. Biomarkers of lead exposure and DNA methylation within retrotransposons. Environ. Health Perspect. 118, 790-795 (2010).
    • (2010) Environ. Health Perspect. , vol.118 , pp. 790-795
    • Wright, R.O.1    Schwartz, J.2    Wright, R.J.3
  • 67
    • 84860110624 scopus 로고    scopus 로고
    • DNA methylation changes in whole blood is associated with exposure to the environmental contaminants, mercury, lead, cadmium and bisphenol A, in women undergoing ovarian stimulation for IVF
    • Hanna CW, Bloom MS, Robinson WP et al. DNA methylation changes in whole blood is associated with exposure to the environmental contaminants, mercury, lead, cadmium and bisphenol A, in women undergoing ovarian stimulation for IVF. Hum. Reprod. 27, 1401-1410 (2012).
    • (2012) Hum. Reprod. , vol.27 , pp. 1401-1410
    • Hanna, C.W.1    Bloom, M.S.2    Robinson, W.P.3
  • 68
    • 77749234090 scopus 로고    scopus 로고
    • P16 promoter methylation in Pb2+-exposed individuals
    • Kovatsi L, Georgiou E, Ioannou A et al. p16 promoter methylation in Pb2+-exposed individuals. Clin. Toxicol. 48, 124-128 (2010).
    • (2010) Clin. Toxicol. , vol.48 , pp. 124-128
    • Kovatsi, L.1    Georgiou, E.2    Ioannou, A.3
  • 70
    • 80052599367 scopus 로고    scopus 로고
    • Epigenetic assessment of environmental chemicals detected in maternal peripheral and cord blood samples
    • Arai Y, Ohgane J, Yagi S et al. Epigenetic assessment of environmental chemicals detected in maternal peripheral and cord blood samples. J. Reprod. Dev. 57, 507-517 (2011).
    • (2011) J. Reprod. Dev. , vol.57 , pp. 507-517
    • Arai, Y.1    Ohgane, J.2    Yagi, S.3
  • 71
    • 0025081078 scopus 로고
    • The fetal and infant origins of adult disease
    • Barker DJ. The fetal and infant origins of adult disease. BMJ 301, 1111 (1990). (Pubitemid 20387183)
    • (1990) British Medical Journal , vol.301 , Issue.6761 , pp. 1111
    • Barker, D.J.P.1
  • 72
    • 84455193330 scopus 로고    scopus 로고
    • Infant exposure to lead (Pb) and epigenetic modifications in the aging primate brain: Implications for Alzheimer's disease
    • Bihaqi SW, Huang H, Wu J, Zawia NH. Infant exposure to lead (Pb) and epigenetic modifications in the aging primate brain: implications for Alzheimer's disease. J. Alzheimers Dis. 27, 819-833 (2011).
    • (2011) J. Alzheimers Dis. , vol.27 , pp. 819-833
    • Bihaqi, S.W.1    Huang, H.2    Wu, J.3    Zawia, N.H.4
  • 73
    • 84863102171 scopus 로고    scopus 로고
    • Genome-wide expression and methylation profiling in the aged rodent brain due to early-life Pb exposure and its relevance to aging
    • Dosunmu R, Alashwal H, Zawia NH. Genome-wide expression and methylation profiling in the aged rodent brain due to early-life Pb exposure and its relevance to aging. Mech. Ageing Dev. 133, 435-443 (2012).
    • (2012) Mech. Ageing Dev. , vol.133 , pp. 435-443
    • Dosunmu, R.1    Alashwal, H.2    Zawia, N.H.3
  • 74
    • 79960117245 scopus 로고    scopus 로고
    • Hypothesis: Environmental regulation of 5-hydroxymethylcytosine by oxidative stress
    • Chia N, Wang L, Lu X, Senut MC, Brenner C, Ruden DM. Hypothesis: environmental regulation of 5-hydroxymethylcytosine by oxidative stress. Epigenetics 6, 853-856 (2011).
    • (2011) Epigenetics , vol.6 , pp. 853-856
    • Chia, N.1    Wang, L.2    Lu, X.3    Senut, M.C.4    Brenner, C.5    Ruden, D.M.6
  • 75
    • 78650061153 scopus 로고    scopus 로고
    • Transgenerational epigenetic inheritance: More questions than answers
    • Daxinger L, Whitelaw E. Transgenerational epigenetic inheritance: more questions than answers. Genome Res. 20, 1623-1628 (2010).
    • (2010) Genome Res. , vol.20 , pp. 1623-1628
    • Daxinger, L.1    Whitelaw, E.2
  • 76
    • 67651005621 scopus 로고    scopus 로고
    • Co-exposure to environmental lead and manganese affects the intelligence of school-aged children
    • Kim Y, Kim BN, Hong YC et al. Co-exposure to environmental lead and manganese affects the intelligence of school-aged children. Neurotoxicology 30, 564-571 (2009).
    • (2009) Neurotoxicology , vol.30 , pp. 564-571
    • Kim, Y.1    Kim, B.N.2    Hong, Y.C.3
  • 77
    • 77956928374 scopus 로고    scopus 로고
    • Enhanced learning deficits in female rats following lifetime Pb exposure combined with prenatal stress
    • Cory-Slechta DA, Stern S, Weston D, Allen JL, Liu S. Enhanced learning deficits in female rats following lifetime Pb exposure combined with prenatal stress. Toxicol Sci. 117, 427-438 (2011).
    • (2011) Toxicol Sci. , vol.117 , pp. 427-438
    • Cory-Slechta, D.A.1    Stern, S.2    Weston, D.3    Allen, J.L.4    Liu, S.5


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